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Minireviews of the Neurosciences from Life Sciences
1st Edition - January 1, 1975
Editors: Bernard B. Brodie, R. Bressler
eBook ISBN:
9 7 8 - 1 - 4 8 3 1 - 5 4 7 8 - 7
Minireviews of the Neurosciences from Life Sciences is a collection of minireviews of research in the neurosciences and originally published by the Journal of Life Sciences. These… Read more
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Minireviews of the Neurosciences from Life Sciences is a collection of minireviews of research in the neurosciences and originally published by the Journal of Life Sciences. These minireviews cover a wide range of topics such as the function and organization of the chromaffin vesicle; taste receptor proteins; the role of cyclic nucleotides in visual excitation; and regulation of tryptophan and tyrosine hydroxylase. Comprised of 34 chapters, this volume begins with a discussion on Na,K-ATPase, followed by an analysis of the function and organization of the chromaffin vesicles of the adrenal medulla. Subsequent chapters focus on the nerve growth factor and the acetylcholine receptor; sympathetic regulation of thyroid hormone secretion; the role of cyclic AMP in the action of antidiuretic hormone on the kidney; and neurochemical correlates of synaptically active amino acids. The role of calcium in the central effects of biogenic amines is also examined, along with the brain mechanisms underlying motor control, molecular coding of memory, and opiate receptors. This book should be of value to teachers, researchers, and students.
PREFACE
Chapter 1: SEVERAL TOPICS CONCERNING Na, K-ATPase
Publisher Summary
Localization
Purification
Substrate Specificity
Binding of ATP and ADP-ATP Exchange
Ouabain Binding
Relation to lipid
Reaction mechanism
Posture of the Enzyme in Intact Membranes
Biological Significance
Chapter 2: FUNCTION AND ORGANIZATION OF CHROMAFFIN VESICLE
Publisher Summary
Concluding Remarks
Chapter 3: NERVE GROWTH FACTOR
Publisher Summary
Structure of NGF
The Origin of NGF
Mechanism of NGF Action
Chapter 4: TASTE RECEPTOR PROTEINS
Sweet Receptors
Proteins Characteristic of Taste Buds
Bitter Receptors
Other Taste Receptors
Chapter 5: THE ROLE OF CYCLIC NUCLEOTIDES IN VISUAL EXCITATION
Summary
Chapter 6: THE ACETYLCHOLINE RECEPTOR: PROGRESS REPORT
Publisher Summary
Cells
Membrane Fragments
Solution
Conclusion
Acknowledgements
Chapter 7: REGULATION OF TRYPTOPHAN AND TYROSINE HYDROXYLASE
CONCLUSIONS
Chapter 8: SERUM DOPAMINE β-HYDROXYLASE AS AN INDEX OF SYMPATHETIC FUNCTION
Publisher Summary
Properties of DBH
Release of DBH
Sources and Turnover of Serum DBH in Animals
Assays of Human Serum DBH
Enzymatic assays
Radioimmunoassays
Human Serum DBH Activity in Normal and Disease States
Age
Sex
Physiological Stress
Serum DBH Changes in Disease States
Conclusions
Chapter 9: POSSIBILITIES FOR DRUG DEVELOPMENT BASED ON THE CYCLIC AMP SYSTEM
Publisher Summary
Chapter 10: REGULATION OF PHOSPHORYIASE b TO a CONVERSION IN MUSCLE
Publisher Summary
CONCLUSIONS
Chapter 11: SYMPATHETIC REGULATION OF THYROID HORMONE SECRETION
Publisher Summary
Acknowledgment
Chapter 12: ROLE OF CYCLIC AMP IN THE ACTION OF ANTIDIURETIC HORMONE ON KIDNEY
Publisher Summary
Acknowledgment
Chapter 13: TRANS-SYNAPTIC ENZYME INDUCTION
Publisher Summary
Acknowledgements
Chapter 14: DO CYCLIC NUCLEOTIDES PROMOTE THE TRANS-SYNAPTIC INDUCTION OF TYROSINE HYDROXYLASE?
Publisher Summary
INTRODUCTION
NICOTINIC RECEPTORS AND CYCLIC NUCLEOTIDES OF ADRENAL MEDULLA
TRANS-SYNAPTIC INDUCTION OF TH IN ADRENAL MEDULLA: INVOLVEMENT OF CYCLIC NUCLEOTIDES
ADRENAL DEMEDULLATION: A MODEL TO STUDY TRANS-SYNAPTIC CONTROL OF TH ACTIVITY IN SYMPATHETIC GANGLIA
INDUCTION OF TH ACTIVITY IN SYMPATHETIC GANGLIA OF ADRENAL DEMEDULLATED RATS: INVOLVEMENT OF CYCLIC NUCLEOTIDES
CONCLUSIONS
Chapter 15: SUBSTANCE P
Summary
Discovery and Partial Purification of Substance P
The Isolation of a Sialogogic Peptide; its Characterization as Substance P
Radioimmunoassay For Substance P
Physiological Roles of Substance P
Chapter 16: TO SPRITZ OR NOT TO SPRITZ: THE DOUBTFUL VALUE OF AIMLESS IONTOPHORESIS
Publisher Summary
Technical Considerations
BIOLOGIC CONSIDERATIONS
PHARMACOLOGIC CONSIDERATIONS
ACTIONS OF CATECHOLAMINES IN THE NERVOUS SYSTEM
Conclusions
Chapter 17: THE USE OF AUTORADIOGRAPHIC TECHNIQUES FOR THE IDENTIFICATION AND MAPPING OF TRANSMITTER-SPECIFIC NEURONES IN THE BRAIN
Publisher Summary
MONOAMINES
AMINO ACIDS
CONCLUSIONS
Chapter 18: NEUROTRANSMITTER UPTAKE: A TOOL IN IDENTIFYING NEUROTRANSMITTER-SPECIFIC PATHWAYS
Publisher Summary
Brief Review of the Literature
Methods and Their Uses
Chapter 19: REGULATION OF SEROTONIN SYNTHESIS
Summary
Introduction
Role of Tryptophan in the Regulation of 5-HT Synthesis
Rate of Tryptophan Hydroxylation: A second regulatory Factor of 5-HT Synthesis
Discussion
Chapter 20: SOME FACTORS IN THE REGULATION OF CENTRAL SEROTONERGIC SYNAPSES
Summary
Introduction
The Biochemical Anatomy of the Serotonergic System in the Brain
Factors Influencing the Supply of Substrate To the Presynaptic Biosynthetic Apparatus
Regulation of the Activity or Amount of Tryptophan Hydroxylase in Brain
A Degradative Process for 5-HT That May be Related to Synaptic Function
Chapter 21: NEUROCHEMICAL CORRELATES OF SYNAPTICALLY ACTIVE AMINO ACIDS
Publisher Summary
CONCLUSIONS
Chapter 22: THE ROLE OF CALCIUM IN THE CENTRAL EFFECTS OF BIOGENIC AMINES
Publisher Summary
Biogenic Amines in the Cerebral Cortex
The Action of Calcium on Cortical Neurones
Metallic Cations and Cerebral Neurones
Studies with Calcium Antagonists
Chapter 23: ANOTHER LOOK AT THE MONOAMINE OXIDASES AND THE MONOAMINE OXIDASE INHIBITOR DRUGS
Publisher Summary
SEPARATION OF MULTIPLE FORMS OF MAO BY ELECTROPHORESIS
THE USE OF SELECTIVE SUBSTRATES AND DRUGS TO DEMONSTRATE MULTIPLE FORMS OF MAO.
SOME PROPERTIES OF THE MAO’S
LOCALIZATION OF THE MAO’S
HUMAN PLATELET MAO
THE CONSEQUENCES OF ADMINISTERING SPECIFIC MAO INHIBITOR DRUGS ON AMINE METABOLISM IN BRAIN
CONCLUSIONS
Chapter 24: THE ROLE OF CATECHOLAMINES AND ACETYLCHOLINE IN THE REGULATION OF ENDOCRINE FUNCTION
Publisher Summary
Adrenal Medulla.
Kidney: Juxtaglomerular Cells.
Kidney: Erythrogenin-Secreting Cells.
Pancreatic Islets: β Cells.
Pancreatic Islets: α Cells.
Pineal.
Parathyroid Gland.
Calcitonin-Secreting and Gastrointestinal Endocrine Cells.
Control of Thyroid, Adrenocorticoid and Gonadal Secretion.
Hypothalamic Control of Anterior Pituitary Secretion.
ACTH.
TSH.
Growth Hormone.
LH and FSH.
Prolactin.
Intermediate Lobe of the Pituitary.
Posterior Pituitary Secretion.
Conclusion.
Chapter 25: THE NEUROENDOCRINOLOGY OF HUMAN SLEEP
Discussion
Chapter 26: Role of Brain Monoamines in Male Sexual Behavior
Publisher Summary
Effect of PCPA on the sexual behavior of the male rat.
Effect of PCPA on the sexual behavior of other animal species.
Role of testosterone and other hormones in the PCPA effect.
Effect of reserpine and tetrabenazine.
Brain catecholamines and sexual behavior.
Conclusion.
Chapter 27: AREA POSTREMA: CHEMORECEPTOR TRIGGER ZONE FOR VOMITING - IS THAT ALL?
Publisher Summary
Topology of the area postrema.
Ultrastructural features and barrier properties.
Nerve cells, fibers and humors.
Vomiting and other functions of AP.
Chapter 28: NORADRENERGIC MEDIATION OF TRAUMATIC SPINAL CORD AUTODESTRUCTION
Summary
Chemical NE Studies
Supporting Experimental Evidence For The NE Spinal Injury Hypothesis
Central Versus Peripheral Origin Of Injured Spinal Cord NE Elevation.
Summary
Chapter 29: THE MECHANISMS OF ACTION OF L-DOPA IN PARKINSON’S DISEASE
Publisher Summary
I l-dopa as a Dopamine replenishing drug
II L-Dopa Therapy and Displacement of Brain Serotonin
III 3-0-Methyl-Dopa - Depot Source for Dopamine?
IV The Role of Norepinephrine
V Condensation Products of Dopamine And the Antiparkinson Action of L-Dopa
Chapter 30: SOME SPECULATIONS CONCERNING A POSSIBLE BIOCHEMICAL BASIS OF MINIMAL BRAIN DYSFUNCTION
Publisher Summary
The extent of the minimal brain dysfunction syndrome
A Possible Biochemical Basis for MBD
Chapter 31: BRAIN MECHANISMS IN MOTOR CONTROL
Publisher Summary
1 The Cerebral Motor Cortex
2 The Cerebellum and the Basal Ganglia
3 Aspects of Movement
4 Outlook for Future Research
Chapter 32: MOLECULAR CODING OF MEMORY
Publisher Summary
Chemical Correlates of Learning and Memory
Biological Assay
Validity of the Bioassay Approach
Chemical Properties of the Active Substances
Specificity of the Behavioral Bioassays
Is a molecular code necessary?
Chapter 33: THE BIOCHEMICAL BASIS OF LEARNING AND MEMORY
Publisher Summary
Acknowledgements
Chapter 34: OPIATE RECEPTORS
- No. of pages: 504
- Language: English
- Published: January 1, 1975
- Imprint: Pergamon
- eBook ISBN: 9781483154787