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Molecular Pharmaceutics and Nano Drug Delivery
Fundamentals and Challenges
- 1st Edition - October 17, 2023
- Editors: Umesh Gupta, Amit K. Goyal
- Language: English
- Paperback ISBN:9 7 8 - 0 - 3 2 3 - 9 1 9 2 4 - 1
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 9 1 4 1 5 - 4
Molecular Pharmaceutics and Nano Drug Delivery: Fundamentals and Challenges provides a thorough resource for both beginners and established scientists, bringing fundament… Read more
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Request a sales quoteMolecular Pharmaceutics and Nano Drug Delivery: Fundamentals and Challenges provides a thorough resource for both beginners and established scientists, bringing fundamental knowledge about key challenges of these carriers down to the molecular level. The book satisfies the need of availability of literature at single platform with the detailed knowledge to understand crucial aspects, such as regulatory, clinical, toxicological and the formulation requirements of these carriers. This is a valuable resource for graduates, pharmaceutical researchers and anyone working on aspects of pharmaceutics, molecular pharmaceutics and nano-drug/gene delivery.
So called ‘novel drug delivery systems’ are numerous, with each having different approaches to their production, characterization and evaluation. The proper understanding of these dosage forms, as well as their critical attributes such as toxicity and regulatory requirements are aspects which researchers should know before they begin working on these carriers. This book provides this critical information.
- Provides a conceptual understanding of Molecular Pharmaceutics and drug/gene delivery systems of biological origin
- Presents a detailed description and discussion on nanotechnological carriers, from basics to advances, including gene delivery and protein-oriented delivery
- Includes regulatory and toxicological requirements for novel drug delivery systems
- Cover image
- Title page
- Table of Contents
- Copyright
- List of contributors
- Preface
- Chapter 1. Protein and enzyme-based nanoformulations
- Abstract
- 1.1 Introduction
- 1.2 Challenges associated with protein and enzymes delivery
- 1.3 Nanocarrier system for protein and enzyme delivery
- 1.4 Conclusion
- References
- Chapter 2. Vaccines and sera
- Abstract
- 2.1 Introduction
- 2.2 Vaccine types and generations
- 2.3 Immunization
- 2.4 Immunology of vaccines
- 2.5 Side effects and safety of vaccines
- 2.6 Vaccine preparation
- 2.7 Vaccines evaluation and standardization
- 2.8 Regulatory consideration of vaccines
- 2.9 Licensed vaccines
- 2.10 Sera
- 2.11 Revolutions in serum therapy
- 2.12 General method of preparation of sera
- 2.13 Evaluation of sera
- 2.14 Standardization of sera
- 2.15 Regulatory consideration of sera
- 2.16 Marketed products of vaccines and sera
- 2.17 Challenges to vaccine and sera success
- 2.18 New approaches for vaccines and sera
- 2.19 Conclusion
- References
- Chapter 3. Aptamers and antisense oligonucleotide-based delivery
- Abstract
- 3.1 What is the aptamer?
- 3.2 Aptamer design
- 3.3 Drug delivery by aptamers
- 3.4 Binding to different molecules
- References
- Chapter 4. Monoclonal antibodies: recent development in drug delivery
- Abstract
- 4.1 Introduction
- 4.2 The molecular mechanisms of therapeutic antibody
- 4.3 Advantages and disadvantages of mAbs
- 4.4 Pharmacokinetics versus tumor targeting
- 4.5 Approaches for developing targeted monoclonal antibodies
- 4.6 Novel drug delivery systems for mAbs
- 4.7 Formulation challenges of mAbs
- 4.8 Future trends of mAbs
- 4.9 Conclusion
- References
- Chapter 5. Hormonal delivery systems
- Abstract
- 5.1 Introduction
- 5.2 Hormones as pharmacotherapeutics
- 5.3 Novel drug delivery systems for hormones
- 5.4 Conclusion and future perspectives
- References
- Chapter 6. Vesicular drug delivery systems: a novel approach in current nanomedicine
- Abstract
- 6.1 Introduction
- 6.2 Type of vesicles
- 6.3 Engineered vesicles for therapeutic purposes
- 6.4 Pharmaceutical application of vesicles
- 6.5 Conclusions and outlooks
- References
- Chapter 7. Polymeric micelles in drug delivery and targeting
- Abstract
- Abbreviations
- 7.1 Introduction
- 7.2 Polymeric micelles
- 7.3 Characterization and evaluation of polymeric micelles
- 7.4 Application of polymeric micelles in drug delivery
- 7.5 Challenges associated with clinical translation
- 7.6 Conclusion
- Acknowledgments
- References
- Chapter 8. Physicochemical characterization of drug delivery systems based on nanomaterials
- Abstract
- 8.1 Introduction
- 8.2 Nanomaterial shape/morphology
- 8.3 Size average, distribution, and nanomaterial concentration
- 8.4 Nanomaterial surface properties
- 8.5 Nanomaterial-active pharmaceutical ingredient structure, composition, and crystal form
- 8.6 Active pharmaceutical ingredient content
- 8.7 Active pharmaceutical ingredient degradation products, other impurities, and stability assessment
- 8.8 Active pharmaceutical ingredient release assay
- References
- Chapter 9. Inorganic and metal-based nanoparticles
- Abstract
- 9.1 Introduction
- 9.2 Enhanced permeability and retention effect
- 9.3 Blood–brain barrier
- 9.4 Neurological disease
- Acknowledgment
- References
- Chapter 10. Dendrimers: promises and challenges in drug delivery
- Abstract
- 10.1 Introduction
- 10.2 Structural architecture and properties
- 10.3 Nomenclature
- 10.4 Synthesis of dendrimer
- 10.5 Types of dendrimers
- 10.6 Challenges of dendrimer in drug delivery
- 10.7 Biomedical applications of dendrimer
- 10.8 Diagnostic applications
- 10.9 Conclusion
- References
- Chapter 11. Development of advanced diagnostic platform for detection of infectious diseases
- Abstract
- 11.1 Introduction
- 11.2 Traditional laboratory techniques for the diagnosis and treatment of diseases
- 11.3 Recent emerging technology for diagnosis of infectious diseases
- 11.4 Other diagnostic approaches and future perspective
- 11.5 Conclusion
- Acknowledgments
- Conflicts of interest
- References
- Chapter 12. Fundamentals of a targeted drug delivery system
- Abstract
- Abbreviations
- 12.1 Introduction
- 12.2 Approaches for drug delivery
- 12.3 Mechanism of drug targeting
- 12.4 Targeted drug delivery systems
- 12.5 Targeted drug delivery systems for the management of different disorders
- 12.6 Characterization of targeted drug delivery systems
- 12.7 Toxicology and regulatory aspect of targeted drug delivery systems
- 12.8 Conclusion and future perspectives
- References
- Chapter 13. Assessment of nanotoxicology through in vitro techniques and image-based assays
- Abstract
- 13.1 Introduction
- 13.2 Nanotoxicology
- 13.3 Image-based approaches for assessing nanotoxicity
- 13.4 Regulations
- 13.5 Conclusions
- References
- Chapter 14. Gene therapy: advocacies, perspectives, and ethical provocations
- Abstract
- 14.1 Introduction
- 14.2 Types of gene therapy
- 14.3 Basic methodologies for gene therapy
- 14.4 Current status and recent trends in gene therapy
- 14.5 Delivery systems in gene therapy
- 14.6 Ethical concerns of gene therapy
- 14.7 Challenges to gene therapy
- 14.8 A summary of progress and prospects of gene therapy
- References
- Index
- No. of pages: 404
- Language: English
- Edition: 1
- Published: October 17, 2023
- Imprint: Academic Press
- Paperback ISBN: 9780323919241
- eBook ISBN: 9780323914154
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Umesh Gupta
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