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Multiscale Cell-Biomaterials Interplay in Musculoskeletal Tissue Engineering and Regenerative Medicine

  • 1st Edition - November 28, 2023
  • Latest edition
  • Editors: J. Miguel Oliveira, Rui L. Reis, Sandra Pina
  • Language: English

Multiscale Cell-Biomaterials Interplay in Musculoskeletal Tissue Engineering and Regenerative Medicine addresses the key concepts involved in the interactions between cells and… Read more

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Description

Multiscale Cell-Biomaterials Interplay in Musculoskeletal Tissue Engineering and Regenerative Medicine addresses the key concepts involved in the interactions between cells and biomaterials in the musculoskeletal tissue engineering and regenerative medicine field. The updated developments and challenges of the mechanisms/mechanobiology and structure-function properties of those interactions, as well as emerging technologies underlying tissue-engineered scaffolding, are carefully discussed. Lastly, cell engineering and cell-based therapies, growth factors/drugs properties, vascularization, immunomodulation are also outlined.

Given the large number of musculoskeletal disorders and related injuries that can affect muscles, bones and joints and lead to severe complications of the neuromuscular system, it is imperative to develop new treatment strategies to delay or repair associated diseases and to promote optimal long-term health.

Key features

  • Presents the fundamentals of the complex interplay of cells with biomaterials in musculoskeletal tissue engineering
  • Includes coverage of stem cells and cell-based therapies, in vitro and in vivo models, nanotechnology, bioprinting, computational modeling, regulatory and clinical translation, and much more
  • Written by global leaders in the field

Readership

Students, Scientists, Professionals, Undergraduate and Graduate Students in Tissue Engineering, Regenerative Medicine, Biology, Bioengineering, Materials Science, and Nanotechnology

Table of contents

Section 1: Fundamentals of cell-biomaterials interactions

1. Introduction

2. Fundamentals and mechanisms

3. Cellular signaling processes

4. Cell-protein interactions

5. The microenvironment: Recreate the ECM

6. Surface modifications – topography, porosity

7. Chemotaxis: Soluble morphogens and Growth factors

8. Cell-biomaterials: Vascularization

9. Cell-biomaterials in Immunomodulation

10. Mechanobiology regulation

11. Electrical/Magnetic stimulation

Section 2: Multiscale design, structure/function and processing technologies

12. Introduction

13. Design of polymeric biomaterials at multiscale

14. Design of Calcium phosphates cements: Structure/function

15. Biomimetic micro-/nano- scales design

16. Cells-biomaterials structure-function at different length scales

17. Computational modelling involved in multiscale design

18. Hydrogel systems design: Structure/function

19. Scaffolding design and structure/function: Electrospinning

20. Scaffolding design and structure/function: Advanced manufacturing

21. Scaffolding design and structure/function: Bioprinting

22. Dynamic models for investigating structure/function of biomaterials: Bioreactors

23. Dynamic models for investigating cell-biomaterials interactions: Microfluidics

24. Complex in vitro models for studying cell-biomaterials interactions

25. In vivo animal models 26. Regulatory and clinical translation

Product details

  • Edition: 1
  • Latest edition
  • Published: December 1, 2023
  • Language: English

About the editors

JO

J. Miguel Oliveira

J. Miguel Oliveira, BSc, PhD is the Director of Pre-Clinical Research at the FIFA MEDICAL CENTER, Estádio do Dragão, Porto, PT since Fev. 2013. Currently, he is a Lecturer in Doctoral Programme in Tissue Engineering, Regenerative Medicine and Stem Cells at UMinho, PT. He is also an Invited lecturer at the Faculty of Medicine, U. Porto (since Sept. 2013) and Dept. of Polymer Eng., UM, PT. Dr. Oliveira has published over 220 scientific contributions in scientific journals. Miguel Oliveira was approved 17 patents, published 5 books, 3 special issue in scientific journals, and more than 90 book chapters in books with international circulation. In addition, he is member of the advisory board of the Journal of Materials Science: Materials in Medicine, International Journal of Tissue Engineering, Journal ISRN Biomaterials, The Journal of Experimental Orthopaedics, Journal “Recent Patents on Corrosion Science”, and referee in more than 40 international journals.
Affiliations and expertise
Principal Investigator with Habilitation and Vice President of Institute 3B's, 3B’s Research Group, Institute 3B’s, University of Minho, Braga, Portugal

RR

Rui L. Reis

Dr. Rui Reis is Vice-President for Research and Innovation of University of Minho, Portugal, Director of 3B’s Research Group and Director of ICVS/3B´s Associate Laboratory, both of UMinho. He’s the CEO of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, the Coordinator of the Discoveries Centre for Regenerative and Precision Medicine, the Global Past-President of the Tissue Engineering and Regenerative Medicine International Society and the Editor-in-chief of the Journal of Tissue Engineering and Regenerative Medicine. He’s edited 18 books, 10 special issue journals, 280 book chapters and has more than 1225 published works listed on ISI Web of Knowledge, being an inventor of around 70 patents. He’s been awarded many important international prizes, including the TERMIS-EU contributions to the literature Award and the TERMIS-EU Career Achievement Award, and recently the UNESCO- International Life Sciences Award and the IET A. F. Harvey Engineering Research Prize.
Affiliations and expertise
President of Institute 3B’s, University of Minho; Director of the Associated Laboratory ICVS/3B’s and of the European Institute of Excellence in Tissue Engineering and Regenerative Medicine (EXPERTISSUES); Full Professor of Tissue Engineering, Regenerative Medicine and Stem Cells, University of Minho, Barco, Portugal

SP

Sandra Pina

Sandra Pina is Assistant Researcher at 3B’s Research Group, Institute 3B’s, University of Minho, Barco, Portugal.
Affiliations and expertise
Assistant Researcher, 3B’s Research Group, Institute 3B’s, University of Minho, Barco, Portugal

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