Middleton's Allergy 2-Volume Set
Principles and Practice
- 10th Edition - April 14, 2026
- Latest edition
- Editors: A. Wesley Burks, Robyn E. O'Hehir, David H. Broide, Leonard B. Bacharier, Gurjit K. Khurana Hershey, R. Stokes Peebles, Stephen R. Durham, Mübeccel Akdis
- Language: English
As both a practical reference for clinicians and researchers and an effective self-assessment tool for board preparation, Middleton's Allergy: Principles and Practice remain… Read more
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As both a practical reference for clinicians and researchers and an effective self-assessment tool for board preparation, Middleton's Allergy: Principles and Practice remains the #1 authoritative resource in the field. This fully revised 10th Edition brings you up to date with recent advancements in basic science and clinical applications regarding allergy practice and disease mechanisms, offering unparalleled guidance on the full spectrum of allergy across the lifespan.
- Uses a concise, logically organized, and consistent chapter structure, with each chapter featuring an opening outline and Summary of Important Concepts box—all designed to make this comprehensive text easily navigable for learning, research, and clinical application
- Contains new content on COVID-19, vaccines, the microbiome, and allergic diseases as related to the effects of climate change, as well as thorough updates throughout the text
- Addresses recent innovations in the diagnosis, prevention, and management of allergic disorders, including emerging global issues, the advent of precision medicine, and new immunologic therapies
- Features 730+ full-color illustrations and offers even more multiple-choice questions online with answers and explanations for effective, efficient self-assessment and study
- Shares the experience and knowledge of a highly renowned editorial board led by Drs. A. Wesley Burks and Robyn E. O’Hehir in coordination with Drs. David H. Broide, Leonard B. Bacharier, Gurjit K. Khurana Hershey, and R. Stokes Peebles, Jr. The 10th Edition expands its international perspective with the addition of two new esteemed editors: Drs. Stephen Durham of UK and Mübeccel Akdis of Switzerland
- An eBook version is included with purchase. The eBook allows you to access all of the text, figures and references, with the ability to search, customize your content, make notes and highlights, and have content read aloud. Additional digital ancillary content may publish up to 6 weeks following the publication date
Allergists and immunologists
Contributors
Foreword
Preface
VOLUME 1
SECTION A Basic Sciences Underlying Allergy and Immunology
1 Innate Immunity
2 Adaptive Immunity
3 Immunoglobulin Structure and Function
4 Immune Tolerance
5 Cytokines in Allergic Inflammation
6 Cellular Adhesion in Inflammation
7 Chemokines
8 The Complement System
9 Lipid Mediators of Hypersensitivity and Inflammation
10 Molecular Biology and Genetic Engineering
11 Biology of Lymphocytes
12 Innate Lymphoid Cells
13 Antigen Presenting Dendritic Cells
14 Biology of Mast Cells and Their Mediators
15 Biology of Basophils
16 Biology of Eosinophils
17 Biology of Neutrophils
18 Biology of Monocytes and Macrophages
19 Airway Epithelial Cells
20 Airway Smooth Muscle in Asthma
21 Pathophysiology of Allergic Inflammation
22 Genetics and Epigenetics in Allergic Diseases
23 Omic and Systems Biology Approaches to Allergic Disease
24 Immunobiology of IgE and IgE Receptors
25 Neuronal Control of Airway Function in Allergy
SECTION B Aerobiology and Allergens
26 The Structure and Function of Allergens
27 Aerobiology of Outdoor Allergens
28 Indoor Allergens
29 Preparation and Standardization of Allergens and Allergen Extracts
30 Air Pollution: Indoor and Outdoor
SECTION C The Skin
31 Structure of the Skin and Cutaneous Immunology
32 Atopic Dermatitis
33 Contact Dermatitis
34 Urticaria and Angioedema
35 Hereditary Angioedema and Bradykinin‑Mediated Angioedema
36 Immune Complexes in Disease
SECTION D The Eye
37 Allergic Diseases of the Eye
SECTION E Respiratory Tract
38 The Nose and Control of Nasal Airflow
39 Allergic and Nonallergic Rhinitis
40 Rhinosinusitis and Nasal Polyps
41 Development, Structure, and Physiology in Normal Lung and in Asthma
42 Respiratory Tract Mucosal Immunology
43 Airway Mucus and the Mucociliary System
44 Epidemiology of Asthma and Allergic Diseases
45 Ontogeny of Immune Development and Its Relationship to Allergic Diseases and Asthma
46 Climate Change: Allergic Diseases and Asthma
47 Mouse Models of Allergic Airways Disease
48 Diagnosis of Asthma in Infants and Children
49 Management of Asthma in Infants and Children
50 Diagnosis of Asthma in Adults
51 Management of Asthma in Adolescents and Adults
52 Emergency Treatment and Approach to the Patient With Acute Asthma
53 Approach to the Patient With Exercise‑Induced Bronchoconstriction
54 Asthma and Allergic Diseases During Pregnancy
55 Occupational Allergy and Asthma
56 Pathology of Asthma
57 Allergic Bronchopulmonary Aspergillosis, Hypersensitivity Pneumonitis, and Epidemic Thunderstorm Asthma
58 Immunologic Nonasthmatic Diseases of the Lung
59 Approaches to the Patient With Chronic Cough
60 Bronchial and Nasal Challenge Testing
61 Lung Imaging
62 Pharmaceutical Aerosols and Aerosol Drug Delivery Systems
VOLUME 2
SECTION F Gastrointestinal Tract
63 Gastrointestinal Mucosal Immunology
64 Eosinophilic Gastrointestinal Disorders
SECTION G Systemic Disease
65 Clinical Significance of Immunoglobulin E
66 In Vivo Methods for the Study and Diagnosis of IgE‑Mediated Allergy
67 Approach to the Patient With Recurrent Infections
68 Primary Immunodeficiency Diseases
69 Treatment of Primary Immunodeficiency Diseases
70 HIV Infection and Allergic Disease
71 Laboratory Tests for Allergic and Immunodeficiency Diseases
72 Eosinophilia and Eosinophil‑Related Disorders
73 Mastocytosis
74 Anaphylaxis
75 Insect Allergy
76 Drug Allergy
77 Hypersensitivity to Aspirin and Other Nonsteroidal Antiinflammatory Drugs
78 Reactions to Foods
79 Oral Food Challenge Testing
80 Food Allergy Management, Prevention, and Therapy
81 Adverse Reactions to Vaccines
SECTION H Therapeutics
82 Allergen Immunotherapy for Inhalant Allergens
83 Principles of Pharmacotherapeutics
84 Precision Medicine in Allergic Disorders
85 Optimizing Adherence in Practice
86 Anti–Immunoglobulin E Therapy
87 Cytokine‑Specific Therapy in Asthma
88 Histamine and Antihistamines
89 Inhaled β2‑Agonists
90 Anticholinergic Therapies
91 Glucocorticoids
92 Antileukotriene Therapy in Asthma
93 Unconventional Theories and Unproven Methods in Allergy
94 Complementary and Integrative Health
Foreword
Preface
VOLUME 1
SECTION A Basic Sciences Underlying Allergy and Immunology
1 Innate Immunity
2 Adaptive Immunity
3 Immunoglobulin Structure and Function
4 Immune Tolerance
5 Cytokines in Allergic Inflammation
6 Cellular Adhesion in Inflammation
7 Chemokines
8 The Complement System
9 Lipid Mediators of Hypersensitivity and Inflammation
10 Molecular Biology and Genetic Engineering
11 Biology of Lymphocytes
12 Innate Lymphoid Cells
13 Antigen Presenting Dendritic Cells
14 Biology of Mast Cells and Their Mediators
15 Biology of Basophils
16 Biology of Eosinophils
17 Biology of Neutrophils
18 Biology of Monocytes and Macrophages
19 Airway Epithelial Cells
20 Airway Smooth Muscle in Asthma
21 Pathophysiology of Allergic Inflammation
22 Genetics and Epigenetics in Allergic Diseases
23 Omic and Systems Biology Approaches to Allergic Disease
24 Immunobiology of IgE and IgE Receptors
25 Neuronal Control of Airway Function in Allergy
SECTION B Aerobiology and Allergens
26 The Structure and Function of Allergens
27 Aerobiology of Outdoor Allergens
28 Indoor Allergens
29 Preparation and Standardization of Allergens and Allergen Extracts
30 Air Pollution: Indoor and Outdoor
SECTION C The Skin
31 Structure of the Skin and Cutaneous Immunology
32 Atopic Dermatitis
33 Contact Dermatitis
34 Urticaria and Angioedema
35 Hereditary Angioedema and Bradykinin‑Mediated Angioedema
36 Immune Complexes in Disease
SECTION D The Eye
37 Allergic Diseases of the Eye
SECTION E Respiratory Tract
38 The Nose and Control of Nasal Airflow
39 Allergic and Nonallergic Rhinitis
40 Rhinosinusitis and Nasal Polyps
41 Development, Structure, and Physiology in Normal Lung and in Asthma
42 Respiratory Tract Mucosal Immunology
43 Airway Mucus and the Mucociliary System
44 Epidemiology of Asthma and Allergic Diseases
45 Ontogeny of Immune Development and Its Relationship to Allergic Diseases and Asthma
46 Climate Change: Allergic Diseases and Asthma
47 Mouse Models of Allergic Airways Disease
48 Diagnosis of Asthma in Infants and Children
49 Management of Asthma in Infants and Children
50 Diagnosis of Asthma in Adults
51 Management of Asthma in Adolescents and Adults
52 Emergency Treatment and Approach to the Patient With Acute Asthma
53 Approach to the Patient With Exercise‑Induced Bronchoconstriction
54 Asthma and Allergic Diseases During Pregnancy
55 Occupational Allergy and Asthma
56 Pathology of Asthma
57 Allergic Bronchopulmonary Aspergillosis, Hypersensitivity Pneumonitis, and Epidemic Thunderstorm Asthma
58 Immunologic Nonasthmatic Diseases of the Lung
59 Approaches to the Patient With Chronic Cough
60 Bronchial and Nasal Challenge Testing
61 Lung Imaging
62 Pharmaceutical Aerosols and Aerosol Drug Delivery Systems
VOLUME 2
SECTION F Gastrointestinal Tract
63 Gastrointestinal Mucosal Immunology
64 Eosinophilic Gastrointestinal Disorders
SECTION G Systemic Disease
65 Clinical Significance of Immunoglobulin E
66 In Vivo Methods for the Study and Diagnosis of IgE‑Mediated Allergy
67 Approach to the Patient With Recurrent Infections
68 Primary Immunodeficiency Diseases
69 Treatment of Primary Immunodeficiency Diseases
70 HIV Infection and Allergic Disease
71 Laboratory Tests for Allergic and Immunodeficiency Diseases
72 Eosinophilia and Eosinophil‑Related Disorders
73 Mastocytosis
74 Anaphylaxis
75 Insect Allergy
76 Drug Allergy
77 Hypersensitivity to Aspirin and Other Nonsteroidal Antiinflammatory Drugs
78 Reactions to Foods
79 Oral Food Challenge Testing
80 Food Allergy Management, Prevention, and Therapy
81 Adverse Reactions to Vaccines
SECTION H Therapeutics
82 Allergen Immunotherapy for Inhalant Allergens
83 Principles of Pharmacotherapeutics
84 Precision Medicine in Allergic Disorders
85 Optimizing Adherence in Practice
86 Anti–Immunoglobulin E Therapy
87 Cytokine‑Specific Therapy in Asthma
88 Histamine and Antihistamines
89 Inhaled β2‑Agonists
90 Anticholinergic Therapies
91 Glucocorticoids
92 Antileukotriene Therapy in Asthma
93 Unconventional Theories and Unproven Methods in Allergy
94 Complementary and Integrative Health
Review of the previous edition:
"Since its inception, this two-volume book has served as a comprehensive resource for allergists, specifically fellows-in-training.The present edition continues the reputation of the original, enjoying contributions from over 200 experts in the field." --Massoud Mahmoudi, DO, PhD (University of California San Francisco) Doodys Review Service
"Since its inception, this two-volume book has served as a comprehensive resource for allergists, specifically fellows-in-training.The present edition continues the reputation of the original, enjoying contributions from over 200 experts in the field." --Massoud Mahmoudi, DO, PhD (University of California San Francisco) Doodys Review Service
- Edition: 10
- Latest edition
- Published: April 14, 2026
- Language: English
AB
A. Wesley Burks
Affiliations and expertise
Dean, UNC School of Medicine; CEO of UNC Health, The University of North Carolina at Chapel Hill, USARO
Robyn E. O'Hehir
Affiliations and expertise
Alfred Hospital and Monash University, Department of Allergy, Immunology, and Respiratory Medicine, AustraliaDB
David H. Broide
Affiliations and expertise
Professor of Medicine, University of California San, USALB
Leonard B. Bacharier
Affiliations and expertise
Vanderbilt University, Doctors' Office Tower, USAGK
Gurjit K. Khurana Hershey
Affiliations and expertise
Department of Pediatrics, Cincinnati Children’s Hospital, USARP
R. Stokes Peebles
R. Stokes Peebles is Professor of Medicine in the Division of Allergy, Pulmonary and Critical Care Medicine at Vanderbilt University Medical Center, Nashville, Tennessee.
Affiliations and expertise
Professor of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USASD
Stephen R. Durham
Affiliations and expertise
National Heart and Lung Institute, Imperial College, Guy Scadding Building, UKMA
Mübeccel Akdis
Affiliations and expertise
Swiss Institute of Allergy and Asthma Research, University of Zurich, Switzerland