Muscle Biopsy: A Practical Approach
Expert Consult; Online and Print
- 3rd Edition - October 6, 2006
- Latest edition
- Authors: Victor Dubowitz, Caroline A. Sewry
- Language: English
Highly Commended, RSM Awards 2007Highly Commended, Basic and Clinical Sciences, BMA Awards 2007In this book, Professor Victor Dubowitz manages to bridge the gap between clinical sy… Read more
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Description
Description
Highly Commended, RSM Awards 2007
Highly Commended, Basic and Clinical Sciences, BMA Awards 2007
In this book, Professor Victor Dubowitz manages to bridge the gap between clinical syndromes/disorders and their underlying pathologies. An internationally renowned figure in the field of muscle disease, Professor Dubowitz skillfully guides you through the complexities of pathologic diagnoses and their implications for clinical treatment. This reference describes the techniques of obtaining a muscle biopsy and examines the histochemical, histological, electron microscopical and molecular appearance of normal muscle and the pathology of individual muscle disease.
Highly Commended, Basic and Clinical Sciences, BMA Awards 2007
In this book, Professor Victor Dubowitz manages to bridge the gap between clinical syndromes/disorders and their underlying pathologies. An internationally renowned figure in the field of muscle disease, Professor Dubowitz skillfully guides you through the complexities of pathologic diagnoses and their implications for clinical treatment. This reference describes the techniques of obtaining a muscle biopsy and examines the histochemical, histological, electron microscopical and molecular appearance of normal muscle and the pathology of individual muscle disease.
Key features
Key features
- Covers the entire range of diagnostic/investigative techniques, providing you with all of the necessary tools to formulate an accurate diagnosis.
- Offers a combination of clinical and pathological experience for a unique perspective on a complex and difficult area of diagnosis.
- Addresses the "knowledge explosion" over the last 10 years in the fields of molecular genetics and immunocytochemistry, including all of the latest clinically relevant investigative techniques.
- Focuses on diagnostic techniques and on the diagnostic interpretation of results, giving you a portable reference book and a bench book in a single volume.
Readership
Readership
Neuropathologists, Neurologists, Pathologists, Residents, Fellows, and Health Science Libraries
Table of contents
Table of contents
Section 1 The Biopsy: Normal and Diseased Muscle
1. The procedure of muscle biopsy
2. Histological and histochemical stains and reactions
3. Normal muscle
4. Definition of pathological changes seen in muscle biopsies
5. Ultrastructural changes in diseased muscle
6. Immunohistochemistry
7. How to read a biopsy
Section 2 Pathological Muscle: Individual Diseases
8. Classification of neuromuscular disorders
9. Neurogenic disorders
10. Muscular dystrophies and allied disorders I: Duchenne and Becker muscular dystrophy
11. Muscular dystrophies and allied disorders II: limb-girdle muscular dystrophies
12. Muscular dystrophies and allied disorders III: congenital muscular dystrophies
13. Muscular dystrophies and allied disorders IV: Emeryƒ{Driefuss muscular dystrophies and Bethlem myopathy
14. Muscular dystrophies and allied disorders V: facioscapulohumeral dystrophy, myotonic dystrophy, oculopharyngeal muscular dystrophy
15. Congenital myopathies
16. Myofibrillar myopathies
17. Metabolic myopathies I: glycogenoses
18. Metabolic myopathies II: lipid related disorders and mitochondrial myopathies
19. Endocrine disorders
20. Ion channel disorders
21. Myasthenic syndromes
22. Inflammatory myopathies
23. Toxic and drug-induced myopathies
Russell Lane, Charing Cross Hospital
Appendix 1. Glossary of commonly used terms
References
Index
1. The procedure of muscle biopsy
2. Histological and histochemical stains and reactions
3. Normal muscle
4. Definition of pathological changes seen in muscle biopsies
5. Ultrastructural changes in diseased muscle
6. Immunohistochemistry
7. How to read a biopsy
Section 2 Pathological Muscle: Individual Diseases
8. Classification of neuromuscular disorders
9. Neurogenic disorders
10. Muscular dystrophies and allied disorders I: Duchenne and Becker muscular dystrophy
11. Muscular dystrophies and allied disorders II: limb-girdle muscular dystrophies
12. Muscular dystrophies and allied disorders III: congenital muscular dystrophies
13. Muscular dystrophies and allied disorders IV: Emeryƒ{Driefuss muscular dystrophies and Bethlem myopathy
14. Muscular dystrophies and allied disorders V: facioscapulohumeral dystrophy, myotonic dystrophy, oculopharyngeal muscular dystrophy
15. Congenital myopathies
16. Myofibrillar myopathies
17. Metabolic myopathies I: glycogenoses
18. Metabolic myopathies II: lipid related disorders and mitochondrial myopathies
19. Endocrine disorders
20. Ion channel disorders
21. Myasthenic syndromes
22. Inflammatory myopathies
23. Toxic and drug-induced myopathies
Russell Lane, Charing Cross Hospital
Appendix 1. Glossary of commonly used terms
References
Index
Review quotes
Review quotes
"The third edition of this book...has surpassed my expectations. The quality of the book overall is excellent, from the production and layout to the illustrations, diagrams and index. The range of muscle diseases included spans both adults and children, with an integrated approach to diagnosis including clinical, genetic, biochemical and pathological features. Overall, this book has been a highlight of the past year for me. It deserves to do very well indeed and will be of immense value beyond its target readership." BMA Awards 2007
Product details
Product details
- Edition: 3
- Latest edition
- Published: October 6, 2006
- Language: English
About the authors
About the authors
VD
Victor Dubowitz
Affiliations and expertise
Emeritus Professor of Paediatrics
Dubowitz Neuromuscular Centre
Institute of Child Health
London, UKCS
Caroline A. Sewry
Affiliations and expertise
Professor of Muscle Pathology
Dubowitz Neuromuscular Centre
Institute of Child Health/Great Ormond Street Hospital for Children
London, UK;
Wolfson Centre for Inherited Neuromuscular Diseases
Department of Musculoskeletal Pathology
Robert Jones and Agnes Hunt Orthopaedic Hospital
Oswestry, UKView book on ScienceDirect
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