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Elsevier

Microbiome and Tumorigenesis

Dysbiosis in Different Cancers

  • 1st Edition, Volume 1 - January 29, 2027
  • Latest edition
  • Editors: Sanjana Mehrotra, Vijay Kumar Prajapati
  • Language: English

Microbiome and Tumorigenesis: Dysbiosis in Different Cancers examines the intricate relationship between the human microbiome and cancer. Organized into three parts, the book o… Read more

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Description

Microbiome and Tumorigenesis: Dysbiosis in Different Cancers examines the intricate relationship between the human microbiome and cancer. Organized into three parts, the book opens with the conceptual and ecological foundations of the human microbiome and dysbiosis, tracing how microbial imbalance contributes to tumor development. The second part examines how microbiome dysbiosis drives carcinogenesis, covering its effects on tumor immunity, the dual role of microbial metabolites as both oncogenic drivers and protective effectors, and the contribution of fungal and viral dysbiosis to cancer development and treatment. The third part surveys dysbiosis across organ-specific cancers, including gastrointestinal, skin, oral, lung, head and neck, liver, and gynecologic malignancies. This book is a valuable resource for researchers, clinicians, and students seeking to understand the complex interplay between the microbiome and cancer, with insights into potential therapeutic strategies and future research directions.

Key features

  • Covers the conceptual and ecological foundations of the human microbiome and the mechanisms underlying dysbiosis
  • Explains how microbiome dysbiosis contributes to carcinogenesis through effects on tumor immunity and microbial metabolites
  • Highlights the emerging role of fungal and viral dysbiosis in cancer development and treatment
  • Surveys dysbiosis across major organ-specific cancers, including gastrointestinal, skin, oral, lung, head and neck, liver, and gynecologic malignancies

Readership

Researchers and Academic involved in microbiome research, cancer biology, immunology, molecular biology, and related fields

Table of contents

Part I: About Microbiome and Dysbiosis


1. The Human Microbiome: Conceptual Foundations, Ecological Organization, and Determinants


2. Revisiting Dysbiosis: Concepts, Ecological Principles and Clinical Consequences


3. From Dysbiosis to Tumorigenesis: The Expanding Role of the Microbiome in Cancer Biology

Part II: Microbiome Dysbiosis and Carcinogenesis


4. Microbiome and Innate Immune Responses: Effect on Tumor Immunity


5. Dual Roles of Microbial Metabolites in Cancer: From Oncogenic Drivers to Protective Effectors


6. Role of Fungal and Viral Microbiome Dysbiosis in Human Cancer Development and Treatment

Part III: Dysbiosis in Organ Specific Cancers


7. Microbial Signatures of Gastrointestinal Cancers


8. Skin Microbiota, Skin Health, and the Development of Skin Cancers


9. Microbial Influences on Carcinogenesis: The Role of Oral Microbiota


10. Lung Microbiome and Lung Carcinogenesis


11. Microbiome in Head and Neck Cancer: Current and Future Perspectives


12. The Liver Microbiome in Hepatocarcinogenesis


13. Microbial Dysbiosis and Gynecologic Malignancies: Focus on the Vaginal Niche

Product details

  • Edition: 1
  • Latest edition
  • Volume: 1
  • Published: January 29, 2027
  • Language: English

About the editors

SM

Sanjana Mehrotra

Dr. Mehrotra has a decade of research experience in the field of genetics of complex disorders like glaucoma, cancer and infectious diseases. Dr. Mehrotra is presently investigating the microbiome dysbiosis in PKDL and oral cancer. She has performed genetic association studies to explore the role of autophagy genes in modifying genetic susceptibility to oral cancer. She uses bioinformatic tools for performing pathway analysis and finding hub genes in different solid tumors that have the potential to be developed as diagnostic and prognostic biomarkers. She has published 24 research articles in peer reviewed international journals and 4 book chapters with reputed publishers. She has published her research work in the prestigious international journals such as the Nature Genetics, Journal of Cellular Physiology, Frontiers in Cellular Infection and Microbiology etc.

Affiliations and expertise
Assistant Professor, Department of Human Genetics, Amritsar, Punjab, India

VP

Vijay Kumar Prajapati

Dr. Vijay Kumar Prajapati is an Associate Professor in the Department of Biochemistry at the University of Delhi South Campus, New Delhi, India. He specializes in cell-death research, parasitology, and therapeutic developments for infectious diseases. He has published extensively in international journals and contributed chapters to reputable publishers. He is a recipient of the INSA Medal for Young Scientist from the Indian National Science Academy and an Associate of the Indian Academy of Sciences, Bengaluru. His work has appeared in leading journals spanning infectious diseases and cellular physiology, reflecting a high scholarly impact and a broad research portfolio.

Affiliations and expertise
Associate Professor, Department of Biochemistry, University of Delhi South Campus, India