Mims' Medical Microbiology
With STUDENT CONSULT Online Access
- 4th Edition - October 3, 2007
- Latest edition
- Authors: Richard Goering, Hazel M. Dockrell, Mark Zuckerman, Derek Wakelin, Ivan Roitt, Cedric Mims, Peter L. Chiodini
- Language: English
MIMS' MEDICAL MICROBIOLOGY offers thorough and up-to-date coverage of microbiology and basic immunology, through a clinically relevant, systems-based approach. The textbook… Read more
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Description
Description
MIMS' MEDICAL MICROBIOLOGY offers thorough and up-to-date coverage of microbiology and basic immunology, through a clinically relevant, systems-based approach. The textbook emphasises the microbiology of the agents causing disease, and the diseases affecting individual organ systems. Through thorough cross referencing, the reader can easily find what they need, whether seeking information from a systems or a microbe perspective. Nearly 500 illustrations support the text, and summary introductory and summary key facts boxes strengthen the clarity and usefulness of the text.
Key features
Key features
- Systems-based approach to microbiology reflects integrated and case-based teaching
- Stresses the role of the immune system in infectious disease, in line with the move towards integrated, systems-based teaching (where for example diseases like meningitis are taught as part of a Nervous system module)
- Chapter Introduction boxes (now revised to be in bullet points), Summary Headings throughout each chapter and Key Facts boxes at the end of each chapter allow easy access to key concepts, and valuable review tools
- Extensively cross-referenced Pathogen Review section means the reader can navigate the text either through a systems-based or a pathogen-based path, as they choose
Table of contents
Table of contents
1. Microbes as parasites
• The varieties of microbes
• Living inside or outside cells
• Systems of classification
2. The bacteria
• Structure
• Nutrition
• Growth and division
• Gene expression
• Extrachromosomal elements
• Mutation and gene transfer
• Survival under adverse conditions
• The genomics of medically important bacteria
3. The viruses
• Infection of host cells
• Replication
• Outcome of viral infection
• Major groups of viruses
4. The fungi
• Major groups of disease-causing fungi
5. The protozoa
6. The helminths and arthropods
• The helminths
• The arthropods
7. Prions
• ‘Rogue protein’ pathogenesis
• Development and transmission of prion diseases
• Medical problems posed by prion disease
8. The host–parasite relationship
• The normal flora
• Symbiotic associations
• The characteristics of parasitism
• The evolution of parasitism
9. The innate defenses of the body
• Defense against entry into the body
• Defenses once the microorganism penetrates the body
10. Adaptive responses provide a ‘quantum leap’ in effective defense
• The role of antibodies
• The role of T lymphocytes
• Extracellular attack on large infectious agents
• Local defenses at mucosal surfaces
11. The cellular basis of adaptive immune responses
• B and T cell receptors
• Clonal expansion of lymphocytes
• The role of memory cells
• Stimulation of lymphocytes
• Cytokines
• Regulatory mechanisms
• Tolerance mechanisms
12. Background to the infectious diseases
• Host–parasite relationships
• Causes of infectious diseases
• The biologic response gradient
13. Entry, exit and transmission
• Sites of entry
• Exit and transmission
• Types of transmission between humans
• Transmission from animals
14. Immune defenses in action
• Complement
• Acute phase proteins and pattern recognition receptors
• Fever
• Natural killer cells
• Phagocytosis
• Cytokines
• Antibody-mediated immunity
• Cell-medited immunity
• Recovery from infection
15. Spread and replication
• Features of surface and systemic infections
• Mechanisms of spread through the body
• Genetic determinants of spread and replication
• Other factors affecting spread and replication
16. Parasite survival strategies and persistent infections
• Parasite survival strategies
• Concealment of antigens
• Antigenic variation
• Immunosuppression
• Persistent infections
17. Pathologic consequences of infection
• Pathology caused directly by the microorganism
• Pathologic activation of natural immune mechanisms
• Pathologic consequences of the immune response
• Skin rashes
• Viruses and cancer
Introduction to Section 4: The Clinical Manifestations of Infection
18. Upper respiratory tract infections
• The common cold
• Pharyngitis and tonsillitis
• Parotitis
• Otitis and sinusitis
• Acute epiglottitis
• Oral cavity infections
• Laryngitis and tracheitis
• Diphtheria
19. Lower respiratory tract infections
• Acute infections
• Chronic infections
• Parasitic infections
20. Urinary tract infections
• Acquisition and etiology
• Pathogenesis
• Clinical features and complications
• Laboratory diagnosis
• Treatment
• Prevention
21. Sexually transmitted diseases
• STDs and sexual behavior
• Syphilis
• Gonorrhea
• Chlamydial infection
• Other causes of inguinal lymphadenopathy
• Mycoplasmas and non-gonococcal urethritis
• Other causes of vaginitis and urethritis
• Genital herpes
• Human papillomavirus infection
• Human immunodeficiency virus
• Opportunistic STDs
• Arthropod infestations
22. Gastrointestinal tract infections
• Diarrheal diseases caused by bacterial or viral infection
• Food poisoning
• Helicobacter pylori and gastric ulcer disease
• Parasites and the gastrointestinal tract
• Systemic infection initiated in the gastrointestinal tract
23. Obstetric and perinatal infections
• Infections occurring in pregnancy
• Congenital infections
• Infections occurring around the time of birth
24. Central nervous system infections
• Invasion of the central nervous system
• The body’s response to invasion
• Meningitis
• Encephalitis
• Neurologic diseases of possible viral etiology
• Spongiform encephalopathy caused by scrapie-type agents
• CNS disease caused by parasites
• Brain abscesses
• Tetanus and botulism
25. Infections of the eye
• Conjunctivitis
• Infection of the deeper layers of the eye
26. Infections of the skin, soft tissue, muscle and associated systems
• Bacterial infections of skin, soft tissue and muscle
• Mycobacterial diseases of the skin
• Fungal infections of the skin
• Parasitic infections of the skin
• Mucocutaneous lesions caused by viruses
• Smallpox
• Measles
• Rubella
• Other infections producing skin lesions
• Kawasaki syndrome
• Viral infections of muscle
• Parasitic infections of muscle
• Joint and bone infections
• Infections of the hemopoietic system
27. Vector-borne infections
• Arboviruses infections
• Infections caused by Rickettsiae
• Borrelia infections
• Protozoal infections
• Helminth infections
28. Multisystem zoonoses
• Arenavirus infections
• Korean hemorrhagic fever
• Marburg and Ebola hemorrhagic fevers
• Q fever
• Anthrax
• Plague
• Yersinia enterocolitica infection
• Tularemia
• Pasteurella multocida infection
• Leptospirosis
• Rat bite fever
• Brucellosis
• Helminth infections
29. Fever of unknown origin
• Definitions of fever of unknown origin
• Causes of FUO
• Investigation of classical FUO
• Treatment of FUO
• FUO in specific patient groups
• Infective endocarditis
30. Infections in the compromised host
• The compromised host
• Infections of the host with deficient innate immunity due to physical factors
• Infections associated with secondary adaptive immunodeficiency
• Other important opportunist pathogens
31. Strategies for control: an introduction
• Epidemiologic considerations
• Detection and diagnosis
• Chemotherapy versus vaccination
• Control versus eradication
32. Diagnosis of infection and assessment of host defense mechanisms
• Aims of the clinical microbiology laboratory
• Specimen processing
• Non-cultural techniques for the laboratory diagnosis of infection
• Cultivation (culture) of microorganisms
• Identification of microorganisms grown in culture
• Antibody detection methods for the diagnosis of infection
• Assessment of host defense systems
• Protocols for specimen processing
33. Attacking the enemy: antimicrobial agents and chemotherapy
• Selective toxicity
• Discovery and design of antibacterial agents
• Classification of antibacterial agents
• Resistance to antibacterial agents
• Classes of antibacterial agents
• Inhibitors of cell wall synthesis
• Inhibitors of protein synthesis
• Inhibitors of nucleic acid synthesis
• Antimetabolites affecting nucleic acid synthesis
• Other agents that affect DNA
• Inhibitors of cytoplastic membrane function
• Urinary tract antiseptics
• Antituberculous agents
• Antibacterial agents in practice
• Antibiotic assays
• Antiviral therapy
• Antifungal agents
• Antiparasitic agents
• Use and misuse of antimicrobial agents
34. Vaccination
• The aims of vaccination
• Requirements of a good vaccine
• Types of vaccine
• Special considerations
• Community-based control by vaccination
• Factors influencing the success of vaccination
• Current vaccine practice
35. Passive and non-specific immunotherapy
• Passive immunization with antibody
• Non-specific cellular immunostimulation
• Correction of host immunodeficiency
36. Hospital infection, sterilization and disinfection
• Common hospital-acquired infections
• Important causes of hospital infection
• Sources and routes of spread of hospital infection
• Host factors and hospital infection
• Consequences of hospital infection
• Prevention of hospital infection
• Investigating hospital infection
• Sterilization and disinfection
Appendix – Pathogen parade
Answers
Index
• The varieties of microbes
• Living inside or outside cells
• Systems of classification
2. The bacteria
• Structure
• Nutrition
• Growth and division
• Gene expression
• Extrachromosomal elements
• Mutation and gene transfer
• Survival under adverse conditions
• The genomics of medically important bacteria
3. The viruses
• Infection of host cells
• Replication
• Outcome of viral infection
• Major groups of viruses
4. The fungi
• Major groups of disease-causing fungi
5. The protozoa
6. The helminths and arthropods
• The helminths
• The arthropods
7. Prions
• ‘Rogue protein’ pathogenesis
• Development and transmission of prion diseases
• Medical problems posed by prion disease
8. The host–parasite relationship
• The normal flora
• Symbiotic associations
• The characteristics of parasitism
• The evolution of parasitism
9. The innate defenses of the body
• Defense against entry into the body
• Defenses once the microorganism penetrates the body
10. Adaptive responses provide a ‘quantum leap’ in effective defense
• The role of antibodies
• The role of T lymphocytes
• Extracellular attack on large infectious agents
• Local defenses at mucosal surfaces
11. The cellular basis of adaptive immune responses
• B and T cell receptors
• Clonal expansion of lymphocytes
• The role of memory cells
• Stimulation of lymphocytes
• Cytokines
• Regulatory mechanisms
• Tolerance mechanisms
12. Background to the infectious diseases
• Host–parasite relationships
• Causes of infectious diseases
• The biologic response gradient
13. Entry, exit and transmission
• Sites of entry
• Exit and transmission
• Types of transmission between humans
• Transmission from animals
14. Immune defenses in action
• Complement
• Acute phase proteins and pattern recognition receptors
• Fever
• Natural killer cells
• Phagocytosis
• Cytokines
• Antibody-mediated immunity
• Cell-medited immunity
• Recovery from infection
15. Spread and replication
• Features of surface and systemic infections
• Mechanisms of spread through the body
• Genetic determinants of spread and replication
• Other factors affecting spread and replication
16. Parasite survival strategies and persistent infections
• Parasite survival strategies
• Concealment of antigens
• Antigenic variation
• Immunosuppression
• Persistent infections
17. Pathologic consequences of infection
• Pathology caused directly by the microorganism
• Pathologic activation of natural immune mechanisms
• Pathologic consequences of the immune response
• Skin rashes
• Viruses and cancer
Introduction to Section 4: The Clinical Manifestations of Infection
18. Upper respiratory tract infections
• The common cold
• Pharyngitis and tonsillitis
• Parotitis
• Otitis and sinusitis
• Acute epiglottitis
• Oral cavity infections
• Laryngitis and tracheitis
• Diphtheria
19. Lower respiratory tract infections
• Acute infections
• Chronic infections
• Parasitic infections
20. Urinary tract infections
• Acquisition and etiology
• Pathogenesis
• Clinical features and complications
• Laboratory diagnosis
• Treatment
• Prevention
21. Sexually transmitted diseases
• STDs and sexual behavior
• Syphilis
• Gonorrhea
• Chlamydial infection
• Other causes of inguinal lymphadenopathy
• Mycoplasmas and non-gonococcal urethritis
• Other causes of vaginitis and urethritis
• Genital herpes
• Human papillomavirus infection
• Human immunodeficiency virus
• Opportunistic STDs
• Arthropod infestations
22. Gastrointestinal tract infections
• Diarrheal diseases caused by bacterial or viral infection
• Food poisoning
• Helicobacter pylori and gastric ulcer disease
• Parasites and the gastrointestinal tract
• Systemic infection initiated in the gastrointestinal tract
23. Obstetric and perinatal infections
• Infections occurring in pregnancy
• Congenital infections
• Infections occurring around the time of birth
24. Central nervous system infections
• Invasion of the central nervous system
• The body’s response to invasion
• Meningitis
• Encephalitis
• Neurologic diseases of possible viral etiology
• Spongiform encephalopathy caused by scrapie-type agents
• CNS disease caused by parasites
• Brain abscesses
• Tetanus and botulism
25. Infections of the eye
• Conjunctivitis
• Infection of the deeper layers of the eye
26. Infections of the skin, soft tissue, muscle and associated systems
• Bacterial infections of skin, soft tissue and muscle
• Mycobacterial diseases of the skin
• Fungal infections of the skin
• Parasitic infections of the skin
• Mucocutaneous lesions caused by viruses
• Smallpox
• Measles
• Rubella
• Other infections producing skin lesions
• Kawasaki syndrome
• Viral infections of muscle
• Parasitic infections of muscle
• Joint and bone infections
• Infections of the hemopoietic system
27. Vector-borne infections
• Arboviruses infections
• Infections caused by Rickettsiae
• Borrelia infections
• Protozoal infections
• Helminth infections
28. Multisystem zoonoses
• Arenavirus infections
• Korean hemorrhagic fever
• Marburg and Ebola hemorrhagic fevers
• Q fever
• Anthrax
• Plague
• Yersinia enterocolitica infection
• Tularemia
• Pasteurella multocida infection
• Leptospirosis
• Rat bite fever
• Brucellosis
• Helminth infections
29. Fever of unknown origin
• Definitions of fever of unknown origin
• Causes of FUO
• Investigation of classical FUO
• Treatment of FUO
• FUO in specific patient groups
• Infective endocarditis
30. Infections in the compromised host
• The compromised host
• Infections of the host with deficient innate immunity due to physical factors
• Infections associated with secondary adaptive immunodeficiency
• Other important opportunist pathogens
31. Strategies for control: an introduction
• Epidemiologic considerations
• Detection and diagnosis
• Chemotherapy versus vaccination
• Control versus eradication
32. Diagnosis of infection and assessment of host defense mechanisms
• Aims of the clinical microbiology laboratory
• Specimen processing
• Non-cultural techniques for the laboratory diagnosis of infection
• Cultivation (culture) of microorganisms
• Identification of microorganisms grown in culture
• Antibody detection methods for the diagnosis of infection
• Assessment of host defense systems
• Protocols for specimen processing
33. Attacking the enemy: antimicrobial agents and chemotherapy
• Selective toxicity
• Discovery and design of antibacterial agents
• Classification of antibacterial agents
• Resistance to antibacterial agents
• Classes of antibacterial agents
• Inhibitors of cell wall synthesis
• Inhibitors of protein synthesis
• Inhibitors of nucleic acid synthesis
• Antimetabolites affecting nucleic acid synthesis
• Other agents that affect DNA
• Inhibitors of cytoplastic membrane function
• Urinary tract antiseptics
• Antituberculous agents
• Antibacterial agents in practice
• Antibiotic assays
• Antiviral therapy
• Antifungal agents
• Antiparasitic agents
• Use and misuse of antimicrobial agents
34. Vaccination
• The aims of vaccination
• Requirements of a good vaccine
• Types of vaccine
• Special considerations
• Community-based control by vaccination
• Factors influencing the success of vaccination
• Current vaccine practice
35. Passive and non-specific immunotherapy
• Passive immunization with antibody
• Non-specific cellular immunostimulation
• Correction of host immunodeficiency
36. Hospital infection, sterilization and disinfection
• Common hospital-acquired infections
• Important causes of hospital infection
• Sources and routes of spread of hospital infection
• Host factors and hospital infection
• Consequences of hospital infection
• Prevention of hospital infection
• Investigating hospital infection
• Sterilization and disinfection
Appendix – Pathogen parade
Answers
Index
Review quotes
Review quotes
"This is a useful book for understanding immunology, as it puts it across in a clear and concise way. It also clarifies microbe classification, beyond what you find in clinical books. The depth of the information in the book is easy to follow and understand, and is good level for any medical student. The book also comes with access to student consult, with all its online goodies.
With its easy to use layout and useful summaries at the end of each section it will also be helpful during revision, especially to clear up any areas of difficulty. To top it off it even has little historical information boxes to provide a break from studying."
Medical Student, Glasgow University, UK
"I found myself wishing that I had been able to access such a textbook during my own training back in the eighties. Overall this book is an impressive achievement. It is clearly written, makes great use of full colour diagrams, illustration and pictures. It is up to date and is written by leaders in the field. The contribution of Peter Chiodini to this textbook results in an excellent coverage of modern parasitology...an excellent textbook to accompany an undergraduate medical course in medical microbiology."
Professor John Croall, The Bulletin of the Royal College of Pathologists. April 2008, Number 142
BMA Book Awards 2008 - Commended
"I like the way the book is set out focusing on the interactions between host and pathogen. It’s easy to find information with clear tables, illustrations, good subject headings etc. Information is well-summarised in various sections including "Pathogen parade". This book is a very good holistic approach to learning microbiology with a focus not only on pathogens but on the complex relationships with the host. There is a right amount of detail for the intended readership with information clearly summarised. The excellent accompanying illustrations enhance the text."
With its easy to use layout and useful summaries at the end of each section it will also be helpful during revision, especially to clear up any areas of difficulty. To top it off it even has little historical information boxes to provide a break from studying."
Medical Student, Glasgow University, UK
"I found myself wishing that I had been able to access such a textbook during my own training back in the eighties. Overall this book is an impressive achievement. It is clearly written, makes great use of full colour diagrams, illustration and pictures. It is up to date and is written by leaders in the field. The contribution of Peter Chiodini to this textbook results in an excellent coverage of modern parasitology...an excellent textbook to accompany an undergraduate medical course in medical microbiology."
Professor John Croall, The Bulletin of the Royal College of Pathologists. April 2008, Number 142
BMA Book Awards 2008 - Commended
"I like the way the book is set out focusing on the interactions between host and pathogen. It’s easy to find information with clear tables, illustrations, good subject headings etc. Information is well-summarised in various sections including "Pathogen parade". This book is a very good holistic approach to learning microbiology with a focus not only on pathogens but on the complex relationships with the host. There is a right amount of detail for the intended readership with information clearly summarised. The excellent accompanying illustrations enhance the text."
Product details
Product details
- Edition: 4
- Latest edition
- Published: October 3, 2007
- Language: English
About the authors
About the authors
RG
Richard Goering
Affiliations and expertise
Professor and Chair, Department of Medical Microbiology and Immunology, Creighton University School of Medicine, Omaha, Nebraska, USAHD
Hazel M. Dockrell
Affiliations and expertise
Professor of Immunology, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UKMZ
Mark Zuckerman
Affiliations and expertise
Consultant Virologist and Honorary Senior Lecturer, South London Specialist Virology Centre, King’s College Hospital NHS Foundation Trust, King’s College London School of Medicine, London, UKDW
Derek Wakelin
Affiliations and expertise
University of Nottingham, Nottingham, UKIR
Ivan Roitt
Affiliations and expertise
Hon Director, Middlesex Centre for Investigative & Diagnostic Oncology, School of Health & Social Sciences, Middlesex University, London, UKCM
Cedric Mims
Affiliations and expertise
Guy's Hospital Medical School, London, UKPC
Peter L. Chiodini
Affiliations and expertise
Consultant Parasitologist, Hospital for Tropical Diseases, London; Honorary Professor, London School of Hygiene and Tropical Medicine, London, UK