MicroRNA in Regenerative Medicine
- 2nd Edition - May 8, 2023
- Editor: Chandan K. Sen
- Language: English
- Hardback ISBN:9 7 8 - 0 - 1 2 - 8 2 0 7 1 9 - 2
- eBook ISBN:9 7 8 - 0 - 1 2 - 8 2 0 7 2 2 - 2
Regulating virtually all biological processes, the genome’s 2,654 newly discovered variants of mature microRNAs – short ribonucleic acid molecules found in eukaryotic cells – ho… Read more
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Request a sales quoteRegulating virtually all biological processes, the genome’s 2,654 newly discovered variants of mature microRNAs – short ribonucleic acid molecules found in eukaryotic cells – hold a key role in the body’s toolkit of regenerative and reparative capacities. Identifying how to activate and deliver these specialist molecules may aid in the repair and regeneration of major tissue and organ damage in future therapies.
In MicroRNA and Regenerative Medicine, Second Edition, over 50 leading experts address foundational and emerging topics in the field. Concisely summarizing and evaluating key findings from new research and their translational application, contributors examine current and future significance of clinical research in the miRNA area. Coverage encompasses all major aspects of fundamental stem cell and developmental biology, including the uses of miRNA in cell and tissue plasticity, developmental biology, tissue repair, and regeneration. In particular, contributors provide focused coverage of methodologies for regenerative intervention and tissue engineering.
Topics new to this edition include proteomic changes during tissue repair and regeneration, horizontal transfer of miRNAs in tissue regeneration, tissue stemness, peripheral nerve regeneration, miRNA as biomarkers, microRNA in pregnancy and embryo development, exogenous and diet derived microRNA in tissue development, ocular microRNA, mitochondrial microRNA, sensory hair cell death and regeneration, and microRNA in senescence.
- Features chapter contributions from international leaders in the field, covering the spectrum from bench to bedside
- Includes short, applied chapters offering focused discussion and practical examples
- Incorporates multi-color text layout with more than 150 color figures to illustrate important findings
Researchers working in stem cell biology, tissue or organ engineering, genomics, epigenetics, and molecular, cell, and developmental biology
Regenerative medicine physicians; students of stem cell biology, tissue or organ engineering, genomics, epigenetics, and molecular, cell, and developmental biology
Regenerative medicine physicians; students of stem cell biology, tissue or organ engineering, genomics, epigenetics, and molecular, cell, and developmental biology
- Cover
- Title page
- Table of Contents
- Copyright
- Contributors
- Part 1: Stem Cells
- Chapter 1: MicroRNA Biogenesis in Regenerative Medicine
- Abstract
- 1.1: INTRODUCTION
- 1.2: MACRO IMPACT OF miRNAs
- 1.3: miRNA BIOGENESIS: DIFFERENT PATHS TO THE SAME DESTINATION
- 1.4: MECHANISMS OF miRNA-INDUCED TRANSLATIONAL REPRESSION
- 1.5: miRNA REGULATION
- 1.6: METHODS FOR miRNA PROFILING
- 1.7: BIOINFORMATICS ANALYSIS OF miRNAs
- 1.8: miRNA APPLICATIONS IN REGENERATIVE MEDICINE
- 1.9: miRNAs AND STEM CELLS
- 1.10: EXOSOMAL miRNA IN CELLULAR CROSSTALK
- 1.11: CONCLUSIONS AND FUTURE PERSPECTIVES
- 1.12: CHAPTER QUESTIONS
- REFERENCES
- FURTHER READING
- Chapter 2: Control of Pluripotency and Reprogramming
- Abstract
- 2.1: INTRODUCTION
- 2.2: BASIC PROPERTIES OF STEM CELLS
- 2.3: PLURIPOTENCY
- 2.4: NUCLEAR REPROGRAMMING
- 2.5: CONCLUSIONS
- 2.6: CHAPTER QUESTIONS
- REFERENCES
- FURTHER READING
- Chapter 3: Epigenetic Modification of MicroRNAs
- Abstract
- 3.1: INTRODUCTION
- 3.2: THE EPIGENETIC LANDSCAPE OF A HEALTHY CELL
- 3.3: miRNAs AND EPIGENETIC REGULATION
- 3.4: A GENERALIZED MODEL FOR EPIGENETIC REGULATION OF miRNAs IN DETERMINING CELL FATE
- 3.5: EPIGENETIC MODIFICATIONS AND REGENERATIVE MEDICINE
- 3.6: EPIGENETIC MODIFYING DRUGS
- 3.7: THE CLINICAL RELEVANCE OF miRNAs AND EPIGENETIC MODIFYING DRUGS
- 3.8: CONCLUSIONS AND FUTURE PERSPECTIVES
- 3.9: CHAPTER QUESTIONS
- REFERENCES
- FURTHER READING
- Chapter 4: MicroRNAs and Mesenchymal Stem Cells in Diabetic Wound Healing
- Abstract
- 4.1: MicroRNA AND MSC IN GENERAL AND IN WOUND HEALING
- 4.2: DIABETES AND WOUND HEALING
- 4.3: INFLAMMATION: MicroRNA, MSCs, AND THEIR INTERACTION
- 4.4: NEOVASCULARIZATION: miRNA, MSCs, AND THEIR INTERACTION
- 4.5: EXTRACELLULAR MATRIX REMODELING: miRNA, MSC, AND THEIR INTERACTION
- 4.6: RE-EPITHELIALIZATION: miRNAs, MSCs, AND THEIR INTERACTION
- 4.7: FUTURE DIRECTIONS
- REFERENCES
- Chapter 5: miRNAs in Cancer Stem Cells
- Abstract
- ACKNOWLEDGMENTS
- 5.1: INTRODUCTION
- 5.2: miRNA REGULATION OF NORMAL STEM CELLS
- 5.3: miRNA REGULATION OF CANCER STEM CELLS
- 5.4: REGULATION OF miRNAs TO INHIBIT CANCER STEM CELLS
- 5.5: CONCLUSIONS AND FUTURE PERSPECTIVES
- 5.6: CHAPTER QUESTIONS
- REFERENCES
- FURTHER READING
- Chapter 6: MicroRNAs in Neural Stem Cells
- Abstract
- 6.1: INTRODUCTION
- 6.2: FIRST INSIGHTS: DICER-KNOCKOUT MICE
- 6.3: miRNA CONTROL OF NSC STATUS AND PROGRESSION ALONG DIFFERENTIATION
- 6.4: miRNAs AS NEURONAL FATE DETERMINANTS
- 6.5: CONCLUSIONS AND FUTURE PERSPECTIVES
- 6.6: CHAPTER QUESTIONS
- REFERENCES
- ONLINE RESOURCES
- FURTHER READING
- Chapter 7: MicroRNAs in Embryonic Stem Cells
- Abstract
- ACKNOWLEDGMENTS
- 7.1: INTRODUCTION
- 7.2: STEM CELLS AND PLURIPOTENCY
- 7.3: miRNAs IN EMBRYONIC STEM CELLS
- 7.4: THE ROLE OF miRNAs IN CELLULAR REPROGRAMMING
- 7.5: CONCLUSIONS AND FUTURE PERSPECTIVES
- 7.6: CHAPTER QUESTIONS
- REFERENCES
- FURTHER READING
- Chapter 8: MicroRNAs: Molecular Rheostats Regulating Stem Cells Self-Renewal and Therapeutic Implications
- Abstract
- 8.1: INTRODUCTION
- 8.2: STEM CELLS
- 8.3: FACTORS ESSENTIAL FOR MAINTENANCE OF STEM CELL SELF-RENEWAL
- 8.4: miRNA BIOGENESIS AND MODE OF ACTION
- 8.5: INDUCED PLURIPOTENT STEM CELLS AND miRNAs
- 8.6: CONCLUSIONS AND FUTURE PERSPECTIVES
- 8.7: CHAPTER QUESTIONS
- REFERENCES
- ONLINE RESOURCES
- Chapter 9: MicroRNAs in Endothelial Progenitor Cells
- Abstract
- 9.1: INTRODUCTION
- 9.2: EPCs AND CARDIOVASCULAR DISEASES
- 9.3: EPCs AND ANGIOGENESIS-BASED TISSUE REPAIR
- 9.4: EPCs IN TUMOR ANGIOGENESIS
- 9.5: CONTROVERSY IN IDENTIFICATION OF EPCs
- 9.6: miRNA PROFILES IN EPCs
- 9.7: REGULATION OF miRNAs IN EPCs IN DISEASES
- 9.8: TARGETING miRNAs IN EPC THERAPY
- 9.9: CONCLUSIONS AND FUTURE PERSPECTIVES
- 9.10: CHAPTER QUESTIONS
- REFERENCES
- ONLINE RESOURCES
- FURTHER READING
- Part 2: Development
- Chapter 10: MicroRNA Function in Muscle Homeostasis and Regenerative Medicine
- Abstract
- 10.1: INTRODUCTION
- 10.2: BONE DEVELOPMENT AND REMODELING
- 10.3: SKELETAL MUSCLE DEVELOPMENT AND REGENERATION
- 10.4: MicroRNAs IN DIFFERENTIATION AND REGENERATIVE MEDICINE
- 10.5: CONCLUSIONS AND FUTURE PERSPECTIVES
- 10.6: CHAPTER QUESTIONS
- References
- Chapter 11: MicroRNAs in Renal Development and Regeneration
- Abstract
- 11.1: INTRODUCTION
- 11.2: miRNA BIOGENESIS
- 11.3: NEPHROGENESIS AND THE ROLE OF miRNAs IN KIDNEY DEVELOPMENT
- 11.4: ROLE OF SPECIFIC miRNAs AND THEIR TARGETS IN KIDNEY DEVELOPMENT
- 11.5: THE ROLE OF miRNAs IN KIDNEY REGENERATION
- 11.6: THE ROLE OF miRNAs IN DEVELOPMENTAL KIDNEY DISEASE
- 11.7: BARRIERS TO REGENERATION AND miRNA PATHWAYS
- 11.8: CONCLUSION
- REFERENCES
- Chapter 12: MicroRNAs in Pancreas and Islet Development and Function
- Abstract
- 12.1: INTRODUCTION
- 12.2: THE ROLE OF miRNAs IN ADULT ISLET FUNCTION AND DIABETES
- 12.3: miRNAs IN THE MOUSE AND HUMAN DEVELOPING PANCREAS
- 12.4: miRNAs INVOLVED WITH IN VITRO DIFFERENTIATION OF HUMAN STEM CELL INTO β-CELLS
- 12.5: CURRENT TECHNIQUES TO STUDY miRNA FUNCTION
- 12.6: CONCLUSIONS AND FUTURE PERSPECTIVES
- 12.7: CHAPTER QUESTIONS
- REFERENCES
- ONLINE RESOURCES
- FURTHER READING
- Chapter 13: MicroRNAs in Skeletal Muscle Differentiation
- Abstract
- 13.1: INTRODUCTION
- 13.2: myomiRs
- 13.3: NONMUSCLE-SPECIFIC miRNAs IN SKELETAL MUSCLE DEVELOPMENT
- 13.4: FUNCTIONAL CHARACTERIZATION OF miRNAs IN MOUSE MODELS
- 13.5: miRNAs AND SKELETAL MUSCLE DISEASES
- 13.6: CONCLUSIONS AND FUTURE PERSPECTIVES
- 13.7: CHAPTER QUESTIONS
- REFERENCES
- ONLINE RESOURCES
- FURTHER READING
- Chapter 14: MicroRNAs in Bone Formation and Homeostasis
- Abstract
- 14.1: INTRODUCTION
- 14.2: PHYSIOLOGICAL BONE REMODELING
- 14.3: OSTEOPOROSIS
- 14.4: MicroRNAs IN BONE MASS MAINTENANCE
- 14.5: MicroRNAs IN PATHOLOGICAL BONE REMODELING
- 14.6: miRNAs IN RARE BONE DISEASES
- 14.7: CLINICAL POTENTIAL OF miRNAs
- 14.8: CONCLUSIONS AND FUTURE PERSPECTIVES
- REFERENCES
- Part 3: Repair
- Chapter 15: MicroRNAs With Mega Functions in Cardiac Remodeling and Repair: The Micromanagement of Matters of the Heart
- Abstract
- 15.1: INTRODUCTION
- 15.2: miRNAs IN CARDIAC DEVELOPMENT AND FUNCTION
- 15.3: miRNAs IN CARDIAC REMODELING
- 15.4: MODULATION OF miRNA EXPRESSION TO LIMIT REMODELING AND FOR MYOCARDIAL REPAIR
- 15.5: miRNAs IN CARDIAC DYSFUNCTION
- 15.6: CONCLUSIONS AND FUTURE PERSPECTIVES
- 15.7: CHAPTER QUESTIONS
- REFERENCES
- ONLINE RESOURCES
- FURTHER READING
- Chapter 16: MicroRNAs in Liver Disease
- Abstract
- 16.1: INTRODUCTION
- 16.2: MicroRNAs IN VIRAL HEPATITIS B INFECTION
- 16.3: MicroRNAs IN VIRAL HEPATITIS C INFECTION
- 16.4: MicroRNAs IN ALCOHOL-ASSOCIATED LIVER DISEASE
- 16.5: miRNAs IN NONALCOHOLIC FATTY LIVER DISEASE
- 16.6: miRNAs IN DRUG-INDUCED LIVER INJURY
- 16.7: miRNA IN PRIMARY BILIARY CHOLANGITIS
- 16.8: miRNA IN PRIMARY SCLEROSING CHOLANGITIS
- 16.9: miRNAs IN LIVER FIBROSIS
- 16.10: miRNAs IN LIVER CANCER
- 16.11: SUMMARY
- CONFLICTS OF INTERESTS
- REFERENCES
- Chapter 17: Role of MicroRNAs in Vascular Remodeling and Repair
- Abstract
- 17.1: INTRODUCTION
- 17.2: miRNAs IN VASCULAR REMODELING
- 17.3: miRNAs IN TISSUE REGENERATION
- 17.4: miRNAs IN REGENERATIVE CELL THERAPY
- 17.5: CLINICAL RESEARCH STUDIES OF miRNAs
- 17.6: CONCLUSIONS AND FUTURE PERSPECTIVES
- 17.7: CHAPTER QUESTIONS
- REFERENCES
- ONLINE RESOURCES
- FURTHER READING
- Chapter 18: MicroRNAs in Skin Fibrosis
- Abstract
- 18.1: INTRODUCTION
- 18.2: miRNA REGULATION OF SKIN FIBROSIS
- 18.3: CLINICAL APPLICATIONS OF miRNAs IN SKIN FIBROSIS
- 18.4: CONCLUSIONS AND FUTURE PERSPECTIVES
- 18.5: CHAPTER QUESTIONS
- References
- Chapter 19: miRNAs in Bone Repair
- Abstract
- 19.1: INTRODUCTION
- 19.2: BONE REMODELING AND BONE REPAIR
- 19.3: miRNAs IN FRACTURE REPAIR
- 19.4: miRNAs IN OSTEOBLASTS
- 19.5: miRNAs IN VASCULAR ENDOTHELIAL CELLS
- 19.6: miRNAs IN OSTEOCLASTS
- 19.7: CHALLENGES FOR miRNA-BASED THERAPEUTICS IN BONE REPAIR
- 19.8: CONCLUSIONS AND FUTURE PERSPECTIVES
- 19.9: CHAPTER QUESTIONS
- REFERENCES
- ONLINE RESOURCES
- FURTHER READING
- Chapter 20: MicroRNA Regulation of Angiogenesis
- Abstract
- 20.1: INTRODUCTION
- 20.2: ROLE OF miRs IN ENDOTHELIAL CELLS
- 20.3: TRANSLATION FROM BENCH TO CLINIC
- 20.4: CHALLENGES AND FUTURE DIRECTIONS
- 20.5: CONCLUSION
- 20.6: ESSAY QUESTIONS
- REFERENCES
- FURTHER READING
- Chapter 21: Micromanaging Inflammation and Tissue Repair
- Abstract
- ACKNOWLEDGMENTS
- 21.1: INTRODUCTION
- 21.2: INFLAMMATION IN TISSUE REPAIR
- 21.3: miRNA AND THE CONTROL OF INFLAMMATION
- 21.4: MicroRNA CONTROL OF INFLAMMATORY MEDIATORS
- 21.5: CONCLUSIONS AND FUTURE PERSPECTIVES
- 21.6: CHAPTER QUESTIONS
- REFERENCES
- Chapter 22: MicroRNA Regulation of mTOR Function
- Abstract
- 22.1: INTRODUCTION
- 22.2: THE mTOR PROTEIN
- 22.3: mTOR IN CANCER
- 22.4: mTOR IN THE NERVOUS SYSTEM
- 22.5: MECHANISMS OF mTOR REGULATION
- 22.6: miRNA REGULATION OF mTOR FUNCTION
- 22.7: miRNAs AS A TOOL TO PROMOTE mTOR-MEDIATED NS REGENERATION
- 22.8: CONCLUSIONS AND FUTURE PERSPECTIVES
- 22.9: CHAPTER QUESTIONS
- REFERENCES
- ONLINE RESOURCES
- FURTHER READING
- Part 4: Regeneration
- Chapter 23: OxymiRs in Regenerative Medicine
- Abstract
- 23.1: INTRODUCTION
- 23.2: OxymiRs IN DEVELOPMENTAL BIOLOGY
- 23.3: OxymiRs IN WOUND HEALING
- 23.4: OxymiRs IN STEM CELL REGENERATION
- 23.5: OxymiRs IN TISSUE ENGINEERING AND REGENERATIVE MEDICINE
- 23.6: CONCLUSIONS AND FUTURE PERSPECTIVES
- 23.7: CHAPTER QUESTIONS
- REFERENCES
- Chapter 24: miRNAs in Transitions: EMT, MET, and EndoMT
- Abstract
- 24.1: INTRODUCTION
- 24.2: Molecular Mechanisms Regulating EMT, MET, and EndoMT
- 24.3: MET IN SOMATIC REPROGRAMMING
- 24.4: CONCLUSIONS AND FUTURE PERSPECTIVES
- 24.5: CHAPTER QUESTIONS
- REFERENCES
- FURTHER READING
- Chapter 25: miRNA in Cardiac Regeneration
- Abstract
- 25.1: INTRODUCTION
- 25.2: MicroRNAs
- 25.3: CHALLENGES AND FUTURE DIRECTIONS
- 25.4: CONCLUSION
- 25.5: ESSAY-TYPE QUESTIONS
- 25.6: SHORT ANSWER QUESTIONS
- 25.7: ANSWERS
- REFERENCES
- Chapter 26: MicroRNAs in Liver Regeneration
- Abstract
- 26.1: INTRODUCTION
- 26.2: DIFFERENTIAL REGULATION OF MicroRNAs DURING LIVER REGENERATION
- 26.3: miRNA DELIVERY
- 26.4: miRNAs IN THE TREATMENT OF LIVER DISEASES
- 26.5: DIFFICULTIES IN STUDYING miRNAs IN LIVER REGENERATION
- 26.6: CONCLUSIONS AND FUTURE PERSPECTIVES
- 26.7: CHAPTER QUESTIONS
- REFERENCES
- ONLINE RESOURCES
- Chapter 27: Regulation of Bone Homeostasis and Regeneration by MicroRNAs
- Abstract
- ACKNOWLEDGMENT
- COMPETING INTERESTS
- 27.1: INTRODUCTION
- 27.2: BIOGENESIS AND FUNCTION OF MicroRNAs
- 27.3: ADVANCES IN THE STRATEGIES FOR miRNA TARGET IDENTIFICATION
- 27.4: OSTEOCLASTS
- 27.5: OSTEOBLASTS
- 27.6: OSTEOCYTES
- 27.7: MicroRNAs AND OSTEOCLASTS (Figure 27.2, Table 27.2)
- 27.8: MicroRNAs AND OSTEOBLASTS/OSTEOCYTES (Figure 27.3, Tables 27.3 and 27.4)
- 27.9: miRNAs AND BONE REMODELING (Figure 27.4)
- 27.10: OPPORTUNITIES AND CHALLENGES OF miRNA-BASED THERAPEUTICS
- REFERENCES
- Chapter 28: MitomiRs in Regenerative Medicine
- Abstract
- 28.1: MITOCHONDRIA OVERVIEW
- 28.2: MITOCHONDRIAL SMALL NONCODING RNA
- 28.3: LESSONS LEARNT FROM STEM CELLS AND AGING
- 28.4: MitomiRs AND CELLULAR DIFFERENTIATION
- 28.5: MITOCHONDRIAL NANOTUBES AND EXOSOMES
- 28.6: CONCLUSION
- References
- Part 5: Methodology
- Chapter 29: MicroRNA Bioinformatics
- Abstract
- 29.1: INTRODUCTION
- 29.2: MicroRNAs IN REGENERATIVE MEDICINE
- 29.3: BIOINFORMATIC TOOLS RELATED TO miRNA BIOGENESIS AND FUNCTIONS
- 29.4: CONCLUSION
- CONFLICTS OF INTEREST
- FUNDING STATEMENT
- AUTHORS’ CONTRIBUTIONS
- REFERENCES
- Part 6: Intervention
- Chapter 30: MicroRNAs and Exosomes in Cancer Diagnosis and Therapy
- Abstract
- 30.1: INTRODUCTION
- 30.2: miRNA BIOGENESIS
- 30.3: EXOSOME BIOGENESIS
- 30.4: EXOSOMES IN miRNA BIOGENESIS
- 30.5: THE LINK BETWEEN EXOSOMES AND miRNA EXPRESSION PATTERNS
- 30.6: THE LINK BETWEEN EXOSOMES AND miRNA BIOLOGICAL FUNCTION AND ITS APPLICATION TO CANCER
- 30.7: CONCLUSIONS AND FUTURE PERSPECTIVES
- 30.8: CHAPTER QUESTIONS
- REFERENCES
- ONLINE RESOURCES
- FURTHER READING
- Chapter 31: Drug–MicroRNA Cross-Talk
- Abstract
- ACKNOWLEDGMENTS
- 31.1: INTRODUCTION
- 31.2: miRNAs AND THEIR IMPACT ON DRUG METABOLISM
- 31.3: miRNAs AS DRUGS
- 31.4: CONCLUSIONS AND FUTURE PERSPECTIVES
- 31.5: CHAPTER QUESTIONS
- REFERENCES
- ONLINE RESOURCE
- Chapter 32: Delivery and Biological Activity of Therapeutic miRNAs and miRNA Modifiers
- Abstract
- ACKNOWLEDGMENTS
- 32.1: INTRODUCTION
- 32.2: ALTERING miRNA FUNCTIONS AS A NOVEL THERAPEUTIC APPROACH
- 32.3: BIOMOLECULES FOR miRNA THERAPEUTICS
- 32.4: PHYSICAL APPROACHES FOR miRNA DELIVERY
- 32.5: VECTOR-BASED miRNA DELIVERY AND EXPRESSION
- 32.6: NONVIRAL DELIVERY
- 32.7: CHEMICAL MODIFICATIONS OF ANTI-miRNAs OR miRNA-MIMICKING MOLECULES
- 32.8: SELECTED EXAMPLES OF miRNA REPLACEMENT THERAPEUTICS
- 32.9: SELECTED EXAMPLES OF miRNA-TARGETING THERAPEUTICS
- 32.10: A NOVEL FRONTIER: miRNA REPLACEMENT AND miRNA TARGETING FOR iPSC PRODUCTION
- 32.11: CONCLUSIONS AND FUTURE PERSPECTIVES
- 32.12: CHAPTER QUESTIONS
- REFERENCES
- ONLINE RESOURCES
- FURTHER READING
- Chapter 33: Circulating MicroRNAs as Biomarkers and Diagnosis Tool for Diseases
- Abstract
- ACKNOWLEDGMENT
- 33.1: INTRODUCTION
- 33.2: EVALUATING CIRCULATING miRNA EXPRESSION
- 33.3: CIRCULATING miRNAs IN LUNG DISEASE
- 33.4: CIRCULATING miRNAs in CARDIOVASCULAR DISEASES
- 33.5: EXTRACELLULAR miRNAs IN SEPSIS THE ICU AND VIRAL DISEASES
- 33.6: miRNAs IN CNS DEVELOPMENT AND STEM CELLS “NEUROGENESIS”
- 33.7: CIRCULATING miRNAs IN AGING
- 33.8: BEYOND BIOMARKERS
- 33.9: CLINICAL APPLICATIONS OF miRNAs
- 33.10: CONCLUSIONS AND FUTURE PERSPECTIVES
- 33.11: CHAPTER QUESTIONS
- REFERENCES
- ONLINE RESOURCES
- FURTHER READING
- Chapter 34: MicroRNAs in Gut Health: Modulation of Host-Microbial Interactions in the Gastrointestinal Tract
- Abstract
- 34.1: INTRODUCTION
- 34.2: GUT HEALTH
- 34.3: miRNAs AND THE GIT DEVELOPMENT DURING EARLY LIFE
- 34.4: miRNAs AND MUCOSAL IMMUNE SYSTEM DURING EARLY LIFE
- 34.5: REGULATORY ROLES OF miRNAs IN THE GIT
- 34.6: miRNAs AND GUT MICROBIOME
- 34.7: CONCLUDING REMARKS
- REFERENCES
- Part 7: Tissue Engineering
- Chapter 35: Nuclear Architecture and Transcriptional Regulation of MicroRNAs
- Abstract
- ACKNOWLEDGMENTS
- 35.1: INTRODUCTION
- 35.2: HIGHER-ORDER DNA STRUCTURE
- 35.3: NUCLEAR ORGANIZATION
- 35.4: GENE REGULATORY ELEMENTS
- 35.5: DNA-DEPENDENT RNA TRANSCRIPTION
- 35.6: NONCODING RNA
- 35.7: MicroRNAs
- 35.8: CONCLUSIONS AND FUTURE PERSPECTIVES
- 35.9: CHAPTER QUESTIONS
- REFERENCES
- FURTHER READING
- Chapter 36: MicroRNAs in Tissue Engineering and Regenerative Medicine
- Abstract
- 36.1: INTRODUCTION
- 36.2: miRNA BIOGENESIS AND FUNCTION
- 36.3: METHODS FOR IDENTIFYING miRNA–mRNA INTERACTIONS
- 36.4: miRNAs IN CELL AND TISSUE DEVELOPMENT
- 36.5: miRNAs IN REGENERATIVE MEDICINE AND TISSUE ENGINEERING
- 36.6: CONCLUSIONS AND FUTURE PERSPECTIVES
- 36.7: CHAPTER QUESTIONS
- REFERENCES
- Chapter 37: Tissue Nanotransfection in Regenerative Medicine
- Abstract
- 37.1: INTRODUCTION
- 37.2: GENE DELIVERY IN REGENERATIVE MEDICINE
- 37.3: TISSUE NANOTRANSFECTION
- 37.4: SIMULATION STUDY OF TNT PROCESS
- 37.5: FABRICATION OF TNT CHIPS
- 37.6: TISSUE NANOTRANSFECTION IN TISSUE REGENERATION AND REPROGRAMMING
- 37.7: CONCLUSION AND FUTURE PERSPECTIVES
- 37.8: CHAPTER QUESTIONS
- REFERENCES
- Index
- No. of pages: 1132
- Language: English
- Edition: 2
- Published: May 8, 2023
- Imprint: Academic Press
- Hardback ISBN: 9780128207192
- eBook ISBN: 9780128207222
CS
Chandan K. Sen
Dr. Chandan K Sen is a tenured Professor of Surgery, Executive Director of The Ohio State University Comprehensive Wound Center and Director of the Ohio State University's Center for Regenerative Medicine & Cell Based Therapies. He is also the Associate Dean for Research at The Ohio State University Wexner Medical Center. After completing his Masters of Science in Human Physiology from the University of Calcutta, Dr. Sen received his PhD in Physiology from the University of Kuopio in Finland. Dr. Sen trained as a postdoctoral fellow at the University of California at Berkeley's Molecular and Cell Biology department. His first faculty appointment was in the Lawrence Berkeley National Laboratory in California. In fall of 2000, Dr. Sen moved to The Ohio State University where established a program on tissue injury and repair. Currently, Dr. Sen is a Professor and Vice Chair of Research of Surgery. Dr. Sen serves on the editorial board of numerous scientific journals. He is the Editor in Chief of Antioxidants & Redox Signaling(www.liebertpub.com/ars) with a current impact factor of 8.456. He is the Section Editor of microRNA of Physiological Genomics, a journal of the American Physiological Society. Dr. Sen and his team have published over 250 scientific publications. He has a H-index of 64 and is currently cited 2000 times every year.
Affiliations and expertise
Professor of Surgery, Executive Director of The Ohio State University Comprehensive Wound Center, Columbus, Ohio, USARead MicroRNA in Regenerative Medicine on ScienceDirect