Multifunctional Nanocomposites for Targeted Drug Delivery in Cancer Therapy

Multifunctional Nanocomposites for Targeted Drug Delivery in Cancer Therapy explores the design, synthesis, and application of different multifunctional nanocomposites drug delivery system for cancer treatment. It encompasses initial chapters discussing introductory information about cancer, followed by chapters focusing on the detailed information about various novel drug delivery systems for treatment of several organ site cancers such as prostate, skin, breast, lung, liver, pancreas, stomach, colon, blood, mouth and throat.

It is a valuable resource for cancer researchers, oncologists, graduate students, and members of biomedical research who need to understand more about novel nanotechnologies applied to cancer treatment.

Cover image
Title page
Table of Contents
Copyright
Dedication
List of contributors
Chapter 1. Introduction: an overview of the multifunctional nanocomposites
Abstract
1.1 Introduction
1.2 Structure and manufacturing processes for nanocomposite
1.3 Properties of nanocomposites
1.4 Classification of multifunctional nanocomposite
1.5 Applications of multifunctional nanocomposites
1.6 Conclusion
Acknowledgment
Conflict of interest
Consent for publication
References
Chapter 2. Multifunctional nanocarrier-mediated approaches and conventional therapies for effective treatment of cancer
Abstract
2.1 Introduction
2.2 Pitfalls associated with traditional cancer therapy
2.3 Targeting mechanisms employed in cancer therapy
2.4 Multifunctional nanoparticles in therapeutics
2.5 Challenges and limitations of targeted cancer therapies
2.6 Limitations of targeted cancer therapies
2.7 Conclusion
Abbreviations
References
Chapter 3. Autophagy-targeted drug delivery system in the management of cancer
Abstract
3.1 Introduction
3.2 Autophagy and its role in the pathogenesis of cancer
3.3 Pharmacodynamic targets for autophagy-mediated cancer management
3.4 Mammalian target of rapamycin-mediated signaling pathway in autophagy
3.5 Mitophagy: a special case of autophagy
3.6 Roles of lncRNAs and miRNAs in regulating autophagy
3.7 Autophagy-targeted drugs/agents in the management of cancer
3.8 Autophagy targeted drug delivery system
3.9 Silver-based nanoparticles
3.10 Gold-based nanoparticles
3.11 Metal oxide-based nanoparticles
3.12 Silicabased nanoparticles
3.13 Gene-targeted drug delivery system
3.14 Liposome-based drug delivery system
3.15 Conclusion and future prospects
References
Chapter 4. Multifunctional nanocarrier-mediated codelivery for targeting and treatment of prostate cancer
Abstract
4.1 Introduction
4.2 Pathophysiology of prostate cancer
4.3 Treatment options for prostate cancer
4.4 Challenges in the treatment of prostate cancer
4.5 Mechanism of drug targeting
4.6 Potential targets of multifunctional nanocarriers in codelivery of drugs
4.7 Multifunctional nanocarriers in codelivery of anticancer drugs to target prostate cancer
4.8 Ideal characteristics of multifunctional nanocarriers
4.9 Patents and clinical trials
4.10 Clinical trials and marketed products
4.11 Conclusion and future perspectives
References
Chapter 5. Multifunctional nanocarrier-mediated delivery for targeting and treating skin cancer
Abstract
5.1 Introduction
5.2 Physiological barriers in skin cancer targeting
5.3 The semipermeable, nonporous nature of skin
5.4 Hydrophilic routes through the skin barrier: their location and nature
5.5 Dermis
5.6 Hypodermis
5.7 Need and employment of nanocarriers-based formulations in skin cancer treatment
5.8 Strategies involved in multifunctional nanocarriers targeting skin cancer
5.9 Nanocarriers involve in chemotherapy drug delivery for skin cancer
5.10 Strategies for messenger ribonucleic acid vaccine therapy for skin cancer treatment
5.11 Nanocarriers targeting immunotherapy
5.12 Nanocarriers used in combination therapy for targeting skin cancer
5.13 Patents on nanocarriers targeting skin cancer
5.14 Conclusion
References
Chapter 6. Multifunctional nanocomposites for targeted drug delivery in breast cancer therapy
Abstract
6.1 Introduction
6.2 Types of nanoparticles in cancer therapy
6.3 Nanomaterials used for cancer
6.4 Strategies for targeting of nanoparticles at requisite site
6.5 Stimuli-responsive functionalized nanocomposites
References
Chapter 7. Recent advancement of hybrid nanoparticles synthesis and applications in lung cancer management
Abstract
7.1 Introduction
7.2 Hybrid nanoparticles—synthesis strategy
7.3 Hybrid nanoparticles and its application in diagnosis
7.4 Hybrid nanoparticles utilized in the lung cancer therapy
7.5 Conclusions and future perspectives
References
Chapter 8. Multifunctional nanocrystals for liver cancer
Abstract
8.1 Introduction
8.2 Techniques for nanocrystal formulation
8.3 Liver cancer and challenges in drug delivery
8.4 Drug targeting
8.5 Recent advancements in liver cancer targeting and future prospects
8.6 Conclusion
References
Chapter 9. Nanocarrier-mediated delivery targeting for pancreatic cancer
Abstract
9.1 Introduction
9.2 Pancreatic cancer
9.3 Current approaches for the treatment of pancreatic cancer
9.4 Advantages of nanocarriers over conventional drug delivery system
9.5 Role of nanocarriers in the treatment of pancreatic cancer
9.6 Future prospectives
References
Chapter 10. Nanocarrier-mediated delivery for targeting stomach cancer
Abstract
10.1 Introduction
10.2 Types of gastric cancer
10.3 Risk factors associated with gastric cancer
10.4 Treatment
10.5 Nanomedicine
10.6 Nanocarriers for drug delivery in gastric cancer
10.7 Gene therapy in gastric cancer
10.8 Cytotoxic gene therapy
10.9 Antisense therapy
10.10 p53 gene
10.11 Natural phytochemicals in gastric cancer
10.12 Marketed formulation for gastric cancer treatment
10.13 Conclusion and future perspectives
References
Chapter 11. Nanocarrier-mediated delivery for targeting colon cancer
Abstract
11.1 Introduction
11.2 Symptoms and causes
11.3 Nanocarrier-based targeted drug delivery strategies in colon cancer
11.4 Approaches for nanocarrier-mediated colon-specific drug delivery
11.5 Phyto-nanocarrier-based strategies for targeting colon cancer
References
Chapter 12. Multifunctional nanocomposites for blood cancer
Abstract
12.1 Introduction
12.2 Leukemia
12.3 Nanocomposites
12.4 Polymeric-based nanocomposites
12.5 Aptamer-loaded nanocomposites
12.6 Hyaluronic acid-loaded nanocomposites
12.7 Folic acid-targeted nanocomposites
12.8 Magnetic nanocomposites
12.9 Clay-based nanocomposites
12.10 Graphene nanocomposites
References
Chapter 13. Multifunctional nanocarrier-mediated codelivery for targeting and treatment of mouth and throat cancer
Abstract
13.1 Introduction
13.2 Lipid vesicle based nanoconjugation
13.3 Metal in combination with siRNA
13.4 Dendrimer-based conjugated multifunctional nanoparticles
13.5 Photodynamic therapy
13.6 Mesosporous silica nanoparticles
13.7 Other studies
13.8 Conclusions
References
Chapter 14. Nanocarrier-mediated delivery for targeting for prostate cancer
Abstract
14.1 Introduction
14.2 Pathophysiology of the prostate gland and prostate cancer
14.3 Advantages and implications of targeted nanocarrier for prostate cancer
14.4 Various synthetic and biological nanotechnology-based outlooks for targeting prostate cancer follow several routes
14.5 Current prostate cancer treatment approaches with their limitations
14.6 Nanotechnology awaiting possibilities in prostate cancer management
14.7 Nanotheranostics for managing prostate cancer
14.8 Various types of nanocarriers used in prostate cancer treatment
14.9 Conclusion
References
Index

AY

Awesh K. Yadav

Dr. Awesh K. Yadav has received his B.Pharm, M.Pharm, and PhD from Dr. Hari Singh Gour University Sagar (MP). He is currently working as Assistant Professor in the Department of Pharmaceutics at the National Institute of Pharmaceutical Education and Research Raebareli, India. He has more than 15 years of teaching and industrial experience in various institutes and industries. He has written dozens of quality research publications in journals of national and international repute. He has also published four books and seven book chapters. He has been awarded the best citation award for his publication in the International Journal of Pharmaceutics in 2005. Dr. Yadav’s current research interest includes targeted and controlled novel drug delivery systems for the delivery of various bioactives such as anticancer drugs, anti-Alzheimer's drugs, anti-Parkinson drugs, anti-malarial drugs, sun-screening agents, etc.

Affiliations and expertise

Assistant Professor, Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research Raebareli, A Transit Campus at Bijnor-Sesendi Road, Sarojini Nagar, Near CRPF Base Camp, Lucknow, Uttar Pradesh, India

RS

Rahul Shukla

Dr. Rahul Shukla is currently working as an Assistant Professor (Contract) at Department of Pharmaceutics, NIPER Raebareli, India, He has a PhD in Pharmaceutical Sciences from CSIR CDRI and J.N.U New Delhi, India, an M.Pharm from IIT BHU,Varanasi, India and B.Pharm from Jamia Hamdard, New Delhi. He has more than ten years of research and academic experience with more than 30 publications and 10 book chapters to his credit. He has filed 7 Indian Patent and 1 Copyright. Recently he has edited a book on the Role of Novel Drug Delivery Vehicles in Nanobiomedicine. His current research interests include targeted drug delivery systems, particle engineering, controlled delivery for neurodegenerative diseases, dendrimer mediated drug delivery, solubilization and bioavailability enhancements.

Affiliations and expertise

Assistant Professor, Department of Pharmeceutics, National Institute of Pharmaceutical Education and Research, Raebareli, Uttar Pradesh, India

RU

Rewati Raman Ujjwal

Dr. Rewati Raman Ujjwal currently working as Postdoctoral research associate in the Orthopedics department at University of Massachusetts Chan Medical School, Worcester, MA, USA. He has achieved his integrated M.Sc from School of Chemical Sciences, National Institute of Science Education and Research, Bhubaneswar, India and Ph.D from Department of Science and Humanities, Rajiv Gandhi Institute of Petroleum Technology, Amethi, India. He has worked as Postdoctoral Researcher at National Institute of Pharmaceutical Education and Research, Raebareli UP. He has more than 18 quality research publications in journals of international repute. He has published 3 book chapters along with filed one international patent and 2 Indian Patent as well. He has been awarded a DST-SERB national postdoctoral fellowship 2019. His research interests are the synthesis and functional modification of biomaterials for drug delivery and sensing studies and detail study of its methodology.

Affiliations and expertise

Postdoctoral Research Associate, Department of Orthopedics, University of Massachusetts Chan Medical School, Worcester, MA, USA

AY

Awesh K. Yadav

Dr. Awesh K. Yadav has received his B.Pharm, M.Pharm, and PhD from Dr. Hari Singh Gour University Sagar (MP). He is currently working as Assistant Professor in the Department of Pharmaceutics at the National Institute of Pharmaceutical Education and Research Raebareli, India. He has more than 15 years of teaching and industrial experience in various institutes and industries. He has written dozens of quality research publications in journals of national and international repute. He has also published four books and seven book chapters. He has been awarded the best citation award for his publication in the International Journal of Pharmaceutics in 2005. Dr. Yadav’s current research interest includes targeted and controlled novel drug delivery systems for the delivery of various bioactives such as anticancer drugs, anti-Alzheimer's drugs, anti-Parkinson drugs, anti-malarial drugs, sun-screening agents, etc.

Affiliations and expertise

Assistant Professor, Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research Raebareli, A Transit Campus at Bijnor-Sesendi Road, Sarojini Nagar, Near CRPF Base Camp, Lucknow, Uttar Pradesh, India

RS

Rahul Shukla

Dr. Rahul Shukla is currently working as an Assistant Professor (Contract) at Department of Pharmaceutics, NIPER Raebareli, India, He has a PhD in Pharmaceutical Sciences from CSIR CDRI and J.N.U New Delhi, India, an M.Pharm from IIT BHU,Varanasi, India and B.Pharm from Jamia Hamdard, New Delhi. He has more than ten years of research and academic experience with more than 30 publications and 10 book chapters to his credit. He has filed 7 Indian Patent and 1 Copyright. Recently he has edited a book on the Role of Novel Drug Delivery Vehicles in Nanobiomedicine. His current research interests include targeted drug delivery systems, particle engineering, controlled delivery for neurodegenerative diseases, dendrimer mediated drug delivery, solubilization and bioavailability enhancements.

Affiliations and expertise

Assistant Professor, Department of Pharmeceutics, National Institute of Pharmaceutical Education and Research, Raebareli, Uttar Pradesh, India

RU

Rewati Raman Ujjwal

Dr. Rewati Raman Ujjwal currently working as Postdoctoral research associate in the Orthopedics department at University of Massachusetts Chan Medical School, Worcester, MA, USA. He has achieved his integrated M.Sc from School of Chemical Sciences, National Institute of Science Education and Research, Bhubaneswar, India and Ph.D from Department of Science and Humanities, Rajiv Gandhi Institute of Petroleum Technology, Amethi, India. He has worked as Postdoctoral Researcher at National Institute of Pharmaceutical Education and Research, Raebareli UP. He has more than 18 quality research publications in journals of international repute. He has published 3 book chapters along with filed one international patent and 2 Indian Patent as well. He has been awarded a DST-SERB national postdoctoral fellowship 2019. His research interests are the synthesis and functional modification of biomaterials for drug delivery and sensing studies and detail study of its methodology.

Affiliations and expertise

Postdoctoral Research Associate, Department of Orthopedics, University of Massachusetts Chan Medical School, Worcester, MA, USA

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Awesh K. Yadav

Rahul Shukla

Rewati Raman Ujjwal

Awesh K. Yadav

Rahul Shukla

Rewati Raman Ujjwal