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Molecular Imaging

Principles and Practice

  • 2nd Edition - August 2, 2021
  • Latest edition
  • Editors: Brian D. Ross, Sanjiv S. Gambhir
  • Language: English

The detection and measurement of the dynamic regulation and interactions of cells and proteins within the living cell are critical to the understanding of cellular biology and pa… Read more

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Description

The detection and measurement of the dynamic regulation and interactions of cells and proteins within the living cell are critical to the understanding of cellular biology and pathophysiology. The multidisciplinary field of molecular imaging of living subjects continues to expand with dramatic advances in chemistry, molecular biology, therapeutics, engineering, medical physics and biomedical applications. Molecular Imaging: Principles and Practice, Volumes 1 and 2, Second Edition provides the first point of entry for physicians, scientists, and practitioners. This authoritative reference book provides a comprehensible overview along with in-depth presentation of molecular imaging concepts, technologies and applications making it the foremost source for both established and new investigators, collaborators, students and anyone interested in this exciting and important field.

Key features

  • The most authoritative and comprehensive resource available in the molecular-imaging field, written by over 170 of the leading scientists from around the world who have evaluated and summarized the most important methods, principles, technologies and data
  • Concepts illustrated with over 600 color figures and molecular-imaging examples
  • Chapters/topics include, artificial intelligence and machine learning, use of online social media, virtual and augmented reality, optogenetics, FDA regulatory process of imaging agents and devices, emerging instrumentation, MR elastography, MR fingerprinting, operational radiation safety, multiscale imaging and uses in drug development
  • This edition is packed with innovative science, including theranostics, light sheet fluorescence microscopy, (LSFM), mass spectrometry imaging, combining in vitro and in vivo diagnostics, Raman imaging, along with molecular and functional imaging applications
  • Valuable applications of molecular imaging in pediatrics, oncology, autoimmune, cardiovascular and CNS diseases are also presented
  • This resource helps integrate diverse multidisciplinary concepts associated with molecular imaging to provide readers with an improved understanding of current and future applications

Readership

Molecular imaging basic scientists, molecular biologists, oncologists, functional and nuclear medicine imaging, radiologists with molecular imaging background/interest

Table of contents

Volume 1
Overview

1. General Principles of Molecular Imaging
Brian D. Ross and Sanjiv Sam Gambhir
Part I: Molecular Imaging Technologies

2. Positron Emission TomographyeMagnetic Resonance Imaging
Farshad Moradi, Ryan L. Brunsing, Vipul R. Sheth and Andrei Iagaru

3. SPECT and SPECT/CT
Brian F. Hutton, Marlies C. Goorden and Freek J. Beekman

4. Principles of Micro X-ray Computed Tomography
Cristian T. Badea

5. Small-Animal SPECT, SPECT/CT, and SPECT/MRI
Ling-Jian Meng and Neal H. Clinthorne

6. Instrumentation and Methods to Combine Small-Animal PET With Other Imaging Modalities
Andrew N. Groll and Craig S. Levin

7. Functional Imaging Using Bioluminescent Reporter Genes in Living Subjects
Scott K. Lyons, Kevin P. Francis and Christopher H. Contag

8. Principles and Practice of Intraoperative Fluorescence Imaging
Dimitris Gorpas, Vasilis Ntziachristos and Jie Tian

9. Molecular Endoscopic Imaging in Cancer
Timo Rath, Markus F. Neurath and Raja Atreya

10. Intravital Microscopy
Shariq M. Usmani and Thorsten R. Mempel

11. Ultrasound
F. Stuart Foster and Emmanuel Cherin

12. Hybrid PET-CT-Ultrasound Imaging
Bertrand Tavitian and Mailyn Perez-Liva

13. Photoacoustic Molecular Imaging: Principles and Practice
Junjie Yao and Lihong V. Wang

14. Inhaled Gas Magnetic Resonance Imaging: Advances, Applications, Limitations, and New Frontiers
Alexander M. Matheson, Caleb Thompson and Grace Parraga

15. Magnetic Particle Imaging for Vascular, Cellular and Molecular Imaging
Prashant Chandrasekharan, Zhi Wei Tay, Xinyi Y. Zhou, Elaine Y. Yu, Barry K.L. Fung, Caylin Colson, Benjamin D. Fellows, Yao Lu, Quincy Huynh, Chinmoy Saayujya, Paul Keselman, Daniel Hensley, Kuan Lu, Ryan Orendorff, Justin Konkle, Emine Ulku Saritas, Bo Zheng, Patrick Goodwill and Steven Conolly

16. Optogenetics
Maria G. Paez Segala and Loren L. Looger

17. Imaging Mass Spectrometry
Richard R. Drake, Danielle A. Scott and Peggi M. Angel

18. CEST (Chemical Exchange Saturation Transfer) MR Molecular Imaging
Guanshu Liu and Peter C.M. van Zijl

19. Molecular Imaging Using Raman Scattering
Stefan Harmsen and Sanjiv Sam Gambhir

20. Synchrotron-Based Dynamic Lung Imaging
Stephen Dubsky

21. Light-Sheet Fluorescence Microscopy for Multiscale Biological Imaging
Jae-Byum Chang, Ruixuan Gao and Fei Chen

22. Cerenkov Imaging
Edwin C. Pratt, Ryo Tamura and Jan Grimm

23. Near-Infrared II Optical Imaging
Shuqing He and Zhen Cheng
Part II: Chemistry of Molecular Imaging

24. Chemistry of Molecular Imaging: An Overview
Silvio Aime, Fabio Travagin, Enzo Terreno and Giovanni B. Giovenzana

25. PET Radiochemistry
Henry F. VanBrocklin

26. SPECT Radiochemistry
Theodosia Maina and Mathew Thakur

27. The Chemistry in Surface Functionalization of Nanoparticles for Molecular Imaging 493
Xianchuang Zheng, Joanna Wang and Jianghong Rao

28. Newer Bioconjugation Methods
Ahmet Krasniqi, Catarina Xavier and Nick Devoogdt

29. Targeted Antibodies and Peptides
Michael R. Lewis, Cathy S. Cutler and Silvia S. Jurisson

30. Antibody-Based Molecular Imaging
Kathryn M. Tully, Veronica L. Nagle, Joshua A. Korsen and Jason S. Lewis

31. Hyperpolarized Magnetic Resonance With Dissolution Dynamic Nuclear Polarization: Principles and Applications
Jan H. Ardenkjaer-Larsen

32. Magnetic Resonance Imaging Agents
Cuihua Wang, Elisenda Rodriguez and John W. Chen

33. Optical Imaging Agents
Luisa Ottobrini, Cristina Martelli and Giovanni Lucignani

34. Photoacoustic Molecular Imaging With Exogenous Agents
Liming Nie, Yajing Liu and Xiaogyuan Chen

35. Ultrasound Contrast Agents
Mark A. Borden, Paul A. Dayton, Connor Slagle and Rachel W. Walmer

36. Theranostics: Agents for Diagnosis and Therapy
Fay Nicolson and Moritz F. Kircher

37. Magnetic Nanoparticles
Ahmad Amirshaghaghi, Zhiliang Cheng, Lee Josephson and Andrew Tsourkas

38. Aptamers for Molecular Imaging
Fre´de´ric Duconge´

39. Nonclinical Product Developmental Strategies, Safety Considerations and Toxicity Profiles of Medical Imaging and Radiopharmaceuticals Products
Adebayo Laniyonu, Yanli Ouyang, Jonathan Cohen, Sunny Awe, Olayinka Dina, Siham Biade, Sally Hargus and Tushar Kokate

40. Intraoperative Molecular Imaging Agents
Stan van Keulen and Eben L. Rosenthal

Volume 2
Part III: Molecular Imaging in Cell and Molecular Biology

41. Protein Engineering for Molecular Imaging
Anna M. Wu

42. Phage Display for Imaging Agent Development
Jessica Hung, Fred Reynolds and Kimberly A. Kelly

43. Molecular Imaging of Gene Therapy
Ramasamy Paulmurugan and Tarik F. Massoud

44. Cell Surveillance Using Magnetic Resonance Imaging
Brooke M. Helfer and Jeff W.M. Bulte

45. Tumor Vasculature
Susan Notohamiprodjo, Zohreh Varasteh, Ambros J. Beer, Gang Niu, Xiaoyuan (Shawn) Chen, Wolfgang Weber and Markus Schwaiger

46. Imaging Hypoxia
Hong Yuan, Gregory M. Palmer and Mark W. Dewhirst

47. Molecular Imaging of ProteineProtein Interactions and Protein Folding
Tarik F. Massoud and Ramasamy Paulmurugan

48. Molecular Imaging of Cellular Signaling Pathways
Kathryn E. Luker

49. Exosome Imaging
Do Won Hwang, Minseok Suh and Dong Soo Lee

50. Gene-Editing Technologies and Applications for Molecular Imaging
Gary D. Luker

51. Reporter Genes for Ultrasound and MRI
Mikhail G. Shapiro

52. Theranostic Approaches Using Live Bacteria
Jung-Joon Min, Mai Thi-Quynh Duong, Thangam Ramar, Sung-Hwan You and Sae-Ryung Kang
Part IV: Applications of Molecular Imaging Oncology

53. Molecular and Functional Imaging and Theranostics of the Tumor Microenvironment
Marie-France Penet, Samata Kakkad, Jesus Pacheco-Torres, Santosh Bharti, Balaji Krishnamachary and Zaver M. Bhujwalla

54. Novel Magnetic Resonance Imaging and Positron Emission Tomography in the RT Planning and Assessment of Response of Malignant Gliomas
David Kamson and Christina Tsien

55. PET Diagnosis and Response Monitoring in Oncology
Richard L. Wahl and Rodney J. Hicks

56. Spectroscopic MRI for Brain Tumor Imaging
Hyunsuk Shim

57. Cancer Detection and Quantification of Treatment Response Using Diffusion-Weighted MRI
Brian D. Ross and Thomas L. Chenevert

58. Prostate Cancer Theranostics
Steven P. Rowe, Mohammad S. Sadaghiani, Rudolf A. Werner, Takahiro Higuchi, Thorsten Derlin, Lilja B. Solnes and Martin G. Pomper

59. Pediatric Molecular Imaging
Heike E. Daldrup-Link
Cardiovascular

60. Imaging Myocardial Metabolism
Robert J. Gropler

61. Congestive Heart Failure
Stephan G. Nekolla, Antti Saraste, Hendrik Sager, Marcus R. Makowski and Markus Schwaiger

62. Molecular Imaging of Atherosclerosis
Eric A. Osborn, Mazen Albaghdadi, Peter Libby and Farouc A. Jaffer

63. Thrombosis and Embolism
Reza Hajhosseiny, Claudia Prieto, Haikun Qi, Alkystis Phinikaridou and Rene´ M. Botnar

64. Molecular Imaging of Stem Cell Therapy in Ischemic Cardiomyopathy
Mark Chandy and Joseph C. Wu
Central Nervous System

65. Central Nervous System Molecular Imaging
Lilja B. Solnes, Andreas H. Jacobs, Jennifer M. Coughlin, Yong Du, Reema Goel, Dima A. Hammoud and Martin G. Pomper

66. Applications, Advances, and Limitations of Molecular Imaging of Brain Receptors
Paul Cumming, Gerhard Gru¨nder, Zabecca Brinson and Dean F. Wong

67. PET and SPECT Imaging of Neurodegenerative Diseases
Alexander Drzezga, Ge´rard N. Bischof, Kathrin Giehl and Thilo van Eimeren

68. PET Imaging of Neuroinflammation
Aisling M. Chaney, Emily M. Deal, Isaac M. Jackson and Michelle L. James
Autoimmunity and Immunology

69. Identifying Musculoskeletal Pain Generators Using Molecular Imaging
Daehyun Yoon, Feliks Kogan, Garry Gold and Sandip Biswal

70. Molecular Imaging of Autoimmune Diseases
Alberto Signore, Arianna Di Paolo and Filippo Galli

71. Molecular Imaging of Diabetes
Lieke Joosten, Marti Boss, Tom Jansen, Maarten Brom, Mijke Buitinga, Erik Aarntzen, Olof Eriksson, Lars Johansson, Bastiaan de Galan and Martin Gotthardt

72. Imaging in Asthma
Avanti Gulhane and Delphine L. Chen

73. Molecular Imaging of Fibrosis
Iris Y. Zhou, Sydney B. Montesi, Eman A. Akam and Peter Caravan

74. Imaging of Bacterial Infections
Alvaro A. Ordon˜ez and Sanjay K. Jain
Part V: Molecular Imaging in Drug Evaluation

75. Molecular and Functional Imaging in Central Nervous System Drug Development
Basil Ku¨nnecke, Michael Honer, Gennaro Pagano and Markus Rudin

76. PET Imaging in Cancer Clinical Trials
David A. Mankoff

77. Magnetic Resonance Imaging: Cardiovascular Applications for Clinical Trials
Chun Yuan, Zach Miller and Xue-Qiao Zhao

78. Imaging of Gene and Cell-Based Therapies: Basis and Clinical Trials
Andreas H. Jacobs, Sonja Schelhaas, Thomas Viel, Yannic Waerzeggers, Alexandra Winkeler, Bastian Zinnhardt and Juri Gelovani
Part VI: Image Quantitation/Analytics

79. Virtual and Augmented Reality Technologies in Molecular and Anatomical Imaging
Suman B. Mondal and Samuel Achilefu

80. Quantification of Radiotracer Uptake Into Tissue
Michael M. Graham

81. Pharmacokinetic Modeling
Sung-Cheng (Henry) Huang

82. Online Social Media: Concepts and Practices for Molecular Imaging Professionals
Chadwick L. Wright, Michelle I. Knopp and Michael V. Knopp

83. The Regulatory Process for Imaging Agents and Devices
Matthew F. Covington, Sally W. Schwarz and John M. Hoffman

84. Operational Radiation Safety for PET-CT, SPECT-CT, and Cyclotron Facilities
Pat Zanzonico

85. Bridging Spatial Scales From Radiographic Images to Cellular and Molecular Properties in Cancers
Natarajan Raghunand and Robert A. Gatenby

86. AI/Machine Learning in Medical Imaging
Maryellen L. Giger

87. Retrospective Registration in Molecular Imaging
Brian D. Ross, Thomas L. Chenevert and Charles R. Meyer

88. Image Processing Analytics: Enhancements and Segmentation
Lubomir Hadjiiski, Ravi Samala and Heang-Ping Chan

89. Magnetic Resonance Fingerprinting: Basic Concepts and Applications in Molecular Imaging
Kathleen Ropella-Panagis and Nicole Seiberlich

90. MR Elastography
Patrick J. Navin, Sudhakar Kundapur Venkatesh and Richard L. Ehman

Product details

  • Edition: 2
  • Latest edition
  • Published: August 2, 2021
  • Language: English

About the editors

BR

Brian D. Ross

Dr. Ross is the Director of the Center for Molecular Imaging at the University of Michigan, which provides state-of-the-art imaging services for the research community and offering a broad range of imaging systems (two IVIS bioluminescent/fluorescent imaging systems, an Agilent 7 Tesla horizontal bore MRI system, a Siemens PET/CT, a Trifoil Imaging SPECT/CT, and a Bruker CT system). As part of CMI, his research helps to develop applications for imaging to allow for investigations of cancer growth and response to therapy including noninvasive detection of molecular signaling events in living tissue.
Affiliations and expertise
Roger A. Berg Research Professor of Radiology; Director, Center for Molecular Imaging; Associate Chair for Basic Science Research; Professor of Biological Chemistry; University of Michigan School of Medicine, Ann Arbor, Michigan, USA

SG

Sanjiv S. Gambhir

Dr. Gambhir served as the Director of the Molecular Imaging Program at Stanford (MIPS) and Canary Center at Stanford for Cancer Early Detection. He has authored over 600 publications, has over 40 patents pending or granted, has been featured on the cover of over 25 journals including the Nature Series, Science, and Science Translational Medicine. He was on the editorial board of several journals including Nano Letters, Nature Clinical Practice Oncology, and Science Translational Medicine. He mentored post-doctoral fellows and graduate students from diverse disciplines. His research focused on the development of imaging assays to monitor fundamental cellular/molecular events in living subjects with an emphasis on the detection and management of cancer. A particular interest of his research and lab was early cancer detection including combining in vivo and in vitro diagnostics.
Affiliations and expertise
Virginia & D.K. Ludwig Professor of Radiology and Bioengineering; Director, Molecular Imaging Program at Stanford (MIPS); Director, Canary Center for Cancer Early Detection at Stanford; Chief, Division of Nuclear Medicine; Stanford University School of Medicine, Stanford, California, USA

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