Lupus, An Issue of Rheumatic Disease Clinics of North America
- 1st Edition, Volume 47-3 - July 6, 2021
- Imprint: Elsevier
- Editors: Zahi Touma, Alfred Kim
- Language: English
- Hardback ISBN:9 7 8 - 0 - 3 2 3 - 8 3 5 5 6 - 5
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 8 3 5 5 7 - 2
This issue of Rheumatic Disease Clinics, guest edited by Dr. Alfred Kim and Zahi Touma, will discuss a number of key topics surrounding Lupus. This issue is one of four selected… Read more
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Request a sales quoteThis issue of Rheumatic Disease Clinics, guest edited by Dr. Alfred Kim and Zahi Touma, will discuss a number of key topics surrounding Lupus. This issue is one of four selected each year by series Consulting Editor, Dr. Michael Weisman. Topics discussed in this issue include, but are not limited to: Interferons in SLE, NETosis and neutrophils in SLE, AMP update in lupus nephritis, Patient-reported outcomes, Complement, T cells in SLE, B cells in SLE, Outcome measures for SLE clinical trials, Mitochondrial physiology in SLE, Pregnancy, Lupus cohorts, Innovative trials and new opportunities in SLE, Classification and diagnosis of SLE, and Updates on SLE Treatment.
- Cover image
- Title page
- Table of Contents
- Copyright
- Contributors
- Forthcoming Issues
- Foreword
- Preface
- Interferons in Systemic Lupus Erythematosus
- Key points
- Introduction
- Discussion
- Summary
- Clinics care points
- Disclosure
- Neutrophil Dysregulation in the Pathogenesis of Systemic Lupus Erythematosus
- Key points
- Introduction
- Summary
- The Power of Systems Biology: Insights on Lupus Nephritis from the Accelerating Medicines Partnership
- Key points
- Introduction
- Single-cell analysis of kidney in lupus nephritis
- Urine as a surrogate tissue
- Peripheral blood cell analyses
- Computational developments
- Anticipating the potential of phase 2
- Summary
- Clinics care points
- Patient-Reported Outcomes in Lupus
- Key points
- Introduction
- Patient-reported outcomes to evaluate impact of systemic lupus erythematosus on patient life
- Patient-reported outcome tools to evaluate disease severity in systemic lupus erythematosus
- Discussion
- Clinics care points
- T Cells in Systemic Lupus Erythematosus
- Key points
- Introduction
- Overview of T cells and T-helper subsets, and evidence of T-cell dysfunction in systemic lupus erythematosus
- T-cell metabolism in systemic lupus erythematosus
- Genetics and epigenetics of T cells contributing to systemic lupus erythematosus
- T-cell biomarkers and therapeutics in development
- Summary
- Clinics care points
- B Cells in Systemic Lupus Erythematosus: From Disease Mechanisms to Targeted Therapies
- Key points
- Mechanisms underpinning B cell tolerance breaks in systemic lupus erythematosus
- B cell effector functions in systemic lupus erythematosus
- B cell–targeted therapies for human lupus
- Summary
- Clinics care points
- Systemic Lupus Erythematosus Outcome Measures for Systemic Lupus Erythematosus Clinical Trials
- Key points
- Introduction
- Primary endpoints in systemic lupus erythematosus randomized controlled trials
- Organ-specific outcome measures
- Treat to target endpoints: the Lupus Low Disease Activity State
- Summary and future work
- Clinics care points
- Abnormal Mitochondrial Physiology in the Pathogenesis of Systemic Lupus Erythematosus
- Key points
- Introduction
- The role of mitochondria in energy metabolism in health
- Abnormal mitochondrial bioenergetics in systemic lupus erythematosus
- Mitochondrial oxidative stress in the pathogenesis of systemic lupus erythematosus
- Impaired mitochondrial repair in systemic lupus erythematous
- Targeting mitochondria in the treatment of systemic lupus erythematosus
- Summary
- Clinics care points
- Management of Pregnancy in Lupus
- Key points
- Introduction
- Peripartum risk
- Fetal and neonatal complications
- Management and risk factor mitigation
- Summary
- Clinics care points
- Lupus Cohorts
- Key points
- Types of cohorts
- International cohorts
- National cohorts
- Institutional
- Pediatric lupus cohorts
- Clinics care points
- Innovative Trials and New Opportunities in SLE
- Key points
- Introduction
- Discussion
- Summary
- Clinics care points
- Disclosure
- Systemic Lupus Erythematosus Classification and Diagnosis
- Key points
- Performance characteristics
- When do you consider systemic lupus erythematosus?
- Antinuclear antibodies
- The European League against Rheumatism/American College of Rheumatology criteria rules
- Systemic lupus erythematosus organ and serologic manifestations
- Summary
- Clinics care points
- Treatment Update in Systemic Lupus Erythematous
- Key points
- Introduction
- Update on specific pharmacotherapies
- Glucocorticoids
- Antimalarials
- Immunosuppressants
- Biologics and targeted therapies
- Combination or sequential therapy
- Summary/future directions
- Clinics care points
- Disclosure
- Edition: 1
- Volume: 47-3
- Published: July 6, 2021
- Imprint: Elsevier
- No. of pages: 240
- Language: English
- Hardback ISBN: 9780323835565
- eBook ISBN: 9780323835572
ZT
Zahi Touma
Affiliations and expertise
Assistant Professor of Medicine, University of Toronto; Clinician Scientist, Krembil Research Institute
Toronto, Ontario, Canada