Long’s Principles and Practice of Pediatric Infectious Diseases
- 7th Edition - October 22, 2026
- Latest edition
- Editors: David Kimberlin, Grace Aldrovandi, Adam Ratner, Jose R. Romero
- Language: English
Through six outstanding editions, Principles and Practice of Pediatric Infectious Diseases has been a highly regarded, go-to resource for authoritative information on infectious di… Read more
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Description
Description
Through six outstanding editions, Principles and Practice of Pediatric Infectious Diseases has been a highly regarded, go-to resource for authoritative information on infectious diseases in children and adolescents. In this fully revised 7th Edition, new editor-in-chief Dr. David Kimberlin leads a team of outstanding new editors, Drs. Grace M. Aldrovandi, Adam J. Ratner, and José R. Romero, who bring fresh perspectives to this fast-changing field. A veritable "who's who" of global authorities have contributed nearly 300 practical, comprehensive chapters to this concise, easy to manage, and richly illustrated text.
Key features
Key features
- Features an easy-access format with high-yield information boxes, highlighted key points, and an abundance of detailed illustrations and at-a-glance tables
- Allows quick look-up by clinical presentation, pathogen, or type of host; utilizes uniform headings, tone, and style throughout, with strategic keywords to improve discoverability and navigation; and provides integrated cross-references to help you move seamlessly between related chapters
- Provides new content on conditions that mimic infectious diseases, such as hemophagocytic lymphohistiocytosis, macrophage activation syndrome, multisystem inflammatory syndrome in children, and Kawasaki disease
- Expands coverage of new morbidities and evidence-based strategies to prevent healthcare-associated infections
- Highlights new vaccines recently approved or currently in development
- Contains updated insights on the evolving spectrum of illness from SARS-CoV-2 and Zika viruses
- Offers a deeper look at intrauterine infection as part of the approach to neonates with suspected infection
- An invaluable reference for ID specialists, pediatricians, and pediatric and ID residents; trainees, clinicians, microbiologists, and researchers in fields related to neonates, children, or adolescents; and hospital infection control officers and related policy-making groups
- An eBook version is included with purchase. The eBook allows you to access all of the text, figures, and references, with the ability to search, make notes and highlights, and have content read aloud. Additional digital ancillary content may publish after the publication date
Readership
Readership
Advanced/subspecialty text intended for pediatric ID specialists, general ID specialists, pediatricians, pediatric and ID residents
Table of contents
Table of contents
PART I UNDERSTANDING, CONTROLLING, AND PREVENTING INFECTIOUS DISEASES
SECTION A. EPIDEMIOLOGY AND CONTROL OF INFECTIOUS DISEASES
1. Principles of Epidemiology and Public Health
2. Pediatric Healthcare Epidemiology, Infection Prevention, and Antimicrobial Stewardship
3. Infections Associated With Group Childcare
4. Infectious Diseases in Refugee and Internationally Adopted Children
SECTION B. PREVENTION OF INFECTIOUS DISEASES
5. Passive Immunization
6. Active Immunization
7. Antimicrobial Chemoprophylaxis
8. Protection of Travelers
SECTION C. HOST DEFENSES AGAINST INFECTIOUS DISEASES
9. Immunologic Development and Susceptibility to Infection
10. Fever and the Inflammatory Response
PART II CLINICAL SYNDROMES AND CARDINAL FEATURES OF INFECTIOUS DISEASES: APPROACH TO DIAGNOSIS AND INITIAL MANAGEMENT
SECTION A. SEPTICEMIA AND TOXIN- AND INFLAMMATION-MEDIATED SYNDROMES
11. Sepsis and Septic Shock
12. Hemophagocytic Lymphohistiocytosis and Macrophage Activation Syndrome
SECTION B. CARDINAL SYMPTOM COMPLEXES
13. Mucocutaneous Symptom Complexes
14. Fever Without Localizing Signs
15. Prolonged, Recurrent, and Periodic Fever Syndromes
16. Lymphatic System and Generalized Lymphadenopathy
17. Cervical Lymphadenitis and Neck Infections
18. Mediastinal and Hilar Lymphadenopathy
19. Abdominal and Retroperitoneal Lymphadenopathy
20. Localized Lymphadenitis, Lymphadenopathy, and Lymphangitis
21. Respiratory Tract Symptom Complexes
22. Abdominal Symptom Complexes
23. Neurologic Syndromes
24. Musculoskeletal Symptom Complexes
SECTION C. ORAL INFECTIONS AND UPPER AND MIDDLE RESPIRATORY TRACT INFECTIONS
25. Infections of the Oral Cavity
26. The Common Cold
27. Pharyngitis
28. Infections Related to the Upper and Middle Airways
29. Otitis Media
30. Otitis Externa and Necrotizing Otitis Externa
31. Mastoiditis
32. Sinusitis
SECTION D. LOWER RESPIRATORY TRACT INFECTIONS
33. Bronchiolitis
34. Acute Pneumonia and Its Complications
35. Persistent and Recurrent Pneumonia
36. Pneumonia in the Immunocompromised Host
SECTION E. CARDIAC AND VASCULAR INFECTIONS
37. Endocarditis and Other Intravascular Infections
38. Myocarditis
39. Pericarditis
SECTION F. CENTRAL NERVOUS SYSTEM INFECTIONS
40. Acute Bacterial Meningitis Beyond the Neonatal Period
41. Chronic Meningitis
42. Recurrent Meningitis
43. Aseptic and Viral Meningitis
44. Encephalitis
45. Parainfectious and Postinfectious Neurologic Syndromes
46. Focal Suppurative Infections of the Nervous System
47. Eosinophilic Meningitis
SECTION G. GENITOURINARY TRACT INFECTIONS
48. Urinary Tract Infections, Renal Abscess, and Other Complex Renal Infections
49. Sexually Transmitted Infection Syndromes
50. Genitourinary Skin Mucous Membrane Infections and Inguinal Lymphadenopathy
51. Urethritis, Vulvovaginitis, and Cervicitis
52. Pelvic Inflammatory Disease
53. Epididymitis, Orchitis, and Prostatitis
54. Infectious Diseases Associated With Child Abuse
SECTION H. GASTROINTESTINAL AND TRACT INFECTIONS AND INTOXICATIONS
55. Approach to the Diagnosis and Management of Gastrointestinal Tract Infections
56. Viral Gastroenteritis
57. Inflammatory Enterocolitis
58. Enteric Diseases Transmitted Through Food, Water, and Animal Contact Exposures
SECTION I. INTRAABDOMINAL INFECTIONS
59. Acute Hepatitis
60. Chronic Hepatitis
61. Granulomatous Hepatitis
62. Acute Pancreatitis
63. Cholecystitis and Cholangitis
64. Peritonitis
65. Appendicitis
66. Intraabdominal, Visceral, and Retroperitoneal Abscesses
SECTION J. SKIN AND SOFT-TISSUE INFECTIONS
67. Superficial Bacterial Skin Infections and Cellulitis
68. Erythematous Macules and Papules
69. Vesicles and Bullae
70. Purpura
71. Urticaria and Erythema Multiforme
72. Papules, Nodules, and Ulcers
73. Subcutaneous Tissue Infections and Abscesses
74. Myositis, Pyomyositis, and Necrotizing Fasciitis
SECTION K. BONE AND JOINT INFECTIONS
75. Osteomyelitis
76. Infectious and Inflammatory Arthritis
77. Discitis
78. Transient Synovitis
SECTION L. EYE INFECTIONS
79. Conjunctivitis in the Neonatal Period (Ophthalmia Neonatorum)
80. Conjunctivitis Beyond the Neonatal Period
81. Infective Keratitis
82. Infective Uveitis, Retinitis, and Chorioretinitis
83. Endophthalmitis
84. Preseptal and Orbital Infections
SECTION M. INFECTIONS RELATED TO TRAUMA, ANIMALS, AND TICKS
85. Infection Related to Trauma
86. Infections Related to Burns
87. Infection Related to Bites
88. Infections Related to Pets and Exotic Animals
89. Tickborne Infections
SECTION N. INFECTIONS OF THE FETUS AND NEWBORN
90. Clinical Approach to the Neonate With Suspected Infection
91. Bacterial Infections in the Neonate
92. Viral Infections in the Fetus and Neonate
93. Healthcare-Associated Infections in the Neonate
SECTION O. INFECTIONS AND TRANSPLANTATION
94. Infections in Solid-Organ Transplant Recipients
95. Infections in Hematopoietic Cell Transplant Recipients
SECTION P. INFECTIONS AND CANCER
96. Risk Factors and Infectious Agents in Children With Cancer: Fever and Neutropenia
97. Clinical Syndromes of Infection in Children With Cancer
SECTION Q. INFECTIONS ASSOCIATED WITH HOSPITALIZATION AND MEDICAL DEVICES
98. Healthcare-Associated Infections
99. Clinical Syndromes of Device-Associated Infections
SECTION R. INFECTIONS IN PATIENTS WITH DEFICIENT DEFENSES
100. Evaluation of the Child With Suspected Immunodeficiency
101. Infectious Complications of Antibody Deficiency
102. Infectious Complications of Complement Deficiency and Diseases of Its Dysregulation
103. Infectious Complications of Dysfunction or Deficiency of Polymorphonuclear and Mononuclear Phagocytes
104. Infectious Complications of Cell-Mediated Immunity Other Than AIDS: Primary Immunodeficiencies
105. Infectious Complications in Special Hosts
106. Infections Related to Biologic Response Modifying Drug Therapy
107. Infectious Complications of Corticosteroid Therapy
SECTION S. HUMAN IMMUNODEFICIENCY VIRUS AND THE ACQUIRED IMMUNODEFICIENCY SYNDROME
108. Epidemiology and Prevention of HIV Infection in Infants, Children, and Adolescents
109. Immunopathogenesis of HIV-1. Infection
110. Diagnosis and Clinical Manifestations of HIV Infection
111. Infectious Complications of HIV Infection
112. Management of HIV Infection
PART III ETIOLOGIC AGENTS OF INFECTIOUS DISEASES
SECTION A. BACTERIA
113. Classification of Bacteria
SECTION GRAM-POSITIVE COCCI
114. Staphylococcus aureus
115. Coagulase-Negative Staphylococci and Micrococcaceae
116. Classification of Streptococci
117. Streptococcus pyogenes (Group A Streptococcus)
118. Streptococcus agalactiae (Group B Streptococcus)
119. Enterococcus Species
120. Viridans Streptococci, Streptococcus bovis Group, and Abiotrophia and Granulicatella Species
121. Groups C and G Streptococci
122. Streptococcus pneumoniae
123. Other Gram-Positive, Catalase-Negative Cocci Leuconostoc Species, Pediococcus Species, and Other Genera
SECTION GRAM-NEGATIVE COCCI
124. Neisseria meningitidis
125. Neisseria gonorrhoeae
126. Other Neisseria Species
SECTION GRAM-POSITIVE BACILLI
127. Arcanobacterium haemolyticum
128. Bacillus Species (Including Anthrax)
129. Corynebacterium diphtheriae
130. Other Corynebacteria
131. Listeria monocytogenes
132. Other Gram-Positive Bacilli
133. Mycobacterium tuberculosis
134. Nontuberculous Mycobacteria
135. Nocardia Species
SECTION ENTEROBACTERIACEAE: GRAM-NEGATIVE BACILLI
136. Escherichia coli
137. Klebsiella and Raoultella Species
138. Klebsiella granulomatis: Granuloma Inguinale (Donovanosis)
139. Enterobacter, Cronobacter, and Pantoea Species
140. Citrobacter Species
141. Less Commonly Encountered Enterobacterales
142. Plesiomonas shigelloides
143. Proteus, Providencia, and Morganella Species
144. Serratia Species
145. Salmonella Species
146. Shigella Species
147. Yersinia Species
SECTION NONENTEROBACTERIACEAE: GRAM-NEGATIVE BACILLI
148. Acinetobacter Species
149. Aeromonas Species
150. Less Commonly Encountered Nonenteric Gram-Negative Bacilli
151. Eikenella, Pasteurella, and Chromobacterium Species
152. Moraxella Species
153. Pseudomonas Species and Related Organisms
154. Pseudomonas aeruginosa
155. Burkholderia cepacia Complex and Other Burkholderia Species
156. Stenotrophomonas maltophilia
157. Vibrio cholerae (Cholera)
158. Other Vibrio Species
SECTION GRAM-NEGATIVE COCCOBACILLI
159. Bartonella Species (Cat-Scratch Disease)
160. Brucella Species (Brucellosis)
161. Bordetella pertussis (Pertussis) and Other Bordetella Species
162. Campylobacter jejuni and Campylobacter coli
163. Other Campylobacter Species
164. Capnocytophaga Species
165. Chlamydia pneumoniae
166. Chlamydia trachomatis
167. Chlamydia psittaci
168. Coxiella burnetii (Q Fever)
169. Family Anaplasmataceae (Anaplasmosis, Ehrlichiosis, Neorickettsiosis, and Neoehrlichiosis)
170. Francisella tularensis (Tularemia)
171. Haemophilus influenzae
172. Other Haemophilus Species and Aggregatibacter Species
173. Helicobacter pylori
174. Other Gastric and Enterohepatic Helicobacter Species
175. Kingella Species
176. Legionella Species
177. Rickettsia rickettsii (Rocky Mountain Spotted Fever)
178. Other Rickettsia Species
179. Streptobacillus moniliformis (Rat-Bite Fever)
180. Other Gram-Negative Coccobacilli
SECTION TREPONEMATACEAE (SPIRAL ORGANISMS)
181. Treponema pallidum (Syphilis)
182. Other Treponema Species
183. Leptospira Species (Leptospirosis)
184. Lyme Disease
185. Other Borrelia Species and Spirillum minus
SECTION ANAEROBIC BACTERIA
186. Anaerobic Bacteria: Clinical Concepts and the Microbiome in Health and Disease
187. Clostridium tetani (Tetanus)
188. Clostridium botulinum (Botulism)
189. Clostridioides difficile
190. Other Clostridium Species
191. Bacteroides and Prevotella Species and Other Anaerobic Gram-Negative Bacilli
192. Fusobacterium Species
193. Anaerobic Cocci
194. Anaerobic Gram-Positive Nonsporulating Bacilli (Including Actinomycosis)
SECTION MYCOPLASMA
195. Mycoplasma pneumoniae
196. Other Mycoplasma Species
197. Ureaplasma urealyticum
SECTION B. DISEASES OF POSSIBLE INFECTIOUS OR UNKNOWN ETIOLOGY
198. Kawasaki Disease
199. Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
SECTION C. VIRUSES
200. Classification of Human Viruses
SECTION DNA VIRUSES: POXVIRIDAE
201. Poxviridae
SECTION DNA VIRUSES: HERPESVIRIDAE
202. Introduction to Herpesviridae
203. Herpes Simplex Virus
204. Varicella-Zoster Virus Infection
205. Cytomegalovirus
206. Human Herpesviruses 6. and 7. (Roseola, Exanthem Subitum)
207. Epstein-Barr Virus (Mononucleosis and Lymphoproliferative Disorders)
208. Human Herpesvirus 8. (Kaposi Sarcoma–Associated Herpesvirus)
SECTION DNA VIRUSES: ADENOVIRIDAE
209. Adenoviruses
SECTION DNA VIRUSES: PAPOVAVIRIDAE
210. Human Papillomavirus
211. Human Polyomaviruses
SECTION DNA VIRUSES: HEPADNAVIRIDAE
212. Hepatitis B and Hepatitis D Viruses
SECTION DNA VIRUSES: PARVOVIRIDAE
213. Human Parvoviruses (Parvovirus B19. and Bocavirus)
SECTION RNA VIRUSES: REOVIRIDAE
214. Coltivirus (Colorado Tick Fever)
215. Rotaviruses
SECTION RNA VIRUSES: TOGAVIRIDAE, FLAVIVIRIDAE, AND BUNYAVIRIDAE
216. Togaviridae: Alphaviruses
217. Flaviviruses
218. Bunyaviruses
219. Hepatitis C Virus
220. Rubella Virus
SECTION RNA VIRUSES: CORONAVIRIDAE
221. Human Coronaviruses
SECTION RNA VIRUSES: PARAMYXOVIRIDAE
222. Parainfluenza Viruses
223. Mumps Virus
224. Respiratory Syncytial Virus
225. Human Metapneumovirus
226. Rubeola Virus Measles and Subacute Sclerosing Panencephalitis
SECTION RNA VIRUSES: RHABDOVIRIDAE
227. Rabies
SECTION RNA VIRUSES: ORTHOMYXOVIRIDAE
228. Influenza Viruses
SECTION RNA VIRUSES: ARENAVIRIDAE AND FILOVIRIDAE
229. Filoviruses and Arenaviruses
SECTION RNA VIRUSES: RETROVIRIDAE
230. Introduction to Retroviridae
231. Human T-Cell Lymphotropic Viruses
232. Human Immunodeficiency Virus
SECTION RNA VIRUSES: PICORNAVIRIDAE
233. Introduction to Picornaviridae
234. Polioviruses
235. Enteroviruses and Parechoviruses
236. Hepatitis A Virus
237. Rhinoviruses
SECTION RNA VIRUSES: CALICIVIRIDAE
238. Caliciviruses
239. Astroviruses
240. Hepatitis E Virus
SECTION D. FUNGI
241. Classification of Fungi
242. Candida Species
243. Aspergillus Species
244. Agents of Hyalohyphomycosis and Phaeohyphomycosis
245. Agents of Mucormycosis
246. Malassezia Species
247. Sporothrix schenckii Complex (Sporotrichosis)
248. Cryptococcus Species
249. Histoplasma capsulatum (Histoplasmosis)
250. Pneumocystis jirovecii
251. Blastomyces Species (Blastomycosis)
252. Coccidioides immitis and Coccidioides posadasii (Coccidioidomycosis)
253. Superficial Fungal Infections
254. Agents of Eumycotic Mycetoma: Pseudallescheria boydii and Scedosporium apiospermum
SECTION E. HUMAN PARASITES AND VECTORS
255. Classification of Parasites
256. Ectoparasites (Lice and Scabies)
SECTION PROTOZOA
257. Babesia Species (Babesiosis)
258. Balantioides coli (Formerly Balantidium coli)
259. Blastocystis Species
260. Cryptosporidium Species
261. Endolimax nana
262. Entamoeba histolytica (Amebiasis)
263. Other Entamoeba, Amebae, and Intestinal Flagellates
264. Giardia duodenalis (Giardiasis)
265. Cystoisospora (Isospora) and Cyclospora Species
266. Leishmania Species (Leishmaniasis)
267. Microsporidia
268. Naegleria fowleri
269. Acanthamoeba Species
270. Plasmodium Species (Malaria)
271. Sarcocystis Species
272. Toxoplasma gondii (Toxoplasmosis)
273. Trichomonas vaginalis
274. Trypanosoma Species (Trypanosomiasis)
SECTION NEMATODES
275. Intestinal Nematodes
276. Tissue Nematodes
277. Blood and Tissue Nematodes: Filarial Worms
SECTION CESTODES
278. Diphyllobothriidae, Dipylidium, and Hymenolepis Species
279. Taenia solium, Taenia asiatica, and Taenia saginata: Taeniasis and Cysticercosis
280. Echinococcus Species: Agents of Echinococcosis
281. Taenia (Multiceps) multiceps and Taenia serialis: Coenurosis
SECTION TREMATODES
282. Intestinal Trematodes
283. Clonorchis, Opisthorchis, Fasciola, and Paragonimus Species
284. Blood Trematodes: Schistosomiasis
PART IV LABORATORY DIAGNOSIS AND THERAPY FOR INFECTIOUS DISEASES
SECTION A. THE CLINICIAN AND THE LABORATORY
285. Laboratory Diagnosis of Infection Due to Bacteria, Fungi, and Parasites
286. Laboratory Diagnosis of Infection due to Viruses, Chlamydia, and Mycoplasma
287. Use of Common Clinical Laboratory Tests to Assess Infectious and Inflammatory Diseases
SECTION B. ANTI-INFECTIVE THERAPY
288. Principles of Anti-Infective Therapy
289. Mechanisms and Detection of Antimicrobial Resistance
290. Pharmacokinetic and Pharmacodynamic Basis of Optimal Antimicrobial Therapy
291. Antibacterial Agents
292. Antifungal Agents
293. Topical Antimicrobial Agents
294. Antiviral Agents
295. Antiparasitic Agents
SECTION A. EPIDEMIOLOGY AND CONTROL OF INFECTIOUS DISEASES
1. Principles of Epidemiology and Public Health
2. Pediatric Healthcare Epidemiology, Infection Prevention, and Antimicrobial Stewardship
3. Infections Associated With Group Childcare
4. Infectious Diseases in Refugee and Internationally Adopted Children
SECTION B. PREVENTION OF INFECTIOUS DISEASES
5. Passive Immunization
6. Active Immunization
7. Antimicrobial Chemoprophylaxis
8. Protection of Travelers
SECTION C. HOST DEFENSES AGAINST INFECTIOUS DISEASES
9. Immunologic Development and Susceptibility to Infection
10. Fever and the Inflammatory Response
PART II CLINICAL SYNDROMES AND CARDINAL FEATURES OF INFECTIOUS DISEASES: APPROACH TO DIAGNOSIS AND INITIAL MANAGEMENT
SECTION A. SEPTICEMIA AND TOXIN- AND INFLAMMATION-MEDIATED SYNDROMES
11. Sepsis and Septic Shock
12. Hemophagocytic Lymphohistiocytosis and Macrophage Activation Syndrome
SECTION B. CARDINAL SYMPTOM COMPLEXES
13. Mucocutaneous Symptom Complexes
14. Fever Without Localizing Signs
15. Prolonged, Recurrent, and Periodic Fever Syndromes
16. Lymphatic System and Generalized Lymphadenopathy
17. Cervical Lymphadenitis and Neck Infections
18. Mediastinal and Hilar Lymphadenopathy
19. Abdominal and Retroperitoneal Lymphadenopathy
20. Localized Lymphadenitis, Lymphadenopathy, and Lymphangitis
21. Respiratory Tract Symptom Complexes
22. Abdominal Symptom Complexes
23. Neurologic Syndromes
24. Musculoskeletal Symptom Complexes
SECTION C. ORAL INFECTIONS AND UPPER AND MIDDLE RESPIRATORY TRACT INFECTIONS
25. Infections of the Oral Cavity
26. The Common Cold
27. Pharyngitis
28. Infections Related to the Upper and Middle Airways
29. Otitis Media
30. Otitis Externa and Necrotizing Otitis Externa
31. Mastoiditis
32. Sinusitis
SECTION D. LOWER RESPIRATORY TRACT INFECTIONS
33. Bronchiolitis
34. Acute Pneumonia and Its Complications
35. Persistent and Recurrent Pneumonia
36. Pneumonia in the Immunocompromised Host
SECTION E. CARDIAC AND VASCULAR INFECTIONS
37. Endocarditis and Other Intravascular Infections
38. Myocarditis
39. Pericarditis
SECTION F. CENTRAL NERVOUS SYSTEM INFECTIONS
40. Acute Bacterial Meningitis Beyond the Neonatal Period
41. Chronic Meningitis
42. Recurrent Meningitis
43. Aseptic and Viral Meningitis
44. Encephalitis
45. Parainfectious and Postinfectious Neurologic Syndromes
46. Focal Suppurative Infections of the Nervous System
47. Eosinophilic Meningitis
SECTION G. GENITOURINARY TRACT INFECTIONS
48. Urinary Tract Infections, Renal Abscess, and Other Complex Renal Infections
49. Sexually Transmitted Infection Syndromes
50. Genitourinary Skin Mucous Membrane Infections and Inguinal Lymphadenopathy
51. Urethritis, Vulvovaginitis, and Cervicitis
52. Pelvic Inflammatory Disease
53. Epididymitis, Orchitis, and Prostatitis
54. Infectious Diseases Associated With Child Abuse
SECTION H. GASTROINTESTINAL AND TRACT INFECTIONS AND INTOXICATIONS
55. Approach to the Diagnosis and Management of Gastrointestinal Tract Infections
56. Viral Gastroenteritis
57. Inflammatory Enterocolitis
58. Enteric Diseases Transmitted Through Food, Water, and Animal Contact Exposures
SECTION I. INTRAABDOMINAL INFECTIONS
59. Acute Hepatitis
60. Chronic Hepatitis
61. Granulomatous Hepatitis
62. Acute Pancreatitis
63. Cholecystitis and Cholangitis
64. Peritonitis
65. Appendicitis
66. Intraabdominal, Visceral, and Retroperitoneal Abscesses
SECTION J. SKIN AND SOFT-TISSUE INFECTIONS
67. Superficial Bacterial Skin Infections and Cellulitis
68. Erythematous Macules and Papules
69. Vesicles and Bullae
70. Purpura
71. Urticaria and Erythema Multiforme
72. Papules, Nodules, and Ulcers
73. Subcutaneous Tissue Infections and Abscesses
74. Myositis, Pyomyositis, and Necrotizing Fasciitis
SECTION K. BONE AND JOINT INFECTIONS
75. Osteomyelitis
76. Infectious and Inflammatory Arthritis
77. Discitis
78. Transient Synovitis
SECTION L. EYE INFECTIONS
79. Conjunctivitis in the Neonatal Period (Ophthalmia Neonatorum)
80. Conjunctivitis Beyond the Neonatal Period
81. Infective Keratitis
82. Infective Uveitis, Retinitis, and Chorioretinitis
83. Endophthalmitis
84. Preseptal and Orbital Infections
SECTION M. INFECTIONS RELATED TO TRAUMA, ANIMALS, AND TICKS
85. Infection Related to Trauma
86. Infections Related to Burns
87. Infection Related to Bites
88. Infections Related to Pets and Exotic Animals
89. Tickborne Infections
SECTION N. INFECTIONS OF THE FETUS AND NEWBORN
90. Clinical Approach to the Neonate With Suspected Infection
91. Bacterial Infections in the Neonate
92. Viral Infections in the Fetus and Neonate
93. Healthcare-Associated Infections in the Neonate
SECTION O. INFECTIONS AND TRANSPLANTATION
94. Infections in Solid-Organ Transplant Recipients
95. Infections in Hematopoietic Cell Transplant Recipients
SECTION P. INFECTIONS AND CANCER
96. Risk Factors and Infectious Agents in Children With Cancer: Fever and Neutropenia
97. Clinical Syndromes of Infection in Children With Cancer
SECTION Q. INFECTIONS ASSOCIATED WITH HOSPITALIZATION AND MEDICAL DEVICES
98. Healthcare-Associated Infections
99. Clinical Syndromes of Device-Associated Infections
SECTION R. INFECTIONS IN PATIENTS WITH DEFICIENT DEFENSES
100. Evaluation of the Child With Suspected Immunodeficiency
101. Infectious Complications of Antibody Deficiency
102. Infectious Complications of Complement Deficiency and Diseases of Its Dysregulation
103. Infectious Complications of Dysfunction or Deficiency of Polymorphonuclear and Mononuclear Phagocytes
104. Infectious Complications of Cell-Mediated Immunity Other Than AIDS: Primary Immunodeficiencies
105. Infectious Complications in Special Hosts
106. Infections Related to Biologic Response Modifying Drug Therapy
107. Infectious Complications of Corticosteroid Therapy
SECTION S. HUMAN IMMUNODEFICIENCY VIRUS AND THE ACQUIRED IMMUNODEFICIENCY SYNDROME
108. Epidemiology and Prevention of HIV Infection in Infants, Children, and Adolescents
109. Immunopathogenesis of HIV-1. Infection
110. Diagnosis and Clinical Manifestations of HIV Infection
111. Infectious Complications of HIV Infection
112. Management of HIV Infection
PART III ETIOLOGIC AGENTS OF INFECTIOUS DISEASES
SECTION A. BACTERIA
113. Classification of Bacteria
SECTION GRAM-POSITIVE COCCI
114. Staphylococcus aureus
115. Coagulase-Negative Staphylococci and Micrococcaceae
116. Classification of Streptococci
117. Streptococcus pyogenes (Group A Streptococcus)
118. Streptococcus agalactiae (Group B Streptococcus)
119. Enterococcus Species
120. Viridans Streptococci, Streptococcus bovis Group, and Abiotrophia and Granulicatella Species
121. Groups C and G Streptococci
122. Streptococcus pneumoniae
123. Other Gram-Positive, Catalase-Negative Cocci Leuconostoc Species, Pediococcus Species, and Other Genera
SECTION GRAM-NEGATIVE COCCI
124. Neisseria meningitidis
125. Neisseria gonorrhoeae
126. Other Neisseria Species
SECTION GRAM-POSITIVE BACILLI
127. Arcanobacterium haemolyticum
128. Bacillus Species (Including Anthrax)
129. Corynebacterium diphtheriae
130. Other Corynebacteria
131. Listeria monocytogenes
132. Other Gram-Positive Bacilli
133. Mycobacterium tuberculosis
134. Nontuberculous Mycobacteria
135. Nocardia Species
SECTION ENTEROBACTERIACEAE: GRAM-NEGATIVE BACILLI
136. Escherichia coli
137. Klebsiella and Raoultella Species
138. Klebsiella granulomatis: Granuloma Inguinale (Donovanosis)
139. Enterobacter, Cronobacter, and Pantoea Species
140. Citrobacter Species
141. Less Commonly Encountered Enterobacterales
142. Plesiomonas shigelloides
143. Proteus, Providencia, and Morganella Species
144. Serratia Species
145. Salmonella Species
146. Shigella Species
147. Yersinia Species
SECTION NONENTEROBACTERIACEAE: GRAM-NEGATIVE BACILLI
148. Acinetobacter Species
149. Aeromonas Species
150. Less Commonly Encountered Nonenteric Gram-Negative Bacilli
151. Eikenella, Pasteurella, and Chromobacterium Species
152. Moraxella Species
153. Pseudomonas Species and Related Organisms
154. Pseudomonas aeruginosa
155. Burkholderia cepacia Complex and Other Burkholderia Species
156. Stenotrophomonas maltophilia
157. Vibrio cholerae (Cholera)
158. Other Vibrio Species
SECTION GRAM-NEGATIVE COCCOBACILLI
159. Bartonella Species (Cat-Scratch Disease)
160. Brucella Species (Brucellosis)
161. Bordetella pertussis (Pertussis) and Other Bordetella Species
162. Campylobacter jejuni and Campylobacter coli
163. Other Campylobacter Species
164. Capnocytophaga Species
165. Chlamydia pneumoniae
166. Chlamydia trachomatis
167. Chlamydia psittaci
168. Coxiella burnetii (Q Fever)
169. Family Anaplasmataceae (Anaplasmosis, Ehrlichiosis, Neorickettsiosis, and Neoehrlichiosis)
170. Francisella tularensis (Tularemia)
171. Haemophilus influenzae
172. Other Haemophilus Species and Aggregatibacter Species
173. Helicobacter pylori
174. Other Gastric and Enterohepatic Helicobacter Species
175. Kingella Species
176. Legionella Species
177. Rickettsia rickettsii (Rocky Mountain Spotted Fever)
178. Other Rickettsia Species
179. Streptobacillus moniliformis (Rat-Bite Fever)
180. Other Gram-Negative Coccobacilli
SECTION TREPONEMATACEAE (SPIRAL ORGANISMS)
181. Treponema pallidum (Syphilis)
182. Other Treponema Species
183. Leptospira Species (Leptospirosis)
184. Lyme Disease
185. Other Borrelia Species and Spirillum minus
SECTION ANAEROBIC BACTERIA
186. Anaerobic Bacteria: Clinical Concepts and the Microbiome in Health and Disease
187. Clostridium tetani (Tetanus)
188. Clostridium botulinum (Botulism)
189. Clostridioides difficile
190. Other Clostridium Species
191. Bacteroides and Prevotella Species and Other Anaerobic Gram-Negative Bacilli
192. Fusobacterium Species
193. Anaerobic Cocci
194. Anaerobic Gram-Positive Nonsporulating Bacilli (Including Actinomycosis)
SECTION MYCOPLASMA
195. Mycoplasma pneumoniae
196. Other Mycoplasma Species
197. Ureaplasma urealyticum
SECTION B. DISEASES OF POSSIBLE INFECTIOUS OR UNKNOWN ETIOLOGY
198. Kawasaki Disease
199. Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
SECTION C. VIRUSES
200. Classification of Human Viruses
SECTION DNA VIRUSES: POXVIRIDAE
201. Poxviridae
SECTION DNA VIRUSES: HERPESVIRIDAE
202. Introduction to Herpesviridae
203. Herpes Simplex Virus
204. Varicella-Zoster Virus Infection
205. Cytomegalovirus
206. Human Herpesviruses 6. and 7. (Roseola, Exanthem Subitum)
207. Epstein-Barr Virus (Mononucleosis and Lymphoproliferative Disorders)
208. Human Herpesvirus 8. (Kaposi Sarcoma–Associated Herpesvirus)
SECTION DNA VIRUSES: ADENOVIRIDAE
209. Adenoviruses
SECTION DNA VIRUSES: PAPOVAVIRIDAE
210. Human Papillomavirus
211. Human Polyomaviruses
SECTION DNA VIRUSES: HEPADNAVIRIDAE
212. Hepatitis B and Hepatitis D Viruses
SECTION DNA VIRUSES: PARVOVIRIDAE
213. Human Parvoviruses (Parvovirus B19. and Bocavirus)
SECTION RNA VIRUSES: REOVIRIDAE
214. Coltivirus (Colorado Tick Fever)
215. Rotaviruses
SECTION RNA VIRUSES: TOGAVIRIDAE, FLAVIVIRIDAE, AND BUNYAVIRIDAE
216. Togaviridae: Alphaviruses
217. Flaviviruses
218. Bunyaviruses
219. Hepatitis C Virus
220. Rubella Virus
SECTION RNA VIRUSES: CORONAVIRIDAE
221. Human Coronaviruses
SECTION RNA VIRUSES: PARAMYXOVIRIDAE
222. Parainfluenza Viruses
223. Mumps Virus
224. Respiratory Syncytial Virus
225. Human Metapneumovirus
226. Rubeola Virus Measles and Subacute Sclerosing Panencephalitis
SECTION RNA VIRUSES: RHABDOVIRIDAE
227. Rabies
SECTION RNA VIRUSES: ORTHOMYXOVIRIDAE
228. Influenza Viruses
SECTION RNA VIRUSES: ARENAVIRIDAE AND FILOVIRIDAE
229. Filoviruses and Arenaviruses
SECTION RNA VIRUSES: RETROVIRIDAE
230. Introduction to Retroviridae
231. Human T-Cell Lymphotropic Viruses
232. Human Immunodeficiency Virus
SECTION RNA VIRUSES: PICORNAVIRIDAE
233. Introduction to Picornaviridae
234. Polioviruses
235. Enteroviruses and Parechoviruses
236. Hepatitis A Virus
237. Rhinoviruses
SECTION RNA VIRUSES: CALICIVIRIDAE
238. Caliciviruses
239. Astroviruses
240. Hepatitis E Virus
SECTION D. FUNGI
241. Classification of Fungi
242. Candida Species
243. Aspergillus Species
244. Agents of Hyalohyphomycosis and Phaeohyphomycosis
245. Agents of Mucormycosis
246. Malassezia Species
247. Sporothrix schenckii Complex (Sporotrichosis)
248. Cryptococcus Species
249. Histoplasma capsulatum (Histoplasmosis)
250. Pneumocystis jirovecii
251. Blastomyces Species (Blastomycosis)
252. Coccidioides immitis and Coccidioides posadasii (Coccidioidomycosis)
253. Superficial Fungal Infections
254. Agents of Eumycotic Mycetoma: Pseudallescheria boydii and Scedosporium apiospermum
SECTION E. HUMAN PARASITES AND VECTORS
255. Classification of Parasites
256. Ectoparasites (Lice and Scabies)
SECTION PROTOZOA
257. Babesia Species (Babesiosis)
258. Balantioides coli (Formerly Balantidium coli)
259. Blastocystis Species
260. Cryptosporidium Species
261. Endolimax nana
262. Entamoeba histolytica (Amebiasis)
263. Other Entamoeba, Amebae, and Intestinal Flagellates
264. Giardia duodenalis (Giardiasis)
265. Cystoisospora (Isospora) and Cyclospora Species
266. Leishmania Species (Leishmaniasis)
267. Microsporidia
268. Naegleria fowleri
269. Acanthamoeba Species
270. Plasmodium Species (Malaria)
271. Sarcocystis Species
272. Toxoplasma gondii (Toxoplasmosis)
273. Trichomonas vaginalis
274. Trypanosoma Species (Trypanosomiasis)
SECTION NEMATODES
275. Intestinal Nematodes
276. Tissue Nematodes
277. Blood and Tissue Nematodes: Filarial Worms
SECTION CESTODES
278. Diphyllobothriidae, Dipylidium, and Hymenolepis Species
279. Taenia solium, Taenia asiatica, and Taenia saginata: Taeniasis and Cysticercosis
280. Echinococcus Species: Agents of Echinococcosis
281. Taenia (Multiceps) multiceps and Taenia serialis: Coenurosis
SECTION TREMATODES
282. Intestinal Trematodes
283. Clonorchis, Opisthorchis, Fasciola, and Paragonimus Species
284. Blood Trematodes: Schistosomiasis
PART IV LABORATORY DIAGNOSIS AND THERAPY FOR INFECTIOUS DISEASES
SECTION A. THE CLINICIAN AND THE LABORATORY
285. Laboratory Diagnosis of Infection Due to Bacteria, Fungi, and Parasites
286. Laboratory Diagnosis of Infection due to Viruses, Chlamydia, and Mycoplasma
287. Use of Common Clinical Laboratory Tests to Assess Infectious and Inflammatory Diseases
SECTION B. ANTI-INFECTIVE THERAPY
288. Principles of Anti-Infective Therapy
289. Mechanisms and Detection of Antimicrobial Resistance
290. Pharmacokinetic and Pharmacodynamic Basis of Optimal Antimicrobial Therapy
291. Antibacterial Agents
292. Antifungal Agents
293. Topical Antimicrobial Agents
294. Antiviral Agents
295. Antiparasitic Agents
Review quotes
Review quotes
Review of the previous edition:
"As a pediatric infectious disease clinician, I find this book to be a helpful reference for both clinical work as well as lecture preparation when engaging learners." --©Doody’s Review Service, 2022, Bradford Becken, MD (University of Nebraska Medical Center)
"As a pediatric infectious disease clinician, I find this book to be a helpful reference for both clinical work as well as lecture preparation when engaging learners." --©Doody’s Review Service, 2022, Bradford Becken, MD (University of Nebraska Medical Center)
Product details
Product details
- Edition: 7
- Latest edition
- Published: December 10, 2026
- Language: English
About the editors
About the editors
David Kimberlin
Editor
David Kimberlin, MD is Professor/Co-Director, Division of Pediatric Infectious Diseases/Sergio B. Stagno, MD Endowed Chair in Pedaitric Infectious Diseases/Vice Chair for Clinical and Translational Research at Children’s Alabama, Birmingham. Dr. Kimberlin is a world renowned pediatric infectious diseases specialist at the University of Alabama, is at the fulcrum of NIH- sponsored multicentered clinical trials especially related to antiviral therapy, is the chief editor of the Red Book Report of the Committee on Infectious Diseases of the American Academy of Pediatrics, and a national leader in academic and subspecilty societies. He has been a contributor of critical chapters in PPPID since its inception.
Affiliations and expertise
Distinguished Professor Department of Pediatrics Division of Pediatric Infectious Diseases University of Alabama Heersink School of Medicine Birmingham, AlabamaGrace Aldrovandi
Editor
Affiliations and expertise
Chief, Division of Infectious Diseases, UCLA Mattel Children’s Hospital, Professor of Pediatrics, David Geffen School of Medicine, University of California, Los Angeles, CA, USAAdam Ratner
Editor
Affiliations and expertise
Professor, Department of Pediatrics and Department of Microbiology, Director, Division of Pediatric Infectious Diseases, NYU Grossman School of Medicine, NYU Langone Health, New York, NY, USAJose R. Romero
Editor
Affiliations and expertise
Centers for Disease Control and Prevention, USA