
Metalloenzymes
From Bench to Bedside
- 1st Edition - August 30, 2023
- Imprint: Academic Press
- Editors: Claudiu T. Supuran, William Alexander Donald
- Language: English
- Paperback ISBN:9 7 8 - 0 - 1 2 - 8 2 3 9 7 4 - 2
- eBook ISBN:9 7 8 - 0 - 1 2 - 8 2 4 2 3 5 - 3
Metalloenzymes: From Bench to Bedside offers a thorough overview of metalloenzymes, spanning biochemical and structural features, pharmacology, and biotechnological applicati… Read more

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Request a sales quoteMetalloenzymes: From Bench to Bedside offers a thorough overview of metalloenzymes, spanning biochemical and structural features, pharmacology, and biotechnological applications. After a brief overview, international experts in the field discuss a wide range of magnesium, calcium, zinc, manganese, nickel, iron, copper, cadmium, molybdenum, and tungsten enzymes, along with catalytic roles within their active sites. With a uniform approach throughout, each chapter includes the structure and function of the enzyme, physiologic and pathologic roles, inhibitors and activators of the enzyme (and their design), and clinical agents or compounds applied in medicine and drug discovery. This book enables scientists across academia and industry to adopt ongoing metalloenzyme research, and continuous discovery of novel metalloenzymes, in new life science studies and clinical applications.
- Examines a range of metalloenzymes, from biochemistry to pharmacology and drug design
- Each chapter examines enzyme structure and function, physiologic and pathologic roles, inhibitors and activators, and clinical application
- Features chapter contributions from international experts in the field
1. Introduction to metalloenzymes
Section II
2. Magnesium and calcium-containing enzymes
2.1. DNA and RNA polymerase
2.2. Reverse transcriptase
2.3. Integrase
2.4. Nucleases
2.5. Terminases
2.6. Cyclin-dependent kinase 2 (CDK2)
2.7. Ketol acid reductoisomerase (KARI)
2.8. Catechol-O-methyltransferase (COMT)
2.9. D-Ala-D-Ala ligase
2.10. Sarco/endoplasmic reticulum calcium ATPase
2.11. Paraoxonases
Section III
3. Zinc enzymes
3.1. Carbonic anhydrases
3.2. Metallo-beta-lactamases
3.3. Bacterial zinc proteases
(clostridium collagenases, anthrax LF, botulinum and tetanus toxins, elastase B.)
3.4. Matrix metalloproteases
3.5. A Disintegrin and Metalloenzymes (ADAMs) and tumor necrosis factor-alpha-converting enzyme (TACE)
3.6. Angiotensin converting enzyme
3.7. Histidinol dehydrogenases
3.8. Histone deacetylases and other epigenetic targets
3.9. Protein prenyl transferases
3.10. CD73
3.11. Adenosine deaminase
3.12. Glyoxalase II
3.13. Aminopeptidase N
3.14 Glutamate carboxypeptidase II
3.15. AMP deaminase (AMPD)
3.16. Phosphodiesterase IV
3.17. Neutral endopeptidase (neprilysin)
3.18. VanX
3.19. Lpx
3.20. 19S proteasome regulatory subunit Rpn11
3.21. Class II fructose-1,6-biphosphate aldolase
Section IV. Other metalloenzymes
4. Manganese enzymes
4.1. Bacterial iota-carbonic anhydrases
4.2. Human arginases
4.3. Parasite (protozoan) arginases, Igor Almeida
4.4. 1-Deoxyxylulose-5-phosphate reductase isomerase
4.5. Methionine aminopeptidase
4.6. Imidazole glycerol phosphate dehydratase
5. Nickel enzymes
5.1. Glyoxalase I,
5.2. Bacterial ureases,
5.3. Acetyl-coenzyme A synthase/decarbonylase
5.4. Methyl-coenzyme M reductase
5.5. Lactate racemase
6. Iron enzymes (heme-containing)
6.1. COX
6.2. Cytochrome P450 (inhibitors for the metabolism of drugs, e.g., colbicistat)
6.3. Lanosterol 14α-demethylase
7. Iron enzymes (non-heme containing, Fe(II) or Fe(III) proteins)
7.1. Mono – and dioxygenases (including 4-hydroxyphenylpyruvate dioxygenase)
7.2. Indoleamine 2,3-dioxygenase
7.3. Non-heme di-iron catalases
7.4. Lysyl hydroxylases
7.5. 5-Lypoxygenase
7.6. Peptide deformylase (previously considered zinc enzyme)
7.7. Jumonji domain lysine demethylase (JmJc KDM)
8. Copper enzymes
8.1. Superoxide dismutase
8.2. Formylglycine-generating enzyme (FGE)
8.3. Tyrosinase
9. Cadmium enzymes
9.1. Cadmium CAs, G De Simone
10. Molybdenum enzymes
10.1. Nitrate reductase (NR), sulfite oxidase (SO), xanthine oxidoreductase (XOR), and aldehyde oxidase (AO)
10.2. Molybdenum cofactor of mARC (mitochondrial Amidoxime Reducing Component)
11. Tungsten-containing enzymes
- Edition: 1
- Published: August 30, 2023
- No. of pages (Paperback): 634
- Imprint: Academic Press
- Language: English
- Paperback ISBN: 9780128239742
- eBook ISBN: 9780128242353
CS
Claudiu T. Supuran
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