Microbial Biofilms and Cancer - Part A
- 1st Edition, Volume 224 - October 1, 2026
- Latest edition
- Editors: Dibyajit Lahiri, Moupriya Nag, Debasmita Bhattacharya, Gargi Bhattacharya
- Language: English
This book provides a comprehensive and multidisciplinary exploration of the emerging biological connection between microbial biofilms, chronic infection, genetic instability, and… Read more
Description
Description
The opening chapters establish the molecular and genetic foundations of biofilm-associated carcinogenesis. The role of horizontal gene transfer within biofilms and its potential oncogenic consequences is examined alongside genetic profiling of biofilm-associated cancers. Particular emphasis is placed on the signaling pathways that may be hijacked by biofilms and the epigenetic mechanisms governing biofilm biology and host–microbe interactions. The book further explores how biofilms can modulate antitumor immunity and contribute to cancer progression, while genetic instability and biofilm-driven mutations are considered as potential mechanisms linking persistent microbial colonization with malignant transformation.
A further dimension of the book focuses on the therapeutic and translational potential of biofilm biology. Bacterial metabolites are examined as emerging sources of anticancer molecules and as potential tools for developing innovative cancer chemotherapeutics. At the same time, the book critically addresses the dual nature of biofilms, considering their potential applications alongside associated biological risks, environmental consequences, biosafety concerns, and legal challenges.
The latter part of the book introduces an emerging AI- and nanotechnology-enabled paradigm for infection–cancer surveillance and diagnostics. Advanced nanostructured biosensors, AI-assisted multiplexed platforms, metaheuristic optimization, and integrated surveillance technologies are presented as approaches for simultaneous detection and monitoring of infectious and cancer-associated biomarkers. The application of AI to wastewater surveillance further expands the discussion toward a One Health framework, connecting environmental pathogen monitoring with potential cancer-risk assessment.
The final contribution integrates genomics, metagenomics, and artificial intelligence to investigate infection-associated genomic signatures in Bacteroides fragilis, demonstrating how multi-omics and computational approaches can facilitate biomarker discovery and improve understanding of infection–cancer relationships.
Collectively, the book brings together microbiology, molecular oncology, genomics, epigenetics, immunology, metabolomics, nanotechnology, biosensing, artificial intelligence, environmental surveillance, and One Health. It provides an integrated perspective on the emerging biofilm–infection–cancer axis, highlighting both fundamental mechanisms and opportunities for diagnosis, prevention and therapeutic intervention.
The book is intended for researchers, academicians, clinicians, biotechnologists, microbiologists, cancer biologists, bioinformaticians, nanotechnologists, environmental scientists, and advanced postgraduate students interested in the rapidly evolving interface between microbial biology and cancer.
Key features
Key features
- Integrative Biofilm–Infection–Cancer Perspective: Provides a multidisciplinary examination of how biofilms influence carcinogenesis through horizontal gene transfer, oncogenic signaling, epigenetic reprogramming, immune modulation, genetic instability, and microbial metabolites, establishing a comprehensive framework for understanding the biofilm–cancer axis.
- Convergence of Biotechnology, Nanotechnology and AI: Highlights emerging AI-driven nanobiosensors, multiplexed diagnostics, metaheuristic optimization, multi-omics, and intelligent surveillance platforms for early detection and monitoring of infection-associated cancer risks.
- From Molecular Mechanisms to One Health Translation: Bridges fundamental molecular biology with therapeutic opportunities, environmental consequences, biosafety and legal considerations, while incorporating wastewater surveillance and AI-enabled pathogen/cancer-risk assessment within an integrated One Health framework.
Readership
Readership
Table of contents
Table of contents
Karthiyaini Damodharan
2. Oxidative Stress and Its Contribution to Cancer Mutagenesis
Vikas Kumar
3. Biofilms and Beyond: The Impact of Porphyromonas gingivalis on Oral Squamous Cell Carcinoma
A K M Shafiul Kadir
4. Unique Therapeutic Potential of Bacterial Metabolites for Cancer Chemotherapy
Anusuya Debnath
5. Mechanism of biofilm formation and host interaction.e
Parul Thapar
6. Chapter 15: Genetic Profiling of Biofilm-Associated Cancers: Towards Personalised Medicine
Dipro Mukherjee
7. therapeutic strategies, disrupting biofilm host genetic cosstralk
Goyal Surbhi
8. Microbial Allies in Malignancy: The Role of Porphyromonas gingivalis and Candida Biofilms in Oral Squamous Cell Carcinoma
A K M Shafiul Kadir
9. Biofilm-Induced Hypoxia and Its Role in Tumor Progression
Jefry Winner G and Soumiya Nadar
10. Cytokine and Chemokine Dysregulation by Biofilm components
Arindam Ganguly, Debasis Mitra, Gustavo Santoyo, Suman Suman, Riyan Kaibarta, Soumyadip Pal, Sourav Chattaraj and Mousumi Ganguly
11. Biofilms in Specific Cancers: Helicobacter pylori, Fusobacterium nucleatum, Porphyromonas gingivalis, Escherichia coli, and Candida
Sougata Rajak, Panteha Torabian, Naiera M. Helmy Mohamed, Neethu Asokan, Reham Hamed Abdelaziz and Saanya Chaturvedi
12. The Dual Nature of Biofilms Used in Cancer: Emerging Threats Amidst Benefits, Environmental Consequences, and Legal Challenges
Debina Mitra and Upasana Singh
13. 06. Microbial Toxins and Their Role in Oncogenesis
Mukta Sharma
14. horizontal gene transfer in biofilms and its oncogenic potential
Muhammad Kamran, Rashna Jahangir, Hannana Maryam, Samra Maqsood, Mahnoor Fatima, Abid Ali, Muhammad Bilal Habib and Naseer Ali Shah
15. Role of Biofilm In Cancer Invasion
Sahana Ghosh
16. biofilm driven chronic inflammation and tumorigenesis.
Kartik Kailaskumar Adake, Shreyas Joshi and Shreya Pande
17. Genetic profiling of Biofilm associated cancers
Sampanna Roy, Sourav Ghosh, Surajit Hansda, Sayantani Karmakar, Gargi Ghosh and Semanti Ghosh
18. Key Signaling Pathways Hijacked by Biofilms
Sujay Ghosh and Anwesha Acharyya
19. Epigenetic Processes Involved in the Biology of Biofilms
Richard A. Stein
20. biofilm mediated immune modulation in cancer progression
Rupsa Bhattacharya
21. Introduction: biofilms in cancer- an underestimated threat
Avijit Chakraborty and Rupsa Bhattacharya
22. genetic instability and mutations driven by biofilms
Rupsa Bhattacharya
Product details
Product details
- Edition: 1
- Latest edition
- Volume: 224
- Published: October 1, 2026
- Language: English
About the editors
About the editors
DL
Dibyajit Lahiri
Dr. Dibyajit Lahiri is an Associate Professor in the Department of Biotechnology at the University of Engineering & Management, Kolkata, India, where he conducts advanced interdisciplinary research in microbiology, biofilms, antimicrobial resistance, and microbial biotechnology. His scholarly work emphasizes understanding the mechanisms of microbial biofilm formation and inhibition, particularly on medically relevant surfaces and environmental substrates, and exploring innovative strategies for combating biofilm-associated antimicrobial resistance.
Dr. Lahiri has authored and co-authored a substantial body of scholarly work, with over 100 publications including high-impact journal articles, book chapters, and reviews. His research portfolio covers topics such as biofilm-mediated degradation of environmental pollutants, novel antibiofilm agents (including nanoscale and natural compounds), and biotechnological applications of microbial systems, with an h-index around 38 reflecting significant citation impact and academic influence.
He has contributed to major scientific discussions on microbial biofilms in diverse contexts, including their roles in chronic infections, environmental microplastic degradation, and biofuel production, demonstrating both fundamental and applied research orientations. His collaborative research outputs also include contributions to antimicrobial peptide studies and microbial electrochemical systems.
Dr. Lahiri serves as editor and contributor to scholarly publications in his field, and he participates actively in international research networks and editorial activities. His work is regularly presented at scientific forums and continually contributes to advancing microbial biotechnology and strategies to mitigate biofilm-associated challenges in health, industry, and the environment.MN
Moupriya Nag
Moupriya Nag is presently working as Associate Professor in the Department of Biotechnology, University of Engineering & Management, Kolkata. Her research interests includes single molecule Biophysics of protein unfolding/refolding and protein aggregation kinetics and its mechanism of action especially the amyloid proteins in neurodegenerative disorders. Recently, her research focuses on functional amyloids in bacteria and their relation in forming biofilms. Her work deals with developing novel antimicrobial and anti-biofilm compounds from natural sources including plants, microbes and green synthesized nanoparticles. She has about seven years of teaching experience in Biophysics, Bioinformatics, Bioprocess and Biotechnology, Enzyme Technology, Computing, Molecular Modelling and Drug Design. She has also published many research articles in the peer-reviewed international journals and authored/edited or co-authored/edited numerous books/book chapters. She is also a member of many scientific societies like Indian Biophysical Society and Indian Science Congress Association.
DB
Debasmita Bhattacharya
Dr. Debasmita Bhattacharya obtained her Masters and Doctoral degree in Cellular, Molecular and Integrative Physiology, Faculty of Health from York University. She did her Post-Doctoral fellowship in Dr. David Hood’s lab at York University. At present, her research focusses on the functional outcome of mitochondrial transplantation in stem and progenitor cells. She is also investigating the implications of lysosomal malfunction in cellular model and finding strategies to mitigate it in order to improve health. She has proven expertise in stem cell biology, cellular physiology, cancer biology, mitochondrial biology and exercise physiology. One of her studies entitled “p107 mediated mitochondrial function controls muscle stem cell proliferative fates” has been published in Nature Communications and has been appreciated by eminent scholars in the field. Bhattacharya has disseminated her research through peer reviewed journal articles, as well as poster and oral presentations at top tier academic conferences. She worked as Professor at Humber College, Canada in Biotechnology and Biomedical Sciences Department. Currently she is the Professor in the Department of Basic Science and Humanities, Institute of Engineering and Management, University of Engineering and Management, Kolkata
GB
Gargi Bhattacharya
Dr. Gargi Bhattacharya is a Microbiologist with over nine years of post-MD professional experience in clinical microbiology, serology, molecular biology, and infection control. She completed her MBBS from North Bengal Medical College and MD in Microbiology from the Calcutta School of Tropical Medicine, where she was a Gold Medalist, followed by DNB in Microbiology. She is currently associated with Ruby General Hospital and has previously worked with Ashok Laboratory and Nursing Home and Medinova Diagnostic Services. Her expertise includes NABL-accredited laboratory quality systems and infection control, with specialized training from JIPMER, Puducherry. Her research interests include antimicrobial resistance, bacterial persistence, biofilm-associated infections, and antimicrobial stewardship. She has published research and case reports on multidrug resistance, Staphylococcus aureus, Staphylococcus cohnii, anthrax, and urinary tract infections. She is a member of IAMM and the Antimicrobial Stewardship Society, India.