Metal Nanoparticles for Drug Delivery and Diagnostic Applications
- 1st Edition - October 22, 2019
- Editors: Muhammad Raza Shah, Muhammad Imran, Shafi Ullah
- Language: English
- Paperback ISBN:9 7 8 - 0 - 1 2 - 8 1 6 9 6 0 - 5
- eBook ISBN:9 7 8 - 0 - 1 2 - 8 1 6 9 6 1 - 2
Metal Nanoparticles for Drug Delivery and Diagnostic Applications addresses the lifecycle of metal nanoparticles, from synthesis and characterization, to applications in drug deli… Read more
Metal Nanoparticles for Drug Delivery and Diagnostic Applications addresses the lifecycle of metal nanoparticles, from synthesis and characterization, to applications in drug delivery and targeting. It is an important resource for those in biomaterials, nanomedicine and pharmaceutical sciences, exploring gold, silver and iron-based drug delivery systems for controlled and targeted delivery of potential drugs and genes for enhanced clinical efficacy. Nanotechnology is widely used in drug delivery due to its ability to reduce plasma fluctuation of drugs, high solubility, and efficiency, the relatively low cost of nanoscale products, and enhancement of patient comfort, hence this resource is a welcome edition to the science.
- Illustrates the progression of nanoparticle therapeutics from basic research to applications
- Explores new opportunities and ideas for developing and improving technologies in nanomedicine and nanobiology
- Discusses the toxicity of different types of metal nanoparticles and how to ensure their safe use
materials scientists, biomedical scientists, pharmaceutical scientists
1. Metal nanoparticles toxicity: role of physicochemical aspects 1
1.1 Introduction 1
1.2 Mechanisms of metallic nanoparticles toxicity 2
1.3 Effect of physicochemical properties on toxicity of metallic nanoparticles 3
1.4 Conclusion 9
References 9
2. Erythrocytes modified (coated) gold nanoparticles for effective drug delivery 13
2.1 Introduction 13
2.2 Nanotechnology and their advancement 14
2.3 Nanosize passage from micro to nanoparticles 15
2.4 Why modern therapeutics diverging to nanoscales? 17
2.5 Nanomaterials and their exploded applications 17
2.6 Metallic nanoparticles 18
2.7 Cells based drug delivery system 18
2.8 Blood cells based derived drug delivery system 20
2.9 Gold nanoparticles 21
2.10 Erythrocytes modified (coated) gold nanoparticles cargo 23
2.11 Application of erythrocytes coated gold nanoparticles 26
2.12 Conclusion 26
References 27
3. Biosynthesized metal nanoparticles as potential Alzheimer’s disease therapeutics 31
3.1 Introduction 31
3.2 Mechanisms and popular hypothesis of Alzheimer’s disease 32
3.3 Neurodegenerative disorders and status of Alzheimer’s disease 33
3.4 Epidemiology/prevalence, continent-based statistics of Alzheimer’s disease 33
3.5 Present therapeutic issues, concerns, disadvantages of Alzheimer’s disease therapies 34
3.6 Nanomedicines for Alzheimer’s disease with specific reference to the metal nanoparticles 36
3.7 Biogenic nanoparticles as promising Alzheimer’s disease theranostic agents 37
3.8 Conclusion and future prospects 39
References 39
4. Gold nanoparticles in cancer diagnosis and therapy 43
4.1 Introduction 43
4.2 Gold nanoparticles 45
4.3 Gold nanoparticles in cancer therapy and diagnosis 46
4.4 Gold nanoparticles in clinical trials 52
4.5 Safety concerns of gold nanoparticles 52
4.6 Conclusion 53
References 53
5. Gold nanorods: new generation drug delivery platform 59
5.1 Introduction 59
5.2 Optical properties 61
5.3 Synthesis 62
5.4 Catalytic method 69
5.5 Self-assembly of gold nanorods 69
5.6 Gold nanorods applications in diagnostics 71
5.7 Gold nanorod applications in drug delivery 75
5.8 Conclusion 79
References 80
6. Surface engineered gold nanorods: intelligent delivery system for cancer therapy 85
6.1 Introduction 85
6.2 Nanotechnology 87
6.3 Conclusion 94
References 95
7. Role of gold- and silver-based nanoparticles in stem cells differentiation 99
7.1 Introduction 99
7.2 Effect on osteogenic differentiation 100
7.3 Effect on chondrogenic differentiation 103
7.4 Effect on adipogenic differentiation 104
7.5 Role of nanoparticles in neuronal differentiation 105
7.6 Role of nanoparticles in cardiac differentiation 105
7.7 Effect on stem cells growth and proliferation 106
7.8 Effect on reactive oxygen species 107
7.9 Nanoparticles in wound healing 108
7.10 Nanoparticles in cancer stem cells 109
7.11 Cytotoxicity of nanoparticles on stem cells 111
7.12 Conclusion 112
References 112
8. Nanosilver at the interface of biomedical applications, toxicology, and synthetic strategies 119
8.1 Ag nanomaterials 120
8.2 Synthetic strategies of silver nanomaterials 123
8.3 Characterization 125
8.4 Biomedical applications of silver nanomaterials 127
8.5 Toxicology of silver nanomaterials 129
8.6 Summary and future perspectives 134
References 134
9. Silver nanoparticles: a promising nanoplatform for targeted delivery of therapeutics and optimized therapeutic efficacy 141
9.1 Introduction 141
9.2 Biomedical applications of silver nanoparticles 143
9.3 Summary and future prospects 163
Acknowledgment 165
References 165
Further reading 173
10. Bactericidal potentials of silver nanoparticles: novel aspects against multidrug resistance bacteria 175
10.1 Introduction 175
10.2 Mechanisms for bacterial antibiotic resistance 176
10.3 Silver nanoparticles 177
10.4 Antibacterial spectrum of silver nanoparticles 178
10.5 Antibacterial spectrum of silver nanoparticles against multidrug resistance bacteria 179
10.6 Mechanisms of silver nanoparticles bactericidal activity 180
10.7 Conclusion 184
References 184
11. Magnetic nanoparticles: drug delivery and bioimaging applications 189
11.1 Introduction 189
11.2 Synthesis of magnetic nanoparticles 193
11.3 Drug delivery and bioimaging applications 197
11.4 Conclusion 207
References 208
12. Surface functionalized magnetic nanoparticles for targeted cancer therapy and diagnosis 215
12.1 Introduction 216
12.2 Considerations for magnetic nanoparticles design 217
12.3 Functionalization of target specific magnetic nanoparticles 220
12.4 Surface functionalization chemistry 225
12.5 Magnetic nanoparticles targeting strategies and diagnosis 228
12.6 Conclusion 231
References 232
Further reading 236
13. Clinical implications of metals-based drug-delivery systems 237
13.1 Nanotechnology: an introduction 237
13.2 Types of nanoparticles 238
13.3 Biomedical applications of metal nanoparticles 243
13.4 Drawbacks of nanoparticles in drug-delivery system 251
13.5 Conclusion 252
References 253
14. pH-sensitive drug delivery systems 259
14.1 Introduction 259
14.2 Classification of pH-sensitive drug delivery systems 261
14.3 Synthesis of pH-sensitive drug delivery systems 268
14.4 Structure and architecture of pH-sensitive drug delivery systems 269
14.5 Applications of pH-sensitive drug delivery systems at different levels 271
14.6 Conclusion 275
References 276
15. Ionic liquid
15.1 Introduction 280
15.2 Classes of ionic liquids 282
15.3 Nanoparticles 286
15.4 Classification of nanoparticles 286
15.5 Synthesis of nanoparticles 289
15.6 Conclusion 295
References 296
16. Biomedical applications of magnetic nanoparticles 301
16.1 Introduction 302
16.2 Synthesis of magnetic nanoparticles 303
16.3 Surface modification of magnetic nanoparticles 309
16.4 Biomedical applications of magnetic nanoparticles 316
16.5 Conclusion 322
References 323
Index 329
- Edition: 1
- Published: October 22, 2019
- Language: English
MS
Muhammad Raza Shah
Muhammad Raza Shah is a full professor at the International Center for Chemical and Biological Sciences, HEJ Research Institute of Chemistry, University of Karachi, Pakistan. He is also the Head of the Center for Bioequivalence Studies and Clinical Research. He is a recipient of several awards, including the Tamgha-i-Imtiaz Award from the President of Pakistan, the Salam Prize, the Professor Atta ur Rahman Gold Medal, and the Dr M Raziuddin Siddiqi Prize, by the Pakistan Academy of Sciences, for scientists under 40 years of age, in the field of chemistry. Professor Shah has authored six books and edited four books, in addition to contributing over 350 peer-reviewed journal papers. One of his authored books was declared as best book of 2017 by the Government of Pakistan’s Higher Education Commission.
Affiliations and expertise
Professor, International Center for Chemical and Biological Sciences, H.E.J. Research Institute of Chemistry University, Karachi, PakistanMI
Muhammad Imran
Muhammad Imran is a graduate student and based at the International Center for Chemical and Biological Sciences, H.E.J. Research Institute of Chemistry University of Karachi, Pakistan.
Affiliations and expertise
International Center for Chemical and Biological Sciences, H.E.J. Research Institute of Chemistry, University of Karachi, PakistanSU
Shafi Ullah
Shafi Ullah is a graduate student and based at the International Center for Chemical and Biological Sciences, H.E.J. Research Institute of Chemistry University of Karachi, Pakistan.
Affiliations and expertise
International Center for Chemical and Biological Sciences, H.E.J. Research Institute of Chemistry, University of Karachi, PakistanRead Metal Nanoparticles for Drug Delivery and Diagnostic Applications on ScienceDirect