Molecular Genetics Pt 3
- 1st Edition - January 1, 1979
- Imprint: Academic Press
- Editor: Herbert Taylor
- Language: English
- Hardback ISBN:9 7 8 - 0 - 1 2 - 6 8 4 4 0 3 - 0
- Paperback ISBN:9 7 8 - 0 - 1 2 - 4 3 1 3 8 6 - 6
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 1 5 1 8 7 - 0
Molecular Genetics, Part III: Chromosome Structure explores the structure and modification of DNA, chromatin, and higher order organization and possible subunits of chromosomes at… Read more
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Request a sales quoteMolecular Genetics, Part III: Chromosome Structure explores the structure and modification of DNA, chromatin, and higher order organization and possible subunits of chromosomes at the molecular level. It describes major changes in concepts of chromatin structure and packaging of DNA based on studies of nuclease digests and electron micrographs; the role of restriction endonucleases in molecular genetics; the involvement of DNA topoisomerases in concerted breaking and rejoining of DNA backbone bonds; enzymatic methylation of DNA; and transcriptional units in eukaryotic chromosomes. Organized into seven chapters, this volume begins with an overview of the general properties of type I and type II restriction enzymes, basic aspects of restriction enzyme technology, and applications of restriction enzyme technology to the study of chromosome structure and function. It then discusses recombinant DNA technology; possible biological roles of DNA topoisomerases; recognition and control sequences in nucleic acids; composition and substructure of nucleosomes; analysis of chromosome fibers by electron microscopy; organization of fibers into chromosomes; and functional aspects of organization of chromosome fibers. Molecular biologists, geneticists, scientists, and electron microscopists will find this book extremely helpful.
Contributors to Part III
Preface
Contents of Part I and Part II
Chapter I The Role of Restriction Endonucleases in Molecular Genetics
I. Introduction
II. General Properties of Restriction Enzymes
III. Basic Aspects of Restriction Enzyme Technology
IV. Applications of Restriction Enzyme Technology to the Study of Chromosome Structure and Function
V. Recombinant DNA Technology
VI. Concluding Remarks
References
Chapter II DNA Topoisomerases: Enzymes That Catalyze the Concerted Breaking and Rejoining of DNA Backbone Bonds
I. Introduction
II. Eco DNA Topoisomerase I
III. Other Prokaryotic DNA Topoisomerases
IV. Eukaryotic DNA Topoisomerases
V. Possible Biological Roles of DNA Topoisomerases
VI. Other Proteins with Properties Similar to DNA Topoisomerases
References
Chapter III Enzymatic Methylation of DNA: Patterns and Possible Regulatory Roles
I. Introduction
II. Restriction and Modification in Bacterial Cells
III. Sites of Methylation in DNA
IV. Patterns of Methylation of DNA and the Cell Division Cycle
V. Changes in Methylation during Differentiation and Development
VI. Methylating Enzymes Isolated from Cells
VII. Inactivation or Activation of the X Chromosome
VIII. Biological Clocks in Cell Division
IX. Hypothesis on the Control of Replication by Methylation
X. Other Models for Regulatory or Developmental Roles of Methylation
Addendum
References
Chapter IV Transcriptional Units in Eukaryotic Chromosomes
I. Introduction
II. Genome Organization and Transcription
III. Multiple-Copy Genes
IV. Single-Copy Genes
V. Perspectives
References
Chapter V Recognition and Control Sequences in Nucleic Acids
I. Introduction
II. Transcription
III. Regulation of Transcription by Sequence-Specific DNA Binding Proteins
IV. DNA Synthesis
V. Codon Selection in mRNA
VI. A Brief Overview of Other Sequences That Play Roles in Gene Expression
VII. Rapid Nucleic Acid Sequencing Methods
References
Chapter VI Nucleosomes: Composition and Substructure
I. Introduction
II. Histones
III. Nucleosomes—Discovery, Isolation, and Composition
IV. Nucleosome Structure
V. Concluding Remarks
References
Chapter VII Nucleosomes and Higher Levels of Chromosomal Organization
I. Introduction
II. The Concept of the Chromosome Fiber
III. Components of Chromosome Fibers
IV. Molecular Organization of Chromosome Fibers
V. Organization of Fibers into Chromosomes
VI. Functional Aspects of Chromosome Fiber Organization
References
Index
- Edition: 1
- Published: January 1, 1979
- No. of pages (eBook): 406
- Imprint: Academic Press
- Language: English
- Hardback ISBN: 9780126844030
- Paperback ISBN: 9780124313866
- eBook ISBN: 9780323151870
HT
Herbert Taylor
Affiliations and expertise
National Institutes of Health, Bethesda, Maryland, U.S.A.Read Molecular Genetics Pt 3 on ScienceDirect