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MacSween's Pathology of the Liver
- 8th Edition - November 14, 2022
- Authors: Alastair D. Burt, Linda D. Ferrell, Stefan G. Hübscher
- Language: English
- Hardback ISBN:9 7 8 - 0 - 7 0 2 0 - 8 2 2 8 - 3
- eBook ISBN:9 7 8 - 0 - 7 0 2 0 - 8 2 2 9 - 0
Written and edited by an international team of renowned authorities, MacSween's Pathology of the Liver, 8th Edition, remains the field’s definitive reference on liver pathology.… Read more
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Request a sales quoteWritten and edited by an international team of renowned authorities, MacSween's Pathology of the Liver, 8th Edition, remains the field’s definitive reference on liver pathology. This must-have text is ideal for surgical pathologists in practice and in training who examine liver specimens on a day-to-day basis. It provides invaluable assistance in recognizing the huge variety of appearances of the liver that result from infections, tumors, and tumor-like lesions, as well as organ damage caused by drugs and toxins. With expert, comprehensive coverage of all malignant and benign hepatobiliary disorders, MacSween’s is a convenient, one-stop resource for use in the reporting room as well as in personal study.
Shares the knowledge and experience of a “who’s who” list of experts in the field of hepatobiliary pathology, led by editors Alastair D. Burt, Linda D. Ferrell, and Stefan G. Hübscher.
Features more than 1,000 high-quality, full color illustrations, providing a complete visual guide to each tumor or tumor-like lesion.
Discusses advances in molecular diagnostic testing, its capabilities, and its limitations, including targeted/personalized medicine.
Incorporates the latest TNM staging and WHO classification systems, as well as new diagnostic biomarkers and their utility in differential diagnosis, newly described variants, and new histologic entities.
Includes relevant data from ancillary techniques (immunohistochemistry, cytogenetics, and molecular genetics), giving you the necessary tools required to master the latest breakthroughs in diagnostic technology.
Provides you with all of the necessary diagnostic tools to make a complete and accurate pathologic report, including clinicopathologic background throughout.
Directs you to the most recent and authoritative sources for further reading with a comprehensive reference list that highlights key articles and up-to-date citations.
An eBook version is included with purchase. The eBook allows you to access all of the text, figures and references, with the ability to search, customize your content, make notes and highlights, and have content read aloud.
General surgical pathologists in practice and in training
- Cover Image
- Title Page
- Copyright
- Dedication
- Contributors
- Table of Contents
- Chapter 1 Structure, Function and Responses to Injury
- Development of the liver
- Macroanatomy of the liver
- Microanatomy of the liver
- Cholangiocytes
- Fibrosis
- Vascular injury and remodelling
- Evolution of chronic liver diseases
- The liver in biopsy, surgical and autopsy specimens
- References
- Chapter 2 Cellular and Molecular Techniques
- Liver biopsy
- Routine handling, fixation and staining of liver specimens
- Immunohistochemistry
- Molecular techniques
- Other microscopic and optical techniques
- Digital pathology for deep learning approaches and daily practice
- References
- Chapter 3 Developmental and Inherited Liver Disease
- Diagnostic approach to histology
- Neonatal hepatitis
- Biliary atresia
- Paucity of intrahepatic bile ducts
- Bile duct anomalies, congenital bile duct dilations and ductal plate malformation disorders
- Cystic fibrosis
- Hereditary disorders of bile acid synthesis and bilirubin metabolism
- Disorders of porphyrin metabolism
- Disorders of carbohydrate metabolism and related conditions
- Disorders of glycoprotein and glycolipid metabolism
- Endoplasmic reticulum storage diseases
- Disorders of amino acid metabolism
- Disorders of lipoprotein and lipid metabolism
- Peroxisomal disorders
- Mitochondriopathies (mitochondrial cytopathies) and related conditions
- Disorders of copper metabolism
- Disorders of manganese metabolism
- Primary immunodeficiencies
- Histiocytic and haemophagocytic syndromes
- Miscellaneous disorders
- Anatomical anomalies
- References
- Chapter 4 Disorders of Iron Overload
- Iron metabolism and homeostasis
- Hereditary iron overload
- Miscellaneous iron overload
- Acquired/secondary iron overload
- The role of the liver biopsy in iron overload
- References
- Chapter 5 Fatty Liver Disease
- Spectrum of fatty liver disease
- Alcohol-related liver disease
- Pathology of alcohol-related liver disease
- Diagnosis and prognosis of alcohol-related liver disease: role of liver biopsy
- Treatment of alcohol-related liver disease and histopathological features of resolution
- Nonalcoholic fatty liver disease
- Pathology of nonalcoholic fatty liver disease
- Differential diagnosis of nonalcoholic fatty liver disease
- Nonalcoholic fatty liver and nonalcoholic steatohepatitis concurrent with other liver disease
- Histopathological features of prognostic significance
- Nonalcoholic fatty liver and nonalcoholic steatohepatitis in other clinical settings
- Treatment of nonalcoholic fatty liver disease
- References
- Chapter 6 Hepatitis Due to Hepatotropic Viruses
- Acute viral hepatitis
- Chronic viral hepatitis
- Individual types of viral hepatitis
- References
- Chapter 7 Non-Hepatotropic Viral, Bacterial and Parasitic Infections of the Liver
- RNA viral infections
- DNA viral infections
- Rickettsial and chlamydial infections
- Bacterial infections
- Mycobacterial infections
- Mycotic infections
- Protozoal infections
- Helminth infections
- HIV infection and AIDS
- References
- Chapter 8 Autoimmune Hepatitis
- Definition
- Epidemiology
- Demographic features
- Pathogenesis
- Clinical features
- Diagnosis
- Classification
- Histopathology
- Variant forms of cholestatic liver disease (‘overlap syndromes’)
- Diagnostic difficulties
- Treatment
- Role of liver biopsy
- References
- Chapter 9 Bile Duct Diseases
- Normal morphology
- Biliary epithelial injury
- Classification of cholangiopathy and cholangitis
- Immunological features of biliary diseases
- Pathological features secondary to impaired bile flow
- Diseases primarily affecting intrahepatic bile ducts
- Diseases affecting extrahepatic and intrahepatic biliary tree
- Diseases primarily affecting extrahepatic bile ducts
- Pathology of the peribiliary glands
- References
- Chapter 10 Diseases of the Gallbladder
- Normal gallbladder
- Routine specimen processing
- Congenital anomalies
- Gallstones
- Cholecystitis
- Other inflammatory diseases of the gallbladder
- Diverticular disease
- Ischaemia and infarction
- Non-neoplastic mucosal alterations
- Non-neoplastic tumour-like lesions
- Preinvasive epithelial neoplasia
- Malignant neoplasms
- Acknowledgment
- References
- Chapter 11 Vascular Disorders
- Portal vein lesions
- Hepatic artery-related lesions
- Sinusoidal lesions
- Hepatic vein lesions
- Paediatric and developmental vascular lesions
- Nodular hyperplastic lesions
- Vascular lesions in cirrhosis
- References
- Chapter 12 Hepatic Injury due to Drugs, Dietary and Herbal Supplements, Chemicals and Toxins
- Importance of drug-induced hepatic injury
- Clinico-pathological-mechanistic classification of hepatotoxic agents
- The morphological patterns of toxic hepatic injury
- Clinical presentations and outcomes
- Chemicals and environmental agents causing hepatic injury
- Trinitrotoluene and other nitroaromatic and nitroaliphatic compounds
- Hepatotoxic herbal remedies, dietary supplements and weight loss products
- Liver disease due to medicinal agents
- Diagnostic considerations in causality assessment of drug-induced liver injury
- Treatment and prevention of drug-induced liver injury
- References
- Chapter 13 Tumours and Tumour-Like Lesions
- Diagnostic approach: morphological patterns
- Benign hepatocellular tumours and tumour-like lesions
- Malignant hepatocellular tumours and precursor lesions
- Biliary tumours and tumour-like lesions
- Vascular tumours
- Nonvascular mesenchymal tumours and tumour-like lesions
- Other tumours and tumour-like lesions
- Leukaemia and myeloproliferative disease
- Lymphomas and lymphoreticular neoplasms
- Metastatic tumours
- References
- Chapter 14 Transplantation Pathology
- General aspects of liver transplantation
- Examination of native hepatectomy specimens
- Pathological changes in post-reperfusion biopsies of donor liver and bile duct and preservation/reperfusion injury
- Liver allograft rejection
- Infections
- Vascular disorders
- Biliary complications
- Disease recurrence
- De novo disease
- Other histological findings in post-transplant biopsies
- Drug toxicity in liver allograft recipients
- Liver disease after haematopoietic cell (bone marrow and peripheral stem cell) transplantation
- References
- Chapter 15 Liver in Systemic Disease
- Introduction
- Nonspecific reactive hepatitis
- Space-occupying lesions in the liver
- Hepatic granulomas
- Nutritional liver disease
- The liver in gastrointestinal diseases
- The liver in pancreatic diseases
- The liver in endocrine diseases
- The liver in pregnancy
- The liver in haematological diseases
- The liver in connective tissue and joint diseases
- The liver in renal diseases
- The liver in amyloidosis and monoclonal immunoglobulin deposition disease
- The liver in cardiovascular diseases
- The liver and lung disease
- Miscellaneous liver involvement in other diseases
- References
- Index
- No. of pages: 1134
- Language: English
- Edition: 8
- Published: November 14, 2022
- Imprint: Elsevier
- Hardback ISBN: 9780702082283
- eBook ISBN: 9780702082290
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Alastair D. Burt
Professor Alastair Burt has a long-standing interest in the pathogenesis of liver fibrosis. This is an important part of progressive liver disease and an essential component for the development of cirrhosis. He played a pivotal role in establishing the principal cell type involved in fibrogenesis is the hepatic stellate cell and was the first to characterise their cell kinetics in the response to injury establishing that there is not only proliferation of these cells in response to necrosis but a phenotypic modulation to myofibroblast-like cell
Affiliations and expertise
Professor of Precision and Molecular Pathology, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK; Emeritus Professor Faculty of Health and Medical Sciences, University of Adelaide, AustraliaLF
Linda D. Ferrell
Linda Ferrell, M.D. is a liver pathologist, Professor of Pathology, Vice Chair of Clinical Services, and Director of Surgical Pathology at UCSF. She specializes in the diagnosis of liver disorders such as: benign liver tumors, cirrhosis, hepatitis B, hepatitis C, hepatocellular carcinoma, vascular lesions, metastastic cancer to the liver, liver transplantation, nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH).
Affiliations and expertise
Emerita Professor, Anatomic Pathology, University of California San Francisco, San Francisco, CA, USASH
Stefan G. Hübscher
Professor Stefan G Hubscher graduated from Birmingham University in 1979 and has worked and trained there ever since. While his main clinical work has been in liver pathology, he also has strong interests in hepatic, biliary and pancreatic malignancy.
Affiliations and expertise
Emeritus Professor of Hepatic Pathology, University of Birmingham, Birmingham, UK