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Multifunctional Nanocomposites for Targeted Drug Delivery in Cancer Therapy
- 1st Edition - November 23, 2023
- Authors: Awesh K. Yadav, Rahul Shukla, Rewati Raman Ujjwal
- Editors: Awesh K. Yadav, Rahul Shukla, Rewati Raman Ujjwal
- Language: English
- Paperback ISBN:9 7 8 - 0 - 3 2 3 - 9 5 3 0 3 - 0
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 9 5 3 0 4 - 7
Multifunctional Nanocomposites for Targeted Drug Delivery in Cancer Therapy explores the design, synthesis, and application of different multifunctional nanocomposites drug deli… Read more
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Request a sales quoteMultifunctional Nanocomposites for Targeted Drug Delivery in Cancer Therapy explores the design, synthesis, and application of different multifunctional nanocomposites drug delivery system for cancer treatment. It encompasses initial chapters discussing introductory information about cancer, followed by chapters focusing on the detailed information about various novel drug delivery systems for treatment of several organ site cancers such as prostate, skin, breast, lung, liver, pancreas, stomach, colon, blood, mouth and throat.
It is a valuable resource for cancer researchers, oncologists, graduate students, and members of biomedical research who need to understand more about novel nanotechnologies applied to cancer treatment.
- Discusses a wide range of promising approaches for the diagnosis and treatment of cancer using the latest advancement in cutting-edge nanomedical technologies
- Presents chapters dedicated to each cancer type and the best nanocomposite therapies used, making the content easily discoverable by readers
- Written by world-renowned experts and researchers in the areas of nanomedicine, drug delivery and cancer research to explore thoroughly the topic with diverse perspectives
Cancer researchers, oncologists, pharmaceutical science. Medical doctors, biomaterials researchers, graduate students
- Cover image
- Title page
- Table of Contents
- Copyright
- Dedication
- List of contributors
- Chapter 1. Introduction: an overview of the multifunctional nanocomposites
- Abstract
- 1.1 Introduction
- 1.2 Structure and manufacturing processes for nanocomposite
- 1.3 Properties of nanocomposites
- 1.4 Classification of multifunctional nanocomposite
- 1.5 Applications of multifunctional nanocomposites
- 1.6 Conclusion
- Acknowledgment
- Conflict of interest
- Consent for publication
- References
- Chapter 2. Multifunctional nanocarrier-mediated approaches and conventional therapies for effective treatment of cancer
- Abstract
- 2.1 Introduction
- 2.2 Pitfalls associated with traditional cancer therapy
- 2.3 Targeting mechanisms employed in cancer therapy
- 2.4 Multifunctional nanoparticles in therapeutics
- 2.5 Challenges and limitations of targeted cancer therapies
- 2.6 Limitations of targeted cancer therapies
- 2.7 Conclusion
- Abbreviations
- References
- Chapter 3. Autophagy-targeted drug delivery system in the management of cancer
- Abstract
- 3.1 Introduction
- 3.2 Autophagy and its role in the pathogenesis of cancer
- 3.3 Pharmacodynamic targets for autophagy-mediated cancer management
- 3.4 Mammalian target of rapamycin-mediated signaling pathway in autophagy
- 3.5 Mitophagy: a special case of autophagy
- 3.6 Roles of lncRNAs and miRNAs in regulating autophagy
- 3.7 Autophagy-targeted drugs/agents in the management of cancer
- 3.8 Autophagy targeted drug delivery system
- 3.9 Silver-based nanoparticles
- 3.10 Gold-based nanoparticles
- 3.11 Metal oxide-based nanoparticles
- 3.12 Silicabased nanoparticles
- 3.13 Gene-targeted drug delivery system
- 3.14 Liposome-based drug delivery system
- 3.15 Conclusion and future prospects
- References
- Chapter 4. Multifunctional nanocarrier-mediated codelivery for targeting and treatment of prostate cancer
- Abstract
- 4.1 Introduction
- 4.2 Pathophysiology of prostate cancer
- 4.3 Treatment options for prostate cancer
- 4.4 Challenges in the treatment of prostate cancer
- 4.5 Mechanism of drug targeting
- 4.6 Potential targets of multifunctional nanocarriers in codelivery of drugs
- 4.7 Multifunctional nanocarriers in codelivery of anticancer drugs to target prostate cancer
- 4.8 Ideal characteristics of multifunctional nanocarriers
- 4.9 Patents and clinical trials
- 4.10 Clinical trials and marketed products
- 4.11 Conclusion and future perspectives
- References
- Chapter 5. Multifunctional nanocarrier-mediated delivery for targeting and treating skin cancer
- Abstract
- 5.1 Introduction
- 5.2 Physiological barriers in skin cancer targeting
- 5.3 The semipermeable, nonporous nature of skin
- 5.4 Hydrophilic routes through the skin barrier: their location and nature
- 5.5 Dermis
- 5.6 Hypodermis
- 5.7 Need and employment of nanocarriers-based formulations in skin cancer treatment
- 5.8 Strategies involved in multifunctional nanocarriers targeting skin cancer
- 5.9 Nanocarriers involve in chemotherapy drug delivery for skin cancer
- 5.10 Strategies for messenger ribonucleic acid vaccine therapy for skin cancer treatment
- 5.11 Nanocarriers targeting immunotherapy
- 5.12 Nanocarriers used in combination therapy for targeting skin cancer
- 5.13 Patents on nanocarriers targeting skin cancer
- 5.14 Conclusion
- References
- Chapter 6. Multifunctional nanocomposites for targeted drug delivery in breast cancer therapy
- Abstract
- 6.1 Introduction
- 6.2 Types of nanoparticles in cancer therapy
- 6.3 Nanomaterials used for cancer
- 6.4 Strategies for targeting of nanoparticles at requisite site
- 6.5 Stimuli-responsive functionalized nanocomposites
- References
- Chapter 7. Recent advancement of hybrid nanoparticles synthesis and applications in lung cancer management
- Abstract
- 7.1 Introduction
- 7.2 Hybrid nanoparticles—synthesis strategy
- 7.3 Hybrid nanoparticles and its application in diagnosis
- 7.4 Hybrid nanoparticles utilized in the lung cancer therapy
- 7.5 Conclusions and future perspectives
- References
- Chapter 8. Multifunctional nanocrystals for liver cancer
- Abstract
- 8.1 Introduction
- 8.2 Techniques for nanocrystal formulation
- 8.3 Liver cancer and challenges in drug delivery
- 8.4 Drug targeting
- 8.5 Recent advancements in liver cancer targeting and future prospects
- 8.6 Conclusion
- References
- Chapter 9. Nanocarrier-mediated delivery targeting for pancreatic cancer
- Abstract
- 9.1 Introduction
- 9.2 Pancreatic cancer
- 9.3 Current approaches for the treatment of pancreatic cancer
- 9.4 Advantages of nanocarriers over conventional drug delivery system
- 9.5 Role of nanocarriers in the treatment of pancreatic cancer
- 9.6 Future prospectives
- References
- Chapter 10. Nanocarrier-mediated delivery for targeting stomach cancer
- Abstract
- 10.1 Introduction
- 10.2 Types of gastric cancer
- 10.3 Risk factors associated with gastric cancer
- 10.4 Treatment
- 10.5 Nanomedicine
- 10.6 Nanocarriers for drug delivery in gastric cancer
- 10.7 Gene therapy in gastric cancer
- 10.8 Cytotoxic gene therapy
- 10.9 Antisense therapy
- 10.10 p53 gene
- 10.11 Natural phytochemicals in gastric cancer
- 10.12 Marketed formulation for gastric cancer treatment
- 10.13 Conclusion and future perspectives
- References
- Chapter 11. Nanocarrier-mediated delivery for targeting colon cancer
- Abstract
- 11.1 Introduction
- 11.2 Symptoms and causes
- 11.3 Nanocarrier-based targeted drug delivery strategies in colon cancer
- 11.4 Approaches for nanocarrier-mediated colon-specific drug delivery
- 11.5 Phyto-nanocarrier-based strategies for targeting colon cancer
- References
- Chapter 12. Multifunctional nanocomposites for blood cancer
- Abstract
- 12.1 Introduction
- 12.2 Leukemia
- 12.3 Nanocomposites
- 12.4 Polymeric-based nanocomposites
- 12.5 Aptamer-loaded nanocomposites
- 12.6 Hyaluronic acid-loaded nanocomposites
- 12.7 Folic acid-targeted nanocomposites
- 12.8 Magnetic nanocomposites
- 12.9 Clay-based nanocomposites
- 12.10 Graphene nanocomposites
- References
- Chapter 13. Multifunctional nanocarrier-mediated codelivery for targeting and treatment of mouth and throat cancer
- Abstract
- 13.1 Introduction
- 13.2 Lipid vesicle based nanoconjugation
- 13.3 Metal in combination with siRNA
- 13.4 Dendrimer-based conjugated multifunctional nanoparticles
- 13.5 Photodynamic therapy
- 13.6 Mesosporous silica nanoparticles
- 13.7 Other studies
- 13.8 Conclusions
- References
- Chapter 14. Nanocarrier-mediated delivery for targeting for prostate cancer
- Abstract
- 14.1 Introduction
- 14.2 Pathophysiology of the prostate gland and prostate cancer
- 14.3 Advantages and implications of targeted nanocarrier for prostate cancer
- 14.4 Various synthetic and biological nanotechnology-based outlooks for targeting prostate cancer follow several routes
- 14.5 Current prostate cancer treatment approaches with their limitations
- 14.6 Nanotechnology awaiting possibilities in prostate cancer management
- 14.7 Nanotheranostics for managing prostate cancer
- 14.8 Various types of nanocarriers used in prostate cancer treatment
- 14.9 Conclusion
- References
- Index
- No. of pages: 434
- Language: English
- Edition: 1
- Published: November 23, 2023
- Imprint: Academic Press
- Paperback ISBN: 9780323953030
- eBook ISBN: 9780323953047
AY
Awesh K. Yadav
Dr. Awesh K. Yadav has received his B.Pharm, M.Pharm, and PhD from Dr. Hari Singh Gour University Sagar (MP). He is currently working as Assistant Professor in the Department of Pharmaceutics at the National Institute of Pharmaceutical Education and Research Raebareli, India. He has more than 15 years of teaching and industrial experience in various institutes and industries. He has written dozens of quality research publications in journals of national and international repute. He has also published four books and seven book chapters. He has been awarded the best citation award for his publication in the International Journal of Pharmaceutics in 2005. Dr. Yadav’s current research interest includes targeted and controlled novel drug delivery systems for the delivery of various bioactives such as anticancer drugs, anti-Alzheimer's drugs, anti-Parkinson drugs, anti-malarial drugs, sun-screening agents, etc.
Affiliations and expertise
Assistant Professor, Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research Raebareli, A Transit Campus at Bijnor-Sesendi Road, Sarojini Nagar, Near CRPF Base Camp, Lucknow, Uttar Pradesh, IndiaRS
Rahul Shukla
Dr. Rahul Shukla is currently working as an Assistant Professor (Contract) at Department of Pharmaceutics, NIPER Raebareli, India, He has a PhD in Pharmaceutical Sciences from CSIR CDRI and J.N.U New Delhi, India, an M.Pharm from IIT BHU,Varanasi, India and B.Pharm from Jamia Hamdard, New Delhi. He has more than ten years of research and academic experience with more than 30 publications and 10 book chapters to his credit. He has filed 7 Indian Patent and 1 Copyright. Recently he has edited a book on the Role of Novel Drug Delivery Vehicles in Nanobiomedicine. His current research interests include targeted drug delivery systems, particle engineering, controlled delivery for neurodegenerative diseases, dendrimer mediated drug delivery, solubilization and bioavailability enhancements.
Affiliations and expertise
Assistant Professor, Department of Pharmeceutics, National Institute of Pharmaceutical Education and Research, Raebareli, Uttar Pradesh, IndiaRU
Rewati Raman Ujjwal
Dr. Rewati Raman Ujjwal currently working as Postdoctoral research associate in the Orthopedics department at University of Massachusetts Chan Medical School, Worcester, MA, USA. He has achieved his integrated M.Sc from School of Chemical Sciences, National Institute of Science Education and Research, Bhubaneswar, India and Ph.D from Department of Science and Humanities, Rajiv Gandhi Institute of Petroleum Technology, Amethi, India. He has worked as Postdoctoral Researcher at National Institute of Pharmaceutical Education and Research, Raebareli UP. He has more than 18 quality research publications in journals of international repute. He has published 3 book chapters along with filed one international patent and 2 Indian Patent as well. He has been awarded a DST-SERB national postdoctoral fellowship 2019. His research interests are the synthesis and functional modification of biomaterials for drug delivery and sensing studies and detail study of its methodology.
Affiliations and expertise
Postdoctoral Research Associate, Department of Orthopedics, University of Massachusetts Chan Medical School, Worcester, MA, USAAY
Awesh K. Yadav
Dr. Awesh K. Yadav has received his B.Pharm, M.Pharm, and PhD from Dr. Hari Singh Gour University Sagar (MP). He is currently working as Assistant Professor in the Department of Pharmaceutics at the National Institute of Pharmaceutical Education and Research Raebareli, India. He has more than 15 years of teaching and industrial experience in various institutes and industries. He has written dozens of quality research publications in journals of national and international repute. He has also published four books and seven book chapters. He has been awarded the best citation award for his publication in the International Journal of Pharmaceutics in 2005. Dr. Yadav’s current research interest includes targeted and controlled novel drug delivery systems for the delivery of various bioactives such as anticancer drugs, anti-Alzheimer's drugs, anti-Parkinson drugs, anti-malarial drugs, sun-screening agents, etc.
Affiliations and expertise
Assistant Professor, Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research Raebareli, A Transit Campus at Bijnor-Sesendi Road, Sarojini Nagar, Near CRPF Base Camp, Lucknow, Uttar Pradesh, IndiaRS
Rahul Shukla
Dr. Rahul Shukla is currently working as an Assistant Professor (Contract) at Department of Pharmaceutics, NIPER Raebareli, India, He has a PhD in Pharmaceutical Sciences from CSIR CDRI and J.N.U New Delhi, India, an M.Pharm from IIT BHU,Varanasi, India and B.Pharm from Jamia Hamdard, New Delhi. He has more than ten years of research and academic experience with more than 30 publications and 10 book chapters to his credit. He has filed 7 Indian Patent and 1 Copyright. Recently he has edited a book on the Role of Novel Drug Delivery Vehicles in Nanobiomedicine. His current research interests include targeted drug delivery systems, particle engineering, controlled delivery for neurodegenerative diseases, dendrimer mediated drug delivery, solubilization and bioavailability enhancements.
Affiliations and expertise
Assistant Professor, Department of Pharmeceutics, National Institute of Pharmaceutical Education and Research, Raebareli, Uttar Pradesh, IndiaRU
Rewati Raman Ujjwal
Dr. Rewati Raman Ujjwal currently working as Postdoctoral research associate in the Orthopedics department at University of Massachusetts Chan Medical School, Worcester, MA, USA. He has achieved his integrated M.Sc from School of Chemical Sciences, National Institute of Science Education and Research, Bhubaneswar, India and Ph.D from Department of Science and Humanities, Rajiv Gandhi Institute of Petroleum Technology, Amethi, India. He has worked as Postdoctoral Researcher at National Institute of Pharmaceutical Education and Research, Raebareli UP. He has more than 18 quality research publications in journals of international repute. He has published 3 book chapters along with filed one international patent and 2 Indian Patent as well. He has been awarded a DST-SERB national postdoctoral fellowship 2019. His research interests are the synthesis and functional modification of biomaterials for drug delivery and sensing studies and detail study of its methodology.
Affiliations and expertise
Postdoctoral Research Associate, Department of Orthopedics, University of Massachusetts Chan Medical School, Worcester, MA, USARead Multifunctional Nanocomposites for Targeted Drug Delivery in Cancer Therapy on ScienceDirect