Mesenchymal Stem Cells
Biological Concepts, Current Advances, Opportunities and Challenges
- 1st Edition - May 26, 2023
- Latest edition
- Authors: Leisheng Zhang, Zhongchao Han, Jialun Wang, Zongjin Li, Qing Huang
- Language: English
Mesenchymal Stem Cells: Biological Concepts, Current Advances, Opportunities and Challenges systematically summarizes and discusses the basic concepts and latest updates of mesenc… Read more
Mesenchymal Stem Cells: Biological Concepts, Current Advances, Opportunities and Challenges systematically summarizes and discusses the basic concepts and latest updates of mesenchymal stem cells (MSCs) in the past 60 years, as well as the latest progress of clinical translational research and regulatory policy at home and abroad, which will be of great practical significance for promoting and guiding the future development of stem cell production and regenerative medicine.
- Systematically introduces the latest updates on Mesenchymal stem cells (MSCs), helping readers have a systematic understanding of MSCs
- Summarizes knowledge on MSC-based cytotherapy in clinical practice to benefit clinicians and help them design MSC-relevant clinical trials
- Introduces newly developed concepts of MSC-based tissue engineering
Researchers on stem cell research (postgraduates and in industry). Final year undergrads in biomedical fields interested in stem cell research
1. Introduction of mesenchymal stem/stromal cells
1.1 The definition of MSCs
1.2 The characteristics and biology of MSCs
1.3 The classification of MSCs
1.4 The origins and development of MSCs
1.5 The safety and efficacy of MSCs
1.6 The regulation and molecular mechanism of MSCs
1.7 The standardization and industrialization of MSCs
2. The application of MSCs in regenerative medicine
2.1 The application of MSCs in hematological diseases
2.2 The application of MSCs in digestive diseases
2.3 The application of MSCs in neurological diseases
2.4 The application of MSCs in endocrine diseases
2.5 The application of MSCs in immune diseases
2.6 The application of MSCs in movement diseases
2.7 The application of MSCs in respiratory diseases
2.8 The application of MSCs in urogenital diseases
3. Biomaterials and MSCs composites in regenerative medicine
3.1 Introduction to the types and characteristics of stem cells
3.2 Introduction to biomaterials and tissue engineering
3.3 Construction and application of different biomaterials/MSC composites 000
3.4 Biomaterials and intermittent stem cells
3.5 Other aspects
4. The enhanced therapeutic potential of MSC with biomaterials application
4.1 Introduction
4.2 MSCs-based therapy
4.3 Challenges for MSCs-based therapy
4.4 Characteristics of biomaterials
4.5 Classification of biomaterials
4.6 Three-dimensional culture of MSCs with biomaterials
4.7 Therapeutic potential of MSC with biomaterials
4.8 Conclusion
5. Mesenchymal stem cells: A promising weapon for cancer therapy
5.1 Introduction
5.2 The potential of MSCs for cancer therapy
5.3 The advantages and limitations of MSCs in cancer therapy
5.4 Modification strategies to enhance MSC therapy
5.5 Modified MSCs in cancer therapeutics
5.6 Conclusion and future perspectives
- Edition: 1
- Latest edition
- Published: May 26, 2023
- Language: English
LZ
Leisheng Zhang
Dr. Leisheng Zhang’s interests mainly focus on the biological function and molecular mechanism of mesenchymal stem/stromal cells (MSCs), including early development from human pluripotent stem cells (hPSCs), cellular phenotype and genomic analysis, and applied transformation research. He and his colleagues have identified a number of master regulators (TWIST1, MSX2, PRAME) during early MSC development. Simultaneously, his group has been working on immune cells, and, in particular, natural killer (NK) cells, on the basis of single cell sequencing and Raman spectroscopy. Representative studies of his group are available in journals such as Cell Research (2015), Journal of Hematology & Oncology (2017), Stem Cell Reports (2018), Stem Cell Research & Therapy (2018, 2019a, 2019b, 2020, 2021), Stem Cell Reviews and Reports (2020), Cell & Bioscience (2020), Cell Proliferation (2021), Stem Cells International (2020, 2021), and the American Journal of Cancer Research (2021).
Affiliations and expertise
Professor, Nankai University School of Medicine and Nanchang University, Nankai, ChinaZH
Zhongchao Han
Professor Zhongchao Han’s research interests mainly focus on the fundamental and clinical studies of mesenchymal stem/stromal cells (MSCs), including cellular phenotype and genomic analysis, applied transformation research, and, in particular, the perinatal tissue-derived MSCs. Professor Han’s research aims to systematically reveal the multifaceted characteristics of MSCs derived from healthy donors and clinical patients, both at the cellular and molecular levels, together with MSC-based cyto-therapy for refractory and recurrent disease management. During the past 30 years, his team has published over 250 research articles and review articles on mesenchymal stem/stromal cells.
Affiliations and expertise
Chinese Academy of Medical Sciences and Peking Union Medical Colleague, State Key Laboratory of Experimental Hematology and National Clinical Research Center for Blood Disease, Institute of Hematology & Blood Diseases Hospital, Professor, Academician, Heping, ChinaJW
Jialun Wang
Professor Jialun Wang’s research interests mainly focus on the translational medicine of mesenchymal stem/stromal cells (MSCs), including clinical trials, MSC-based new drugs, and animal disease models. Professor Wang has published many articles and United States patents on MSC-derived exosomes, and MSC-based preclinical and clinical trials.
Affiliations and expertise
Health-Biotech. Biotech. Co. Ltd., National Engineering Technology Center for Cell Products, Professor, Vice President of the Research Institute, Shangrao, ChinaZL
Zongjin Li
Professor Zongjin Li’s research interests mainly focus on stem cell biology and molecular imaging. During the past 30 years, a series of innovative studies have been performed by Professor Li’s team on stem cell therapy, stem cell differentiation, cell labelling, multimodal molecular imaging tracing of stem cells, and so on. Professor Li has published over 100 articles on stem cells and exosomes.
Affiliations and expertise
Nankai University School of Medicine, Nankai, ChinaQH
Qing Huang
Professor Qing Huang’s research interests mainly focus on biophysics, physical chemistry, the applications of nuclear technology, ion beams interacting with organisms, and cyto-therapy. During the past 30 years, Professor Huang has published over 100 articles in the field.
Affiliations and expertise
Key Laboratory of Radiation Technology and Biophysics, Institute of Biology and Hefei Institute of Physical Science, Chinese Academy of Sciences, Hefei, ChinaRead Mesenchymal Stem Cells on ScienceDirect