Myelodysplastic Syndromes, An Issue of the Clinics in Laboratory Medicine

1st Edition, Volume 43-4 - October 24, 2023
Editor: Alexa J. Siddon
Language: English
Hardback ISBN:
9 7 8 - 0 - 4 4 3 - 1 2 9 9 9 - 5
eBook ISBN:
9 7 8 - 0 - 4 4 3 - 1 3 0 0 0 - 7

In this issue of Clinics in Laboratory Medicine, guest editor Dr. Alexa J. Siddon brings her considerable expertise to the topic of Myelodysplastic Syndromes. Top experts in the… Read more

Myelodysplastic Syndromes, An Issue of the Clinics in Laboratory Medicine

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In this issue of Clinics in Laboratory Medicine, guest editor Dr. Alexa J. Siddon brings her considerable expertise to the topic of Myelodysplastic Syndromes. Top experts in the field discuss the various aspects of rare myelodysplastic syndromes and its treatments, detection, and characteristics. Topics include molecular changes in myelodysplastic syndromes; MDS with mutated SF3B1; myeloid neoplasms with mutated TP53; mimics of myelodysplastic syndromes; myeloid neoplasms with germline predisposition; and more.

Cover image
Title page
Table of Contents
Copyright
Contributors
Forthcoming Issues
Preface
Flow Cytometric Assessment of Myelodysplastic Syndromes/Neoplasms
Key points
Introduction
Normal myeloid and erythroid maturation
Population identification
Erythroid maturation
Immunophenotypic abnormalities associated with myelodysplastic syndromes/neoplasms
Abnormalities on myeloid progenitors
Abnormalities on maturing granulocytic cells
Immunophenotypic abnormalities associated with genetic aberrations
Immunophenotypic alterations in reactive/regenerative conditions
Flow cytometry in the diagnostic work up of myelodysplastic syndromes/neoplasms
Summary
Clinics care points
Conflict of interest statement
Molecular Techniques and Gene Mutations in Myelodysplastic Syndromes
Key points
Introduction
Molecular testing in myelodysplastic syndrome
Gene mutations in myelodysplastic syndrome
Discussion
Summary
Clinics care points
Funding and conflicts of interest
Premalignant Clonal Hematopoiesis (Clonal Hematopoiesis of Indeterminate Potential and Clonal Cytopenia of Undetermined Significance)
Key points
Introduction
Clinical implications of clonal hematopoiesis
Distinction from myelodysplastic syndrome and risk of progression
Therapy-Related Clonal Hematopoiesis
Unique clonal cytopenia syndromes
Discussion
Summary
Clinics care points
Disclosure
Funding
Morphologic Characteristics of Myelodysplastic Syndromes
Key points
Introduction
Role of morphology in diagnosis
Components of the morphologic evaluation
Features of dysplasia
Differential diagnosis for morphologic dysplasia
Classification of myelodysplastic syndromes
Impact of morphologic findings on prognosis and classification
Summary
Clinics care points
Significance of SF3B1 Mutations in Myeloid Neoplasms
Key points
Introduction
SF3B1 gene
Alternative clonal and nonclonal causes of ring sideroblasts
Classification changes from 2016 to now
Prognostic and treatment implications of SF3B1 mutations
Other myeloid neoplasms that can present with ring sideroblasts or SF3B1 mutations
Summary
Clinics care points
Contributions
Funding
Diagnosis and Classification of Myelodysplastic Syndromes with Mutated TP53
Key points
Introduction
Biology of TP53 in hematopoiesis
TP53 mutations in myelodysplastic syndromes and acute myeloid leukemia
Summary
Clinics care points
Funding and conflicts of interest
Germline Predisposition to Myeloid Neoplasms: Diagnostic Concepts and Classifications
Key points
Introduction
Hematologic neoplasms with germline predisposition without a constitutional disorder affecting multiple organ systems
Hematologic neoplasms with germline predisposition associated with a constitutional platelet disorder
Hematologic neoplasms with germline predisposition associated with a constitutional disorder affecting multiple organ systems
Summary
Clinics care points
Conflict of interest statement
Childhood Myelodysplastic Syndrome
Key points
Introduction/classification
Epidemiology
Presentation and laboratory findings
Morphology
Immunophenotype
Cytogenetics
Molecular findings
Prognosis
Therapeutic options
Differential diagnosis
Summary
Clinics care points
Disclosure
Acute Myeloid Leukemia Arising from Myelodysplastic Syndromes
Key points
Introduction and history
Incidence
Morphologic features
Genetic and molecular features
Clinical therapies
Summary
Clinics care points
Transfusion Support of Patients with Myelodysplastic Syndromes
Key points
Introduction
Summary
Clinics care points
Disclosure
Treatment Considerations of Myelodysplastic Syndromes/Neoplasms for Pathologists
Key points
Goals
Introduction
How pathologists and clinicians should collaborate to better therapeutic decisions in myelodysplastic syndromes?
Summary
Future directions
Clinics care points
Disclosure

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Myelodysplastic Syndromes, An Issue of the Clinics in Laboratory Medicine

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Alexa J. Siddon