MR Linac Radiotherapy
A New Personalized Treatment Approach
- 1st Edition, Volume 8 - December 1, 2022
- Editors: Sara L. Hackett, Cem Onal, Enis Ozyar
- Language: English
- Paperback ISBN:9 7 8 - 0 - 3 2 3 - 9 1 6 8 9 - 9
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 9 8 5 4 8 - 2
MR Linac Radiotherapy: A New Personalized Treatment Approach comprises both clinical and physical aspects of this new technology. The book covers treatment planning, workflow… Read more
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Request a sales quoteMR Linac Radiotherapy: A New Personalized Treatment Approach comprises both clinical and physical aspects of this new technology. The book covers treatment planning, workflow and technical issues about MR-Linac. Specially, the clinical use of MR-Linac according to different cancer types is presented by experienced physicians. This is a unique guide for medical physicists, RTTs, dosimetrists and physicians, as well as radiation oncologists and their teams. The MR Linac combines two technologies - a magnetic resonance imaging scanner and a linear accelerator - to precisely locate tumors, tailor the shape of radiation beams in real-time, and precisely deliver doses of radiation, even to moving tumors.
This highly innovative technology is very new, and the number of newly installed MR-Linac machines will gradually increase worldwide. However, as there is no published book as a guideline, this book will help new MR-Linac users and centers planning to have MR-Linac.
- Presents the first book on MR Linac Radiotherapy
- Comprises both clinical and physical aspects of this new technology
- Written by leading editors and authors in the field
Physicians, medical physicists, RTTs, dosimetrists, radiation oncologists
- Cover image
- Title Page
- Table of Contents
- Copyright
- Contributors
- Preface
- Chapter 1: Rationale for the MR-linac
- Abstract
- Optimal radiotherapy
- MR-guided radiotherapy
- Opportunities of MR-guided radiotherapy
- Concluding remarks
- References
- Chapter 2: Basics of MR imaging for the radiation oncologist
- Abstract
- Introduction
- MR imaging
- MR linac (MRL) in radiation oncology
- Current trends in MRL
- Outlook of MRI in radiation oncology
- Concluding remarks
- References
- Chapter 3: Technical concepts of MRI-Linac (MRL)
- Abstract
- Introduction: The challenges of a hybrid MRI-Linac system
- Perpendicular systems
- Inline systems
- Concluding remarks
- References
- Chapter 4: Linac dosimetry in a magnetic field
- Abstract
- Introduction
- Physics
- Systems and configurations
- Measurements in B-fields
- Reference dosimetry
- Linac reference conditions
- Uncertainty
- Additional concepts
- Concluding remarks
- References
- Chapter 5: MR safety considerations for MRI-guided radiotherapy
- Abstract
- Introduction
- Magnetic field-induced hazards
- Safety considerations for MR in RT
- Device considerations
- Concluding remarks
- References
- Chapter 6: Robust online adaptive planning: Toward a uniform MR-LINAC treatment planning technique
- Abstract
- Introduction
- Initial approach to treatment planning
- Chasing further efficiencies and MPT
- Principles of a uniform MR-LINAC planning technique
- Making the MPT base plan (SBRT for pancreas)
- Adapting an MPT plan (SBRT for pancreas)
- Incorporating MPT—An evaluation
- Concluding remarks
- Acknowledgment
- References
- Chapter 7: Immobilization and patient positioning considerations when using MRI for radiotherapy treatment planning
- Abstract
- Introduction
- Utilizing magnetic resonance imaging (MRI) for radiotherapy treatment planning (RTP)
- General principles and equipment
- MRI systems
- MRI scanning protocols
- Workforce and training
- Patient communication
- Coil bridges
- Safe and efficient patient setup
- Site-specific considerations
- Brain
- Head and neck
- Thorax and abdomen
- Breast
- Pelvis
- Spine
- Limbs
- Concluding remarks
- References
- Chapter 8: Treatment planning and delivery workflow steps in MR-guided adaptive RT
- Abstract
- Introduction
- Reference treatment planning workflow steps
- Treatment delivery
- Quality assurance of daily replanning
- Concluding remarks
- References
- Chapter 9: QA of MR-linac
- Abstract
- Geometric machine QA of MR-linac
- Dosimetric QA of MR-linac
- QA of MR-linac images and center position
- Patient-specific QA
- Concluding remarks
- References
- Chapter 10: Changing role of radiation therapy technologists in magnetic resonance-guided radiotherapy
- Abstract
- Introduction
- Implementation
- “Business as usual”
- Training
- Conditions and infrastructure
- Concluding remarks
- References
- Chapter 11: Central nervous system tumors
- Abstract
- Introduction
- Multiparametric MRI for MR Linac neuroimaging
- Clinical applications for MR Linac therapy in the CNS
- Concluding remarks
- References
- Chapter 12: Esophageal cancer
- Abstract
- Introduction
- Staging
- Evidence-based treatment approaches for locoregional disease
- Selection for nonoperative management
- Rationale for MR-guided radiotherapy in esophageal cancer
- Interfraction tumor shape adaptation
- Intrafraction tumor motion
- Treatment-related toxicity
- Targeted selected dose escalation
- Target volume determination and delineation guidelines
- Simulation
- Treatment planning
- Concluding remarks
- References
- Chapter 13: Lung tumors
- Abstract
- Concluding remarks
- References
- Chapter 14: Breast cancer: Role of MR-guided radiation therapy
- Abstract
- Introduction
- External beam radiotherapy
- MRI-guided APBI
- Published treatment outcomes
- Concluding remarks
- References
- Chapter 15: MR-guided radiotherapy for liver tumors: Hepatocarcinomas, cholangiocarcinomas, and liver metastases
- Abstract
- Introduction
- Stereotactic body radiotherapy for liver tumor before MRI-guided radiotherapy (MRgRT) era
- MRI-guided radiotherapy (MRgRT) for primary and secondary hepatic malignancies
- Appendix: Supplementary material
- Appendix: Supplementary material
- Concluding remarks
- References
- Chapter 16: Pancreatic cancers
- Abstract
- Introduction
- General management
- Radiation therapy
- Concluding remarks
- References
- Chapter 17: MR linac radiation therapy: A real-time personalized approach for prostate cancer
- Abstract
- Introduction
- Practical considerations
- Definitive radiotherapy
- Definitive treatment intro
- Patient selection
- Planning and treatment delivery
- Current clinical evidence
- Other considerations
- Postoperative radiotherapy
- Limitations
- Future directions
- Concluding remarks
- References
- Chapter 18: Online MR-guided radiotherapy in rectal cancer—Dose escalation and beyond
- Abstract
- Evolution of the current standard multimodality treatment of rectal cancer: From blunt resection to total neoadjuvant therapy
- Role of magnetic resonance imaging in the staging of rectal cancer
- Potential benefit of online MR-guided radiotherapy in rectal cancer
- Organ preservation in case of a clinical complete response to radiotherapy
- Data available on online adaptive MR-guided radiotherapy
- Concluding remarks
- References
- Chapter 19: Oligometastatic disease: Adrenal, lymph nodes, bone
- Abstract
- Introduction
- Stereotactic body radiotherapy trials (SBRT): Success and toxicity
- MR-guided SBRT for metastatic disease: Dosimetric data and case reports
- MR-guided SBRT for oligometastatic disease: Clinical data
- Future perspectives
- Concluding remarks
- Appendix: Supplementary material
- Appendix: Supplementary material
- References
- Chapter 20: Gynecological tumors
- Abstract
- Introduction
- The use of MRg-RT in cervical cancer
- The use of MRg-RT in endometrial cancer
- The use of MRg-RT in ovarian cancer
- Special conditions
- Concluding remarks
- References
- Further reading
- Chapter 21: Magnetic resonance-guided radiotherapy in pediatric cancers
- Abstract
- Introduction
- Major tumor types, local approaches, and outcomes
- Radiotherapy-related toxicity profile for major pediatric tumor types
- Is late toxicity avoidable by MRgRT?
- Survey on the potential role of MRgRT in pediatric radiotherapy among future users
- The ideal niche for MRgRT in pediatric patients
- Current challenges for MRgRT in pediatrics
- Concluding remarks
- References
- Chapter 22: MR-guided SBRT for unusual tumors (cardiac, kidney, bladder)
- Abstract
- Cardiac and pericardiac tumors
- Bladder cancer
- Kidney
- Oligometastatic RCC
- Concluding remarks
- References
- Chapter 23: Patient reported outcomes in the use of MR-guided radiotherapy
- Abstract
- Patient experience
- PROMs
- Concluding remarks
- References
- Chapter 24: Use of artificial intelligence in MR-guided RT
- Abstract
- Artificial intelligence in the MR-guided RT workflow
- AI1: Automatic segmentation
- AI2: Synthetic CT
- AI3: Automatic planning
- AI4: Automatic QA
- AI5: Motion management
- Concluding remarks
- References
- Chapter 25: Radiomics for MR-Linacs: State of the art and future directions
- Abstract
- The radiomics concept
- Radiomics experiences on MR-Linac
- Concluding remarks
- References
- Index
- No. of pages: 562
- Language: English
- Edition: 1
- Volume: 8
- Published: December 1, 2022
- Imprint: Academic Press
- Paperback ISBN: 9780323916899
- eBook ISBN: 9780323985482
SH
Sara L. Hackett
Sara Hackett completed her B.Sc. (Hons) in Physics and Mathematics at the University of Western Australia in 2003, was awarded a Ph.D. with Distinction in 2008 by the same institute. She trained as a Medical Physicist, specializing in Radiotherapy, and received her certification in 2010. During this period she also completed an M.Sc. in Medical Physics with the Royal Melbourne Institute of Technology. After working as a postdoctoral fellow at the Université catholique de Louvain and the University of Oxford, she joined the Experimental Medical Physics group at University Medical Center Utrecht (UMCU) as a postdoctoral physis fellow to work on the clinical introduction of the MR-linac.
Dr. Hackett now works as a clinical physicist at UMCU with the primary responsibility for treatment planning. The Radiotherapy department has three MR-linacs, as well as ten Agility linacs. She is involved with lung radiotherapy on the MR-linac and is supervising M.Sc. and Ph.D. students in the development of gating, tracking and real-time-adapted radiotherapy.
Affiliations and expertise
University Medical Center, Utrecht, The Randstad, The NetherlandsCO
Cem Onal
Prof. Cem Onal is the founder and Chair of the Radiation Oncology Department at Baskent University. Prof. Onal completed his residency in radiation oncology in 2004 at Hacettepe University School of Medicine in Ankara. His primary research interests are prostate cancer, breast cancer, and gynecological malignancies. He has extensive experience using intensity modulated radiotherapy and image guided radiotherapy to treat prostate cancer, as well as brachytherapy for gynecological tumors, stereotactic radiotherapy, and radiosurgery. He is the director of the MR-Linac unit and has extensive experience treating prostate cancer and abdominal tumors with MR-Linac. He is also skilled in computed tomography-guided brachytherapy, intensity modulated radiotherapy, image-guided radiotherapy, stereotactic body radiotherapy/radiosurgery, and helical tomotherapy.
He has over 150 articles published in international and national journals. He has also presented over 350 international and national abstracts at various scientific meetings. He serves as the editorial board member and peer reviewer in several journals.
Affiliations and expertise
Baskent University Faculty of Medicine, Department of Radiation Oncology, Ankara, TurkeyEO
Enis Ozyar
Enis Ozyar M.D., graduated from Ankara University, Medical School, Ankara, Turkey in 1985 and finished his residency at Hacettepe University, School of Medicine, Department of Radiation Oncology, Ankara in 1993. He worked at the same department between 1993-2008. He obtained his associate professorship degree in 1998 and professorship degree in 2003. He was appointed as Chair and Professor of Radiation Oncology at the Acibadem MAA University, School of Medicine, Department of Radiation Oncology, Istanbul, Turkey in 2008.
Dr. Ozyar currently works at flaghship hospital – Acibadem Maslak Hospital – of the Acibadem Health Group (AHG). AHG is the largest private health care group in Turkey and have 8 Radiation Oncology centers equipped with high tech systems such as MRIdien Mr-Linac, IGRT-IMRT-SRT linac systems, robotic linacs, Gammaknife, brachytherapy and intraoperative radiotherapy. Dr. Ozyar is also working as coordinator of Radiation Oncology Centers of AHG. He is also charing Acibadem RTT school and Health Physics programme of Acibadem MAA University.
His main interest areas are head and neck cancer, prostate cancer, gynecological cancers, sterotactic radiotherapy and MR guided radiotherapy.
Dr. Ozyar published more than 100 manuscripts published in international SCI journals. His h-index is 27.
Affiliations and expertise
Department of Radiation Oncology, Acibadem MAA University, Istanbul, TurkeyRead MR Linac Radiotherapy on ScienceDirect