Modulation by Molecular Interactions

Contributors

Foreword

Preface

I. Cell Biology


1. The LDL Receptor and HMG-CoA Reductase—Two Membrane Molecules That Regulate Cholesterol Homeostasis


2. The Cellular Entry of EGF and Transferrin: A Problem in Intracellular Sorting


3. Receptor-Mediated Transport of Acid Hydrolases to Lysosomes


4. Diagnostic and Therapeutic Applications of Sphingolipid Hydrolyzing Enzymes


5. Platelet-Derived Growth Factor: Structure, Function, and Roles in Normal and Transformed Cells


6. Regulation of Glutamine Synthetase in Cultured 3T3-L1 Adipocytes by Insulin, Hydrocortisone, and Cyclic AMP


7. Scrapie Prions, Brain Amyloid, and Senile Dementia


8. Coupled Ionic and Enzymatic Regulation of Sperm Behavior


9. Regulation of Cell Interactions during Skeletal Muscle Development


10. Regulation of the Immune Response in Man by a Cascade of Interactive T Lymphocytes


11. From Membrane to Molecule with the lac Permease of Escherichia coli


12. Glutamine Synthetase from Pseudomonas fluorescens: A Tool for Studying Changes in Cell Permeability and Enzyme Regulation


13. Modulation of Polar Lipid Composition by Aliphatic Chain Unsaturation in Bacteria

II. Protein Interactions


14. On Conformational Changes in the Regulatory Enzyme Aspartate Transcarbamoylase


15. Active-Site Ligand Binding and Subunit Interactions in Glutamine Synthetase from Escherichia coli


16. Biophysical Studies of Escherichia coli Glutamine Synthetase


17. The Regulation of Actin and Myosin by ATP


18. Change in NAD+/NADH Content of S-Adenosyl-L-Homocysteine Hydrolase upon NAD+ Reversible Inactivation by cAMP and 2'- Deoxyadenosine


19. Effectors of Rat Lung cGMP Binding Protein-Phosphodiesterase


20. Thermostabilization of Bacillus caldolyticus Glutamine Synthetase by Intrinsic and Extrinsic Factors


21. The Role of Pyridoxal 5'-Phosphate in Phosphorylase Catalysis


22. Bioregulation of Binding and Dynamics: The Cytochrome P-450CAM Model


23. Fatty Acid Synthase: Elementary Steps in Catalysis and Regulation


24. Multienzyme Complexes of Mammalian Aminoacyl-tRNA Synthetases


25. The Pyruvate Dehydrogenase Complex in Dictyostelium discoideum

III. Metabolic Pathways


26. Pathway of 5-Aminovalerate Degradation by Clostridium aminovalericum


27. Inorganic Pyrophosphate and Polyphosphates as Sources of Energy


28. The Role of Pyridine Nucleotides in Regulating Cellular Metabolism


29. The Fall and Rise of Cellular Glutathione Levels: Enzyme-Based Approaches


30. The Effects of Protein or Amino Acid Intake on the Nitrogen Balance and Antitumor Activity of Glutaminase Treatment


31. On the Regulation of Deoxyhbonucleotide Synthesis


32. Completion of the Degradation Scheme for Nicotinic Acid by Clostridium barkeri


33. Mechanisms of Exogenous Purine Nucleotide Utilization in Bacillus cereus


34. Pyrimidine Nucleoside-Catabolizing Enzymes in Escherichia coli B

IV. Gene Expression


35. Recent Biochemical and Genetic Studies on the Amino Acid Biosynthetic Pathway of the Aspartate Family in Escherichia coli


36. Regulation of Antibiotic Resistance in Bacteria: The Chloramphenicol Acetyltransferase System


37. An in Vitro System to Measure Gene Expression Based on Dipeptide Synthesis


38. Regulation of Enzymes under Nitrogen Control in Pseudomonas aeruginosa


39. Catabolism and Nitrogen Control in Escherichia coli


40. Regulation of Gene Expression of Translation Components in Escherichia coli: Initiation Factors and Aminoacyl tRNA Synthetases


41. Regulatory Features of Spore Development in Bacillus subtilis


42. Bacterial Gene Expression and Biotechnology

Index

Cumulative Contributors Index

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