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Elsevier

MicroRNA in Regenerative Medicine

  • 2nd Edition - May 8, 2023
  • Latest edition
  • Editor: Chandan K. Sen
  • Language: English

Regulating virtually all biological processes, the genome’s 2,654 newly discovered variants of mature microRNAs – short ribonucleic acid molecules found in eukaryotic cells – ho… Read more

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Description

Regulating virtually all biological processes, the genome’s 2,654 newly discovered variants of mature microRNAs – short ribonucleic acid molecules found in eukaryotic cells – hold a key role in the body’s toolkit of regenerative and reparative capacities. Identifying how to activate and deliver these specialist molecules may aid in the repair and regeneration of major tissue and organ damage in future therapies.

In MicroRNA and Regenerative Medicine, Second Edition, over 50 leading experts address foundational and emerging topics in the field. Concisely summarizing and evaluating key findings from new research and their translational application, contributors examine current and future significance of clinical research in the miRNA area. Coverage encompasses all major aspects of fundamental stem cell and developmental biology, including the uses of miRNA in cell and tissue plasticity, developmental biology, tissue repair, and regeneration. In particular, contributors provide focused coverage of methodologies for regenerative intervention and tissue engineering.

Topics new to this edition include proteomic changes during tissue repair and regeneration, horizontal transfer of miRNAs in tissue regeneration, tissue stemness, peripheral nerve regeneration, miRNA as biomarkers, microRNA in pregnancy and embryo development, exogenous and diet derived microRNA in tissue development, ocular microRNA, mitochondrial microRNA, sensory hair cell death and regeneration, and microRNA in senescence.

Key features

  • Features chapter contributions from international leaders in the field, covering the spectrum from bench to bedside
  • Includes short, applied chapters offering focused discussion and practical examples
  • Incorporates multi-color text layout with more than 150 color figures to illustrate important findings

Readership

Researchers working in stem cell biology, tissue or organ engineering, genomics, epigenetics, and molecular, cell, and developmental biology
Regenerative medicine physicians; students of stem cell biology, tissue or organ engineering, genomics, epigenetics, and molecular, cell, and developmental biology

Table of contents

Part 1: Stem Cells

1. MicroRNA Biogenesis in Regenerative Medicine
Subhadip Ghatak and Chandan K. Sen

2. Control of Pluripotency and Reprogramming

3. Epigenetic Modification of MicroRNAs
Subhadip Ghatak, Chandan K. Sen and Durba Pal

4. miRNAs in Bone Marrow–Derived Mesenchymal Stem Cells
Ken Liechty and Junwang Xu

5. miRNAs in Cancer Stem Cells

6. MicroRNAs in Neural Stem Cells

7. MicroRNAs in Embryonic Stem Cells

8. MicroRNAs in Normal and Malignant Myelopoiesis

9. MicroRNAs: Molecular Rheostats Regulating Stem Cells Self-renewal and Therapeutic Implications
Prabha Sampath and Yuk Cheung Cyrus Chan

10. MicroRNAs in Endothelial Progenitor Cells

Part 2: Development

11. MicroRNA Function in Muscle Homeostasis and Regenerative Medicine

12. MicroRNAs in Skin Fibrosis

13. MicroRNAs in Hematopoietic Stem Cell Biology

14. miRNAs in Bone Formation and Homeostasis

15. Lung Development

16. MicroRNAs in Pancreas and Islet Development
Ricardo Pastori

17. MicroRNAs in Skeletal Muscle Differentiation

18. MicroRNAs in Brain Development

19. MicroRNAs in the Retina and in Visual Connectivity

20. MicroRNAs in Neural Crest Development

21. Adipogenesis and Obesity
Leluo Guan

Part 3: Repair

22. MicroRNAs with Mega Functions in Cardiac Remodeling and Repair: The Micromanagement of Matters of the Heart

23. MicroRNAs in Vascular Remodeling and Repair
Costanza Emanueli

24. Skin Wound Healing
Jaideep Banerjee and Chandan K. Sen

25. miRNAs in Bone Repair

26. MicroRNAs as Future Therapeutic Targets for Spinal Cord Injury

27. MicroRNA Regulation of Angiogenesis
Yuk Cheung Cyrus Chan

28. Micromanaging Inflammation and Tissue Repair
Sashwati Roy

29. MicroRNA Regulation of mTOR Function

30. OxymiRs in Regenerative Medicine
Mithun Sinha and Chandan K. Sen

31. MicroRNAs and Exosomes in Cancer Diagnosis and Therapy
Hidetoshi Tahara and Dan Xu

32. Organ Transplantation and MicroRNA Expression

Part 4: Regeneration

33. MicroRNAs in the Control of Neurogenesis in the Developing Cerebral Cortex

34. miRNAs in Transitions: EMT, MET, and EndoMT
Mitsuo Sato

35. MicroRNAs in Cardiac Regeneration
Maurizio C. Capogrossi

36. MicroRNAs in Liver Regeneration

Part 5: Methodology

37. MicroRNA Technology and Small-Molecule Delivery

Part 6: Intervention

38. Drug–MicroRNA Cross-Talk

39. Delivery and Biological Activity of Therapeutic miRNAs and miRNA Modifiers
Roberto Gambari

40. RNA-Based Therapies for Bone Diseases

41. MicroRNA-Mediated Regulation of Cardiovascular Differentiation and Therapeutic Implications

42. Circulating MicroRNAs as Biomarkers
Clay B. Marsh

Part 7: Tissue Engineering

43. Nuclear Architecture and Transcriptional Regulation of MicroRNAs
Sreenivas Chavali

44. MicroRNAs in Tissue Engineering and Regenerative Medicine

45. microRNAs in Renal Development and Regeneration
Jonathan Gleadle

46. Mitochondrial MicroRNA in Tissue Regeneration
Filipe Valente Duarte

47. MicroRNA and Microbiota
Leluo Guan

48. Mitochondrial MicroRNA in Tissue Regeneration
Shirin Elizabeth Khorsandi

49. MicroRNA Detection
Bang-Ce Ye

50. Bone Formation and Homeostasis
Baohong Zhao

51. Bone Formation and Homeostasis
Hanna Taipaleenmäki

52. MicroRNAs in Liver Disease
Suthat Liangpunsakul

53. MicroRNA Bioinformatics
Kanhaiya Singh

54. MicroRNAs in Ischemic Stroke
Savita Khanna

55. MicroRNAs in Senescence
Karamjeet Kaur

56. Ocular miRNA
S.P. Srinivas

Product details

  • Edition: 2
  • Latest edition
  • Published: May 12, 2023
  • Language: English

About the editor

CS

Chandan K. Sen

Dr. Chandan K Sen is a tenured Professor of Surgery, Executive Director of The Ohio State University Comprehensive Wound Center and Director of the Ohio State University's Center for Regenerative Medicine & Cell Based Therapies. He is also the Associate Dean for Research at The Ohio State University Wexner Medical Center. After completing his Masters of Science in Human Physiology from the University of Calcutta, Dr. Sen received his PhD in Physiology from the University of Kuopio in Finland. Dr. Sen trained as a postdoctoral fellow at the University of California at Berkeley's Molecular and Cell Biology department. His first faculty appointment was in the Lawrence Berkeley National Laboratory in California. In fall of 2000, Dr. Sen moved to The Ohio State University where established a program on tissue injury and repair. Currently, Dr. Sen is a Professor and Vice Chair of Research of Surgery. Dr. Sen serves on the editorial board of numerous scientific journals. He is the Editor in Chief of Antioxidants & Redox Signaling(www.liebertpub.com/ars) with a current impact factor of 8.456. He is the Section Editor of microRNA of Physiological Genomics, a journal of the American Physiological Society. Dr. Sen and his team have published over 250 scientific publications. He has a H-index of 64 and is currently cited 2000 times every year.
Affiliations and expertise
Professor of Surgery, Executive Director of The Ohio State University Comprehensive Wound Center, Columbus, Ohio, USA

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