Lyme Disease and the Expanded Spectrum of Blacklegged Tick-Borne Infections, An Issue of Infectious Disease Clinics of North America

1st Edition, Volume 36-3 - September 20, 2022
Editor: Robert P. Smith
Language: English
Hardback ISBN:
9 7 8 - 0 - 3 2 3 - 9 7 2 9 2 - 5
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 9 7 2 9 3 - 2

In this issue of Infectious Disease Clinics of North America, guest editor Dr. Robert P. Smith brings his considerable expertise to the topic of Lyme Disease and the Expanding… Read more

Lyme Disease and the Expanded Spectrum of Blacklegged Tick-Borne Infections, An Issue of Infectious Disease Clinics of North America

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In this issue of Infectious Disease Clinics of North America, guest editor Dr. Robert P. Smith brings his considerable expertise to the topic of Lyme Disease and the Expanding Spectrum of Associated Tick-Borne Illness. With a primary focus on Lyme disease and its complications, the thorough reviews in this issue will also discuss the epidemiology, clinical presentations, diagnosis, treatment and outcomes of other infections transmitted by the black-legged tick in North America. The complexity of the public narrative of these diseases will also be addressed with an eye toward providing the clinician with a context for response.

Cover image
Title page
Table of Contents
Copyright
Contributors
Forthcoming Issues
Preface
Epidemiology of Lyme Disease
Key points
Introduction
Discussion
Clinics care points
Disclaimer
Early Lyme Disease (Erythema Migrans) and Its Mimics (Southern Tick-Associated Rash Illness and Tick-Associated Rash Illness)
Key points
History
Definition
Frequency
Tick bite
Cause
Histologic findings
Pathogenesis
Clinical characteristics
Reinfection
Diagnosis
Differential diagnosis
Coinfections
Treatment
Outcome
Summary
Clinics care points
Early Disseminated Lyme Disease: Cranial Neuropathy, Meningitis, and Polyradiculopathy
Key points
Background
Clinical presentation
Case 1
Case 2
Case 3
Diagnostic approach, clinical, laboratory, and imaging
Summary
Clinics care points
Cardiac Manifestations of Lyme Disease
Key points
Introduction
Pathophysiology
Epidemiology and risk factors
Clinical presentation
Atypical and rare presentations
Evaluation and diagnostics
Other diagnostics
Differential diagnosis
Treatment
Discussion
Summary
Clinics care points
Lyme Arthritis
Key points
Introduction
Clinical presentation
Physical examination
Imaging and additional testing
Summary
Clinics care points
Nervous System Lyme Disease–Facts and Fallacies
Key points
Requirement #1: nervous system disease
Requirement #2: Lyme disease involving the nervous system
Requirement #3: causal relationship between Lyme disease and the neurologic process
Summary
Clinics care points
Lyme Disease in Children
Key points
Introduction
Epidemiology
Clinical manifestations
Diagnostics
Treatment
Prevention
Coinfections
Summary
Clinics care points
Diagnostic Testing for Lyme Disease
Key points
Background
The standardized 2-tiered serology test: standard 2-tier testing
The modified 2-tiered serology test: modified 2-tiered testing
Common issues with serologic testing
Culture
Molecular techniques
Cerebrospinal fluid analytics
Investigational tests
Summary
Clinics care points
Disclosure
Persistent Symptoms After Treatment of Lyme Disease
Key points
Chronic Lyme disease and posttreatment Lyme disease
Posttreatment Lyme disease symptoms and syndrome
Summary
Clinics care points
Disclosures
Human Granulocytic Anaplasmosis
Key points
Introduction
Background
Vector-borne transmission
Blood transfusion and organ transplant–related transmission
Epidemiology
Human infection
Symptoms
Physical examination
Evaluation
Outcomes
Complications
Treatment
Prevention
Summary
Clinics care points
Human Babesiosis
Key points
Introduction
Pathogens
Transmission
Epidemiology
Pathogenesis
Clinical manifestations
Diagnosis
Treatment
Summary
Clinics care points
Powassan Virus Encephalitis
Key points
Introduction
Ecology
Epidemiology
Tick identification and skin pathology
Clinical evaluation
Imaging
Diagnostic approach
Neuropathology
Therapeutic options and clinical outcomes
Discussion
Clinics care points
When to Think About Other Borreliae:: Hard Tick Relapsing Fever (Borrelia miyamotoi), Borrelia mayonii, and Beyond
Key points
Introduction
Etiology, Ecology, and Epidemiology
Clinical presentation
Evaluation
Therapeutic options
Other Borrelia species
Prevention
Discussion
Disclosures
The Role of the Infectious Disease Consultation in Lyme Disease
Key points
Introduction
Background
Components of the consultation
Initial prognosis
Validation
Misdiagnosis and misattribution
Expectations
Consensus
Diagnostic uncertainty and management
Hope
The Fringe
Case—“chronic lyme disease?”
Case discussion
Role as an educator
Final thoughts
Disclosures

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Lyme Disease and the Expanded Spectrum of Blacklegged Tick-Borne Infections, An Issue of Infectious Disease Clinics of North America

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Immediately download your ebook while waiting for your print delivery. No promo code needed.

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Robert P. Smith