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Mims' Medical Microbiology and Immunology
- 7th Edition - December 20, 2023
- Authors: Richard Goering, Hazel M. Dockrell, Mark Zuckerman, Peter L. Chiodini
- Language: English
- Paperback ISBN:9 7 8 - 0 - 4 4 3 - 1 0 7 4 7 - 4
- Paperback ISBN:9 7 8 - 0 - 3 2 3 - 9 3 7 2 5 - 2
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 1 0 7 4 3 - 6
MIMS’ Medical Microbiology and Immunology is loved internationally for its thorough yet easy-to-follow coverage of microbiology, infectious diseases, and immunology as a dynami… Read more
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Request a sales quoteMIMS’ Medical Microbiology and Immunology is loved internationally for its thorough yet easy-to-follow coverage of microbiology, infectious diseases, and immunology as a dynamic interplay between microbes and host. Covering the fundamentals of these closely linked disciplines, MIMS’ takes a systems approach to elaborate on epidemiology, clinical presentation, pathogenesis, and diagnostic approaches, as well as treatment and infection control considerations, supplemented by case-based examples. Complex scientific and clinical concepts are explained clearly and simply with the help of illustrations and a range of accompanying online content. Students will come away with a deep understanding of topics and processes, and will return to this book for reference time and again.
- Clear writing and easy-to-understand explanations – perfect for students learning to grasp the fundamentals of both microbiology and immunology
- User-friendly format with colour coding, key concept boxes, and dynamic illustrations for easy navigation
- Organised by body system – goes beyond the ‘bug parade’ to help you understand clinical context
- Pathogen Parade (electronic supplement) – a quick cross-referenced glossary of viruses, bacteria, parasites, and fungi
- Vaccine Parade (electronic supplement) – quick-reference coverage of the most commonly used vaccines in current clinical practice
- Clinical cases and multiple-choice self-assessments (electronic supplement) support learning
- Cover image
- Title page
- Copyright
- Foreword 7th Edition
- Foreword 6th Edition
- Preface
- Contributors
- Introduction
- Contents
- Section 1 The Adversaries – Pathogens
- 1 Pathogens as parasites
- THE VARIETIES OF PATHOGENS
- LIVING INSIDE OR OUTSIDE CELLS
- SYSTEMS OF CLASSIFICATION
- 2 The bacteria
- Structure
- Nutrition
- Growth and Division
- Gene Expression
- Survival Under Adverse Conditions
- Mobile Genetic Elements
- Mutation and Gene Transfer
- The Genomics of Medically Important Bacteria
- 3 The viruses
- MAJOR GROUPS OF VIRUSES
- INFECTION OF HOST CELLS
- REPLICATION
- OUTCOME OF VIRAL INFECTION
- 4 The fungi
- MAJOR GROUPS OF DISEASE-CAUSING FUNGI
- 5 The protozoa
- Protozoa can infect all the major tissues and organs of the body
- Protozoa have evolved many sophisticated strategies to avoid host responses
- Protozoa use a variety of routes to infect humans
- 6 The helminths
- LIFE CYCLES
- HELMINTHS AND DISEASE
- 7 The arthropods
- 8 Prions
- A SPECTRUM OF NEURODEGENERATIVE DISORDERS—TRANSMISSIBLE SPONGIFORM ENCEPHALOPATHY
- ROGUE PROTEIN PATHOGENESIS
- DEVELOPMENT, TRANSMISSION AND DIAGNOSIS OF PRION DISEASES
- PREVENTION AND TREATMENT OF PRION DISEASES
- 9 The host–parasite relationship
- THE MICROBIOTA AND MICROBIOME
- SYMBIOTIC ASSOCIATIONS
- THE CHARACTERISTICS OF PARASITISM
- THE EVOLUTION OF PARASITISM
- Section 2 The adversaries – host defences
- 10 The innate defences of the body
- DEFENCES AGAINST ENTRY INTO THE BODY
- DEFENCES ONCE THE MICROORGANISM PENETRATES THE BODY
- 11 Adaptive immune responses bring specificity
- LYMPHOID TISSUES: PRIMARY AND SECONDARY
- SECONDARY LYMPHOID ORGANS
- SUBSETS OF T CELLS
- ANTIBODY STRUCTURE AND FUNCTION
- RECIRCULATION OF T AND B CELLS
- 12 Cooperation leads to effective immune responses
- COOPERATION MEANS GREATER EFFICIENCY AND SPECIFICITY
- OPSONIZATION BY ANTIBODY ENHANCES PHAGOCYTOSIS AND LEADS TO COMPLEMENT ACTIVATION
- BENEFICIAL INFLAMMATORY REACTIONS CAN ALSO BE ENHANCED BY ANTIBODIES
- ACTIVATION OF T CELLS INVOLVES ANTIGEN-PRESENTING CELLS AND ADDITIONAL COSTIMULATORY SIGNALS
- B-CELL ACTIVATION
- CLONAL EXPANSION
- ANTIBODY PRODUCTION INVOLVES A SERIES OF STEPS WITHIN THE GERMINAL CENTRE
- CYTOKINES PLAY AN IMPORTANT PART IN THESE CELL–CELL INTERACTIONS
- IMMUNOLOGIC MEMORY ENABLES A SECOND INFECTION WITH THE SAME MICROBE TO BE DEALT WITH MORE EFFECTIVELY
- ARMIES MUST BE KEPT UNDER CONTROL
- Section 3 The Conflicts
- 13 Background to the infectious diseases
- HOST–PARASITE RELATIONSHIPS
- CAUSES OF INFECTIOUS DISEASES
- THE BIOLOGIC RESPONSE GRADIENT
- 14 Entry, exit and transmission
- SITES OF ENTRY
- EXIT AND TRANSMISSION
- TYPES OF TRANSMISSION BETWEEN HUMANS
- TRANSMISSION FROM ANIMALS
- 15 Immune defences in action
- COMPLEMENT
- ACUTE PHASE PROTEINS AND PATTERN RECOGNITION RECEPTORS
- FEVER
- NATURAL KILLER CELLS
- PHAGOCYTOSIS
- CYTOKINES
- ANTIBODY-MEDIATED IMMUNITY
- CELL-MEDIATED IMMUNITY
- RECOVERY FROM INFECTION
- 16 Spread and replication
- FEATURES OF SURFACE AND SYSTEMIC INFECTIONS
- MECHANISMS OF SPREAD THROUGH THE BODY
- GENETIC DETERMINANTS OF SPREAD AND REPLICATION
- OTHER FACTORS AFFECTING SPREAD AND REPLICATION
- 17 Parasite survival strategies and persistent infections
- PARASITE SURVIVAL STRATEGIES
- CONCEALMENT OF ANTIGENS
- ANTIGENIC VARIATION
- IMMUNOSUPPRESSION
- PERSISTENT INFECTIONS
- 18 Pathologic consequences of infection
- PATHOLOGY CAUSED DIRECTLY BY MICROORGANISMS
- DIARRHOEA
- PATHOLOGIC ACTIVATION OF NATURAL IMMUNE MECHANISMS
- PATHOLOGIC CONSEQUENCES OF THE IMMUNE RESPONSE
- SKIN RASHES
- VIRUSES AND CANCER
- Section 4 Clinical Manifestation and Diagnosis of Infections by Body System
- 19 Upper respiratory tract infections
- RHINITIS
- PHARYNGITIS AND TONSILLITIS
- PAROTITIS
- OTITIS AND SINUSITIS
- ACUTE EPIGLOTTITIS
- ORAL CAVITY INFECTIONS
- 20 Lower respiratory tract infections
- LARYNGITIS AND TRACHEITIS
- DIPHTHERIA
- WHOOPING COUGH
- ACUTE BRONCHITIS
- ACUTE EXACERBATIONS OF CHRONIC BRONCHITIS
- BRONCHIOLITIS
- RESPIRATORY SYNCYTIAL VIRUS INFECTION
- HANTAVIRUS PULMONARY SYNDROME
- PNEUMONIA
- BACTERIAL PNEUMONIA
- VIRAL PNEUMONIA
- HUMAN CORONAVIRUS INFECTIONS
- PARAINFLUENZA VIRUS INFECTION
- ADENOVIRUS INFECTION
- HUMAN METAPNEUMOVIRUS INFECTION
- HUMAN BOCAVIRUS INFECTION
- INFLUENZA VIRUS INFECTION
- MEASLES VIRUS INFECTION
- CYTOMEGALOVIRUS INFECTION
- TUBERCULOSIS
- CYSTIC FIBROSIS
- LUNG ABSCESS
- FUNGAL INFECTIONS
- PARASITIC INFECTIONS
- 21 Urinary tract infections
- ACQUISITION AND AETIOLOGY
- PATHOGENESIS
- CLINICAL FEATURES AND COMPLICATIONS
- LABORATORY DIAGNOSIS
- TREATMENT
- PREVENTION
- 22 Sexually transmitted infections
- STIs AND SEXUAL BEHAVIOUR
- SYPHILIS
- Gonorrhoea
- Chlamydial Infection
- OTHER CAUSES OF INGUINAL LYMPHADENOPATHY
- Mycoplasmas and Nongonococcal Urethritis
- OTHER CAUSES OF VAGINITIS AND URETHRITIS
- Genital Herpes
- HUMAN PAPILLOMAVIRUS INFECTION
- Monkeypox, previously a rare viral zoonosis, emerged in 2022 as aN STI
- HUMAN IMMUNODEFICIENCY VIRUS
- Opportunist STIs
- Arthropod Infestations
- 23 Gastrointestinal tract infections
- DIARRHOEAL DISEASES CAUSED BY BACTERIAL OR VIRAL INFECTION
- FOOD POISONING—BACTERIALTOXIN–ASSOCIATED DIARRHOEA
- VIRAL CAUSES OF DIARRHOEA
- HELICOBACTER PYLORI AND GASTRIC ULCER DISEASE
- PARASITES AND THE GASTROINTESTINAL TRACT
- MICROSPORIDIA
- OTHER INTESTINAL PROTOZOA
- SYSTEMIC INFECTION INITIATED IN THE GASTROINTESTINAL TRACT
- 24 Obstetric and perinatal infections
- INFECTIONS OCCURRING IN PREGNANCY
- CONGENITAL INFECTIONS
- INFECTIONS OCCURRING AROUND THE TIME OF BIRTH
- 25 Central nervous system infections
- INVASION OF THE CENTRAL NERVOUS SYSTEM
- THE BODY’S RESPONSE TO INVASION
- MENINGITIS
- ENCEPHALITIS
- NEUROLOGIC DISEASES OF POSSIBLE VIRAL AETIOLOGY
- SPONGIFORM ENCEPHALOPATHIES CAUSED BY SCRAPIE-TYPE AGENTS
- CNS DISEASE CAUSED BY PARASITES
- BRAIN ABSCESSES
- TETANUS AND BOTULISM
- 26 Infections of the eye
- CONJUNCTIVITIS
- INFECTION OF THE DEEPER LAYERS OF THE EYE
- 27 Infections of the skin, soft tissue, muscle and associated systems
- BACTERIAL INFECTIONS OF SKIN, SOFT TISSUE AND MUSCLE
- MYCOBACTERIAL DISEASES OF THE SKIN
- FUNGAL INFECTIONS OF THE SKIN
- PARASITIC INFECTIONS OF THE SKIN
- MUCOCUTANEOUS MANIFESTATIONS OF VIRAL INFECTIONS
- MEASLES VIRUS INFECTION
- RUBELLA VIRUS INFECTION
- OTHER MACULOPAPULAR RASHES ASSOCIATED WITH VIRAL INFECTIONS
- OTHER INFECTIONS PRODUCING SKIN LESIONS
- KAWASAKI DISEASE
- VIRAL INFECTIONS OF MUSCLE
- POSTVIRAL FATIGUE SYNDROME
- PARASITIC INFECTIONS OF MUSCLE
- JOINT AND BONE INFECTIONS
- INFECTIONS OF THE HAEMOPOIETIC SYSTEM
- 28 Vectorborne infections
- ARBOVIRUS INFECTIONS
- INFECTIONS CAUSED BY RICKETTSIAE
- BORRELIA INFECTIONS
- PROTOZOAL INFECTIONS
- HELMINTH INFECTIONS
- 29 Multisystem zoonoses
- Viral haemorrhagic fever is a multisystem syndrome triggered by a group of viruses that cause severe damage to the vascular system
- ARENAVIRUS INFECTIONS
- EBOLA AND MARBURG HAEMORRHAGIC FEVERS
- Q FEVER
- ANTHRAX
- PLAGUE
- YERSINIA ENTEROCOLITICA INFECTION
- TULARAEMIA
- PASTEURELLA MULTOCIDA INFECTION
- LEPTOSPIROSIS
- RAT-BITE FEVER
- BRUCELLOSIS
- HELMINTH INFECTIONS
- 30 Fever of unknown origin
- DEFINITIONS OF FEVER OF UNKNOWN ORIGIN
- CAUSES OF FUO
- INVESTIGATION OF CLASSIC FUO
- TREATMENT OF FUO
- FUO IN SPECIFIC PATIENT GROUPS
- INFECTIVE ENDOCARDITIS
- 31 Infections in the compromised host
- THE COMPROMISED HOST
- INFECTIONS OF THE HOST WITH DEFICIENT INNATE IMMUNITY DUE TO PHYSICAL FACTORS
- INFECTIONS ASSOCIATED WITH SECONDARY ADAPTIVE IMMUNODEFICIENCY
- OTHER IMPORTANT OPPORTUNIST PATHOGENS
- Section 5 Diagnosis and Control
- 32 Diagnosis of infection and assessment of host defence mechanisms
- AIMS OF THE CLINICAL MICROBIOLOGY LABORATORY
- SPECIMEN PROCESSING
- CULTIVATION (CULTURE) OF MICROORGANISMS
- IDENTIFICATION OF MICROORGANISMS GROWN IN CULTURE
- NONCULTURAL TECHNIQUES FOR THE LABORATORY DIAGNOSIS OF INFECTION
- ANTIBODY DETECTION METHODS FOR THE DIAGNOSIS OF INFECTION
- ASSESSMENT OF HOST DEFENCE SYSTEMS
- PUTTING IT ALL TOGETHER: DETECTION, DIAGNOSIS, EPIDEMIOLOGY
- 33 Epidemiology and control of infectious diseases
- WHAT IS EPIDEMIOLOGY?
- OUTCOME MEASUREMENTS
- TYPES OF EPIDEMIOLOGIC STUDIES
- TRANSMISSION OF INFECTIOUS DISEASE
- VACCINE EFFICACY
- 34 Attacking the enemy: antimicrobial agents and chemotherapy
- SELECTIVE TOXICITY
- DISCOVERY AND DESIGN OF ANTIMICROBIAL AGENTS
- CLASSIFICATION OF ANTIBACTERIAL AGENTS
- RESISTANCE TO ANTIBACTERIAL AGENTS
- CLASSES OF ANTIBACTERIAL AGENTS
- INHIBITORS OF CELL WALL SYNTHESIS
- INHIBITORS OF PROTEIN SYNTHESIS
- INHIBITORS OF NUCLEIC ACID SYNTHESIS
- ANTIMETABOLITES AFFECTING NUCLEIC ACID SYNTHESIS
- OTHER AGENTS THAT AFFECT DNA
- INHIBITORS OF CYTOPLASMIC MEMBRANE FUNCTION
- URINARY TRACT ANTISEPTICS
- ANTITUBERCULOSIS AGENTS
- ANTIBACTERIAL AGENTS IN PRACTICE
- ANTIBIOTIC ASSAYS
- ANTIVIRAL THERAPY
- ANTIFUNGAL AGENTS
- ANTIPARASITIC AGENTS
- CONTROL BY CHEMOTHERAPY VERSUS VACCINATION
- CONTROL VERSUS ERADICATION
- USE AND MISUSE OF ANTIMICROBIAL AGENTS
- 35 Protecting the host: vaccination
- VACCINATION—A 400-YEAR HISTORY
- Edward Jenner (1749–1823)
- AIMS OF VACCINATION
- VACCINES CAN BE OF DIFFERENT TYPES
- Live attenuated vaccines
- Nonliving vaccines
- Genetically engineered vaccines
- NONSPECIFIC BENEFICIAL EFFECTS OF VACCINES
- Vaccines in current use
- New vaccines in development
- 36 Specific and nonspecific immunotherapy
- ADOPTIVE IMMUNOTHERAPY WITH T CELLS
- PASSIVE IMMUNOTHERAPY WITH ANTIBODIES
- NONSPECIFIC CELLULAR MODULATION
- CORRECTION OF HOST IMMUNODEFICIENCY
- 37 Infection control
- COMMON HOSPITAL INFECTIONS
- IMPORTANT CAUSES OF HOSPITAL INFECTION
- Urinary tract infections
- Surgical wound infections
- Pneumonia
- Bloodstream infections
- Gastrointestinal infections
- SOURCES AND ROUTES OF SPREAD OF HOSPITAL INFECTION
- HOST FACTORS AND HOSPITAL INFECTION
- CONSEQUENCES OF HOSPITAL INFECTION
- PREVENTION OF HOSPITAL INFECTION
- INVESTIGATING HAI
- STERILIZATION AND DISINFECTION
- Index
- Pathogen parade
- Viruses
- Hepatitis Viruses
- Bacteria
- Beta-Haemolytic Streptococci
- Alpha-Haemolytic Streptococci
- Gram-Positive Rods
- Gram-Negative Rods
- Other Bacteria
- Fungi
- Helminths
- Vaccine parade
- Section 1: The Adversaries—Pathogens
- Section 2: The Adversaries—Host Defences
- Section 3: The Conflicts
- Section 4: Clinical Manifestation and Diagnosis of Infections by Body System
- Section 5: Diagnosis and Control
- Online Cases
- Bibliography – list of useful websites
- No. of pages: 624
- Language: English
- Edition: 7
- Published: December 20, 2023
- Imprint: Elsevier
- Paperback ISBN: 9780443107474
- Paperback ISBN: 9780323937252
- eBook ISBN: 9780443107436
RG
Richard Goering
Affiliations and expertise
Professor and Chair, Department of Medical Microbiology and Immunology, Creighton University School of Medicine, Omaha, Nebraska.HD
Hazel M. Dockrell
Affiliations and expertise
Professor of Immunology, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UKMZ
Mark Zuckerman
Affiliations and expertise
Consultant Virologist and Honorary Senior Lecturer, South London Specialist Virology Centre, King’s College Hospital NHS Foundation Trust, King’s College London School of Medicine, London, UKPC
Peter L. Chiodini
Affiliations and expertise
Consultant Parasitologist, Hospital for Tropical Diseases, London; Honorary Professor, London School of Hygiene and Tropical Medicine, London, UK