Molecular Biology of Aging
- 1st Edition, Volume 146 - February 18, 2017
- Imprint: Academic Press
- Editor: P. Hemachandra Reddy
- Language: English
- Hardback ISBN:9 7 8 - 0 - 1 2 - 8 1 1 5 3 2 - 9
- eBook ISBN:9 7 8 - 0 - 1 2 - 8 1 1 5 3 3 - 6
Molecular Biology of Aging, the latest volume in the Progress in Molecular Biology and Translational Science series, focuses on placental development and disease.… Read more
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Request a sales quoteMolecular Biology of Aging, the latest volume in the Progress in Molecular Biology and Translational Science series, focuses on placental development and disease.
- Contains contributions from leading authorities on the topic
- Publishes cutting-edge reviews in molecular biology
Students, researchers, microbiologists, molecular biologists
Chapter One: Clinical Aspects of Glucose Metabolism and Chronic Disease
- Abstract
- 1 Introduction
- 2 Diabetes Mellitus
- 3 Cardiovascular Disease
- 4 Chronic Kidney Disease
- 5 Sarcopenia
- 6 The Frailty Syndrome
- 7 Dementia
- 8 Exercise and Brain Metabolism
- 9 Pharmacological Treatments for Dementia
- 10 Reducing Chronic Disease Burden
Chapter Two: Therapeutic Strategies for Mitochondrial Dysfunction and Oxidative Stress in Age-Related Metabolic Disorders
- Abstract
- 1 Introduction
- 2 Global Prevalence of Metabolic Disorders
- 3 Structure and Functions of Mitochondria
- 4 Mitochondrial Dysfunction in Age-Related Metabolic Disorders
- 5 Strategies Directed to Target Mitochondrial Dysfunction
- 6 Concluding Remarks
- Acknowledgments
Chapter Three: MicroRNAs as Peripheral Biomarkers in Aging and Age-Related Diseases
- Abstract
- 1 Introduction
- 2 Circulatory miRNAs
- 3 miRNAs Secretion in Circulatory Biofluids
- 4 Circulatory miRNAs as Biomarkers in Aging and Age-Associated Diseases
- 5 Concluding Remarks
- Acknowledgments
Chapter Four: Molecular Links and Biomarkers of Stroke, Vascular Dementia, and Alzheimer's Disease
- Abstract
- 1 Introduction
- 2 Risk Factors for IS, VaD, and AD
- 3 Molecular Links and Pathways
- 4 Molecular Biomarkers
- 5 Concluding Remarks
- Acknowledgments
Chapter Five: MicroRNAs, Aging, Cellular Senescence, and Alzheimer's Disease
- Abstract
- 1 Introduction
- 2 Biogenesis and Regulation of miRNAs
- 3 miRNA, Aging, and Cellular Senescence
- 4 miRNAs, Cellular Senescence, and Pathways
- 5 miRNAs and Neurodegenerative Diseases
- 6 Concluding Remarks
- Acknowledgments
Chapter Six: Mitochondria-Targeted Molecules as Potential Drugs to Treat Patients With Alzheimer's Disease
- Abstract
- 1 Introduction
- 2 Aβ and Alzheimer's Disease
- 3 Phosphorylated Tau and Alzheimer's Disease
- 4 Synaptic Damage and Alzheimer's Disease
- 5 Decreased Glucose Metabolism and Alzheimer's Disease
- 6 Mitochondria and ROS in Aging and Alzheimer's Disease
- 7 Aβ and Phosphorylated Tau in Mitochondria
- 8 Natural Antioxidants and Mitochondrial Therapeutic Approaches to Alzheimer's Disease
- 9 Human Clinical Trials and Perspective Studies on Alzheimer's Disease
- 10 Therapies for Alzheimer's Disease Using Mitochondria-Targeted Molecules
- 11 Evidence Supporting Neuronal Function in MCAT Mice
- 12 Conclusions and Future Studies
- Acknowledgments
Chapter Seven: Mitochondrial-Targeted Catalase: Extended Longevity and the Roles in Various Disease Models
- Abstract
- 1 Introduction
- 2 Life Span and Healthspan Extension in Mice-Overexpressing Catalase
- 3 The Contribution of mCAT Mouse Models to the Study of Diseases
- 4 Pleotropic or Adverse Effects of mCAT Expression
- 5 Pharmacologic Analogs of mCAT Expression
Chapter Eight: Metabolic Syndrome and the Cellular Phase of Alzheimer's Disease
- Abstract
- 1 Alzheimer's Disease Is a Convergent Syndrome With Mixed Pathologies
- 2 Cellular Phase of AD
- 3 Cross Talk Between MetS and the Cellular Phase of AD
- 4 Targeting SIRT3 to Improve Metabolic Adaptation During the Cellular Phase of AD
- 5 Microglial Priming During MetS
- 6 Peripheral and Central Inflammation Connection
- 7 Overlap of VaD With AD
- 8 Neurovascular Unit Facilitates MetS–AD Cross Talk
- 9 Cerebral Ischemia and AD
Chapter Nine: Mitochondria, Cybrids, Aging, and Alzheimer's Disease
- Abstract
- 1 Introduction
- 2 Mitochondria and Aging
- 3 Mitochondria and Alzheimer's Disease
- 4 AD Cytoplasmic Hybrid (Cybrid) Studies
- 5 Conclusions
- Acknowledgment
Chapter Ten: The Kidney in Aging: Physiological Changes and Pathological Implications
- Abstract
- 1 Introduction
- 2 Evaluation of Renal Function
- 3 Calcium, Phosphorus, and Magnesium Disorders in Aging
- 4 Conclusions
Chapter Eleven: Mitochondrial Perturbation in Alzheimer's Disease and Diabetes
- Abstract
- 1 Introduction
- 2 Mitochondrial Function
- 3 Synaptic Mitochondrial Pathology in AD
- 4 Impact of CypD-Dependent mPTP on Mitochondrial Defects
- 5 Effect of Neuronal PreP Activity and RAGE Signaling on Mitochondrial Dysfunction
- 6 Effects of Methionine Sulfoxide Reductase on Aβ Solubility and Mitochondrial Function
- 7 Impact of Mitochondrial Dynamics in MCI and AD
- 8 Drp1-Mediated Mitochondrial Abnormalities in Diabetes
- 9 Conclusion
- Edition: 1
- Volume: 146
- Published: February 18, 2017
- No. of pages (Hardback): 392
- No. of pages (eBook): 392
- Imprint: Academic Press
- Language: English
- Hardback ISBN: 9780128115329
- eBook ISBN: 9780128115336
PR
P. Hemachandra Reddy
Dr. Reddy is a tenured Professor and Vice Chair of Basic and Translational Research for the Department of Internal Medicine at Texas Tech University Health Sciences Center. He is also a Professor of Neuroscience/Pharmacology, Neurology, Public Health and Speech, and Language and Hearing Departments. His research lab has been involved with research on healthy aging, dementia, and other neurodegenerative diseases, including Huntington’s, Parkinson’s, and multiple sclerosis. In addition, the Reddy lab group is actively working on chronic conditions such as diabetes, obesity, cardiovascular, kidney, stroke, vascular dementia, and other factors associated with dementia. Dr. Reddy is a prolific writer, author, or co-author of more than 237 peer-reviewed articles/chapters/reviews, including publications in such journals as Nature Genetics, Ageing Research Reviews, Redox Biology, Trends in Neurosciences, Trends in Molecular Medicine, Drug Discovery Today, Human Molecular Genetics, and BBA Molecular Basis of Disease. He has received research funding from the National Institutes of Health since 2002. He also serves as Chief Scientific Officer for the Lubbock-based small business company, abSynapTEX, LLC.
Affiliations and expertise
PhD, Texas Tech University Health Sciences Center, Texas, USA
Fellow of American Association for the Advancement of Science, 2020
Fellow of American Neurological Association, 2014
Professor and Vice Chair of Basic and Translational Research Internal Medicine, and adjunct Professor of Neuroscience/Pharmacology, Neurology and Public HealthRead Molecular Biology of Aging on ScienceDirect