Mouse Models of Development and Disease

1st Edition, Volume 148 - April 14, 2022
Editors: Thomas Gridley, Leif Oxburgh
Language: English
Hardback ISBN:
9 7 8 - 0 - 1 2 - 8 1 7 1 3 1 - 8
eBook ISBN:
9 7 8 - 0 - 1 2 - 8 1 7 1 3 2 - 5

Mouse Models of Development and Disease, Volume 148 in the Current Topics in Developmental Biology series, highlights new advances in the field, with this volume presenting ch… Read more

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Mouse Models of Development and Disease, Volume 148 in the Current Topics in Developmental Biology series, highlights new advances in the field, with this volume presenting chapters describing Mouse models of Charcot-Marie-Tooth disease, Mouse models in palate and craniofacial development, Uterine morphogenesis, Improving the translatability of mouse models of Alzheimer's disease, Mouse models for the study of clustered protocadherins, Mechanisms of organ regeneration in the spiny mouse, Comparative studies of organ vascularization, Modeling human urinary tract development and hereditary malformations, Innervation in organogenesis, Between embryo and adult: somatic growth of the kidney, and Mouse models in the study of Notch signaling.

Cover image
Table of Contents
Title Page
Copyright
Contributors
Mouse models of development and disease: Preface
Origins of the field
Current work in the field
Chapter One: Mouse mutagenesis and phenotyping to generate models of development and disease
Abstract
1: The mouse fancy and the early days of mouse genetics
2: Mutagenesis in mice
3: High throughput mutagenesis and phenotyping
4: Looking forward
5: Concluding remarks
Acknowledgments
References
Chapter Two: Mouse models in palate development and orofacial cleft research: Understanding the crucial role and regulation of epithelial integrity in facial and palate morphogenesis
Abstract
1: Introduction
2: Overview of midfacial morphogenesis and periderm differentiation
3: Mouse genetic studies uncover a critical role for the embryonic periderm in orofacial morphogenesis
4: Connections between epithelial integrity and epithelial–mesenchymal interactions regulating orofacial morphogenesis
5: The roles of the periderm and the IRF6-p63 pathway in palatal fusion
6: Concluding remarks
Acknowledgments
References
Chapter Three: Mammalian uterine morphogenesis and variations
Abstract
1: Introduction
2: Human uterine variation
3: Human uterine variation syndromes
4: Conclusion and final remarks
References
Chapter Four: Improving mouse models for the study of Alzheimer's disease
Abstract
1: Introduction
2: Overcoming limitations of existing mouse models relevant to early-onset AD
3: Developing mouse models of late-onset AD (LOAD) through the MODEL-AD consortium
4: Modeling vascular contributions
5: Minimizing species differences to model inflammatory contributions to AD
6: Mouse models at single-cell or cell-state resolution
7: Integrating genetic context into mouse models to better represent the patient
8: Training resources for use of animal models of Alzheimer's disease
9: Conclusions
References
Chapter Five: Mouse models for the study of clustered protocadherins
Abstract
1: Introduction
2: Models to study isoform expression
3: Models to study function
4: Future directions
References
Chapter Six: Wound healing and regeneration in spiny mice (Acomys cahirinus)
Abstract
1: Introduction
2: Natural history and evolution of Acomys species
3: Acomys and the evolution of mammalian wound healing
4: Repair of skin wounds in Acomys
5: Repair of skeletal muscle injury in Acomys
6: Repair of kidney injury and regeneration of organ function in Acomys
7: Repair of cardiac injury in Acomys
8: Common features of Acomys regeneration studies
9: Summary
Acknowledgments
References
Chapter Seven: Plumbing our organs: Lessons from vascular development to instruct lab generated tissues
Abstract
1: Introduction
2: Vascular development: Basic step-wise processes
3: Vascularization of the kidney
4: Organoid technology as a step toward organ replacement
5: Organoids and vascularization
6: The promise of vascular transcriptomes
7: Vascularization of organoids increases epithelial maturity
8: Methods for vascularization of organoids
9: The challenges of organoid culture
10: Perspectives for the future of vascularized engineered tissues
References
Chapter Eight: Innervation in organogenesis
Abstract
1: Introduction
2: Developmental origins of neurons
3: Neurotrophins and axon guidance cues
4: Organ innervation and developmental roles
5: Discussion
References
Chapter Nine: Growth control of the kidney
Abstract
1: Introduction
2: Kidney anatomy
3: Kidney development
4: Cessation of nephrogenesis
5: Nephron endowment
6: Insulin like growth factors in prenatal growth control
7: Growth hormone and insulin like growth factor in postnatal growth control
8: Reactivation of kidney growth in the adult
9: Perspectives
Acknowledgments
References

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Thomas Gridley

Leif Oxburgh