Mechanosensitive Ion Channels, Part B

1st Edition, Volume 59 - April 19, 2007
Editors: Owen P. Hamill, Sidney A. Simon, Dale J. Benos
Language: English
Hardback ISBN:
9 7 8 - 0 - 1 2 - 1 5 3 3 5 9 - 5
eBook ISBN:
9 7 8 - 0 - 0 8 - 0 4 9 4 4 0 - 1

Current Topics in Membranes provides a systematic, comprehensive, and rigorous approach to specific topics relevant to the study of cellular membranes. Each volume is a guest… Read more

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Current Topics in Membranes provides a systematic, comprehensive, and rigorous approach to specific topics relevant to the study of cellular membranes. Each volume is a guest edited compendium of membrane biology. This series has been a mainstay for practicing scientists and students interested in this critical field of biology. Articles covered in the volume include ENaC Proteins in Vascular Smooth Muscle Mechanotransduction; Regulation of the Mechano-Gated K2P Channel TREK-1 by Membrane Phospholipids; MechanoTRPs and TRPA1; TRPC; The Cytoskeletal Connection to Ion Channels as a Potential Mechanosensory Mechanism. Lessons From Polycystin-2 (TRPP2); Lipid Stress at Play: Mechanosensitivity of Voltage-Gated Channels; Hair Cell Mechanotransduction: The Dynamic Interplay between Structure and Function; Pharmacology of Hair Cell MS Channels; Hair Cell Mechanotransduction; Models of Hair Cell Mechanotrasduction; Touch; Mechanosensitive Ion Channels in Dystrophic Muscle; Mechanotransduction in Endothelial Cells;MS Channels in Tumor Cell Migration; Mechanosensitive Channels in Regulating Smooth Muscle Contraction in the GI; Mechanosensitive Ion Channels in Blood-Pressure-Sensing Baroreceptor Neurons.

Foreword
Previous Volumes in Series
Chapter 1: Mechanosensitive Ion Channels of Spiders: Mechanical Coupling, Electrophysiology, and Synaptic Modulation
- Publisher Summary
- I OVERVIEW
- II INTRODUCTION
- III TYPES OF SPIDER MECHANORECEPTORS
- IV MECHANICAL COUPLING
- V MECHANOTRANSDUCTION IN SLIT SENSILLA
- VI DYNAMIC PROPERTIES OF MECHANOTRANSDUCTION AND ACTION POTENTIAL ENCODING
- VII CALCIUM SIGNALING DURING TRANSDUCTION BY SPIDER MECHANORECEPTORS
- VIII SYNAPTIC MODULATION OF SPIDER MECHANORECEPTORS
- IX CONCLUSIONS
- Acknowledgments
Chapter 2: Ion Channels for Mechanotransduction in the Crayfish Stretch Receptor
- Publisher Summary
- I OVERVIEW
- II INTRODUCTION
- III MORPHOLOGY OF THE SRO
- IV FUNCTIONAL PROPERTIES
- V SUMMARY AND DISCUSSION OF FUTURE RESEARCH DIRECTIONS
- Acknowledgments
Chapter 3: Mechanosensitive Ion Channels in Caenorhabditis elegans
- Publisher Summary
- I OVERVIEW
- II INTRODUCTION
- III C. ELEGANS MECHANOSENSITIVE BEHAVIORS
- IV C. ELEGANS DEG/ENaCs
- V C. ELEGANS TRP ION CHANNELS
- VI CONCLUDING REMARKS
Chapter 4: Properties and Mechanism of the Mechanosensitive Ion Channel Inhibitor GsMTx4, a Therapeutic Peptide Derived from Tarantula Venom
- Publisher Summary
- I OVERVIEW
- II INTRODUCTION
- III PROPERTIES AND SPECIFICITY OF GsMTx4
- IV CELLULAR SITES FOR GsMTx4
- V POTENTIAL THERAPEUTIC USES FOR GsMTx4
- VI CONCLUSIONS
Chapter 5: Mechanosensitive Channels in Neurite Outgrowth
- Publisher Summary
- I OVERVIEW
- II INTRODUCTION
- III ENCODING OF GUIDANCE CUES IN AXON PATHFINDING
- IV REQUIREMENT OF TRP CHANNELS IN CALCIUM-DEPENDENT AXON PATHFINDING
- V PHYSICAL GUIDANCE CUES AND ROLE OF MECHANOSENSITIVE ION CHANNELS
- VI ION CHANNELS AS MOLECULAR INTEGRATORS
- VII CONCLUDING REMARKS
- NOTE ADDED IN PROOF
- Acknowledgments
Chapter 6: ENaC Proteins in Vascular Smooth Muscle Mechanotransduction
- Publisher Summary
- I OVERVIEW
- II INTRODUCTION
- III DEG/ENaC/ASIC PROTEINS ARE MEMBERS OF A DIVERSE PROTEIN FAMILY INVOLVED IN MECHANOTRANSDUCTION
- IV INVOLVEMENT OF ENaC PROTEINS IN VASCULAR SMOOTH MUSCLE MECHANOTRANSDUCTION
- V SUMMARY AND FUTURE DIRECTIONS
Chapter 7: Regulation of the Mechano-Gated K_2P Channel TREK-1 by Membrane Phospholipids
- Publisher Summary
- I OVERVIEW
- II INTRODUCTION
- III TREK-1 STIMULATION BY MEMBRANE PHOSPHOLIPIDS
- IV TREK-1 INHIBITION BY MEMBRANE PHOSPHOLIPIDS
- Acknowledgments
Chapter 8: MechanoTRPs and TRPA1
- Publisher Summary
- I OVERVIEW
- II MECHANOTRP CHANNELS
- III CHARACTERISTICS OF TRPA1 GENE AND PROTEIN
- IV TRPA1 EXPRESSION IN MECHANOSENSORY ORGANS
- V FUNCTION OF TRPA1
- VI Proposed Biological Roles for TRPA1
Chapter 9: TRPCs as MS Channels
- Publisher Summary
- I OVERVIEW
- II INTRODUCTION
- III PRACTICAL ASPECTS OF RECORDING MS CHANNELS
- IV DISTINGUISHING DIRECT VS INDIRECT MS CHANNELS
- V EXTRINSIC REGULATION OF STRETCH SENSITIVITY
- VI STRATEGIES TO IDENTIFY MS CHANNEL PROTEINS
- VII GENERAL PROPERTIES OF TRPCs
- VIII EVIDENCE FOR TRPC MECHANOSENSITIVITY
- IX CONCLUSIONS
- Acknowledgments
Chapter 10: The Cytoskeletal Connection to Ion Channels as a Potential Mechanosensory Mechanism: Lessons from Polycystin-2 (TRPP2)
- Publisher Summary
- I OVERVIEW
- II INTRODUCTION
- III ROLE OF ACTIN CYTOSKELETAL DYNAMICS IN PC2-MEDIATED CHANNEL FUNCTION
- IV IDENTIFICATION OF ACTIN-BINDING PROTEIN INTERACTIONS WITH POLYCYSTIN-2
- V EFFECT OF HYDROOSMOTIC PRESSURE ON PC2 CHANNEL FUNCTION: ROLE OF THE CYTOSKELETON IN OSMOSENSORY FUNCTION
- VI THE CHANNEL–CYTOSKELETON INTERFACE: STRUCTURAL–FUNCTIONAL CORRELATES
- VII PERSPECTIVE AND FUTURE DIRECTIONS
Chapter 11: Lipid Stress at Play: Mechanosensitivity of Voltage-Gated Channels
- Publisher Summary
- I OVERVIEW
- II THE SYSTEM COMPONENTS
- III BIG PICTURE ISSUES
- IV REVERSIBLE STRETCH-INDUCED CHANGES IN PARTICULAR VGCs
- V IRREVERSIBLE STRETCH-INDUCED GATING CHANGES IN VGCs
- VI TECHNICAL ISSUES
- VII SUMMARY COMMENTS
- Acknowledgments
Chapter 12: Hair Cell Mechanotransduction: The Dynamic Interplay Between Structure and Function
- Publisher Summary
- I OVERVIEW
- II AUDITORY SYSTEM
- III HAIR BUNDLE STRUCTURE
- IV MET INVOLVES MECHANICALLY GATED CHANNELS
- V WHERE ARE THESE CHANNELS?
- VI THE GATING SPRING THEORY
- VII HOW ARE THE CHANNELS ACTIVATED?
- VIII TO BE OR NOT TO BE TETHERED
- IX CHARACTERIZING CHANNEL PROPERTIES?
- X MET CHANNEL PORE
- XI ADAPTATION
- XII THE DYNAMIC HAIR BUNDLE
- XIII SUMMARY AND FUTURE DIRECTIONS
- Acknowledgments
Chapter 13: Insights into the Pore of the Hair Cell Transducer Channel from Experiments with Permeant Blockers
- Publisher Summary
- I OVERVIEW
- II INTRODUCTION
- III IONIC SELECTIVITY OF THE TRANSDUCER CHANNEL
- IV PERMEATION AND BLOCK OF MECHANORECEPTOR CHANNELS BY FM1-43
- V PERMEATION AND BLOCK OF THE HAIR CELL TRANSDUCER CHANNEL BY AMINOGLYCOSIDE ANTIBIOTICS
- VI TRANSDUCER CHANNEL BLOCK BY AMILORIDE AND ITS DERIVATIVES
- VII CONCLUSIONS
- Acknowledgments
Chapter 14: Models of Hair Cell Mechanotransduction
- Publisher Summary
- I OVERVIEW
- II INTRODUCTION
- III TRANSDUCTION CHANNEL PROPERTIES
- IV GATING
- V ACTIVE HAIR BUNDLE MOTILITY
- VI CONCLUSIONS
Chapter 15: Touch
- Publisher Summary
- I OVERVIEW
- II INTRODUCTION
- III STRUCTURE OF SKIN AND TOUCH RECEPTORS
- IV PHYSIOLOGY OF MECHANORECEPTIVE NERVE FIBERS
- V QUANTITATING MECHANICAL RESPONSES IN ANIMAL MODELS
- VI ELECTROPHYSIOLOGICAL APPROACHES TO MECHANOSENSATION IN RODENTS
- VII MECHANOSENSITIVE ION CHANNELS IN CULTURED SENSORY NEURONS
- VIII GATING MS ION CHANNELS IN DRG NEURONS
- IX CANDIDATE ION CHANNELS
- X VOLTAGE-GATED CHANNELS AND MECHANOSENSATION
- XI INDIRECT SIGNALING BETWEEN SENSORY NEURONS AND NONNEURONAL CELLS
- XII CONCLUSIONS
- Acknowledgments
Chapter 16: Mechanosensitive Ion Channels in Dystrophic Muscle
- Publisher Summary
- I OVERVIEW
- II INTRODUCTION
- III MS CHANNEL EXPRESSION DURING MYOGENESIS
- IV PERMEABILTY PROPERTIES OF MS CHANNELS IN SKELETAL MUSCLE
- V GATING
- VI PHARMACOLOGY
- VII CONCLUSIONS
Chapter 17: MscCa Regulation of Tumor Cell Migration and Metastasis
- Publisher Summary
- I OVERVIEW
- II INTRODUCTION
- III DIFFERENT MODES OF MIGRATION
- IV Ca²⁺ DEPENDENCE OF CELL MIGRATION
- V THE ROLE OF MscCa IN CELL MIGRATION
- VI CAN EXTRINSIC MECHANICAL FORCES ACTING ON MscCa SWITCH ON CELL MIGRATION?
- Acknowledgments
Chapter 18: Stretch-Activated Conductances in Smooth Muscles
- Publisher Summary
- I OVERVIEW
- II INTRODUCTION
- III MECHANOSENSITIVE CONDUCTANCES THAT GENERATE INWARD CURRENTS
- IV MECHANOSENSITIVE CONDUCTANCES THAT GENERATE OUTWARD CURRENTS
Chapter 19: Mechanosensitive Ion Channels in Blood Pressure-Sensing Baroreceptor Neurons
- Publisher Summary
- I OVERVIEW
- II INTRODUCTION
- III BR SENSORY TRANSDUCTION
- IV MECHANOSENSITIVE CHANNELS IN BR NEURONS
- V METHODOLOGICAL LIMITATIONS AND CHALLENGES
- VI SUMMARY AND FUTURE DIRECTIONS
- Acknowledgments
Index

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Mechanosensitive Ion Channels, Part B

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Sidney A. Simon

Dale J. Benos