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Mucosal Vaccines
- 1st Edition - October 14, 1996
- Author: Hiroshi Kiyono
- Editors: Hiroshi Kiyono, Pearay L. Ogra, Jerry R. McGhee
- Language: English
- Hardback ISBN:9 7 8 - 0 - 1 2 - 4 1 0 5 8 0 - 5
- eBook ISBN:9 7 8 - 0 - 0 8 - 0 5 3 7 0 5 - 4
This comprehensive, authoritative treatise covers all aspects of mucosal vaccines including their development, mechanisms of action, molecular/cellular aspects, and practical… Read more
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Request a sales quote- Provides the latest views on mucosal vaccines
- Applies basic principles to the development of new vaccines
- Links basic, clinical, and practical aspects of mucosal vaccines to different infectious diseases
- Unique and user-friendly organization
- No. of pages: 479
- Language: English
- Edition: 1
- Published: October 14, 1996
- Imprint: Academic Press
- Hardback ISBN: 9780124105805
- eBook ISBN: 9780080537054
HK
Hiroshi Kiyono
Since the 1970s, Professor Kiyono has been investigating and characterizing unique features of the mucosal immune system to establish mucosal immunology as an area of the immunology field as well as to develop effective and safe mucosal vaccines against infectious diseases and mucosal immune therapies against allergic and inflammatory diseases. He recently developed cold-chain- and needle-free rice-based vaccines (MucoRice) with the cooperation of agricultural researchers. The vaccine antigens exogenously expressed in MucoRice are temperature-stable for at least 2.5 years and are resistant to digestive enzymes, thus they effectively induce vaccine antigen-specific protective immunity in both systemic and mucosal compartments against toxins produced by pathogenic microorganisms (e.g., cholera toxins). Additionally, his efforts aim to clarify the immunological cross-talk between the mucosal immune system and mucosal environmental factors (e.g., commensal bacteria and dietary materials) in immunological homeostasis. These studies will lead to the development of novel immune therapies against mucosal immune diseases, such as food allergy, rhinitis, and inflammatory bowel diseases.
PO
Pearay L. Ogra
JM
Jerry R. McGhee
HK
Hiroshi Kiyono
Since the 1970s, Professor Kiyono has been investigating and characterizing unique features of the mucosal immune system to establish mucosal immunology as an area of the immunology field as well as to develop effective and safe mucosal vaccines against infectious diseases and mucosal immune therapies against allergic and inflammatory diseases. He recently developed cold-chain- and needle-free rice-based vaccines (MucoRice) with the cooperation of agricultural researchers. The vaccine antigens exogenously expressed in MucoRice are temperature-stable for at least 2.5 years and are resistant to digestive enzymes, thus they effectively induce vaccine antigen-specific protective immunity in both systemic and mucosal compartments against toxins produced by pathogenic microorganisms (e.g., cholera toxins). Additionally, his efforts aim to clarify the immunological cross-talk between the mucosal immune system and mucosal environmental factors (e.g., commensal bacteria and dietary materials) in immunological homeostasis. These studies will lead to the development of novel immune therapies against mucosal immune diseases, such as food allergy, rhinitis, and inflammatory bowel diseases.