Molecular Oncology Diagnostics, An Issue of the Clinics in Laboratory Medicine

1st Edition, Volume 42-3 - September 23, 2022
Editor: Fei Dong
Language: English
Hardback ISBN:
9 7 8 - 0 - 3 2 3 - 8 4 9 3 6 - 4
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 8 4 9 3 7 - 1

In this issue of Clinics in Laboratory Medicine, guest editor Dr. Fei Dong brings his considerable expertise to the topic of Molecular Oncology Diagnostics. Top experts in the… Read more

Molecular Oncology Diagnostics, An Issue of the Clinics in Laboratory Medicine

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In this issue of Clinics in Laboratory Medicine, guest editor Dr. Fei Dong brings his considerable expertise to the topic of Molecular Oncology Diagnostics. Top experts in the field review current practices in molecular oncology diagnostics, highlighting the rapid clinical adoption of next generation sequencing techniques. The articles address key laboratory considerations in the molecular testing of cancer specimens and the impact of advanced testing strategies on patient care.

Cover image
Title page
Table of Contents
Copyright
Contributors
Forthcoming Issues
Preface
Panel Sequencing for Targeted Therapy Selection in Solid Tumors
Key points
Introduction
History
Lung cancer as a paradigm
Extrapolation to other cancer types
Cost and reimbursement
Future avenues
Clinics care points
Molecular Diagnostic Testing for Hematopoietic Neoplasms: Linking Pathogenic Drivers to Personalized Diagnosis
Key points
Introduction
Myeloid neoplasia
Precursor lymphoid neoplasms
Lymphoma and plasma cell neoplasia
Clinics care points
Special Considerations in the Molecular Diagnostics of Pediatric Neoplasms
Key points
Introduction
Discussion
Summary
Clinics care points
Specimen Considerations in Molecular Oncology Testing
Key points
Introduction
Tissue acquisition and processing
Specimen processing and pre-analytic variables influencing specimens
Pre-analytic evaluation and triage of specimen
Summary
Clinics care points
Utility of Single-Gene Testing in Cancer Specimens
Key points
Introduction
Single-gene testing methodology
Pros and cons of single-gene testing
Clinical utility
Summary
Clinics care points
Analytical Principles of Cancer Next Generation Sequencing
Key points
Introduction
Tumor NGS specimen processing considerations
Tumor next generation sequencing assay design considerations
Application-specific assay design considerations
Control samples
Quality control and quality assurance
Summary
Clinics care points
Disclosure
Principles and Validation of Bioinformatics Pipeline for Cancer Next-Generation Sequencing
Key points
Introduction
Background
Discussion
Summary
Clinics care points
Best Practice for Clinical Somatic Variant Interpretation and Reporting
Key points
Introduction
Resources and tools for somatic variant classification and interpretation
Bioinformatics tools and clinical pipelines for somatic variant analysis
Somatic variant classification and interpretation
Funding
Summary
Molecular Detection of Oncogenic Gene Rearrangements
Key points
Introduction
Preanalytical considerations
Karyotyping
Fluorescence in situ hybridization
Massively parallel sequencing
Other emerging technologies
Clinics care points
Copy Number Analysis in Cancer Diagnostic Testing
Key points
Introduction
Discussion
Clinics care points
Molecular Biomarkers of Response to Cancer Immunotherapy
Key points
Introduction
Food and Drug Administration-approved biomarkers
Emerging biomarkers
Summary
Clinics care points
When Tissue Is the Issue: Expanding Cell-Free DNA “Liquid Biopsies” to Supernatants and Nonplasma Biofluids
Key points
Introduction
Preanalytical considerations in cell-free DNA evaluation
Analytical strategies for cell-free DNA evaluation in oncology
Postanalytical cell-free DNA considerations in oncology
Summary
Clinics care points
Germline Testing for the Evaluation of Hereditary Cancer Predisposition
Key points
Introduction
Discussion
Summary and future directions
Clinics care points

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Molecular Oncology Diagnostics, An Issue of the Clinics in Laboratory Medicine

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Fei Dong