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Molecular Diversity and Combinatorial Chemistry
Principles and Applications
- 1st Edition, Volume 24 - September 17, 2004
- Author: Michael C. Pirrung
- Language: English
- Paperback ISBN:9 7 8 - 0 - 0 8 - 0 4 4 5 3 2 - 8
- eBook ISBN:9 7 8 - 0 - 0 8 - 0 9 1 3 9 3 - 3
The field of combinatorial chemistry has seen tremendous growth over the past decade, with a prominence that suggests it will have a continuing impact. Volume 24 in the Tetrahedr… Read more
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Request a sales quoteThe field of combinatorial chemistry has seen tremendous growth over the past decade, with a prominence that suggests it will have a continuing impact.
Volume 24 in the Tetrahedron Organic Chemistry Series represents new approaches to solving problems in chemical reactivity and function. Molecular Diversity and Combinatorial Chemistry emphasises principles and exemplifies these with examples drawn from recent literature and thus is an excellent guide to the conceptual framework of the field.
The textbook includes exercises and worked problems which can provide more independent learning experiences and can also be used by an instructor leading a class on this topic. This volume has been written with the advanced undergraduate and graduate student in mind.
- Making the main concepts of the field of molecular diversity and combinatorial chemistry accessible to non-specialists
- Written specifically for the advanced undergraduate student or graduate student
- An excellent guide to the conceptual framework of the field
Biopolymers constitute natural libraries
Selection and evolution
The expression of genetic information
Combinatorial assembly of antibody genes
Molecular solutions to combinatorial problems
Synthetic Peptide Libraries
Solid-phase peptide synthesis
Peptides on pins
Other iterative deconvolution strategies
Examples of split/couple/mix peptide libraries
Positional scanning
Epilogue
Supports, Linkers, and Reagents for Peptide
Synthesis
Polystyrenes
PEG-grafted supports
Coupling strategies
Supports and Linkers for Small Molecule Synthesis
New resins and linkers
Ring-forming cleavage
Loading
Encoded Combinatorial Chemistry
Directed Sorting
Unnatural Oligomers for Library Synthesis
Peptoids
Azatides
Peptidyl phosphonates
Oligoureas
Analytical Methods for Solid-phase Synthesis
Product identification
Gel-phase NMR
High-resolution magic angle spinning NMR
On-bead infrared spectroscopy
Mass spectrometry
Non-spectroscopic methods
Supported Solution-phase Synthesis
Polyethylene glycols
Dendrimers
Fluorous synthesis
Solution-phase Parallel Synthesis
Scavenging resins
Ion-exchange resins
Supported reagents
Fluorous reagents
Solid-phase extraction
Gas-phase separation
Multi-component Reactions
Chemical Informatics, Diversity, and Library Design
Strategies
Representative flowchart for a library design
Lipinski's Rules
Nucleic Acid Microarrays
Combinatorial Materials Chemistry
Combinatorial Catalyst Discovery
Peptides on Phage
Applications of phage display
Nucleic Acid Selection
Complex Combinatorial and Solid-phase Synthesis
Epibatidine
Mappicine
Dysidiolide
The Big Picture
- No. of pages: 188
- Language: English
- Edition: 1
- Volume: 24
- Published: September 17, 2004
- Imprint: Elsevier Science
- Paperback ISBN: 9780080445328
- eBook ISBN: 9780080913933
MP