Lung Transplantation, An Issue of Thoracic Surgery Clinics

1st Edition, Volume 32-2 - May 6, 2022
Editors: Jasleen Kukreja, Aida Venado
Language: English
Hardback ISBN:
9 7 8 - 0 - 3 2 3 - 8 9 7 6 8 - 6
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 8 9 7 6 9 - 3

In this issue of Thoracic Surgery Clinics, guest editors Drs. Jasleen Kukreja and Aida Venado bring their considerable expertise to the topic of Lung Transplantation. Top experts… Read more

Lung Transplantation, An Issue of Thoracic Surgery Clinics

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In this issue of Thoracic Surgery Clinics, guest editors Drs. Jasleen Kukreja and Aida Venado bring their considerable expertise to the topic of Lung Transplantation. Top experts in the field cover key topics such as inpatient management of the acutely decompensating lung transplant candidate, lung allograft rejection, management of the potential lung donor, postoperative management of lung transplant recipients, and more.

Cover image
Title page
Table of Contents
Copyright
Contributors
Forthcoming Issues
Foreword
Preface
Outpatient Pharmacologic Management of Lung Transplant Candidates on the Waiting List
Key points
Introduction
Antifibrotics
Mechanistic target of rapamycin inhibitors
Cystic fibrosis transmembrane conductance regulator modulators
Pulmonary vasodilators
Anticoagulants
Discussion
Disclosure
Clinics care points
Inpatient Management of the Acutely Decompensating Lung Transplant Candidate
Key points
Introduction
The impact of disease severity on outcomes after lung transplantation
Medical management of acutely decompensating lung transplant candidates
Bridge to transplantation
Rehabilitation during acute decompensation
Triggers for delisting
Summary
Clinics care points
Lung Transplantation for Acute Respiratory Distress Syndrome
Key points
Introduction
Summary
Clinics care points
Disclosure
Management of the Potential Lung Donor
Key points
Introduction
Ventilatory management and blood gas exchange
Fluid management
Cause of death and its implications
Bronchoscopy
Thoracic radiographic imaging
Microbiological culture results and antibiotics
Effect of blood transfusion in donor lung management
Coronavirus disease 2019 screening guidelines
Summary
Future directions
Clinics care points
Donation After Circulatory Death in lung transplantation
Key points
Introduction
Categories of DCD donation
Evaluation of the DCD donor
Tolerated warm ischemia
WLST, including comfort therapy, in controlled DCD
Surgical technique for DCD lung recovery
Role of postmortem pretransplant evaluation of lung quality
Outcomes of DCD LTx
Barriers to DCD LTx
Summary
Clinics care points
Disclosure
Centralized Organ Recovery and Reconditioning Centers
Key points
Introduction
Comparison of organ recovery models
Impact on surgeon burnout
Ex vivo lung perfusion resuscitation facilities
Discussion
Summary
Anesthetic Management During Lung Transplantation – What’s New in 2021?
Key points
Introduction
Key concepts of intraoperative allograft and extrapulmonay end-organ protection
Maintenance of hemodynamic stability during key intraoperative periods
Key concepts of mechanical circulatory support during lung transplantation
Summary
Early Postoperative Management of Lung Transplant Recipients
Key points
Introduction
Patient selection
Intraoperative management
Postoperative management of hemodynamics
Sedation and pain management
Management of graft function
Immunosuppression
Management of infection
Management of other medical complications
Summary
Surgical Complications of Lung Transplantation
Key points
Introduction
Wound complications
Primary graft dysfunction
Airway ischemia
Vascular complications
Bleeding complications
Pleural space complications
Challenges in matching donor and recipient size
Retransplantation
Summary
Clinics care points
Infectious Complications in Lung Transplant Recipients
Key points
Introduction
Antimicrobial prophylaxis
Donor-derived infection
Management of bacterial infections
Infectious risks over time
Management of viral infections
Management of fungal infections
Mycoplasma hominis and ureaplasma urealyticum infections
Summary
Clinics care points
Lung Allograft Rejection
Key points
Introduction
Acute cellular rejection
Antibody-mediated rejection
Summary
Clinics care points
Chronic Lung Allograft Dysfunction
Key points
CLAD definitions
CLAD pathophysiology
Treatment of CLAD
Controversies
Summary
Nonallograft Complications of Lung Transplantation
Key points
Introduction
Summary
Clinics care points
Disclosure
Lung Retransplantation
Key points
Background
Indications for lung retransplantation
Patient evaluation and selection for lung retransplantation
Immunologic aspects of lung retransplantation
Surgical techniques
Postoperative management and other important considerations
Long-term results
Summary
Clinics care points
Disclosure