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Molecular Pathology, An Issue of the Clinics in Laboratory Medicine
- 1st Edition, Volume 44-2 - June 4, 2024
- Editor: Lauren Ritterhouse
- Language: English
- Hardback ISBN:9 7 8 - 0 - 4 4 3 - 2 9 5 6 8 - 3
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 2 9 5 6 9 - 0
In this issue of Clinics in Laboratory Medicine, guest editor Lauren L. Ritterhouse brings her considerable expertise to the topic of molecular pathology. Experts in the field… Read more
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Request a sales quoteIn this issue of Clinics in Laboratory Medicine, guest editor Lauren L. Ritterhouse brings her considerable expertise to the topic of molecular pathology. Experts in the field cover topics such as molecular pathology of lung cancer, gliomas, prostate cancer, and more.
- Contains 14 relevant topics including clinical utilization and designing a test menu; molecular alteration in pediatric solid tumors; pan-cancer molecular biomarkers; and more.
- Provides in-depth clinical reviews on molecular pathology, offering actionable insights for practice.
- Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.
- Cover image
- Title page
- Table of Contents
- Copyright
- Contributors
- Forthcoming Issues
- Preface
- Molecular Methods: Clinical Utilization and Designing a Test Menu
- Key points
- Building your molecular toolbox
- Pre-analytical considerations
- Molecular methods
- Considerations in designing a molecular test menu
- Clinics care points
- Molecular Pathology of Lung Cancer
- Key points
- Overview
- Specimens for testing
- Testing methodology
- Biomarkers for testing
- Programmed death–ligand 1
- Emerging targets
- Summary
- Clinics care points
- Molecular Pathology of Gliomas
- Key points
- Overview
- Differential diagnosis
- Molecular pathology features
- Pediatric low-grade gliomas
- Summary
- Clinics care points
- Molecular Pathology of Prostate Cancer
- Key points
- Overview
- Prostate cancer etiology and germline alterations
- Precursors lesions
- The multifocal and multiclonal nature of prostate cancer
- Clinically relevant molecular alterations
- Assessing metastatic prostate cancer
- Summary
- Molecular Pathology of Urothelial Carcinoma
- Key points
- Overview
- Molecular characterization of invasive urothelial carcinoma
- Molecular taxonomy of urothelial carcinoma
- Molecular updates on histologic variants of urothelial carcinoma
- Summary and future directions
- Molecular Pathology of Ovarian Epithelial Neoplasms: Predictive, Prognostic, and Emerging Biomarkers
- Key points
- Overview
- Histologic subtypes of epithelial tumors
- Clinics care points
- Molecular Approach to Colorectal Carcinoma: Current Evidence and Clinical Application
- Key points
- Overview
- Mismatch repair deficiency and microsatellite instability
- Sporadic mismatch repair deficiency
- Lynch syndrome
- Mismatch repair and microsatellite instability testing
- Prognostic features of microsatellite instability-high cancer
- Therapeutic implications of microsatellite instability-high tumors
- Neurotrophic tyrosine receptor kinase
- Epidermal growth factor receptor and downstream signaling pathways
- Summary
- Clinics care points
- Disclosure
- Molecular Pathology of Gastroesophageal Cancer
- Key points
- Overview
- Esophageal squamous cell carcinoma
- Esophageal adenocarcinoma
- Gastric adenocarcinoma
- Intratumoral genomic heterogeneity in esophageal and gastric adenocarcinoma
- Precision medicine in upper gastrointestinal cancers
- Clinics care points
- Disclosure
- Molecular Pathology of Breast Tumors: Diagnostic and Actionable Genetic Alterations
- Key points
- Overview
- Molecular classification of breast cancer
- Key diagnostic somatic alterations in breast tumors
- Key actionable somatic alterations in breast cancer
- Resistance alterations in breast cancer
- Emerging molecular markers and future trends
- Clinics care points
- Disclosure
- Molecular Alterations in Pediatric Solid Tumors
- Key points
- Overview
- Categorization of pediatric extracranial solid tumors
- Molecular alterations in pediatric bone and soft tissue tumors
- Molecular alterations in organ-based solid tumors
- Differences from adult solid tumors
- Tumor predisposition syndromes in pediatric solid tumors
- Molecular techniques
- Conventional molecular techniques
- Use of next-generation sequencing–based molecular assays in pediatric solid tumors
- Clinics care points
- Emerging concepts
- Summary
- Funding
- Molecular Pathology of Thyroid Tumors: Old Problems and New Concepts
- Key points
- Overview
- The RAS mutant thyroid nodule
- Hürthel cell neoplasms
- Molecular alteration in unusual thyroid tumors
- Determining actionable molecular alterations by immunohistochemistry
- Clinics care points
- Disclosure
- Pan-Cancer Molecular Biomarkers: A Paradigm Shift in Diagnostic Pathology
- Key points
- Overview
- The emergence of pan-cancer molecular biomarkers has been enabled by technological advances in clinical cancer sequencing
- Many targetable mutations are shared across tumors of various primary sites
- Molecular biomarkers beyond single mutations: mutational signatures and tumor mutational burden
- New clinical trial design strategies in the validation of pan-cancer biomarkers
- Summary
- Clinics care points
- Molecular Pathology of Myeloid Neoplasms: Molecular Pattern Recognition
- Key points
- Overview
- Patterns are essential
- The “old” stem cell and clonal hematopoiesis
- Disclosure
- Molecular Pathology of Mature Lymphoid Malignancies
- Key points
- Overview
- Mature B-cell neoplasms
- Mature T-cell and natural killer cell neoplasms
- Summary and future directions
- Clinics care points
- No. of pages: 240
- Language: English
- Edition: 1
- Volume: 44-2
- Published: June 4, 2024
- Imprint: Elsevier
- Hardback ISBN: 9780443295683
- eBook ISBN: 9780443295690