Micro- and Nanotechnology Enabled Applications for Portable Miniaturized Analytical Systems

1st Edition - October 12, 2021
Editors: Sabu Thomas, Mazaher Ahmadi, Abbas Afkhami, Tayyebeh Madrakian, Tuan Anh Nguyen
Language: English
Paperback ISBN:
9 7 8 - 0 - 1 2 - 8 2 3 7 2 7 - 4
eBook ISBN:
9 7 8 - 0 - 1 2 - 8 2 3 7 2 8 - 1

Micro- and Nanotechnology Enabled Applications for Portable Miniaturized Analytical Systems outlines the basic principles of miniaturized analytical devices, such as spectrome… Read more

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Micro- and Nanotechnology Enabled Applications for Portable Miniaturized Analytical Systems outlines the basic principles of miniaturized analytical devices, such as spectrometric, separation, imaging and electrochemical miniaturized instruments. Concepts such as smartphone-enabled miniaturized detection systems and micro/nanomachines are also reviewed. Subsequent chapters explore the emerging application of these mobile devices for miniaturized analysis in various fields, including medicine and biomedicine, environmental chemistry, food chemistry, and forensic chemistry. This is an important reference source for materials scientists and engineers wanting to understand how miniaturization techniques are being used to create a range of efficient, sustainable electronic and optical devices.

Miniaturization describes the concept of manufacturing increasingly smaller mechanical, optical, and electronic products and devices. These smaller instruments can be used to produce micro- and nanoscale components required for analytical procedures. A variety of micro/nanoscale materials have been synthesized and used in analytical procedures, such as sensing materials, sorbents, adsorbents, catalysts, and reactors. The miniaturization of analytical instruments can be applied to the different steps of analytical procedures, such as sample preparation, analytical separation, and detection, reducing the total cost of manufacturing the instruments and the needed reagents and organic solvents.

Cover Image
Title Page
Copyright
Table of Contents
Contributors
Section 1 Fundamentals
Chapter 1 Miniaturization—An introduction to miniaturized analytical devices
Abstract
1.1 Introduction
1.2 Miniaturization in analytical chemistry
1.3 Conclusions
References
Chapter 2 Spectrometric miniaturized instruments
Abstract
2.1 Introduction
2.2 Portable spectrometric miniaturized instrument (PSMI)
2.3 Smartphone-enabled spectrometric miniaturized instruments
2.4 Conclusions
References
Chapter 3 Separation miniaturized instruments
Abstract
3.1 Introduction
3.2 Gas chromatography
3.3 High pressure/performance liquid chromatography
3.4 Capillary electrophoresis
3.5 Ion chromatography
3.6 Hyphenated separation instruments
3.7 Conclusions
References
Chapter 4 Fabrication methods of miniaturized analysis
Abstract
4.1 Introduction
4.2 Types of miniaturized analysis system
4.3 Fabrication methods of paper-based miniaturized analysis system
4.4 Fabrication of polymer-based miniaturized analysis system
4.5 Fabrication methods of glass-based miniaturized analysis system
4.6 Fabrication methods of silicon-based miniaturized analysis system
4.7 Challenges and strategies to improve sensitivity, accuracy, multiplexed detection, and calibration free allowing for mobile and portable miniaturized applications from the perspective of fabrication methods
4.8 Conclusion and future perspectives
Acknowledgment
References
Chapter 5 Miniaturized bioelectrochemical devices
Abstract
5.1 Introduction
5.2 Portable bioelectrochemical devices design
5.3 Lab-on-a-chip PBDs devices
5.4 Conclusions
References
Chapter 6 Electrochemical miniaturized devices
Abstract
6.1 Overview
6.2 Fundamentals of electrochemical (bio)sensors
6.3 Instrumentation electronics
References
Chapter 7 Separation technologies in microfluidics
Abstract
7.1 Introduction
7.2 Chemical separations
7.3 Particle separations
7.4 Discussion and conclusion
References
Chapter 8 Portable microplanar extraction, separation, and quantification devices for bioanalytical and environmental engineering applications
Abstract
8.1 Occurrence and quantification of priority substances in water ecosystems—the problem overview based on the European Union Water Framework Directive
8.2 Advances in development of portable microdevices for detection of various pollutants in water, sewage, and complex biological samples
8.3 Development of portable extraction devices, planar electrophoresis, and microplanar thin-layer chromatography for isolation, separation, and detection of target analytes in complex mixtures involving graphene oxide nanoparticles and/or various natural biopolymers
Authors contributions and additional statements
References
Chapter 9 Approaches to microholes for fabrication of microdevices
Abstract
9.1 Introduction
9.2 Methods for tool wear improvement
9.3 Patterning
9.4 Embedding
9.5 In situ CNT growth
9.6 Microhole applications
9.7 Conclusions
References
Chapter 10 Photonic crystal-based optical devices for photonic intergraded circuits
Abstract
10.1 Introduction
10.2 History of photonic crystals
10.3 Types of photonic crystals
10.4 Numerical methods
10.5 Functional parameters
10.6 Photonic crystal-based demultiplexer
10.7 Applications of 2DPCs
10.8 Conclusion
References
Section 2 Applications of mobile devices in miniaturized analysis
Chapter 11 Lab-on-a-chip miniaturized analytical devices
Abstract
11.1 Introduction
11.2 Lab-on-a-chip devices for clinical diagnostics
11.3 Lab-on-a-chip devices for integrated bioanalysis
11.4 Lab-on-a-chip devices for environmental monitoring
11.5 Lab-on-a-chip devices for quality control
11.6 Point-of-care applications
11.7 Conclusions
References
Chapter 12 Smartphone-enabled miniaturized analytical devices
Abstract
12.1 Introduction
12.2 Colorimetric applications
12.3 Photoluminescent applications
12.4 Biochemiluminescent applications
12.5 Electrochemical applications
12.6 Point-of-care applications
12.7 Implantable sensors
12.8 Wearable sensors
12.9 Future perspectives
References
Chapter 13 Smartphone-based chemical sensors and biosensors for biomedical applications
Abstract
13.1 Introduction
13.2 Smartphone-based electrochemistry sensors
13.3 Smartphone-based spectroscopy sensors
13.4 Smartphone-based wearable sensors for biomedical applications
13.5 Conclusion and future prospect
Acknowledgment
References
Chapter 14 Biomedical applications of mobile devices in miniaturized analysis
Abstract
14.1 Introduction
14.1.1 Features of miniaturization
14.2 Miniaturized analytical systems for qualitative information
14.3 Smartphone-enabled miniaturized biosensing systems
14.4 Commercialized miniaturized biosensors
14.5 Conclusions and perspectives
References
Chapter 15 Lab-on-a-chip analytical devices
Abstract
15.1 Introduction
15.2 Materials used in LOC and fabrication methods
15.3 Applications
15.4 Conclusions and future directions
References
Chapter 16 “Lab-on-a-phone” project: Micro- and nanotechnology-enabled applications for portable miniaturized analytical systems
Abstract
16.1 Introduction
16.2 Smartphone-based biosensing
16.3 Commercial smartphone-based detection systems
16.4 Conclusions
Abbreviations
References
Chapter 17 Hardware–software interfacing in smartphone centered biosensing
Abstract
17.1 Introduction
17.2 Android application framework
17.3 Apple application framework
17.4 Summary
References
Index

Sabu Thomas

Sabu Thomas is a Senior Professor of Mahatma Gandhi University, Kottayam, Kerala, India, and also Chairman of the TrEST Research Park, Trivandrum, India. He is known for his outstanding contributions in polymer science and nanotechnology.

Affiliations and expertise

Professor and Director, International and Interuniversity Centre for Nanoscience and Nanotechnology, Mahatma Gandhi University, India

Mazaher Ahmadi

Dr. Mazaher Ahmadi received his Ph.D. in Analytical Chemistry from Bu-Ali Sina University in 2017. He has been to Alicante University, Spain, and Stockholm University, Sweden, as a visiting researcher in 2015-2016 and 2016-2017, respectively. He became an Assistant Professor of Analytical Chemistry at Bu-Ali Sina University in 2019. His professional experiences also include two post-doctorate research courses at Shiraz University of Medical Science, Iran, and Bu-Ali Sina University, Iran, in 2017-2018 and 2018-2019, respectively. Dr. Ahmadi is an expert in nanotechnology, analytical method development, pollutant removal, and wastewater treatment. He has edited six Elsevier books. He also has contributed eleven book chapters with Elsevier.

Affiliations and expertise

Assistant Professor, Bu-Ali Sina University, Hamedan, Islamic Republic of Iran

Abbas Afkhami

Prof. Abbas Afkhami is a Full Professor of Analytical Chemistry since 2001. He has published more than 310 scientific articles in reputed international journals and two edited Elsevier books in different fields. His research is mainly focused on the development of electrochemical sensors and biosensors. Afkhami has received several awards and honors including the international scientist by ISI (ESI) since 2011, the award of the organization of the Islamic countries (COMSTECH Award), 2009, distinguished professor of the I. R. Iran Universities, 2012, distinguished Analytical chemist of Iran, selected by the Iranian Chemical Society, 2010, and distinguished researcher of Bu-Ali Sina University, selected by the Iranian Ministry of Science, Research and Technology, 2004. He serves as the Editor-in-Chief in Analytical and Bioanalytical Chemistry Research, the editorial board of Green and Sustainable Chemistry, and the board of directors of the Iranian Chemical Society. He also acts as a reviewer in many journals.

Affiliations and expertise

Full Professor, Bu-Ali Sina University, Hamedan, Islamic Republic of Iran

Tayyebeh Madrakian

Prof. Tayyebeh Madrakian is a Full Professor of Analytical Chemistry since 2011. Her research interests comprise separation techniques, including the developing of new approaches and synthesis of novel nanomaterials. She has co-authored 190 scientific articles, 2 Elsevier books, and 10 book chapters. Madrakian was on the list of top 1% most outstanding scientists by Essential Science Indicators (ESI) in 2019. She has recently received several awards and honors including distinguished Analytical chemist of Iran, selected by the Iranian Chemical Society, and the national award of the second Woman and Science festival. Madrakian serves as the editorial board of Nanochemistry Research and board of directors of the Iranian Chemical Society. She also acts as a reviewer in many journals (e.g. Analytica Chimica Acta, Sensors and Actuators B, Talanta, J. Hazardous Materials, Microchemical Journal, Microchimica Acta, Materials Science and Engineering C, Applied Surface Science, Analytical Methods, RSC Advances, New Journal of Chemistry).

Affiliations and expertise

Full Professor, Bu-Ali Sina University, Hamedan, Islamic Republic of Iran

Tuan Anh Nguyen

Tuan Anh Nguyen is Senior Principal Research Scientist at the Institute for Tropical Technology, Vietnam Academy of Science and Technology, Vietnam. He received B.S. in Physics from Hanoi University in 1992, and Ph.D. in Chemistry from the Paris Diderot University (France) in 2003. He was Visiting Scientist at Seoul National University (South Korea, 2004) and University of Wollongong (Australia, 2005). He then worked as Postdoctoral Research Associate and Research Scientist in the Montana State University (USA), 2006-2009. In 2012, he was appointed as the Head of the Microanalysis Department at Institute for Tropical Technology. His research activities include smart sensors, smart networks, smart hospitals, smart cities and digital twins. He edited over 70 Elsevier, 12 CRC Press, 1 Springer, 1 RSC and 2 IGI Global books. He is Editor-In-Chief of "Kenkyu Journal of Nanotechnology & Nanoscience".

Affiliations and expertise

Senior Principal Research Scientist, Institute for Tropical Technology, Vietnam Academy of Science and Technology, Hanoi, Vietnam

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Micro- and Nanotechnology Enabled Applications for Portable Miniaturized Analytical Systems

Purchase options

Institutional subscription on ScienceDirect

Sabu Thomas

Mazaher Ahmadi

Abbas Afkhami

Tayyebeh Madrakian

Tuan Anh Nguyen