Mechanisms of DNA Repair

Contributors

Preface

Chapter 1 Dynamics of Lesion Processing by Bacterial Nucleotide Excision Repair Proteins

I. Structural Insights of Bacterial Nucleotide Excision Repair

II. So Few DNA Repair Proteins, So Much DNA: Defining the Big Problem

III. Damage Searching by UvrA₂ and UvrA₂B₂

IV. Future Directions

Chapter 2 Transcription-Coupled DNA Repair in Prokaryotes

I. Introduction

II. Background: Genomic Heterogeneity in NER and the Discovery of TCR

III. The Role of RNA Polymerase in TCR

IV. The Role of Mfd in TCR

V. The Role of UvrA in TCR

VI. The Role of UvrB in TCR

VII. Other Examples of Transcription-Related DNA Damage Processing in Bacteria

VIII. Conclusions

Chapter 3 The Functions of MutL in Mismatch Repair

I. Overview of DNA Mismatch Repair

II. MutL is a Multidomain Protein

III. Architecture of the Endonuclease Domain

IV. Regulation of the Endonuclease Activity of MutL

V. Concluding Remarks

Chapter 4 The Fpg/Nei Family of DNA Glycosylases

I. Introduction

II. Fpg/Nei Phylogeny

III. Fpg/Nei Structures

IV. Glycosylases Search for Lesions

V. Concluding Remarks

Chapter 5 Regulation of Base Excision Repair in Eukaryotes by Dynamic Localization Strategies

I. Base Excision Repair

II. Dynamic Localization of BER Proteins

III. Hypotheses on the Orchestration of Dynamic Localization

Chapter 6 Oxidized Base Damage and Single-Strand Break Repair in Mammalian Genomes

I. Oxidative DNA Damage and Its Repair in Mammalian Cells

II. Complexity and Sub-pathways of BER/SSBR

III. Nonconserved Terminal Extensions in Mammalian Early BER Proteins

IV. Posttranslational Modifications in Early BER Proteins

V. BER/SSBR Deficiency in Human Diseases

VI. Conclusions and Future Perspectives

Chapter 7 Homologous Recombination in Eukaryotes

I. Meiosis

II. DSB Repair in Somatic Cells

III. RAD52 Epistasis Group

IV. Recombination Mediators

V. RAD51 Paralogs

VI. DSB Repair in Chromatin

VII. Postsynaptic Removal of RAD51

VIII. Second-End Capture

IX. dHJ Dissolution

X. Holliday Junction Resolution

XI. Homeologous Recombination: The Interplay Between Mismatch Repair and HR

XII. Conclusion

Chapter 8 Overview for the Histone Codes for DNA Repair

I. Histone Modifications of Homologous Recombination Repair

II. Histone Modifications of NHEJ

III. Histone Modifications of Nucleotide Excision Repair

IV. Histone Modifications of Base Excision Repair

V. DNA Mismatch Repair and Histone Modifications

Chapter 9 The RSC and INO80 Chromatin-Remodeling Complexes in DNA Double-Strand Break Repair

I. Introduction

II. RSC

III. INO80

IV. Perspectives

Chapter 10 Mechanistic Links Between ATM and Histone Methylation Codes During DNA Repair

I. The DNA Damage Response

II. Ataxia telangiectasia and the ATM Kinase

III. The Tip60 Acetyltransferase

IV. H3K9me3 and DDR

V. Conclusions and Implications for Cancer Therapy

Chapter 11 Exploiting Synthetic Lethal Interactions Between DNA Damage Signaling, Checkpoint Control, and p53 for Targeted Cancer Therapy

I. Introduction

II. The Concept of Synthetic Lethality in Cancer Therapy

III. Synthetic Lethality Between PARP1 and BRCA1/2 as a Model for Enhancing DNA Damage-Induced Cell Death

IV. Synthetic Lethality in the Context of p53 Mutations

V. Potential for Future Therapies

Index