Microfluidic Biosensors

1st Edition - November 5, 2022
Imprint: Academic Press
Editors: Wing Cheung Mak, Aaron Ho Pui Ho
Language: English
Paperback ISBN:
9 7 8 - 0 - 1 2 - 8 2 3 8 4 6 - 2
eBook ISBN:
9 7 8 - 0 - 1 2 - 8 2 3 8 4 7 - 9

Microfluidic Biosensors provides a comprehensive overview covering the most recent emerging technologies on the design, fabrication, and integration of microfluidics with tran… Read more

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Microfluidic Biosensors provides a comprehensive overview covering the most recent emerging technologies on the design, fabrication, and integration of microfluidics with transducers. These form various integrated microfluidic biosensors with device configurations ranging from 2D to 4D levels. Coverage also includes advanced printed microfluidic biosensors, flexible microfluidics for wearable biosensors, autonomous lab-on-a-chip biosensors, CMOS-base microanalysis systems, and microfluidic devices for mobile phone biosensing. The editors and contributors of this book represent both academia and industry, come from a varied range of backgrounds, and offer a global perspective. This book discusses the design and principle of microfluidic systems and uses them for biosensing applications.

The microfluidic fabrication technologies covered in this book provide an up-to-date view, allowing the community to think of new ways to overcome challenges faced in this field. The focus is on existing and emerging technologies not currently being analyzed extensively elsewhere, providing a unique perspective and much-needed content. The editors have crafted this book to be accessible to all levels of academics from graduate students, researchers, and professors working in the fields of biosensors, microfluidics design, material science, analytical chemistry, biomedical devices, and biomedical engineering. It can also be useful for industry professionals working for microfluidic device manufacturers, or in the industry of biosensors and biomedical devices.

Cover image
Title page
Table of Contents
Copyright
List of contributors
Foreword
Chapter 1. Printed microfluidic biosensors and their biomedical applications
Abstract
1.1 Introduction
1.2 Technologies in fabrication and assembly of printed microfluidics
1.3 Integration of printed microfluidics into functional biosensors
1.4 Biomedical applications with printed microfluidic biosensors
1.5 Conclusions and outlooks
References
Chapter 2. Design and fabrication technologies for microfluidic sensors
Abstract
2.1 Introduction
2.2 Design and modeling of microfluidic platforms for sensing
2.3 Fabrication methods
2.4 Characterization and measurement techniques for microfluidic platforms
2.5 Point-of-care microfluidic sensors using hybrid fabrication techniques
2.6 Conclusions and outlooks
2.7 Future outlook
References
Chapter 3. Lab-in-a-fiber biosensors
Abstract
3.1 Introduction
3.2 Basics of lab-in-a-fiber devices
3.3 Lab-in-a-fiber sensors for bioapplications
3.4 Conclusions and outlooks
Funding information
References
Chapter 4. Flexible and mountable microfluidics for wearable biosensors
Abstract
4.1 Introduction
4.2 Flexible materials for microfluidics
4.3 Epidermal microfluidic patches
4.4 Flexible microfluidic contact lenses
4.5 Flexible microfluidic-based smart bandages
4.6 Flexible microfluidic-based wearable mechanical sensors
4.7 Summary and perspectives
References
Chapter 5. Advanced techniques for manufacturing paper-based microfluidic analytical devices
Abstract
5.1 Introduction
5.2 Methods for patterning paper
5.3 Application of microfluidics in diagnostics
5.4 Conclusion
Acknowledgments
References
Chapter 6. Digital microfluidic biosensors
Abstract
6.1 Introduction
6.2 Basics of digital microfluidic devices
6.3 Integrated digital microfluidic devices with sensing technologies
6.4 Conclusions and outlooks
References
Chapter 7. Emerging functional materials for microfluidic biosensors
Abstract
7.1 Introduction
7.2 Materials, properties, and functions for microfluidic biosensors
7.3 Emerging materials for improved signal transduction in microfluidic biosensor
7.4 Conclusions and outlooks
References
Chapter 8. Smartphone and microfluidic systems in medical and food analysis
Abstract
8.1 Introduction
8.2 Scientometric analysis
8.3 Smartphone-based sensing technologies in the medical field
8.4 Smartphone-based sensing technologies in the food analysis field
8.5 Validation requirements and benchmarking
8.6 Conclusion
Acknowledgment
References
Chapter 9. CMOS-based microanalysis systems
Abstract
9.1 Introduction
9.2 Fabrication techniques for microfluidic biosensors
9.3 Detection methods for different analytes
9.4 Biosensor CMOS instrumentation
9.5 Application areas
References
Chapter 10. Microfluidic-based plasmonic biosensors
Abstract
10.1 Introduction
10.2 Plasmonic biosensors
10.3 Patterned metallic structure array for enhanced plasmonic biosensors
10.4 The applications of microfluidic-based plasmonic biosensors
10.5 Conclusion and outlook
References
Chapter 11. Fiber-optic devices for sensing, manipulating, and imaging cells in vitro and in vivo
Abstract
11.1 Introduction
11.2 Basic principles
11.3 Bulk-cell analysis
11.4 Single-cell analysis
11.5 Intravital-cell analysis
11.6 Conclusion
Reference
Index

Wing Cheung Mak

Wing Cheung Mak received his BSc in chemistry and PhD in bioengineering from the Hong Kong University of Science and Technology and became a docent at the Linköping University, Sweden. He has over 20 years of international research experience in Sweden, Singapore, Germany, and Hong Kong focusing on biosensors and materials science. He has expertise in the field of biosensors and bioelectronics, wearable biosensors, lateral-flow membrane-based biosensors, and analytical chemistry and a strong interest in advanced transducer materials and microfluidic design and fabrication strategies to improve biosensor performance. Currently, he is an associate professor in the Department of Biomedical Engineering, The Chinese University of Hong Kong. He has authored over 80 scientific research articles covering the fields of biosensors, bioelectronics, analytical chemistry, materials science, and biomedical engineering. He is actively interested in transferring academic research to industrial applications. He has considerable experience in industrial R&D as a technical manager and entrepreneur of spin-off companies. He is the inventor of several patent families in the field of biosensors and healthcare diagnostics.

Affiliations and expertise

Department of Biomedical Engineering, The Chinese University of Hong Kong, Hong Kong SAR

Aaron Ho Pui Ho

Professor Ho received his BEng and PhD in Electrical and Electronic Engineering from the University of Nottingham. Currently a professor in the Department of Biomedical Engineering, The Chinese University of Hong Kong, he has over 30 years of research experience in academia and industry. Started as a compound semiconductor material scientist, his current interests focus at nano-sized semiconductor materials for photonic and sensor applications, optical instrumentation, surface plasmon resonance biosensors, lab-on-a-chip and biophotonics. As keen supporter of university-industry collaboration, he has founded of a spin-off company to commercialize phase-sensitive surface plasmon resonance biosensors and lab-on-a-disc. He has published over 400 peer-reviewed articles, 33 Chinese and 6 US patents in the field of sensor instrumentation. He is a Fellow of SPIE and HKIE.

Affiliations and expertise

Professor, Department of Biomedical Engineering, Chinese University of Hong Kong, China, People's Republic

Life Sciences

Physical Sciences & Engineering

Social Sciences & Humanities

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