Lung Transplantation, An Issue of Clinics in Chest Medicine

1st Edition, Volume 44-1 - February 13, 2023
Editors: Luis Angel, Stephanie M. Levine
Language: English
Hardback ISBN:
9 7 8 - 0 - 3 2 3 - 9 6 0 7 1 - 7
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 9 6 0 7 2 - 4

In this issue of Clinics in Chest Medicine, guest editors Drs. Luis Angel and Stephanie M. Levine bring their considerable expertise to the topic of Lung Transplantation. Top… Read more

Lung Transplantation, An Issue of Clinics in Chest Medicine

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In this issue of Clinics in Chest Medicine, guest editors Drs. Luis Angel and Stephanie M. Levine bring their considerable expertise to the topic of Lung Transplantation. Top experts in the field cover key topics such as difficult decisions to transplant patients who are older, frail, underweight and obese; organ donation and variability in conversion to lung transplantation; conventional and novel approaches to immunosuppression; acute rejection and chronic allograft dysfunction; and more.

Cover image
Title page
Table of Contents
Copyright
Contributors
Forthcoming Issues
Preface
History of Lung Transplantation
Key points
Introduction
Early experience: the 1960s to 1970s
Beginning of successful lung transplantation: the 1980s
Expansion of lung transplant: the 1990s
Improvements in allocation and guidelines: the 2000s
The current era: the 2010s onward
Summary
Disclosures
The Lung Transplant Candidate, Indications, Timing, and Selection Criteria
Key points
Introduction
Demographics and overview of lung transplant candidacy
Disease-specific indications and timing
Evaluation process
Selection criteria
Special considerations
The role of the referring pulmonologist
Summary
Clinics care points
Disclosure
Listing Dilemmas: Age, Frailty, Weight, Preexisting Cancers, and Systemic Diseases
Key points
Introduction
Summary
Clinics care points
Disclosure
Lung Transplant Procedure of Choice: Bilateral Transplantation Versus Single Transplantation Complications, Quality of Life, and Survival
Introduction
Disease-specific indications for lung transplantation
Interstitial lung diseases
Beyond survival: posttransplant functional status and procedure type
Posttransplantation quality of life outcomes
Associations between procedure type, chronic rejection and other common complications
Ethical and population-based considerations
The native lung: potential complications and risk of cancer
Summary
The Past, Present, and Near Future of Lung Allocation in the United States
Key points
Introduction
Summary
Clinics care points
Funding source
Organ Donation, the Non-Perfect Lung Donor, and Variability in Conversion to Transplant
Key points
Introduction
Organ donation
Factors affecting organ donation
Donor management
Organ utilization
Conclusion
Clinics care points
Expanding the Lung Donor Pool: Donation After Circulatory Death, Ex-Vivo Lung Perfusion and Hepatitis C Donors
Key points
Introduction
Summary
Disclosure
The Highly Sensitized Recipient: Pretransplant and Posttransplant Considerations
Key points
Introduction
Transplanting the highly sensitized patient
Future directions
Summary
Disclosure
Clinics care points
Antibody-Mediated Rejection: Diagnosis and Treatment
Key points
Introduction
Summary
Clinics care points
Critical Care Management of the Lung Transplant Recipient
Key points
Introduction
Summary
Clinics care points
Disclosures
Conventional and Novel Approaches to Immunosuppression in Lung Transplantation
Key points
Introduction
History of immunosuppression
Allorecognition pathways and effector mechanisms
Induction immunosuppression
Maintenance immunosuppression
Adjunctive therapies
Immunosuppression monitoring
Tailoring immunosuppression for recipient factors
Infectious considerations
Renal considerations
Future frontiers in lung transplant immunosuppression
Summary
Clinics care points
Disclosure
Conflict of interest statement
Acute Rejection and Chronic Lung Allograft Dysfunction: Obstructive and Restrictive Allograft Dysfunction
Key points
Introduction
Acute cellular rejection
Chronic lung allograft dysfunction
Summary
Clinics care points
Funding
Appendix. Grading and Analyzing ACR: Toward a New Paradigm
Opportunistic Infections Post-Lung Transplantation: Viral, Fungal, and Mycobacterial
Key points
Introduction
Infection screening and prevention
Viruses
Fungal infections
Mycobacterial infections
Summary
Clinics care points
Disclosure
Common Noninfectious Complications Following Lung Transplantation
Key points
Thoracic complications following lung transplantation
Extrathoracic complications in lung transplantation
Posttransplant lymphoproliferative disorder
Summary
Clinics care points
Disclosures
Lung Transplantation for Coronavirus Disease-2019 Patients and Coronavirus Disease-2019 in Lung Transplant Recipients
Key points
Background
Selection of candidates for lung transplantation
Intraoperative considerations during transplant
Postoperative care of the transplanted patients
Prevention and Specific Post Exposure Prophylaxis
Treatment for Post Lung Transplant Patients with COVID 19 not requiring hospitalization
Treatment for Post Lung Transplant Patients with COVID 19 requiring hospitalization
Clinics care points
Disclosure
Future of Lung Transplantation: Xenotransplantation and Bioengineering Lungs
Key points
Background
Porcine cytomegalovirus
Clinics care points
Disclosure