Molecular, Cellular, and Metabolic Fundamentals of Human Aging
- 1st Edition - October 23, 2022
- Imprint: Academic Press
- Authors: Evandro Fei Fang, Linda Hildegard Bergersen, Brian C. Gilmour
- Language: English
- Paperback ISBN:9 7 8 - 0 - 3 2 3 - 9 1 6 1 7 - 2
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 9 1 6 1 8 - 9
Molecular, Cellular, and Metabolic Fundamentals of Human Aging provides researchers with an overview of the main aging mechanisms and physiology and how they can lead to age-relat… Read more
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Request a sales quoteMolecular, Cellular, and Metabolic Fundamentals of Human Aging provides researchers with an overview of the main aging mechanisms and physiology and how they can lead to age-related diseases and conditions. Topics covered include DNA damage and how ineffective repair can lead to cell and tissue aging and decreased functionality, loss of proteostasis, changes to feeding and fasting pathways, mitochondrial dysfunction, the impact of decreased ability of autophagosomes and autophagosomes, cellular senescence, changes to communication molecules, and the impact of stem cell exhaustion.
The book also considers the impact of aging within the immune system, the relationship between aging and diseases such as cancers and neurodegenerative conditions, and provides an overview on the dialogue surrounding the topic of aging beyond basic biology.
- Covers the basic hallmarks of aging and their relevance in various diseases, such as cancer and Alzheimer’s disease
- Discusses the impact of genetic damage and how changes in genetic expression patterns affect the process of aging
- Highlights recurring themes and key principles shared across the hallmarks of aging
- Considers NAD+ depletion and defective autophagy as emerging aspects that impact human aging
Molecular biologists, gerontologists, biochemists, cell biologists, physiologists. Undergraduate, postgraduate and PhD students working in the area of molecular and cellular aging, and related fields
- Cover image
- Title page
- Table of Contents
- Copyright
- List of contributors
- Foreword
- Preface
- Chapter 1. The hallmarks of aging: decoding aging's mystery
- 1. Aging
- 2. Aging research
- 3. Life span and health span
- 4. The hallmarks of aging
- Section I. The genome
- Chapter 2. Epigenetic aging and its reversal
- 1. Introduction to epigenetics
- 2. Changes in chromatin structure during aging
- 3. Changes in histones during aging
- 4. Changes in histone posttranslational modifications
- 5. Deoxyribonucleic acid methylation in aging
- 6. Noncoding ribonucleic acids in aging
- 7. Reversal of epigenetic aging
- 8. Conclusions and perspectives
- Section II. Metabolism, homeostasis, and communication
- Chapter 3. Nutrient sensing and aging
- 1. AMPK signaling pathway
- 2. mTOR pathway
- 3. SIRT pathway
- 4. IGF-1 pathway
- 5. Calorie restriction and aging
- 6. Conclusion
- Chapter 4. Dysregulated proteostasis: mechanisms and links to aging
- 1. Introduction
- 2. Functional modules of the proteostasis network
- 3. Proteostasis network dysregulation in aging
- 4. Interplay with other aging hallmarks
- 5. Targeting proteostasis for healthy aging
- 6. Concluding remarks
- Section III. Autophagy and bioenergetics
- Chapter 5. Autophagy and bioenergetics in aging
- 1. Compromised autophagy and mitophagy in aging and disease
- 2. Mitochondrial dysfunction
- 3. Mechanisms of mitochondrial dysfunction
- 4. Dysfunctional mitochondria contribute to energy shortages and aging cells
- 5. Conclusions and future perspectives
- Section IV. Senescence
- Chapter 6. Senescence in aging
- 1. What is senescence?
- 2. Current concepts of senescence in aging
- 3. Factors driving and/or triggering senescence in aging
- 4. Stem cell exhaustion in aging
- 5. To develop senotherapies (senolytics and senomorphics) against age-related diseases and beyond
- 6. Methods for analyzing and quantifying senescence in vitro and in vivo
- 7. Concluding remarks
- Section V. Applications
- Chapter 7. Aging and the immune system
- 1. Overview of immunosenescence
- 2. Aging-related lymphoid organs and immunity
- 3. Interplay between immunosenescence and aging process
- 4. Conclusions
- Chapter 8. Canonical and novel strategies to delay or reverse aging
- 1. Approaching aging as a treatable disease
- 2. Nonpharmaceutical interventions against aging
- 3. Pharmaceutical treatments against aging
- 4. Novel approaches to slow or reverse aging
- 5. Outstanding questions and future perspectives
- Index
- Edition: 1
- Published: October 23, 2022
- Imprint: Academic Press
- No. of pages: 260
- Language: English
- Paperback ISBN: 9780323916172
- eBook ISBN: 9780323916189
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Evandro Fei Fang
Evandro Fei Fang is a molecular gerontologist and is currently Associate Professor at the Department of Clinical Molecular Biology, University of Oslo and the Akershus University Hospital, Norway. He has an extensive track record of mechanistic studies on human aging and mitophagy, and his main research interests currently center on exploring the basic molecular mechanisms of human ageing and age-related diseases, with a final goal to develop interventional strategies to improve people's lifespan and healthspan. He is currently pursuing the development of novel anti-ageing compounds using artificial intelligence combined with a cross-species wet-lab validation. Dr. Fang is also co-founder of the Norwegian Centre on Healthy Ageing (NO-Age) and the Norwegian anti-Alzheimer’s disease (NO-AD) networks.
Affiliations and expertise
Associate Professor, University of Oslo and the Akershus University Hospital, NorwayLB
Linda Hildegard Bergersen
Linda Bergersen is Professor and Dean of Research at the Faculty of Dentistry, University of Oslo, Norway, and also serves as Professor of Neurobiology of Aging at the Center of Healthy Aging (CEHA), University of Copenhagen, Denmark. She is also a former athlete who specializes in understanding the link between physical exercise and prevention of neurodegenerative disease. Dr. Bergersen has pioneered the study of how exercise can improve brain health and has expanded from there into further aging fields. She has received a number of awards and fellowships for her research and is also co-founder of the Norwegian Centre for Healthy Ageing (NO-Age).
Affiliations and expertise
Professor, Institute of Oral Biology, University of Oslo, Oslo, Norway; Co-founder of the Norwegian Centre for Healthy Aging (NO-Age), Oslo, NorwayBG
Brian C. Gilmour
Brian Christopher Gilmour is currently a PhD candidate in medicine at the University of Oslo, Norway. Aiming to develop a research career in aging, he is well-acquainted with the functions of the immune system and looking to further develop the relation between the immune system and human aging. He works closely with the Norwegian Centre for Healthy Ageing (NO-Age).
Affiliations and expertise
PhD candidate, University of Oslo, Oslo, NorwayRead Molecular, Cellular, and Metabolic Fundamentals of Human Aging on ScienceDirect