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Mechanosensitive Ion Channels, Part B
1st Edition - April 19, 2007
Editors: Owen P. Hamill, Sidney A. Simon, Dale J. Benos
Hardback ISBN:9780121533595
9 7 8 - 0 - 1 2 - 1 5 3 3 5 9 - 5
eBook ISBN:9780080494401
9 7 8 - 0 - 0 8 - 0 4 9 4 4 0 - 1
Current Topics in Membranes provides a systematic, comprehensive, and rigorous approach to specific topics relevant to the study of cellular membranes. Each volume is a guest… Read more
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Current Topics in Membranes provides a systematic, comprehensive, and rigorous approach to specific topics relevant to the study of cellular membranes. Each volume is a guest edited compendium of membrane biology. This series has been a mainstay for practicing scientists and students interested in this critical field of biology. Articles covered in the volume include ENaC Proteins in Vascular Smooth Muscle Mechanotransduction; Regulation of the Mechano-Gated K2P Channel TREK-1 by Membrane Phospholipids; MechanoTRPs and TRPA1; TRPC; The Cytoskeletal Connection to Ion Channels as a Potential Mechanosensory Mechanism. Lessons From Polycystin-2 (TRPP2); Lipid Stress at Play: Mechanosensitivity of Voltage-Gated Channels; Hair Cell Mechanotransduction: The Dynamic Interplay between Structure and Function; Pharmacology of Hair Cell MS Channels; Hair Cell Mechanotransduction; Models of Hair Cell Mechanotrasduction; Touch; Mechanosensitive Ion Channels in Dystrophic Muscle; Mechanotransduction in Endothelial Cells;MS Channels in Tumor Cell Migration; Mechanosensitive Channels in Regulating Smooth Muscle Contraction in the GI; Mechanosensitive Ion Channels in Blood-Pressure-Sensing Baroreceptor Neurons.
Researchers in cell biology, developmental biology, biochemistry, bioengineering, genetics, immunology, immunochemistry, neuroscience, diabetes, nephrology, embyrology, vascular surgery, cardiology, rheumatology, hematology, bone and joint surgery, cancer research, and angiogenesis.
Foreword
Previous Volumes in Series
Chapter 1: Mechanosensitive Ion Channels of Spiders: Mechanical Coupling, Electrophysiology, and Synaptic Modulation
Publisher Summary
I OVERVIEW
II INTRODUCTION
III TYPES OF SPIDER MECHANORECEPTORS
IV MECHANICAL COUPLING
V MECHANOTRANSDUCTION IN SLIT SENSILLA
VI DYNAMIC PROPERTIES OF MECHANOTRANSDUCTION AND ACTION POTENTIAL ENCODING
VII CALCIUM SIGNALING DURING TRANSDUCTION BY SPIDER MECHANORECEPTORS
VIII SYNAPTIC MODULATION OF SPIDER MECHANORECEPTORS
IX CONCLUSIONS
Acknowledgments
Chapter 2: Ion Channels for Mechanotransduction in the Crayfish Stretch Receptor
Publisher Summary
I OVERVIEW
II INTRODUCTION
III MORPHOLOGY OF THE SRO
IV FUNCTIONAL PROPERTIES
V SUMMARY AND DISCUSSION OF FUTURE RESEARCH DIRECTIONS
Acknowledgments
Chapter 3: Mechanosensitive Ion Channels in Caenorhabditis elegans
Publisher Summary
I OVERVIEW
II INTRODUCTION
III C. ELEGANS MECHANOSENSITIVE BEHAVIORS
IV C. ELEGANS DEG/ENaCs
V C. ELEGANS TRP ION CHANNELS
VI CONCLUDING REMARKS
Chapter 4: Properties and Mechanism of the Mechanosensitive Ion Channel Inhibitor GsMTx4, a Therapeutic Peptide Derived from Tarantula Venom
Publisher Summary
I OVERVIEW
II INTRODUCTION
III PROPERTIES AND SPECIFICITY OF GsMTx4
IV CELLULAR SITES FOR GsMTx4
V POTENTIAL THERAPEUTIC USES FOR GsMTx4
VI CONCLUSIONS
Chapter 5: Mechanosensitive Channels in Neurite Outgrowth
Publisher Summary
I OVERVIEW
II INTRODUCTION
III ENCODING OF GUIDANCE CUES IN AXON PATHFINDING
IV REQUIREMENT OF TRP CHANNELS IN CALCIUM-DEPENDENT AXON PATHFINDING
V PHYSICAL GUIDANCE CUES AND ROLE OF MECHANOSENSITIVE ION CHANNELS
VI ION CHANNELS AS MOLECULAR INTEGRATORS
VII CONCLUDING REMARKS
NOTE ADDED IN PROOF
Acknowledgments
Chapter 6: ENaC Proteins in Vascular Smooth Muscle Mechanotransduction
Publisher Summary
I OVERVIEW
II INTRODUCTION
III DEG/ENaC/ASIC PROTEINS ARE MEMBERS OF A DIVERSE PROTEIN FAMILY INVOLVED IN MECHANOTRANSDUCTION
IV INVOLVEMENT OF ENaC PROTEINS IN VASCULAR SMOOTH MUSCLE MECHANOTRANSDUCTION
V SUMMARY AND FUTURE DIRECTIONS
Chapter 7: Regulation of the Mechano-Gated K2P Channel TREK-1 by Membrane Phospholipids
Publisher Summary
I OVERVIEW
II INTRODUCTION
III TREK-1 STIMULATION BY MEMBRANE PHOSPHOLIPIDS
IV TREK-1 INHIBITION BY MEMBRANE PHOSPHOLIPIDS
Acknowledgments
Chapter 8: MechanoTRPs and TRPA1
Publisher Summary
I OVERVIEW
II MECHANOTRP CHANNELS
III CHARACTERISTICS OF TRPA1 GENE AND PROTEIN
IV TRPA1 EXPRESSION IN MECHANOSENSORY ORGANS
V FUNCTION OF TRPA1
VI Proposed Biological Roles for TRPA1
Chapter 9: TRPCs as MS Channels
Publisher Summary
I OVERVIEW
II INTRODUCTION
III PRACTICAL ASPECTS OF RECORDING MS CHANNELS
IV DISTINGUISHING DIRECT VS INDIRECT MS CHANNELS
V EXTRINSIC REGULATION OF STRETCH SENSITIVITY
VI STRATEGIES TO IDENTIFY MS CHANNEL PROTEINS
VII GENERAL PROPERTIES OF TRPCs
VIII EVIDENCE FOR TRPC MECHANOSENSITIVITY
IX CONCLUSIONS
Acknowledgments
Chapter 10: The Cytoskeletal Connection to Ion Channels as a Potential Mechanosensory Mechanism: Lessons from Polycystin-2 (TRPP2)
Publisher Summary
I OVERVIEW
II INTRODUCTION
III ROLE OF ACTIN CYTOSKELETAL DYNAMICS IN PC2-MEDIATED CHANNEL FUNCTION
IV IDENTIFICATION OF ACTIN-BINDING PROTEIN INTERACTIONS WITH POLYCYSTIN-2
V EFFECT OF HYDROOSMOTIC PRESSURE ON PC2 CHANNEL FUNCTION: ROLE OF THE CYTOSKELETON IN OSMOSENSORY FUNCTION
VI THE CHANNEL–CYTOSKELETON INTERFACE: STRUCTURAL–FUNCTIONAL CORRELATES
VII PERSPECTIVE AND FUTURE DIRECTIONS
Chapter 11: Lipid Stress at Play: Mechanosensitivity of Voltage-Gated Channels
Publisher Summary
I OVERVIEW
II THE SYSTEM COMPONENTS
III BIG PICTURE ISSUES
IV REVERSIBLE STRETCH-INDUCED CHANGES IN PARTICULAR VGCs
V IRREVERSIBLE STRETCH-INDUCED GATING CHANGES IN VGCs
VI TECHNICAL ISSUES
VII SUMMARY COMMENTS
Acknowledgments
Chapter 12: Hair Cell Mechanotransduction: The Dynamic Interplay Between Structure and Function
Publisher Summary
I OVERVIEW
II AUDITORY SYSTEM
III HAIR BUNDLE STRUCTURE
IV MET INVOLVES MECHANICALLY GATED CHANNELS
V WHERE ARE THESE CHANNELS?
VI THE GATING SPRING THEORY
VII HOW ARE THE CHANNELS ACTIVATED?
VIII TO BE OR NOT TO BE TETHERED
IX CHARACTERIZING CHANNEL PROPERTIES?
X MET CHANNEL PORE
XI ADAPTATION
XII THE DYNAMIC HAIR BUNDLE
XIII SUMMARY AND FUTURE DIRECTIONS
Acknowledgments
Chapter 13: Insights into the Pore of the Hair Cell Transducer Channel from Experiments with Permeant Blockers
Publisher Summary
I OVERVIEW
II INTRODUCTION
III IONIC SELECTIVITY OF THE TRANSDUCER CHANNEL
IV PERMEATION AND BLOCK OF MECHANORECEPTOR CHANNELS BY FM1-43
V PERMEATION AND BLOCK OF THE HAIR CELL TRANSDUCER CHANNEL BY AMINOGLYCOSIDE ANTIBIOTICS
VI TRANSDUCER CHANNEL BLOCK BY AMILORIDE AND ITS DERIVATIVES
VII CONCLUSIONS
Acknowledgments
Chapter 14: Models of Hair Cell Mechanotransduction
Publisher Summary
I OVERVIEW
II INTRODUCTION
III TRANSDUCTION CHANNEL PROPERTIES
IV GATING
V ACTIVE HAIR BUNDLE MOTILITY
VI CONCLUSIONS
Chapter 15: Touch
Publisher Summary
I OVERVIEW
II INTRODUCTION
III STRUCTURE OF SKIN AND TOUCH RECEPTORS
IV PHYSIOLOGY OF MECHANORECEPTIVE NERVE FIBERS
V QUANTITATING MECHANICAL RESPONSES IN ANIMAL MODELS
VI ELECTROPHYSIOLOGICAL APPROACHES TO MECHANOSENSATION IN RODENTS
VII MECHANOSENSITIVE ION CHANNELS IN CULTURED SENSORY NEURONS
VIII GATING MS ION CHANNELS IN DRG NEURONS
IX CANDIDATE ION CHANNELS
X VOLTAGE-GATED CHANNELS AND MECHANOSENSATION
XI INDIRECT SIGNALING BETWEEN SENSORY NEURONS AND NONNEURONAL CELLS
XII CONCLUSIONS
Acknowledgments
Chapter 16: Mechanosensitive Ion Channels in Dystrophic Muscle
Publisher Summary
I OVERVIEW
II INTRODUCTION
III MS CHANNEL EXPRESSION DURING MYOGENESIS
IV PERMEABILTY PROPERTIES OF MS CHANNELS IN SKELETAL MUSCLE
V GATING
VI PHARMACOLOGY
VII CONCLUSIONS
Chapter 17: MscCa Regulation of Tumor Cell Migration and Metastasis
Publisher Summary
I OVERVIEW
II INTRODUCTION
III DIFFERENT MODES OF MIGRATION
IV Ca2+ DEPENDENCE OF CELL MIGRATION
V THE ROLE OF MscCa IN CELL MIGRATION
VI CAN EXTRINSIC MECHANICAL FORCES ACTING ON MscCa SWITCH ON CELL MIGRATION?
Acknowledgments
Chapter 18: Stretch-Activated Conductances in Smooth Muscles
Publisher Summary
I OVERVIEW
II INTRODUCTION
III MECHANOSENSITIVE CONDUCTANCES THAT GENERATE INWARD CURRENTS
IV MECHANOSENSITIVE CONDUCTANCES THAT GENERATE OUTWARD CURRENTS
Chapter 19: Mechanosensitive Ion Channels in Blood Pressure-Sensing Baroreceptor Neurons
Publisher Summary
I OVERVIEW
II INTRODUCTION
III BR SENSORY TRANSDUCTION
IV MECHANOSENSITIVE CHANNELS IN BR NEURONS
V METHODOLOGICAL LIMITATIONS AND CHALLENGES
VI SUMMARY AND FUTURE DIRECTIONS
Acknowledgments
Index
No. of pages: 616
Language: English
Published: April 19, 2007
Imprint: Academic Press
Hardback ISBN: 9780121533595
eBook ISBN: 9780080494401
SS
Sidney A. Simon
Affiliations and expertise
Department of Neurobiology, Duke University Medical Center, Durham, NC, USA
DB
Dale J. Benos
Affiliations and expertise
Department of Physiology and Biophysics, University of Alabama, Birmingham, USA