Medical Biochemistry
- 2nd Edition - March 23, 2022
- Imprint: Academic Press
- Authors: Antonio Blanco, Gustavo Blanco
- Language: English
- Paperback ISBN:9 7 8 - 0 - 3 2 3 - 9 1 5 9 9 - 1
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 9 1 6 0 0 - 4
This second edition of Medical Biochemistry is supported by more than 45 years of teaching experience, providing coverage of basic biochemical topics, including the structura… Read more
Purchase options
Institutional subscription on ScienceDirect
Request a sales quoteThis second edition of Medical Biochemistry is supported by more than 45 years of teaching experience, providing coverage of basic biochemical topics, including the structural, physical, and chemical properties of water, carbohydrates, lipids, proteins, and nucleic acids. In addition, the general aspects of thermodynamics, enzymes, bioenergetics, and metabolism are presented in straightforward and easy-to-comprehend language.
This book ties these concepts into more complex aspects of biochemistry using a systems approach, dedicating chapters to the integral study of biological phenomena, including cell membrane structure and function, gene expression and regulation, protein synthesis and post-translational modifications, metabolism in specific organs and tissues, autophagy, cell receptors, signal transduction pathways, biochemical bases of endocrinology, immunity, vitamins and minerals, and hemostasis.
The field of biochemistry is continuing to grow at a fast pace. This edition has been revised and expanded with all-new sections on the cell plasma membrane, the human microbiome, autophagy, noncoding, small and long RNAs, epigenetics, genetic diseases, virology and vaccines, cell signaling, and different modes of programmed cell death. The book has also been updated with full-color figures, new tables, chapter summaries, and further medical examples to improve learning and better illustrate the concepts described and their clinical significance.
- Integrates basic biochemistry principles with molecular biology and molecular physiology
- Illustrates basic biochemical concepts through medical and physiological examples
- Utilizes a systems approach to understanding biological phenomena
- Fully updated for recent studies and expanded to include clinically relevant examples and succinct chapter summaries
Researchers and clinicians in biochemistry, molecular biology, and molecular medicine; medical faculty, and postdocs, medical students
- Cover image
- Title page
- Table of Contents
- Copyright
- Dedication
- Preface
- Cover
- Introduction
- Chapter 1: Chemical composition of living beings
- Abstract
- Biogenic elements
- Biological compounds
- Summary
- Further reading
- Chapter 2: Water
- Abstract
- The water molecule is polar
- Hydrogen bond
- Water as solvent
- Water as an electrolyte
- Equilibrium constant
- Equilibrium of water ionization
- Acids and bases
- The strength of acids and bases
- pH
- Buffers
- Titration curve of acids and bases
- Appendix
- Summary
- Further reading
- Chapter 3: Proteins
- Abstract
- Proteins are macromolecules formed by amino acids
- Amino acids
- Peptides
- Proteins
- Collagen
- Keratins
- Hemoglobin
- Heme
- Globin
- Hemoglobin derivatives
- Abnormal hemoglobins
- Blood plasma proteins
- Main plasma proteins
- Muscle proteins
- Muscle contraction
- Proteomics
- Summary
- Further reading
- Chapter 4: Carbohydrates
- Abstract
- Monosaccharides
- Disaccharides
- Polysaccharides
- Summary
- Further reading
- Chapter 5: Lipids
- Abstract
- Classification
- Fatty acids
- Essential fatty acids
- Simple lipids
- Complex lipids
- Substances associated with lipids
- Summary
- Further reading
- Chapter 6: Nucleic acids
- Abstract
- Nucleotides
- Nucleic acids
- Virus
- Free nucleotides
- Summary
- Further reading
- Chapter 7: Elements of thermodynamics and biochemical kinetics
- Abstract
- Thermodynamics
- The cell as an open system
- Chemical kinetics
- Summary
- Further reading
- Chapter 8: Enzymes
- Abstract
- Enzymes are biological catalysts
- Nomenclature and classification of enzymes
- Chemical nature of enzymes
- Metalloenzymes
- Enzymatic catalysis
- Active site
- Zymogens
- Genetic alterations that affect enzyme function
- Enzyme distribution within the cell
- Multienzyme systems
- Determination of enzyme activity
- Factors that modify enzyme activity
- Enzyme inhibitors
- Regulation of enzyme activity
- Constitutive and inducible enzymes
- Enzymatic processes in cascade
- Isozymes
- Determination of enzymes in the clinical laboratory
- Summary
- Further reading
- Chapter 9: Biological oxidations: Bioenergetics
- Abstract
- The energy-rich intermediate ATP
- Oxidation-reduction
- Biological oxidations
- Respiratory chain
- Oxidative phosphorylation
- Phosphorylation at substrate level
- Other electron transport systems
- Summary
- Further reading
- Chapter 10: Antioxidants
- Abstract
- Reactive species
- Summary
- Further reading
- Chapter 11: Membranes
- Abstract
- Structure
- Transport across membranes
- Passive transport or facilitated diffusion
- Active transport
- Summary
- Further reading
- Chapter 12: Digestion—Absorption
- Abstract
- Saliva
- Gastric secretion
- Pancreatic juice
- Intestinal mucosa
- Bile
- Summary of the digestive process
- Absorption
- Gastrointestinal microbiome
- Summary
- Further reading
- Chapter 13: Metabolism
- Abstract
- Metabolic pathways
- Metabolic studies
- Regulation of metabolism
- Summary
- Further reading
- Chapter 14: Carbohydrate metabolism
- Abstract
- Glucose uptake into cells
- Glucose phosphorylation
- Metabolic pathways for glucose
- Metabolism of other hexoses
- Biosynthesis of oligosaccharides in glycoproteins
- Summary
- Further reading
- Chapter 15: Lipid metabolism
- Abstract
- Plasma lipoprotein metabolism
- Fat metabolism
- Fatty acid biosynthesis
- Eicosanoid biosynthesis
- Triacylglycerol biosynthesis
- Phospholipid biosynthesis
- Congenital disorders of complex lipid catabolism
- Cholesterol metabolism
- Cholesterol biosynthesis
- Alterations of plasma lipids
- Summary
- Further reading
- Chapter 16: Amino acid metabolism
- Abstract
- Essential AA
- Amino acid catabolism
- Metabolic pathways of ammonia
- Other general mechanisms of amino acid metabolism
- Metabolic pathways of AA
- Summary
- Further reading
- Chapter 17: Heme metabolism
- Abstract
- Heme biosynthesis
- Catabolism of heme
- Summary
- Further reading
- Chapter 18: Purine and pyrimidine metabolism
- Abstract
- Purine biosynthesis
- Purine salvage pathway
- Purine catabolism
- Uric acid
- Gout
- Pyrimidine biosynthesis
- Pyrimidine catabolism
- Di- and triphosphate nucleoside biosynthesis
- Deoxyribonucleotide biosynthesis
- Pharmacological approaches to purine and pyrimidine metabolism
- Summary
- Further reading
- Chapter 19: Integration and regulation of metabolism
- Abstract
- Interconversion of carbohydrates, lipids, and amino acids
- Metabolic regulation
- Summary
- Further reading
- Chapter 20: Metabolism in some tissues
- Abstract
- Liver metabolism
- Skeletal muscle metabolism
- Heart metabolism
- Adipose tissue metabolism
- Nervous tissue metabolism
- Summary
- Further reading
- Chapter 21: The genetic information (I)
- Abstract
- DNA replication
- Transcription
- Molecular biology
- Summary
- Further reading
- Chapter 22: The genetic information (II)
- Abstract
- Protein biosynthesis
- Mechanism of protein synthesis
- Genetic mutations
- Oncogenes
- Epigenetics
- Summary
- Further reading
- Chapter 23: Regulation of gene expression
- Abstract
- Gene regulation in eukaryotes
- Gene regulation by noncoding RNAs
- Small noncoding RNAs
- Long noncoding RNAs
- Riboswitches
- Summary
- Further reading
- Chapter 24: Posttranslational protein modifications
- Abstract
- Protein folding
- Pathologies caused by misfolded proteins
- Posttranslational protein modifications
- Summary
- Further reading
- Chapter 25: Biochemical basis of endocrinology (I) receptors and signal transduction
- Abstract
- Receptors
- Signal transduction systems
- Summary
- Further reading
- Chapter 26: Biochemical bases of endocrinology (II) hormones and other chemical intermediates
- Abstract
- Hormones
- Endocrine glands and their hormones
- Placental hormones
- Thyroid hormones
- Adrenal gland hormones
- Pancreatic hormones
- Gonadal hormones
- Parathyroid gland hormones
- Kidney hormones
- Heart hormones
- Gastrointestinal hormones
- Pineal gland hormone
- Eicosanoids
- Growth factors
- Nervous system chemical intermediaries (Neurotransmitters)
- Summary
- Further reading
- Chapter 27: Vitamins
- Abstract
- Fat-soluble vitamins
- Water-soluble vitamins
- Summary
- Further reading
- Chapter 28: Water and acid-base balance
- Abstract
- Water distribution in the body
- Water balance
- Ionic composition of body fluids
- Alterations of the water balance
- H+ concentration in body fluids
- Regulation of H+ concentration
- Carbon dioxide transport
- Regulatory systems
- Respiratory regulation
- Renal regulation
- Regulation of intracellular pH
- Acid-base balance disorders
- H+ excretion regulation
- Laboratory studies in acid-base disorders
- Summary
- Further reading
- Chapter 29: Essential minerals
- Abstract
- Macrominerals
- Trace elements
- Summary
- Further reading
- Chapter 30: Molecular basis of immunity
- Abstract
- Immune system
- Innate system
- Adaptive system
- Genetic diversity of immunoglobulins
- Complement
- Cellular immunity
- Cytokines
- Vaccines
- Summary
- Further reading
- Chapter 31: Hemostasis
- Abstract
- Blood coagulation
- Coagulation disorders
- Summary
- Further reading
- Chapter 32: Cell death
- Abstract
- Apoptosis
- Summary
- Further reading
- Index
- Edition: 2
- Published: March 23, 2022
- No. of pages (Paperback): 908
- No. of pages (eBook): 908
- Imprint: Academic Press
- Language: English
- Paperback ISBN: 9780323915991
- eBook ISBN: 9780323916004
AB
Antonio Blanco
Dr. Antonio Blanco is an M.D. and Ph.D. at the National University of Cordoba, Argentina. He was Research Associate at The Johns Hopkins School of Medicine at Baltimore (US) for 4 years. He has been the Chairman of the Department of Biochemistry of the National University of Cordoba for 31 years and is currently Emeritus Professor of the National University of Cordoba, Argentina. He is also a member of several academic societies, including the National Academy of Sciences, and the National Academy of Physical and Natural Sciences of Argentina.
Affiliations and expertise
Emeritus Professor, National University of Cordoba, Cordoba, ArgentinaGB
Gustavo Blanco
Dr. Gustavo Blanco is an M.D. and Ph.D. from the University of Cordoba, Argentina and currently a Professor at Kansas University Medical Center. Dr. Blanco’s research focuses on renal biology and reproductive biology, as well as regulation and function of Na,K-ATPase isozymes. He has published widely in such peer reviewed journals as the Journal of Medicinal Chemistry, Steroids, Experimental Cell Research, Molecules, Frontiers in Physiology, and the American Journal of Physiology.
Affiliations and expertise
Professor and Kathleen M. Osborn Chair, Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, KS United StatesRead Medical Biochemistry on ScienceDirect