Life-Threatening Effects of Antipsychotic Drugs

1st Edition - August 12, 2016
Editors: Peter Manu, Robert J. Flanagan, Kathlyn J. Ronaldson
Language: English
Hardback ISBN:
9 7 8 - 0 - 1 2 - 8 0 3 3 7 6 - 0
eBook ISBN:
9 7 8 - 0 - 1 2 - 8 0 3 3 9 0 - 6

Life-Threatening Effects of Antipsychotic Drugs describes in detail more than 20 life-threatening effects associated with antipsychotics, presents the best available data on their… Read more

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Life-Threatening Effects of Antipsychotic Drugs describes in detail more than 20 life-threatening effects associated with antipsychotics, presents the best available data on their incidence and case fatality, and gives comprehensive advice on diagnosis, management and preventive strategies. In addition, the book discusses the benefit of antipsychotic medication in a range of therapeutic indications, and demonstrates the gain in life-expectancy associated with clozapine use in severe mental illness despite its serious, potentially life-threatening adverse effects.

List of Contributors
Foreword
- The Art and Science of Balance: Managing the Efficacy and Safety of Antipsychotic Drugs
Preface
Acknowledgments
Symbols and Conventions
Part I: Cardiovascular Adverse Effects of Antipsychotic Drugs
- Chapter 1. Sudden Cardiac Death and Ventricular Arrhythmias
  - Abstract
  - 1.1 Epidemiology
  - 1.2 Pathobiology
  - 1.3 Clinical and Laboratory Features
  - 1.4 Prevention and Management
  - References
- Chapter 2. Myocarditis and Cardiomyopathy
  - Abstract
  - 2.1 Definitions
  - 2.2 Epidemiology
  - 2.3 Genetic Vulnerability
  - 2.4 Pathobiology
  - 2.5 Clinical and Laboratory Features
  - 2.6 Differential Diagnosis
  - 2.7 Complications and Significant Sequelae
  - 2.8 Risk Stratification for Death or Permanent Disability
  - 2.9 Management
  - 2.10 Prevention
  - Acknowledgment
  - References
- Chapter 3. Pulmonary Embolism
  - Abstract
  - 3.1 Epidemiology
  - 3.2 Pathobiology
  - 3.3 Clinical and Laboratory Features
  - 3.4 Prevention and Management
  - References
- Chapter 4. Orthostatic Hypotension
  - Abstract
  - 4.1 Epidemiology
  - 4.2 Pathobiology
  - 4.3 Clinical and Laboratory Features
  - 4.4 Prevention and Management
  - References
Part II: Hematological Complications of Treatment With Antipsychotic Drugs
- Chapter 5. Severe Neutropenia and Agranulocytosis
  - Abstract
  - 5.1 Epidemiology
  - 5.2 Pathobiology
  - 5.3 Clinical and Laboratory Features
  - 5.4 Prevention and Management
  - References
Part III: Antipsychotic-Related Pathology of the Digestive System
- Chapter 6. Gastrointestinal Hypomotility and Dysphagia
  - Abstract
  - 6.1 Gastrointestinal Hypomotility
  - 6.2 Dysphagia and Sialorrhea
  - Acknowledgment
  - References
- Chapter 7. Liver Failure
  - Abstract
  - 7.1 Definition
  - 7.2 Search Strategy
  - 7.3 Epidemiology
  - 7.4 Pathobiology
  - 7.5 Clinical and Laboratory Features
  - 7.6 Management
  - 7.7 Prevention
  - 7.8 Conclusion
  - References
- Chapter 8. Pancreatitis
  - Abstract
  - 8.1 Epidemiology
  - 8.2 Pathobiology
  - 8.3 Clinical and Laboratory Features
  - 8.4 Management
  - References
Part IV: Major Neurological and Neuromuscular Adverse Effects of Antipsychotic Drugs
- Chapter 9. Seizures
  - Abstract
  - 9.1 Epidemiology
  - 9.2 Pathobiology
  - 9.3 Clinical and Laboratory Features
  - 9.4 Prevention and Management
  - Acknowledgment
  - References
- Chapter 10. Neuroleptic Malignant Syndrome
  - Abstract
  - 10.1 Epidemiology
  - 10.2 Pathobiology
  - 10.3 Clinical and Laboratory Features
  - 10.4 Prevention and Management
  - References
- Chapter 11. Heat Stroke and Rhabdomyolysis
  - Abstract
  - 11.1 Heat Stroke
  - 11.2 Rhabdomyolysis
  - References
Part V: Metabolic Complications of Antipsychotic Drug Treatment
- Chapter 12. Type 2 Diabetes Mellitus
  - Abstract
  - 12.1 Epidemiology
  - 12.2 Pathobiology
  - 12.3 Clinical and Laboratory Features
  - 12.4 Prevention and Management
  - 12.5 Conclusion
  - References
Part VI: Other Life-Threatening Effects of Antipsychotic Drugs
- Chapter 13. Interstitial Nephritis and Interstitial Lung Disease
  - Abstract
  - 13.1 Interstitial Nephritis
  - 13.2 Interstitial Lung Disease
  - References
Part VII: Clinical and Forensic Challenges in the Use of Antipsychotic Drugs
- Chapter 14. The Benefits of Antipsychotic Drugs: Symptom Control and Improved Quality of Life
  - Abstract
  - 14.1 Therapeutic Objectives in Schizophrenia
  - 14.2 Pharmacology of Antipsychotic Drugs
  - 14.3 Symptom Reduction in Schizophrenia
  - 14.4 Relapse Prevention and Antipsychotic Maintenance Treatment
  - 14.5 Improving Quality of Life in Patients With Schizophrenia
  - 14.6 Antipsychotic Drugs in Treating Other Psychiatric Disorders
  - References
- Chapter 15. Antipsychotic-Related Mortality: Risk and Strategy for Improved Clinical Management
  - Abstract
  - 15.1 Reduced Life-Expectancy with Severe Mental Illness (SMI)
  - 15.2 Suicide Reduced with Clozapine
  - 15.3 An Obstacle to Clozapine Prescribing: Agranulocytosis
  - 15.4 Diabetic Ketoacidosis: Poor Outcomes with Severe Mental Illness (SMI)
  - 15.5 Strategy for Improved Outcomes
  - References
  - Further Reading
- Chapter 16. Forensic Investigation of Antipsychotic-Related Deaths
  - Abstract
  - 16.1 Introduction
  - 16.2 Clinical and Pathological Correlations
  - 16.3 Toxicological Assessments
  - 16.4 System-Specific Forensic Considerations
  - 16.5 Conclusions
  - References
Guide to the Interpretation of the Results of Some Chemical Pathology Tests
Index

Peter Manu

Peter Manu, MD is Professor of Medicine and Psychiatry at Hofstra University School of Medicine and Adjunct Professor of Clinical Medicine, Psychiatry and Behavioral Sciences at Albert Einstein College of Medicine in New York. He aditionally serves as Director of Medical Services, Hillside Hospital, Long Island Jewish Medical Center. Prior to this, he served as the Medical Director, Alcohol and Drug Abuse Treatment Center at the University of Connecticut Health Center. In 2012 he received the Fulbright Specialist in Public/Global Health award from the U.S. Department of State. He is the author of 5 books, 68 journal articles, and 30 book chapters in psychiatry. He serves as an ad hoc reviewer for 38 journals in the areas of psychology, psychiatry, medicine, and pharmacology.

Affiliations and expertise

Hofstra Northwell School of Medicine and Albert Einstein College of Medicine, New York, NY, USA

Robert J. Flanagan

Professor Bob Flanagan is Consultant Clinical Scientist and Director, Toxicology Unit, King’s College Hospital NHS Foundation Trust and Clinical Lead for Toxicology, Sheffield Teaching Hospital NHS Foundation Trust. He has published over 200 scientific papers and four books. Particular interests have been treatment of mental illness especially as regards use of antipsychotics, notably clozapine, treatment of cancer, especially in respect of the use of tyrosine kinase inhibitors such as imatinib, and the diagnosis of substance abuse, especially misuse of volatiles such as butane. He led on toxicology training for the Association for Clinical Biochemistry for many years, and regularly advises medical professionals, police, coroners, and prosecution and defence lawyers on toxicological issues. He has also acted as a consultant to the United Nations Office for Drugs and Crime, most recently as regards advising on methodology for the detection of drug-facilitated crime, and to the World Health Organization, notably in Serbia/Kosovo in 2007, and also in the Middle East and in India. He is immediate past-President of the British Academy of Forensic Sciences.

Affiliations and expertise

King's College Hospital, London, UK

Kathlyn J. Ronaldson

Affiliations and expertise

Monash University, Melbourne, Australia

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Life-Threatening Effects of Antipsychotic Drugs

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Peter Manu

Robert J. Flanagan

Kathlyn J. Ronaldson