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Microfluidics for Pharmaceutical Applications

From Nano/Micro Systems Fabrication to Controlled Drug Delivery

  • 1st Edition - October 12, 2018
  • Latest edition
  • Editors: Hélder A. Santos, Dongfei Liu, Hongbo Zhang
  • Language: English

Microfluidics for Pharmaceutical Applications: From Nano/Micro Systems Fabrication to Controlled Drug Delivery is a concept-orientated reference that features case studies o… Read more

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Description

Microfluidics for Pharmaceutical Applications: From Nano/Micro Systems Fabrication to Controlled Drug Delivery is a concept-orientated reference that features case studies on utilizing microfluidics for drug delivery applications. It is a valuable learning reference on microfluidics for drug delivery applications and assists practitioners developing novel drug delivery platforms using microfluidics. It explores advances in microfluidics for drug delivery applications from different perspectives, covering device fabrication, fluid dynamics, cutting-edge microfluidic technology in the global drug delivery industry, lab-on-chip nano/micro fabrication and drug encapsulation, cell encapsulation and delivery, and cell- drug interaction screening.

These microfluidic platforms have revolutionized the drug delivery field, but also show great potential for industrial applications.

Key features

  • Presents detailed coverage on the fabrication of novel drug delivery systems with desired characteristics, such as uniform size, Janus particles, and particular or combined responsiveness
  • Includes a variety of case studies that explain principles
  • Focuses on commercialization, cost, safety, society and educational issues of microfluidic applications, showing how microfluidics is used in the real world

Readership

This book will be suitable for Masters and PhD students and for those in the industry.

In addition, the book should appeal to a segment of academic scientists at all levels, from graduate students to professors, who work in related fields.

Table of contents

ForewordHélder A. Santos

Section I: Principle of microfluidics 1. Lab-on-a-Chip technology and microfluidicsSenentxu Lanceros, Antonio Francesko & Vanessa F. Cardoso2. Fluid properties and hydrodynamics of microfluidic systemsYinghe He, David Wibowo & Chun-Xia Zhao3. Diffusion and mixing in microfluidic deviceJing Fan, Shuaijun Li, Ziqian Wu & Zi Chen4. Microfluidic production of multicomponent multiple emulsionsMasatoshi Maeki

Section II: Microfluidics for drug delivery applications 5. Microfabrication and Microfluidic Devices for Drug DeliveryManabu Tokeshi, Masatoshi Maeki a& Nicola Kimura6. Lab-on-a-chip preparation routes for organic nanomaterials for drug deliveryEnza Torino & Enza Torino7. Microfluidic mixing and devices for preparing nanoparticulate drug delivery systemsDongfei Liu, Yuezhou Zhang, Hongbo Zhang & Hélder A. Santos8. Microfluidic production of inorganic nanomaterials for biomedical applicationsManuel Arruebo & Victor Sebastian9. Lab-on-a-chip synthesis of microparticles for drug encapsulation and controlled releaseLiang-Yin Chu & Xiaojie Ju10. Microfluidic technologies for local drug deliveryShrike Zhang & Shabir Hassan11. Droplet-based microfluidics for cell encapsulation and deliveryDong Chen, Zeyong Sun & Ran Chen12. Antibody discovery using microfluidic systemsLinas Mazutis, Greta Stonyte & Karolis Simutis13. Single-cell screening using microfluidic systems Linas Mazutis, Juozas Nainys & Valdemaras Milkus

Section III: Microfluidics for analysis and drug delivery14. Lab-on-a-chip techniques for high throughput proteomics and drug discoveryNauman Khalid, Sania Arif, Isao Kobayashic & Mitsutoshi Nakajimac15. Microfluidics for chemical analysis and sample manipulation for pharmaceutical applicationsTina Marjukka Sikanen

Section IV: Future prospective and commercialization of microfluidic techniques16. Future of microfluidics in research and in the marketAdam Bohr, Stefano Colombo & Henrik Jensen

Product details

  • Edition: 1
  • Latest edition
  • Published: October 18, 2018
  • Language: English

About the editors

HS

Hélder A. Santos

Prof. Santos (D.Sc. Tech., Chem. Eng.) is a Full Professor in Department of Biomedical Engineering at the University of Groningen. He is also Research Director at the University of Helsinki, Faculty of Pharmacy. Prof. Santos is also the co-founder of the startups Capsamedix Oy and Medixmicro Oy, and Coordinator of MSCA-ITN P4 FIT network in tendon repair (~4.1 m€). He holds Visiting Professorships at the Shanghai Jiao Tong University School of Medicine and University of Tartu. Prof. Santos research interests include the development of nanoparticles/nanomedicines and biomaterials for biomedical applications, particularly cancer and heart diseases. His lab makes the unique bridge between medical engineering, pharmaceutical nanotechnology and tissue engineering by combining unique techniques to develop novel therapeutic formulations for translation into the clinic. He is also in Editorial board member of several international journals, and Associate Editor of Nano Select, Smart Materials in Medicine, and Drug Delivery and Translational Research, among others. Prof. Santos has received prestigious awards/grants, for example, the "Talent Prize in Science" in 2010 attributed by the Portuguese Government, ERC Starting Grant in 2013 and ERC Proof-of-Concept Grant in 2018, Young Researcher Award in 2013 attributed by Faculty of Pharmacy, the Academy of Finland Award for Social Impact in 2016, and the CRS Young Investigator Award 2021.
Affiliations and expertise
Drug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland; Helsinki Institute of Life Science (HiLIFE), University of Helsinki, Helsinki, Finland; Department of Biomedical Engineering, University Medical Center Groningen/University of Groningen, Groningen, The Netherlands

DL

Dongfei Liu

Dongfei Liu is a Postdoctoral Fellow and PI at the Division of Pharmaceutical Chemistry and Technology, University of Helsinki, Finland. He has developed a versatile and robust microfluidics platform to prepare extremely stable drug nanocrystals.
Affiliations and expertise
Division of Pharmaceutical Chemistry and Technology, University of Helsinki, Finland

HZ

Hongbo Zhang

Hongbo Zhang is an Assistant Professor at Åbo Akademi, Finland. His research focuses on nanostructured materials prepared by microfluidics for drug delivery applications.
Affiliations and expertise
Assistant Professor, Åbo Akademi, Finland

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