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Nanobioanalytical Approaches to Medical Diagnostics

1st Edition - June 21, 2022

Editors: Pawan Kumar Maurya, Pranjal Chandra

Paperback ISBN:

9 7 8 - 0 - 3 2 3 - 8 5 1 4 7 - 3

eBook ISBN:

9 7 8 - 0 - 3 2 3 - 8 5 1 6 5 - 7

Nanobioanalytical Approaches to Medical Diagnostics reviews a range of nanobiomaterials and bioanalytical nano-devices for medical diagnostics. Nanobiomaterials and nano-devices… Read more

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Nanobioanalytical Approaches to Medical Diagnostics reviews a range of nanobiomaterials and bioanalytical nano-devices for medical diagnostics. Nanobiomaterials and nano-devices are used in various bioanalytical and biochemical systems to provide real-time, point-of-care diagnostics. The specialized properties of nanoparticles allow them to be engineered and adapted to produce the required effect within a bioanalytical or biochemical system – offering targeted and detailed diagnostic results in a range of biomedical applications.

This book covers both traditional biochemical and modern, combined nano-approaches to medical diagnostics. Chapters detail a range of in vitro, in vivo and ex vivo models for nanobioanalytics, including DNA and peptide-based, erythrocyte, microfluidic and more. In addition, sections also look at various different medical diagnostic applications, such as in cancer detection, infectious disease diagnosis and blood glucose sensing.

Cover image
Title page
Table of Contents
Copyright
Contributors
Preface
Chapter 1: Prospects of fluidic force microscopy and related biosensors for medical applications
Abstract
Acknowledgments
1.1: Atomic force microscopy
1.2: Cell biology with AFM
1.3: Fluidic force microscopy
1.4: Single-cell force spectroscopy by FluidFM
1.5: Bacterial adhesion measured by FluidFM
1.6: Eukaryotic cell adhesion
1.7: Additional fluidic force microscopy functions
1.8: Measurements by computer-controlled micropipette
1.9: Label-free biosensors for cell adhesion analysis
1.10: Summary
References
Chapter 2: Point of care diagnostics for cancer: Recent trends and challenges
Abstract
Acknowledgments
2.1: Introduction
2.2: Role of biomarkers in the detection of cancer
2.3: Point-of-care diagnostics for cancer
2.4: Conclusion and future perspectives
References
Chapter 3: Bioelectrochemical methods in biomolecular analysis
Abstract
3.1: Introduction
3.2: Types of bioelectrochemical methods for bimolecular analysis: Working mechanism
3.3: Application of bioelectrochemical system based biosensor
3.4: Bioelectrochemical methods for cell analysis
3.5: Bioelectrochemical methods for cell analysis
3.6: Bioelectrochemical methods for cell culture fabrication and cell stimulation
3.7: Prospective and future trends
References
Chapter 4: Electrochemical nano-aptasensor as potential diagnostic device for thrombin
Abstract
4.1: Introduction
4.2: Aptasensor
4.3: Thrombin
4.4: Application of electrochemical aptasensors in thrombin detection
4.5: Conclusions and future outlook
References
Chapter 5: Antibiotics and analytical methods used for their determination
Abstract
5.1: Introduction
5.2: Antibacterial drugs and the extent of their use
5.3: Conclusion
References
Chapter 6: Integration of microfluidics with biosensing technology for noncommunicable disease diagnosis
Abstract
6.1: Introduction
6.2: Biosensor technology
6.3: Microfluidics technology
6.4: Microfluidics-based biosensors
6.5: Communication technology
6.6: Conclusion
References
Chapter 7: Role and implication of nanomaterials in clinical diagnostics
Abstract
Acknowledgments
7.1: Introduction
7.2: Nanomaterials in bioimaging based diagnostics
7.3: Nanodevices
7.4: Nano-biosensors
7.5: Lateral flow assay
7.6: Safety concerns and limitations of using nanoparticle
7.7: Conclusion and future prospects
References
Chapter 8: Nano-materials in biochemical analysis
Abstract
8.1: Introduction
8.2: Classification of nanoparticles
8.3: Synthesis of nanoparticles
8.4: Functionalization of nanomaterials for biochemical applications
8.5: Biochemical applications of nanoparticles
8.6: Conclusion and future prospects
References
Chapter 9: Lignocellulose-based nanomaterials for diagnostic and therapeutic applications
Abstract
9.1: Introduction
9.2: Lignocellulose and its composition
9.3: Nanoparticles from lignocellulose
9.4: Biomedical applications of LCB nanomaterials
9.5: Conclusion and future prospects
References
Chapter 10: Bioanalytical approaches in detection of free radicals and RONS
Abstract
10.1: Introduction
10.2: Overview of ROS detection methods
10.3: Conventional ex vivo bioanalytical methods
10.4: Conventional in vivo methods
10.5: Advance methods for radical/RNOS detection
10.6: Conclusion
References
Chapter 11: Nano-biosensors for biochemical analysis
Abstract
Acknowledgments
11.1: Introduction
11.2: Biosensors
11.3: AuNP-based biosensors
11.4: Carbon nanotube based biosensors
11.5: Quantum dots based biosensors
11.6: Nanoparticles in analytical biochemistry
11.7: Nanoparticles in bioassays
11.8: Applications
11.9: Conclusion and future perspectives
References
Chapter 12: Nanobiomaterials in biomedicine: Designing approaches and critical concepts
Abstract
12.1: Introduction
12.2: Nanomaterials and it's applications in nanomedicine
12.3: Nanoparticles used in drug delivery system
12.4: Conclusion
References
Chapter 13: Erythrocytes model for oxidative stress analysis
Abstract
Authors contributions
5.1: Oxidative stress
5.2: Oxidative stress and diseases
5.3: Oxidative stress and autoimmune diseases
5.4: Oxidative stress and rheumatoid arthritis
5.5: Oxidative stress and erythrocytes
5.6: Conclusion
References
Chapter 14: Lipid film based biosensors: A protection tool for the public health
Abstract
14.1: Introduction
14.2: Construction of lipid film based nanosensors
14.3: Applications of lipid film based biosensors in clinical analysis for the protection of public health
14.4: Conclusion
References
Index

Pawan Kumar Maurya

Prof. Pawan Kumar Maurya is Dean, School of Life Long Learning & Head of Department of Biochemistry, Central University of Haryana, India. He has done a PhD from the University of Allahabad (A Central University), India & post-doctoral training from Universidade Federal de Sao Paulo-UNIFESP, Brazil; Taipei Medical University (TMU) and National Taiwan University (NTU), Taiwan. He has more than 14 years of teaching and research experience. He is working on biochemical diagnostics, nanomedicine, and clinical biochemistry. He has published over 75 research articles in reputed journals. He has also edited of six books published from Elsevier, USA and Springer-Nature, Singapore. He is recipient of prestigious fellowships: Science without Borders (Government of Brazil) and National Science Council, Taiwan.

Affiliations and expertise

Central University of Haryana, Mahendergarh (Haryana), INDIA

Pranjal Chandra

Dr. Pranjal Chandra earned his Ph.D. from Pusan National University, South Korea and did post-doctoral training at Technion-Israel Institute of Technology, Israel. He has published over 85 research articles in reputed journals and 7 books. He is also a visiting scientist/Professor at IBST, South Korea. Pranjal's research contributions are highly interdisciplinary, spanning a wide range in nanobiotechnology, nanobiosensors, lab-on-chip systems for biomedical diagnostics, and nanomedicine. His work has been highlighted in the World news of Royal Society of Chemistry, Cambridge as "A new system for cancer detection” and also featured as a key scientific article in the Global Medical Discovery news Canada. He is recipient of many prestigious awards and fellowships such as; Ramanujan fellowship and Early Career Research Award (Government of India), BK -21 and NRF fellowship of South Korea, Technion post-doctoral fellowship, Israel, University of Montreal Post-doc fellowship, Canada, NMS Young scientist Award (2016) etc. He is also editorial board member of a dozen international journals including; World journal of methodology, USA; Frontiers of Biosciences, USA; Journal of Biosensors and Bioelectronics, USA etc.

Affiliations and expertise

Assistant Professor and principal investigator, School of Biochemical Engineering Indian Institute of Technology (BHU), Varanasi - Uttar Pradesh 221005, India