Myelodysplastic Syndromes, An Issue of the Clinics in Laboratory Medicine
- 1st Edition, Volume 43-4 - October 24, 2023
- Editor: Alexa J. Siddon
- Language: English
- Hardback ISBN:9 7 8 - 0 - 4 4 3 - 1 2 9 9 9 - 5
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 1 3 0 0 0 - 7
In this issue of Clinics in Laboratory Medicine, guest editor Dr. Alexa J. Siddon brings her considerable expertise to the topic of Myelodysplastic Syndromes. Top experts in the… Read more
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Request a sales quoteIn this issue of Clinics in Laboratory Medicine, guest editor Dr. Alexa J. Siddon brings her considerable expertise to the topic of Myelodysplastic Syndromes. Top experts in the field discuss the various aspects of rare myelodysplastic syndromes and its treatments, detection, and characteristics. Topics include molecular changes in myelodysplastic syndromes; MDS with mutated SF3B1; myeloid neoplasms with mutated TP53; mimics of myelodysplastic syndromes; myeloid neoplasms with germline predisposition; and more.
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Contains 12 practice-oriented topics including premalignant clonal hematopoiesis (CHIP and CCUS); morphologic characteristics of MDS; acute leukemia arising from MDS; treatment considerations of MDS for pathologists; and more.
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Provides in-depth clinical reviews on myelodysplastic syndromes, offering actionable insights for clinical practice.
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Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.
Oncologists
- Cover image
- Title page
- Table of Contents
- Copyright
- Contributors
- Forthcoming Issues
- Preface
- Flow Cytometric Assessment of Myelodysplastic Syndromes/Neoplasms
- Key points
- Introduction
- Normal myeloid and erythroid maturation
- Population identification
- Erythroid maturation
- Immunophenotypic abnormalities associated with myelodysplastic syndromes/neoplasms
- Abnormalities on myeloid progenitors
- Abnormalities on maturing granulocytic cells
- Immunophenotypic abnormalities associated with genetic aberrations
- Immunophenotypic alterations in reactive/regenerative conditions
- Flow cytometry in the diagnostic work up of myelodysplastic syndromes/neoplasms
- Summary
- Clinics care points
- Conflict of interest statement
- Molecular Techniques and Gene Mutations in Myelodysplastic Syndromes
- Key points
- Introduction
- Molecular testing in myelodysplastic syndrome
- Gene mutations in myelodysplastic syndrome
- Discussion
- Summary
- Clinics care points
- Funding and conflicts of interest
- Premalignant Clonal Hematopoiesis (Clonal Hematopoiesis of Indeterminate Potential and Clonal Cytopenia of Undetermined Significance)
- Key points
- Introduction
- Clinical implications of clonal hematopoiesis
- Distinction from myelodysplastic syndrome and risk of progression
- Therapy-Related Clonal Hematopoiesis
- Unique clonal cytopenia syndromes
- Discussion
- Summary
- Clinics care points
- Disclosure
- Funding
- Morphologic Characteristics of Myelodysplastic Syndromes
- Key points
- Introduction
- Role of morphology in diagnosis
- Components of the morphologic evaluation
- Features of dysplasia
- Differential diagnosis for morphologic dysplasia
- Classification of myelodysplastic syndromes
- Impact of morphologic findings on prognosis and classification
- Summary
- Clinics care points
- Significance of SF3B1 Mutations in Myeloid Neoplasms
- Key points
- Introduction
- SF3B1 gene
- Alternative clonal and nonclonal causes of ring sideroblasts
- Classification changes from 2016 to now
- Prognostic and treatment implications of SF3B1 mutations
- Other myeloid neoplasms that can present with ring sideroblasts or SF3B1 mutations
- Summary
- Clinics care points
- Contributions
- Funding
- Diagnosis and Classification of Myelodysplastic Syndromes with Mutated TP53
- Key points
- Introduction
- Biology of TP53 in hematopoiesis
- TP53 mutations in myelodysplastic syndromes and acute myeloid leukemia
- Summary
- Clinics care points
- Funding and conflicts of interest
- Germline Predisposition to Myeloid Neoplasms: Diagnostic Concepts and Classifications
- Key points
- Introduction
- Hematologic neoplasms with germline predisposition without a constitutional disorder affecting multiple organ systems
- Hematologic neoplasms with germline predisposition associated with a constitutional platelet disorder
- Hematologic neoplasms with germline predisposition associated with a constitutional disorder affecting multiple organ systems
- Summary
- Clinics care points
- Conflict of interest statement
- Childhood Myelodysplastic Syndrome
- Key points
- Introduction/classification
- Epidemiology
- Presentation and laboratory findings
- Morphology
- Immunophenotype
- Cytogenetics
- Molecular findings
- Prognosis
- Therapeutic options
- Differential diagnosis
- Summary
- Clinics care points
- Disclosure
- Acute Myeloid Leukemia Arising from Myelodysplastic Syndromes
- Key points
- Introduction and history
- Incidence
- Morphologic features
- Genetic and molecular features
- Clinical therapies
- Summary
- Clinics care points
- Transfusion Support of Patients with Myelodysplastic Syndromes
- Key points
- Introduction
- Summary
- Clinics care points
- Disclosure
- Treatment Considerations of Myelodysplastic Syndromes/Neoplasms for Pathologists
- Key points
- Goals
- Introduction
- How pathologists and clinicians should collaborate to better therapeutic decisions in myelodysplastic syndromes?
- Summary
- Future directions
- Clinics care points
- Disclosure
- No. of pages: 240
- Language: English
- Edition: 1
- Volume: 43-4
- Published: October 24, 2023
- Imprint: Elsevier
- Hardback ISBN: 9780443129995
- eBook ISBN: 9780443130007
AS
Alexa J. Siddon
Affiliations and expertise
Associate Professor, Departments of Laboratory Medicine & Pathology, Hematopathology Fellowship Director, Medical Director, Molecular Diagnostics Laboratory, Medical Director, Clinical Flow Cytometry Laboratory, Yale University School of Medicine