Molecular Pharmaceutics and Nano Drug Delivery

Fundamentals and Challenges

1st Edition - October 17, 2023
Editors: Umesh Gupta, Amit K. Goyal
Language: English
Paperback ISBN:
9 7 8 - 0 - 3 2 3 - 9 1 9 2 4 - 1
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 9 1 4 1 5 - 4

Molecular Pharmaceutics and Nano Drug Delivery: Fundamentals and Challenges provides a thorough resource for both beginners and established scientists, bringing fundament… Read more

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Molecular Pharmaceutics and Nano Drug Delivery: Fundamentals and Challenges provides a thorough resource for both beginners and established scientists, bringing fundamental knowledge about key challenges of these carriers down to the molecular level. The book satisfies the need of availability of literature at single platform with the detailed knowledge to understand crucial aspects, such as regulatory, clinical, toxicological and the formulation requirements of these carriers. This is a valuable resource for graduates, pharmaceutical researchers and anyone working on aspects of pharmaceutics, molecular pharmaceutics and nano-drug/gene delivery.

So called ‘novel drug delivery systems’ are numerous, with each having different approaches to their production, characterization and evaluation. The proper understanding of these dosage forms, as well as their critical attributes such as toxicity and regulatory requirements are aspects which researchers should know before they begin working on these carriers. This book provides this critical information.

Cover image
Title page
Table of Contents
Copyright
List of contributors
Preface
Chapter 1. Protein and enzyme-based nanoformulations
Abstract
1.1 Introduction
1.2 Challenges associated with protein and enzymes delivery
1.3 Nanocarrier system for protein and enzyme delivery
1.4 Conclusion
References
Chapter 2. Vaccines and sera
Abstract
2.1 Introduction
2.2 Vaccine types and generations
2.3 Immunization
2.4 Immunology of vaccines
2.5 Side effects and safety of vaccines
2.6 Vaccine preparation
2.7 Vaccines evaluation and standardization
2.8 Regulatory consideration of vaccines
2.9 Licensed vaccines
2.10 Sera
2.11 Revolutions in serum therapy
2.12 General method of preparation of sera
2.13 Evaluation of sera
2.14 Standardization of sera
2.15 Regulatory consideration of sera
2.16 Marketed products of vaccines and sera
2.17 Challenges to vaccine and sera success
2.18 New approaches for vaccines and sera
2.19 Conclusion
References
Chapter 3. Aptamers and antisense oligonucleotide-based delivery
Abstract
3.1 What is the aptamer?
3.2 Aptamer design
3.3 Drug delivery by aptamers
3.4 Binding to different molecules
References
Chapter 4. Monoclonal antibodies: recent development in drug delivery
Abstract
4.1 Introduction
4.2 The molecular mechanisms of therapeutic antibody
4.3 Advantages and disadvantages of mAbs
4.4 Pharmacokinetics versus tumor targeting
4.5 Approaches for developing targeted monoclonal antibodies
4.6 Novel drug delivery systems for mAbs
4.7 Formulation challenges of mAbs
4.8 Future trends of mAbs
4.9 Conclusion
References
Chapter 5. Hormonal delivery systems
Abstract
5.1 Introduction
5.2 Hormones as pharmacotherapeutics
5.3 Novel drug delivery systems for hormones
5.4 Conclusion and future perspectives
References
Chapter 6. Vesicular drug delivery systems: a novel approach in current nanomedicine
Abstract
6.1 Introduction
6.2 Type of vesicles
6.3 Engineered vesicles for therapeutic purposes
6.4 Pharmaceutical application of vesicles
6.5 Conclusions and outlooks
References
Chapter 7. Polymeric micelles in drug delivery and targeting
Abstract
Abbreviations
7.1 Introduction
7.2 Polymeric micelles
7.3 Characterization and evaluation of polymeric micelles
7.4 Application of polymeric micelles in drug delivery
7.5 Challenges associated with clinical translation
7.6 Conclusion
Acknowledgments
References
Chapter 8. Physicochemical characterization of drug delivery systems based on nanomaterials
Abstract
8.1 Introduction
8.2 Nanomaterial shape/morphology
8.3 Size average, distribution, and nanomaterial concentration
8.4 Nanomaterial surface properties
8.5 Nanomaterial-active pharmaceutical ingredient structure, composition, and crystal form
8.6 Active pharmaceutical ingredient content
8.7 Active pharmaceutical ingredient degradation products, other impurities, and stability assessment
8.8 Active pharmaceutical ingredient release assay
References
Chapter 9. Inorganic and metal-based nanoparticles
Abstract
9.1 Introduction
9.2 Enhanced permeability and retention effect
9.3 Blood–brain barrier
9.4 Neurological disease
Acknowledgment
References
Chapter 10. Dendrimers: promises and challenges in drug delivery
Abstract
10.1 Introduction
10.2 Structural architecture and properties
10.3 Nomenclature
10.4 Synthesis of dendrimer
10.5 Types of dendrimers
10.6 Challenges of dendrimer in drug delivery
10.7 Biomedical applications of dendrimer
10.8 Diagnostic applications
10.9 Conclusion
References
Chapter 11. Development of advanced diagnostic platform for detection of infectious diseases
Abstract
11.1 Introduction
11.2 Traditional laboratory techniques for the diagnosis and treatment of diseases
11.3 Recent emerging technology for diagnosis of infectious diseases
11.4 Other diagnostic approaches and future perspective
11.5 Conclusion
Acknowledgments
Conflicts of interest
References
Chapter 12. Fundamentals of a targeted drug delivery system
Abstract
Abbreviations
12.1 Introduction
12.2 Approaches for drug delivery
12.3 Mechanism of drug targeting
12.4 Targeted drug delivery systems
12.5 Targeted drug delivery systems for the management of different disorders
12.6 Characterization of targeted drug delivery systems
12.7 Toxicology and regulatory aspect of targeted drug delivery systems
12.8 Conclusion and future perspectives
References
Chapter 13. Assessment of nanotoxicology through in vitro techniques and image-based assays
Abstract
13.1 Introduction
13.2 Nanotoxicology
13.3 Image-based approaches for assessing nanotoxicity
13.4 Regulations
13.5 Conclusions
References
Chapter 14. Gene therapy: advocacies, perspectives, and ethical provocations
Abstract
14.1 Introduction
14.2 Types of gene therapy
14.3 Basic methodologies for gene therapy
14.4 Current status and recent trends in gene therapy
14.5 Delivery systems in gene therapy
14.6 Ethical concerns of gene therapy
14.7 Challenges to gene therapy
14.8 A summary of progress and prospects of gene therapy
References
Index

Umesh Gupta

Dr. Umesh Gupta, currently working as Assistant Professor at Department of Pharmacy, Central University of Rajasthan, India, did his bachelor's, master's and doctorate degree in Pharmaceutical Sciences from Dr. H. S. Gour University, India under the mentorship of Prof. NK Jain. He has recently been awarded for “DAAD Research Stays for Academics and Scientists” at Leibniz-institut fur Polymerforschung Dresden, Germany. He has the past experience of Research Scientist at Ranbaxy Research Laboratories, India and Post-Doctoral Research Associate at South Dakota State University, USA. HE is also recipient of Young Scientist Award by Department of Science and Technology, Government of India as well as Ranbaxy Science Scholar Award 2008 by Ranbaxy Research Laboratories, India. He has been awarded more than 3-4 times the overseas travel award by different funding agencies of Indian government to share and present his research at international platform in countries like Germany, USA and Singapore etc. He has more than ten years of research and academic experience. The area of research is mainly focused on dendrimer mediated drug delivery, solubilization and targeting. His laboratory equally focuses on effective brain delivery through nanotechnological carriers such as polymeric micelles, nanoparticles and dendrimers. He has more than 48 publications and seven book chapters to his credit with total citations of more than 2300 (h index of 23 as per Google Scholar).

Affiliations and expertise

Assistant Professor, Department fo Pharmacy, Central University of Rajasthan, India

Amit K. Goyal

Dr. Amit Kumar Goyal is Professor and Head, Department of Pharmacy, Central University of Rajasthan, India. He has more than 15 years of teaching and research experience at postgraduate and graduate level and worked as a Professor & Head, Department of Pharmaceutics, at ISF College of Pharmacy, Punjab, India. Subsequently, he joined as an Associate Professor at Gujarat Forensic Science University, Gandhinagar and after that as a Scientist at National Institute of Animal Biotechnology, Hyderabad. Dr. Goyal has completed his M. Pharm. and Ph. D. from Department of Pharmaceutical Sciences, Dr. H. S. Gour University, Sagar (M.P.). Dr. Goyal is the leading scientist in the field of cutting age platform technology (Nanotechnology) for site specific targeted delivery of drugs and bio-actives. Dr. Goyal is expert in formulation development and delivery of drugs, vaccines and herbal bio-actives. He is working towards the common goals of exploring new ways of delivering herbal/bio-actives ingredient with the use of nanotechnology.

Affiliations and expertise

Professor and Head, Department of Pharmacy, Central University of Rajasthan, India