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Management of Periprosthetic Joint Infections (PJIs)
1st Edition - October 25, 2016
Editors: J.J. Chris Arts, Jan Geurts
Hardback ISBN:9780081002056
9 7 8 - 0 - 0 8 - 1 0 0 2 0 5 - 6
eBook ISBN:9780081002421
9 7 8 - 0 - 0 8 - 1 0 0 2 4 2 - 1
Management of Periprosthetic Joint Infections (PJIs): Management of PJIs discusses periprosthetic joint infection (PJI), a fairly rare occurrence that is nonetheless one of the… Read more
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Management of Periprosthetic Joint Infections (PJIs): Management of PJIs discusses periprosthetic joint infection (PJI), a fairly rare occurrence that is nonetheless one of the most serious complications in joint replacement surgery. Intricate interactions between the pathogen, the host, and the implant can result in PJIs which are not only physically devastating for the patient, but also financially crippling for health authorities and insurance companies.
Actions taken to minimize the risk of PJIs can be extremely challenging for the orthopaedic community. Consequently, new research, which is detailed in this comprehensive book, is being undertaken to minimize and manage these challenging infections.
Provides essential background knowledge on the mechanisms and identification of PJIs
Dedicated chapters focus on the complex, but vital eccentricities between PJIs in different areas of the body
Contains contributions from a mixture of clinical and academic experts in the field, thus ensuring balanced coverage
Clinicians involved in the treatment of PJIs, Biomaterials scientists in academia and industry with an interest in anti-bacterial materials, Orthopaedic surgeons, Pathologists
List of contributors
Preface
Part One: Fundamentals of periprosthetic joint infections
1: Prevention of joint infections
Abstract
1.1 Introduction
1.2 Preoperative considerations
1.3 Prevention of infection in the perioperative period
1.4 Prevention of infection after arthroplasty
1.5 Conclusions and future trends
2: Biofilm formation and the biological response
Abstract
2.1 Introduction
2.2 Biofilm formation
2.3 Resistance to antimicrobial agents
2.4 Host response against biofilm
2.5 Clinical significance of biofilm
2.6 Therapeutic strategies against biofilm
2.7 Future trends
3: Biomaterials in treatment of orthopedic infections
5: Experimental models in orthopedic infection research
Abstract
5.1 Osteomyelitis
5.2 Prostheses, osteosynthesis, and infection
5.3 Treatment
5.4 Infection development and prevention
5.5 Experimental models for orthopedic infections
5.6 Scoring of orthopedic infections in experimental models—(semi) systemic parameters
5.7 Scoring of orthopedic infections in experimental models—imaging and histology
5.8 Concluding remarks
Part Two: Types of periprosthetic joint infections
6: Periprosthetic infection in the hip joint
Abstract
6.1 Introduction
6.2 Definition
6.3 Classification
6.4 Causative organisms
6.5 Diagnosis
6.6 Other new diagnostic tools
6.7 Management
6.8 Management of periprosthetic fracture in the presence of chronic PJI
6.9 The eradication of biofilm: Goals for the future
6.10 Conclusion
7: Infection in total knee arthroplasty
Abstract
7.1 Total knee arthroplasty today
7.2 Infection risks and prevention
7.3 Diagnosis
7.4 Chronic TKA infection
7.5 Management of the infected TKA
7.6 One-stage revision
7.7 Two-stage revision
7.8 Outcomes
7.9 Knee arthrodesis
7.10 Complications
8: Periprosthetic infection in shoulder and elbow joints
Abstract
8.1 Introduction
8.2 Clinical presentation
8.3 Diagnostic testing
8.4 Treatment and outcomes—Shoulder
8.5 Treatment and outcomes—Elbow
8.6 Conclusion and future directions
Part Three: Managing and treating periprosthetic joint infections
9: Practice and guidelines for treating periprosthetic joint infections: Single- and two-stage revision
Abstract
9.1 Introduction
9.2 Patient preparation, implant removal, and surgical debridement
9.3 Analysis of results
9.4 Conclusions and future trends
10: PMMA beads and spacers for local antibiotic administration
Abstract
10.1 History
10.2 Rationale and pharmacokinetics of antibiotic-loaded PMMA
10.3 Beads
10.4 Spacers
11: Pathogen-directed antibiotic therapy
Abstract
11.1 Introduction
11.2 Cultures and diagnosis
11.3 Prophylaxis and empirical therapy
11.4 The pathogens in PJI
11.5 The antibiotics
11.6 Pathogen-directed choice
11.7 Conclusion and areas for further research
Part Four: Case studies
12: Imaging of prosthetic joint infections
Abstract
12.1 Introduction
12.2 Conventional imaging
12.3 Nuclear imaging
12.4 Imaging in the assessment of PJI
Index
No. of pages: 304
Language: English
Published: October 25, 2016
Imprint: Woodhead Publishing
Hardback ISBN: 9780081002056
eBook ISBN: 9780081002421
JA
J.J. Chris Arts
Dr. J.J. Chris Arts is Associate Professor Translational Biomaterials Research Maastricht University Medical Center, the Netherlands and Lecturer and Scientist at Eindhoven University of Technology, the Netherlands. He is also Cofounder of European Society of Tissue Regeneration in Orthopaedics and Trauma, board member of Dutch Society for Biomaterials and Tissue Engineering, Dutch orthopedic Society Biotechnology workgroup and a reviewer for several orthopedic and biomaterials orientated peer-review journals.
Affiliations and expertise
Maastricht University, Eindhoven University and Twente University, The Netherlands
JG
Jan Geurts
Dr. J. A. P. Geurts is an Attending Orthopedic Surgeon, Adult Reconstruction Hip and Infection Unit, Maastricht University Medical Center, the Netherlands. He is also a Board Member of the Dutch Orthopaedic Society, Infection workgroup and a Reviewer for the Dutch Journal of Orthopaedics.
Affiliations and expertise
Maastricht University Medical Center, The Netherlands