Membrane Transporters and Drug Delivery
A Comprehensive and Multidisciplinary Guide
- 1st Edition - November 2, 2026
- Latest edition
- Editors: Elena Puris, Gert Fricker, Tetsuya Terasaki, Mikko Gynther
- Language: English
Membrane Transporters and Drug Delivery: A comprehensive and multidisciplinary guide begins with a comprehensive introduction to membrane transporters, their function, struct… Read more
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Description
Description
Membrane Transporters and Drug Delivery: A comprehensive and multidisciplinary guide begins with a comprehensive introduction to membrane transporters, their function, structure, and regulation mechanisms. It then moves into the impact of diseases on transporters and how this may affect pharmacokinetics. The book also presents the latest advancements in transporter-mediated drug delivery. A unique feature of this book is its detailed exploration of the methodologies used in transporter research, providing readers with a comprehensive understanding of the strengths and limitations of each approach. It examines the roles of both efflux and influx transporters in drug pharmacokinetics and covers different strategies for utilizing membrane transporters for drug delivery and targeting to specific tissues and cell types. The book concludes with a discussion on regulatory and industrial aspects of transporter-related projects and explores the potential of artificial intelligence in transporter and drug delivery research.
Membrane Transporters and Drug Delivery: A comprehensive and multidisciplinary guide begins with a comprehensive introduction to membrane transporters, their function, structure, and regulation mechanisms. It then moves into the impact of diseases on transporters and how this may affect pharmacokinetics. The book also presents the latest advancements in transporter-mediated drug delivery. A unique feature of this book is its detailed exploration of the methodologies used in transporter research, providing readers with a comprehensive understanding of the strengths and limitations of each approach. It examines the roles of both efflux and influx transporters in drug pharmacokinetics and covers different strategies for utilizing membrane transporters for drug delivery and targeting to specific tissues and cell types. The book concludes with a discussion on regulatory and industrial aspects of transporter-related projects and explores the potential of artificial intelligence in transporter and drug delivery research.
Membrane Transporters and Drug Delivery: A comprehensive and multidisciplinary guide begins with a comprehensive introduction to membrane transporters, their function, structure, and regulation mechanisms. It then moves into the impact of diseases on transporters and how this may affect pharmacokinetics. The book also presents the latest advancements in transporter-mediated drug delivery. A unique feature of this book is its detailed exploration of the methodologies used in transporter research, providing readers with a comprehensive understanding of the strengths and limitations of each approach. It examines the roles of both efflux and influx transporters in drug pharmacokinetics and covers different strategies for utilizing membrane transporters for drug delivery and targeting to specific tissues and cell types. The book concludes with a discussion on regulatory and industrial aspects of transporter-related projects and explores the potential of artificial intelligence in transporter and drug delivery research.
Key features
Key features
- • Provides a comprehensive, in-depth exploration of membrane transporters and their role in drug delivery
• Offers a multidisciplinary approach, covering all essential aspects of transporter-related drug delivery research
• Features the latest methodologies used in transporter research, aiding in the selection of appropriate methods for drug development projects
• Highlights strategies for utilizing membrane transporters for drug delivery and targeting to specific tissues and cell types
• Discusses the potential of artificial intelligence in transporter and drug delivery research
Readership
Readership
Researchers in Industry and Academia working in pharmaceutical sciences, drug delivery and pharmaceutical manufacturing
Table of contents
Table of contents
Part I: Basic concepts of membrane transporters
1. Introduction to membrane transporters and drug delivery
2. Structure and mechanism of membrane transporters
3. Regulation of membrane transporters
Part II: Transporters in drug disposition
4. Role of transporters in drug disposition and its clinical significance
5. Transporter-mediated drug-drug interactions
Part III: Transporters in diseases
6. Drug transporters in cancer
7. Transcellular transport at the blood-brain barriers in health and disease
8. Drug Transporters in Liver Disease
9. Ocular drug transporters
Part IV: ABC transporters in drug delivery
10. Role of ABC transporters in drug delivery
11. Strategies targeting ABC transporters for drug delivery
Part V: SLC transporters in drug delivery
12. SLC Transporters: From Preclinical Evaluation to Translational Targets for Drug Delivery
13. Strategies targeting SLC transporters for drug delivery
Part VI: Methods for investigating transporter-mediated drug delivery
14. In vitro and ex vivo methods for studying drug transport
15. In vivo drug transporter studies
16. In silico approaches for prediction of drug-transporter interaction
17. Physiologically Based Pharmacokinetic (PBPK) Modelling to Predict Transporter-Mediated Drug Disposition
18. Transporter pharmacoproteomics as a transformative strategy in drug delivery and pharmacokinetics
19. Pharmacogenomics
20. Human studies
Part VII: Conclusions and Perspectives
21. Regulatory and Industrial Aspects
22. The use of artificial intelligence in transporter research
1. Introduction to membrane transporters and drug delivery
2. Structure and mechanism of membrane transporters
3. Regulation of membrane transporters
Part II: Transporters in drug disposition
4. Role of transporters in drug disposition and its clinical significance
5. Transporter-mediated drug-drug interactions
Part III: Transporters in diseases
6. Drug transporters in cancer
7. Transcellular transport at the blood-brain barriers in health and disease
8. Drug Transporters in Liver Disease
9. Ocular drug transporters
Part IV: ABC transporters in drug delivery
10. Role of ABC transporters in drug delivery
11. Strategies targeting ABC transporters for drug delivery
Part V: SLC transporters in drug delivery
12. SLC Transporters: From Preclinical Evaluation to Translational Targets for Drug Delivery
13. Strategies targeting SLC transporters for drug delivery
Part VI: Methods for investigating transporter-mediated drug delivery
14. In vitro and ex vivo methods for studying drug transport
15. In vivo drug transporter studies
16. In silico approaches for prediction of drug-transporter interaction
17. Physiologically Based Pharmacokinetic (PBPK) Modelling to Predict Transporter-Mediated Drug Disposition
18. Transporter pharmacoproteomics as a transformative strategy in drug delivery and pharmacokinetics
19. Pharmacogenomics
20. Human studies
Part VII: Conclusions and Perspectives
21. Regulatory and Industrial Aspects
22. The use of artificial intelligence in transporter research
Product details
Product details
- Edition: 1
- Latest edition
- Published: November 2, 2026
- Language: English
About the editors
About the editors
EP
Elena Puris
Dr. Puris received her PhD in Drug Research from University of Eastern Finland (Kuopio, Finland) in 2019. Since 2020, she has been working on her project as a Principal Investigator in the group of Prof. Fricker at the University of Heidelberg. Her research project focuses on investigating the roles of membrane transporters in drug delivery and pathogenesis of Alzheimer’s disease. Her work has been supported by the Alexander von Humboldt Foundation, Alzheimer Forschung Initiative e.V. and Taconic Biosciences, Inc. Her research interests include investigating the membrane transporters and their impact on drug delivery and biochemical processes in health and pathological conditions, development of novel drug delivery strategies and studying molecular mechanisms underlying pathogenesis of CNS diseases. To date, she has authored more than 20 articles.
Affiliations and expertise
University of Heidelberg, GermanyGF
Gert Fricker
Dr. Fricker is a full Professor at the Institute of Pharmacy and Molecular Biotechnology in the Faculty of Engineering Sciences, Ruprecht-Karls University Heidelberg, Germany. After studying at the University of Freiburg, Germany, and finishing his PhD in 1986, he worked as Post-Doc in the Department of Clinical Pharmacology, University Hospital Zurich, Switzerland. In 1988 he became research scientist at Sandoz Pharma AG, Basel, Switzerland. As member of the Drug Delivery Systems Department he studied mechanisms of drug permeation across barrier tissues. In the year 1995, he joined Heidelberg University. His main research interests are the permeation of drugs across barrier tissues with particular emphasis on intestine and blood brain barrier as well as the development of drug targeting systems by colloidal drug carriers.
Affiliations and expertise
University of Heidelberg, GermanyTT
Tetsuya Terasaki
Tetsuya Terasaki is currently visiting professor at University of Eastern Finland, Finland and global professor at Keio University, Japan and professor emeritus of Tohoku University, Japan. His major research interests are the molecular pharmacology of blood-brain barrier and quantitative targeted absolute proteomics-based analysis of transporter/enzyme/receptor/channel function. He published extensively in journals, over 330 research articles and 15 review articles and contributed chapters to over 17 books, cited over 20,000 (H-index is 77).
Affiliations and expertise
University of Eastern Finland, FinlandMG
Mikko Gynther
Dr. Gynther is Senior Researcher in the School of Pharmacy at the University of Eastern Finland. He received his PhD from University of Eastern Finland in 2011, after which he worked two years as a postdoctoral researcher in the Department of Drug Design and Pharmacology at the University of Copenhagen, Denmark. After working from 2011 to 2018 as a principal investigator in the School of Pharmacy at the University of Eastern Finland, he worked two years as a junior research group leader in the Internal Medicine VIII, University Hospital Tübingen, Germany and from 2021 to 2023 as a junior research group leader at the Institute of Pharmacy and Molecular Biotechnology, Ruprecht-Karls-University, Heidelberg, Germany. Since 2023 he has worked as a Senior Researcher at the University of Eastern Finland. Dr. Gynther has 20 years of experience in transporter research with the focus of investigating their roles in targeted CNS and anticancer drug delivery as well as the development of means to overcome transporter-mediated anticancer drug resistance. To date, he has authored more than 50 peer-reviewed articles.
Affiliations and expertise
University of Eastern Finland, Finland