Lehne's Pharmacology for Nursing Care

11th Edition - September 10, 2021
Authors: Jacqueline Rosenjack Burchum, Laura D. Rosenthal
Language: English
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 8 2 5 2 6 - 9

Trust Lehne’s to make pharmacology more approachable! Known for its clear explanations of drug prototypes and how they work, Lehne's Pharmacology for Nursing Care, 11th Edition… Read more

Purchase options

Institutional subscription on ScienceDirect

Request a sales quote

Trust Lehne’s to make pharmacology more approachable! Known for its clear explanations of drug prototypes and how they work, Lehne's Pharmacology for Nursing Care, 11th Edition provides a solid understanding of key drugs and their implications for nursing care. A perennial student favorite, this book simplifies complex pharmacology concepts, using large and small print to distinguish need-to-know drug content from the material that’s merely nice to know. It also includes in-depth coverage of physiology, pathophysiology and drug therapy. Written by noted nursing educators Jacqueline Rosenjack Burchum and Laura Rosenthal, this text helps you understand and apply pharmacology principles as opposed to simply memorizing drug facts.

Title of Book
Cover image
Title page
Table of Contents
Evolve Student Resources
Copyright
Dedication
About the Authors
Contributors and Reviewers
Preface
Laying Foundations in Basic Principles
Reviewing Physiology and Pathophysiology
Teaching Through Prototypes
Large Print and Small Print: A Way to Focus on Essentials
Using Clinical Reality to Prioritize Content
Nursing Implications: Demonstrating the Application of Pharmacology in Nursing Practice
What's New in the Book?
Learning Supplements for Students
Teaching Supplements for Instructors
Ways to Use This Textbook
Acknowledgments
Unit I: Introduction
Chapter 1. Orientation to Pharmacology
Four Basic Terms
Properties of an Ideal Drug
The Therapeutic Objective
Factors that Determine the Intensity of Drug Responses
Chapter 2. Application of Pharmacology in Nursing Practice
Evolution of Nursing Responsibilities Regarding Drugs
Application of Pharmacology in Patient Care
Application of Pharmacology in Patient Education
Application of the Nursing Process in Drug Therapy
Chapter 3. Drug Regulation, Development, Names, and Information
Landmark Drug Legislation
Hazardous Drug Exposure
New Drug Development
Drug Names
Over-the-Counter Drugs
Sources of Drug Information
Unit II: Basic Principles of Pharmacology
Chapter 4. Pharmacokinetics
Application of Pharmacokinetics in Therapeutics
A Note to Chemophobes
Passage of Drugs Across Membranes
Absorption
Distribution
Metabolism
Excretion
Time Course of Drug Responses
Chapter 5. Pharmacodynamics
Dose-Response Relationships
Drug-Receptor Interactions
Drug Responses that do not Involve Receptors
Interpatient Variability in Drug Responses
The Therapeutic Index
Chapter 6. Drug Interactions
Drug-Drug Interactions
Drug-Food Interactions
Drug-Supplement Interactions
Chapter 7. Adverse Drug Reactions and Medication Errors
Adverse Drug Reactions
Medication Errors
Chapter 8. Individual Variation in Drug Responses
Body Weight and Composition
Age
Pathophysiology
Tolerance
Placebo Effect
Variability in Absorption
Genetics and Pharmacogenomics
Gender- and Race-Related Variations
Comorbidities and Drug Interactions
Diet
Failure to Take Medicine as Prescribed
Chapter 9. Genetic and Genomic Considerations
Pharmacogenomics
Genomics Education and Competencies
Application of Pharmacogenomics
Genetic Variants that Alter Drug Metabolism
Genetic Variants that Alter Drug Targets
Genetic Variants that Alter Immune Responses to Drugs
Genetic and Pharmacogenomic Testing
Barriers to Pharmacogenomic Application in Practice
Chapter 10. Introduction to Immunomodulators
Monoclonal Antibodies “MAbs”
Tyrosine Kinase Inhibitors “NIBS”
Proteasome Inhibitors “MIBS”
Immunotherapy of the Future
Unit III: Drug Therapy Across The Life Span
Chapter 11. Drug Therapy During Pregnancy and Breast-Feeding
Drug Therapy During Pregnancy: Basic Considerations
Drug Therapy During Pregnancy: Teratogenesis and Other Risks
Drug Therapy During Breast-Feeding
Chapter 12. Drug Therapy in Pediatric Patients
Pharmacokinetics: Neonates And Infants
Pharmacokinetics: Children 1 Year and Older
Adverse Drug Reactions
Dosage Determination
Promoting Adherence
Chapter 13. Drug Therapy in Older Adults
Pharmacokinetic Changes in Older Adults
Pharmacodynamic Changes in Older Adults
Adverse Drug Reactions and Drug Interactions
Promoting Adherence
Considerations for End-of-Life Care
Unit IV: Peripheral Nervous System Drugs
Section 1: Introduction
Chapter 14. Basic Principles of Neuropharmacology
How Neurons Regulate Physiologic Processes
Basic Mechanisms By Which Neuropharmacologic Agents Act
Multiple Receptor Types and Selectivity of Drug Action
An Approach to Learning About Peripheral Nervous System Drugs
Chapter 15. Physiology of the Peripheral Nervous System
Divisions of the Nervous System
Overview of Autonomic Nervous System Functions
Autonomic Nervous System Regulation of Physiologic Processes
Anatomic Considerations
Transmitters of the Peripheral Nervous System
Receptors of the Peripheral Nervous System
Exploring the Concept of Receptor Subtypes
Locations of Receptor Subtypes
Functions of Cholinergic and Adrenergic Receptor Subtypes
Transmitter Life Cycles
Section 2: Cholinergic Drugs
Chapter 16. Muscarinic Agonists
Introduction to Cholinergic Drugs
Muscarinic Agonists
Chapter 17. Muscarinic Antagonists
Muscarinic Antagonists (Anticholinergic Drugs)
Other Muscarinic Antagonists
Drugs for Overactive Bladder
Toxicology of Muscarinic Antagonists
Chapter 18. Cholinesterase Inhibitors and Their Use in Myasthenia Gravis
Reversible Cholinesterase Inhibitors
Irreversible Cholinesterase Inhibitors
Myasthenia Gravis
Chapter 19. Drugs That Block Nicotinic Cholinergic Transmission
Control of Muscle Contraction
Competitive (Nondepolarizing) Neuromuscular Blockers
Depolarizing Neuromuscular Blockers
Therapeutic Uses of Neuromuscular Blockers
Section 3: Adrenergic Drugs
Chapter 20. Adrenergic Agonists
Mechanisms of Adrenergic Receptor Activation
Overview of the Adrenergic Agonists
Therapeutic Applications and Adverse Effects of Adrenergic Receptor Activation
Properties of Representative Adrenergic Agonists
Chapter 21. Adrenergic Antagonists
Alpha-Adrenergic Antagonists
Beta-Adrenergic Antagonists
Chapter 22. Indirect-Acting Antiadrenergic Agents
Centrally Acting Alpha2 Agonists
Unit V: Central Nervous System Drugs
Section 4: Introduction
Chapter 23. Introduction to Central Nervous System Pharmacology
Transmitters of the CNS
The Blood-Brain Barrier
How Do CNS Drugs Produce Therapeutic Effects?
Adaptation of the CNS to Prolonged Drug Exposure
Development of New Psychotherapeutic Drugs
Approaching the Study of CNS Drugs
Section 5: Drugs for Neurodegenerative Disorders
Chapter 24. Drugs for Parkinson Disease
Pathophysiology That Underlies Motor Symptoms
Overview of Motor Symptom Management
Pharmacology of Drugs Used for Motor Symptoms
Nonmotor Symptoms and Their Management
Chapter 25. Drugs for Alzheimer Disease
Pathophysiology
Risk Factors and Symptoms
Drugs for Cognitive Impairment
Drugs for Neuropsychiatric Symptoms
Can We Prevent Alzheimer Disease Or Delay Cognitive Decline?
Chapter 26. Drugs for Multiple Sclerosis
Overview of MS and ITS Treatment
Disease-Modifying Drugs I: Immunomodulators
Disease-Modifying Drugs II: Immunosuppressants
Drugs Used to Manage MS Symptoms
Section 6: Neurologic Drugs
Chapter 27. Drugs for Seizure Disorders
Generation of Seizures
Types of Seizures
How Antiseizure Drugs Work
Basic Therapeutic Considerations
Classification of Antiseizure Drugs
Traditional Antiseizure Drugs
New Generation Antiseizure Drugs
Management of Generalized Convulsive Status Epilepticus
Chapter 28. Drugs for Muscle Spasm and Spasticity
Drugs for Spasticity
Drugs for Localized Muscle Spasm
Other Centrally Acting Muscle Relaxants
Section 7: Drugs for Pain
Chapter 29. Local Anesthetics
Basic Pharmacology of Local Anesthetics
Properties of Individual Local Anesthetics
Clinical use of Local Anesthetics
Chapter 30. General Anesthetics
Inhalation Anesthetics
Intravenous Anesthetics
Chapter 31. Opioid Analgesics, Opioid Antagonists, and Nonopioid Centrally Acting Analgesics
Opioid Analgesics
Opioid Antagonists
Chapter 32. Pain Management in Patients With Cancer
Pathophysiology of Pain
Management Strategy
Assessment and Ongoing Evaluation
Drug Therapy
Nondrug Therapy
Pain Management in Special Populations
Patient Education
Chapter 33. Drugs for Headache
Migraine Headache
Overview of Treatment
Cluster Headaches
Section 8: Psychotherapeutic Drugs
Chapter 34. Antipsychotic Agents and Their Use in Schizophrenia
Schizophrenia: Clinical Presentation and Etiology
First-Generation (Conventional) Antipsychotics
Second-Generation (Atypical) Antipsychotics
Depot Antipsychotic Preparations
Management of Schizophrenia
Chapter 35. Antidepressants
Major Depression: Clinical Features, Pathogenesis, and Treatment Overview
Drugs Used for Depression
Peripartum Depression
Chapter 36. Drugs for Bipolar Disorder
Characteristics of Bipolar Disorder
Treatment of Bipolar Disorder
Mood-Stabilizing Drugs
Antipsychotic Drugs
Chapter 37. Sedative-Hypnotic Drugs
Benzodiazepines
Benzodiazepine-Like Drugs
Ramelteon: A Melatonin Agonist
Suvorexant: An Orexin Antagonist
Barbiturates
Management of Insomnia
Chapter 38. Management of Anxiety Disorders
Generalized Anxiety Disorder
Panic Disorder
Obsessive-Compulsive Disorder
Social Anxiety Disorder
Post-Traumatic Stress Disorder
Chapter 39. Central Nervous System Stimulants and Attention-Deficit/Hyperactivity Disorder
Central Nervous System Stimulants
Attention-Deficit/Hyperactivity Disorder
Section 9: Substance Use Disorders
Chapter 40. Substance Use Disorders I: Basic Considerations
Definitions
Diagnostic Criteria Regarding Substance Use Disorder
Factors That Contribute To Substance Use Disorder
Neurobiology of Substance Use Disorders
Principles of Substance Use Disorder Treatment
The Controlled Substances Act
Chapter 41. Substance Use Disorders II: Alcohol
Basic Pharmacology of Alcohol
Alcohol Use Disorder
Drugs for Alcohol Use Disorder
Chapter 42. Substance Use Disorders III: Nicotine
Basic Pharmacology of Nicotine
Pharmacologic AIDS to Smoking Cessation
Chapter 43. Substance Use Disorders IV: Major Drugs of Abuse Other Than Alcohol and Nicotine
Heroin, Oxycodone, and Other Opioids
Kratom
General Central Nervous System Depressants
Psychostimulants
Marijuana and Related Preparations
Psychedelics
Dissociative Drugs
Dextromethorphan
3,4-Methylenedioxymethamphetamine (MDMA, Ecstasy)
Inhalants
Anabolic Steroids
Unit VI: Drugs That Affect Fluid and Electrolyte Balance
Chapter 44. Diuretics
Review of Renal Anatomy and Physiology
Introduction to Diuretics
Loop Diuretics
Thiazides and Related Diuretics
Potassium-Sparing Diuretics
Mannitol: An Osmotic Diuretic
Chapter 45. Agents Affecting the Volume and Ion Content of Body Fluids
Disorders of Fluid Volume and Osmolality
Acid-Base Disturbances
Potassium Imbalances
Magnesium Imbalances
Unit VII: Drugs That Affect The Heart, Blood Vessels, and Blood
Chapter 46. Review of Hemodynamics
Overview of the Circulatory System
Regulation of Cardiac Output
Regulation of Arterial Pressure
Chapter 47. Drugs Acting on the Renin-Angiotensin-Aldosterone System
Physiology of the Renin-Angiotensin-Aldosterone System
Angiotensin-Converting Enzyme Inhibitors
Angiotensin II Receptor Blockers
Aliskiren: A Direct Renin Inhibitor
Aldosterone Antagonists
Chapter 48. Calcium Channel Blockers
Calcium Channels: Physiologic Functions and Consequences of Blockade
Calcium Channel Blockers: Classification and Sites of Action
NonDihydropyridines: Verapamil and Diltiazem: Agents That Act on Vascular Smooth Muscle and the Heart
Dihydropyridines: Agents That Act Mainly on Vascular Smooth Muscle
Chapter 49. Vasodilators
Basic Concepts in Vasodilator Pharmacology
Pharmacology of Individual Vasodilators
Chapter 50. Drugs for Hypertension
Basic Considerations in Hypertension
Management of Chronic Hypertension
Drugs For Hypertensive Emergencies
Drugs For Hypertensive Disorders of Pregnancy
Chapter 51. Drugs for Heart Failure
Pathophysiology of Heart Failure
Overview of Drugs Used to Treat Heart Failure
Digoxin: A Cardiac Glycoside
Management of Heart Failure
Chapter 52. Antidysrhythmic Drugs
Cardiac Electrophysiology, Dysrhythmias, and the Antidysrhythmic Drugs
Pharmacology of the Antidysrhythmic Drugs
Chapter 53. Drugs That Help Normalize Cholesterol and Triglyceride Levels
Cholesterol
Plasma Lipoproteins
Role of LDL Cholesterol in Atherosclerosis
2018 ACC/AHA Guidelines on the Management of Blood Cholesterol
Drugs and other Products used to Improve Plasma Lipid Levels
Chapter 54. Drugs for Angina Pectoris
Determinants of Cardiac Oxygen Demand and Oxygen Supply
Angina Pectoris: Pathophysiology and Treatment Strategy
Organic Nitrates
Beta Blockers
Calcium Channel Blockers
Ranolazine
Treatment Measures
Chapter 55. Anticoagulant, Antiplatelet, and Thrombolytic Drugs
Coagulation: Physiology and Pathophysiology
Overview of Drugs for Thromboembolic Disorders
Chapter 56. Management of ST-Elevation Myocardial Infarction
Pathophysiology of STEMI
Diagnosis of STEMI
Management of STEMI
Complications of STEMI
Secondary Prevention of STEMI
Chapter 57. Drugs for Hemophilia
Basic Considerations
Preparations Used to Treat Hemophilia
Chapter 58. Drugs for Deficiency Anemias
Red Blood Cell Development
Iron Deficiency
Biochemistry And Physiology of Iron
Iron Deficiency: Causes, Consequences, And Diagnosis
Oral Iron Preparations
Parenteral Iron Preparations
Guidelines For Treating Iron Deficiency
Vitamin B12 Deficiency
Biochemistry and Physiology of Vitamin B12
Vitamin B12 Deficiency: Causes, Consequences, And Diagnosis
Vitamin B12 Preparations: Cyanocobalamin
Guidelines for Treating Vitamin B12 Deficiency
Folic Acid Deficiency
Physiology And Biochemistry of Folic Acid
Folic Acid Deficiency: Causes, Consequences, And Diagnosis
Folic Acid Preparations
Guidelines For Treating Folic Acid Deficiency
Chapter 59. Hematopoietic Agents
Hematopoietic Growth Factors
Erythropoietic Growth Factors
Leukopoietic Growth Factors
Drugs That Mimic Hematopoietic Growth Factors Or Enhance Their Actions
Thrombopoietin Receptor Agonists
Unit VIII: Drugs for Endocrine Disorders
Chapter 60. Drugs for Diabetes Mellitus
Diabetes Mellitus
Insulin
Physiology
Preparations and Administration
Therapeutic Use
Noninsulin Medications for the Treatment Of Diabetes
Oral Drugs
Adjunctive Agents
Noninsulin Injectable Agents
Acute Complications of Poor Glycemic Control
Diabetic Ketoacidosis
Hyperosmolar Hyperglycemic State
Glucagon for Treatment of Severe Hypoglycemia
Chapter 61. Drugs for Thyroid Disorders
Thyroid Physiology
Thyroid Function Tests
Thyroid Pathophysiology
Thyroid Hormone Preparations for Hypothyroidism
Drugs for Hyperthyroidism
Chapter 62. Drugs Related to Hypothalamic and Pituitary Function
Overview of Hypothalamic and Pituitary Endocrinology
Growth Hormone
Prolactin
Antidiuretic Hormone (Vasopressin)
Drugs for Acromegaly
Chapter 63. Drugs for Disorders of the Adrenal Cortex
Physiology of the Adrenocortical Hormones
Pathophysiology of the Adrenocortical Hormones
Agents for Replacement Therapy in Adrenocortical Insufficiency
Agents for Diagnosing Adrenocortical Disorders
Unit IX: Women’s Health
Chapter 64. Estrogens and Progestins: Basic Pharmacology and Noncontraceptive Applications
The Menstrual Cycle
Estrogens
Selective Estrogen Receptor Modulators
Phytoestrogens
Progestins
Menopausal Hormone Therapy
Chapter 65. Birth Control
Effectiveness of Birth Control Methods
Selecting a Birth Control Method
Oral Contraceptives
Combination Contraceptives with Novel Delivery Systems
Long-Acting Contraceptives
Spermicides
Drugs for Medical Abortion
Chapter 66. Drug Therapy for Infertility
Infertility: Causes and Treatment Strategies
Drugs Used to Treat Female Infertility
Chapter 67. Drugs That Affect Uterine Function
Drugs for Preterm Labor
Drugs for Cervical Ripening and Induction of Labor
Drugs for Postpartum Hemorrhage
Drugs for Menorrhagia
Unit X: Men’s Health
Chapter 68. Androgens
Testosterone
Clinical Pharmacology of the Androgens
Androgen Preparations for Male Hypogonadism
Androgen (Anabolic Steroid) Abuse
Chapter 69. Drugs for Male Sexual Dysfunction and Benign Prostatic Hyperplasia
Male Sexual Dysfunction
Erectile Dysfunction
Physiology Of Erection
Oral Drugs For Erectile Dysfunction: PDE5 Inhibitors
Nonoral Drugs For Erectile Dysfunction
Premature Ejaculation
Pathophysiology
Drug Therapy For Premature Ejaculation
Benign Prostatic Hyperplasia
Pathophysiology
Treatment Modalities
Unit XI: Antiinflammatory, Antiallergic, and Immunologic Drugs
Chapter 70. Review of the Immune System
Introduction to the Immune System
Antibody-Mediated (Humoral) Immunity
Cell-Mediated Immunity
Chapter 71. Childhood Immunization
General Considerations
Target Diseases
Specific Vaccines and Toxoids
Experimental Vaccines
Chapter 72. Immunosuppressants
Calcineurin Inhibitors
mTOR Inhibitors
Glucocorticoids
Cytotoxic Drugs
Antibodies
Chapter 73. Antihistamines
Histamine
The Two Types of Antihistamines: H1 Antagonists and H2 Antagonists
Histamine1 Antagonists I: Basic Pharmacology
Histamine1 Antagonists II: Preparations
Chapter 74. Cyclooxygenase Inhibitors: Nonsteroidal Antiinflammatory Drugs and Acetaminophen
Mechanism of Action
Classification of Cyclooxygenase Inhibitors
First-Generation NSAIDs
Second-Generation NSAIDs (COX-2 Inhibitors, Coxibs)
Acetaminophen
AHA Statement on the use of COX Inhibitors for Chronic Pain
Chapter 75. Glucocorticoids in Nonendocrine Disorders
Review of Glucocorticoid Physiology
Pharmacology of Glucocorticoids
Unit XII: Drugs for Bone and Joint Disorders
Chapter 76. Drug Therapy for Rheumatoid Arthritis
Pathophysiology of Rheumatoid Arthritis
Overview of Therapy
Nonsteroidal Antiinflammatory Drugs
Glucocorticoids
Conventional (Traditional) Disease-Modifying Antirheumatic Drugs
Biologic Disease-Modifying Antirheumatic Drugs
Interleukin-6 Receptor Antagonists
Chapter 77. Drug Therapy for Gout
Pathophysiology of Gout
Overview of Drug Therapy
Drugs for Acute Gout Flares
Drugs For Hyperuricemia (Urate-Lowering Therapy)
Chapter 78. Drugs Affecting Calcium Levels and Bone Mineralization
Calcium Physiology
Calcium-Related Pathophysiology
Drugs for Disorders Involving Calcium and Bone Mineralization
Osteoporosis
Unit XIII: Respiratory Tract Drugs
Chapter 79. Drugs for Asthma and Chronic Obstructive Pulmonary Disease
Basic Considerations
Antiinflammatory Drugs
Bronchodilators
Combination Drugs
Management of Asthma and Chronic Obstructive Pulmonary Disease
Management of Chronic Obstructive Pulmonary Disease
Chapter 80. Drugs for Allergic Rhinitis, Cough, and Colds
Drugs for Allergic Rhinitis
Drugs for Cough
Cold Remedies: Combination Preparations
Unit XIV: Gastrointestinal Drugs
Chapter 81. Drugs for Peptic Ulcer Disease
Pathogenesis of Peptic Ulcers
Overview of Treatment
Antibacterial Drugs
Histamine2 Receptor Antagonists
Proton Pump Inhibitors
Other Antiulcer Drugs
Chapter 82. Laxatives
General Considerations
Basic Pharmacology of Laxatives
Laxative Abuse
Chapter 83. Other Gastrointestinal Drugs
Antiemetics
Drugs for Motion Sickness
Antidiarrheal Agents
Drugs for Irritable Bowel Syndrome
Drugs for Inflammatory Bowel Disease
Prokinetic Agents
Palifermin
Pancreatic Enzymes
Drugs used to Dissolve Gallstones
Anorectal Preparations
Unit XV: Nutrition and Complementary Therapy
Chapter 84. Vitamins
What are Vitamins?
Basic Considerations
Fat-Soluble Vitamins
Water-Soluble Vitamins
Chapter 85. Drugs for Weight Loss
Assessment of Weight-Related Health Risk
Pathophysiology
Overview of Obesity Treatment
Weight-Loss Drugs
A Note Regarding Drugs for Weight Loss
Chapter 86. Complementary and Alternative Therapy
Regulation of Dietary Supplements
Private Quality Certification Programs
Standardization of Herbal Products
Adverse Interactions with Conventional Drugs
Some Commonly Used Dietary Supplements
Harmful Supplements to Avoid
Unit XVI: Drugs for Infectious Diseases
Chapter 87. Basic Principles of Antimicrobial Therapy
Selective Toxicity
Classification of Antimicrobial Drugs
Acquired Resistance to Antimicrobial Drugs
Selection of Antibiotics
Host Factors that Modify Drug Choice, Route of Administration, or Dosage
Dosage and Duration of Treatment
Therapy with Antibiotic Combinations
Prophylactic use of Antimicrobial Drugs
Misuses of Antimicrobial Drugs
Monitoring Antimicrobial Therapy
Chapter 88. Drugs That Weaken the Bacterial Cell Wall I: Penicillins
Introduction to the Penicillins
Properties of Individual Penicillins
Chapter 89. Drugs That Weaken the Bacterial Cell Wall II: Other Drugs
Cephalosporins
Carbapenems
Other Inhibitors of Cell Wall Synthesis
Lipoglycoproteins
Chapter 90. Bacteriostatic Inhibitors of Protein Synthesis: Tetracyclines, Macrolides, and Others
Tetracyclines
Macrolides
Other Bacteriostatic Inhibitors of Protein Synthesis
Chapter 91. Aminoglycosides: Bactericidal Inhibitors of Protein Synthesis
Basic Pharmacology of the Aminoglycosides
Properties of Individual Aminoglycosides
Chapter 92. Sulfonamide Antibiotics and Trimethoprim
Sulfonamides
Trimethoprim
Trimethoprim/Sulfamethoxazole
Chapter 93. Drug Therapy for Urinary Tract Infections
Organisms that Cause Urinary Tract Infections
Specific Urinary Tract Infections and Their Treatment
Urinary Tract Antiseptics
Chapter 94. Antimycobacterial Agents
Drugs for Tuberculosis
Drugs for Leprosy (Hansen Disease)
Drugs for Mycobacterium Avium Complex Infection
Chapter 95. Miscellaneous Antibacterial Drugs
Fluoroquinolones
Additional Antibacterial Drugs
Chapter 96. Antifungal Agents
Drugs for Systemic Mycoses
Drugs for Superficial Mycoses
Chapter 97. Antiviral Agents I: Drugs for Non-HIV Viral Infections
Drugs for Infection with Herpes Simplex Viruses and Varicella-Zoster Virus
Drugs for Cytomegalovirus Infection
Viral Hepatitis
Drugs for Influenza
Drugs for Respiratory Syncytial Virus Prophylaxis
Chapter 98. Antiviral Agents II: Drugs for HIV Infection and Related Opportunistic Infections
Pathophysiology
Classification of Antiretroviral Drugs
Drug Interactions
Nucleoside/Nucleotide Reverse Transcriptase Inhibitors
Nonnucleoside Reverse Transcriptase Inhibitors
Protease Inhibitors
Integrase Strand Transfer Inhibitors
HIV Fusion Inhibitors
CCR5 Antagonists
Post-Attachment Inhibitors
Management of HIV Infection
Preventing HIV Infection with Drugs
Prophylaxis and Treatment of Opportunistic Infections
Herpes Simplex Virus Infection
HIV Vaccines
Keeping Current
Chapter 99. Drug Therapy for Sexually Transmitted Infections
Chlamydia Trachomatis Infections
Gonococcal Infections
Nongonococcal Urethritis
Pelvic Inflammatory Disease
Acute Epididymitis
Syphilis
Acquired Immunodeficiency Syndrome
Bacterial Vaginosis
Trichomoniasis
Chancroid
Herpes Simplex Virus Infections
Proctitis
Anogenital Warts
Making Sense of Treatment
Chapter 100. Antiseptics and Disinfectants
General Considerations
Properties of Individual Antiseptics and Disinfectants
Hand Hygiene for Healthcare Workers
Unit XVII: Drugs for Parasitic Diseases
Chapter 101. Anthelmintics
Classification of Parasitic Worms
Helminthic Infestations
Drugs of Choice for Helminthiasis
Chapter 102. Antiprotozoal Drugs I: Antimalarial Agents
Life Cycle of the Malaria Parasite
Types of Malaria
Principles of Antimalarial Therapy
Pharmacology of the Major Antimalarial Drugs
Chapter 103. Antiprotozoal Drugs II: Miscellaneous Agents
Protozoal Infections
Drugs of Choice for Protozoal Infections
Chapter 104. Ectoparasiticides
Ectoparasitic Infestations
Pharmacology of Ectoparasiticides
Unit XVIII: Cancer Therapy
Chapter 105. Basic Principles of Cancer Therapy
What is Cancer?
The Growth Fraction and its Relationship to Chemotherapy
Obstacles to Successful Chemotherapy
Strategies for Achieving Maximum Benefits from Chemotherapy
Major Toxicities of Chemotherapeutic Drugs
Making the Decision to Treat
Looking Ahead
Chapter 106. Anticancer Drugs I: Cytotoxic Agents
Introduction to the Cytotoxic Anticancer Drugs
Alkylating Agents
Platinum Compounds
Antimetabolites
Hypomethylating Agents
Antitumor Antibiotics
Mitotic Inhibitors
Topoisomerase Inhibitors
Miscellaneous Cytotoxic Drugs
Chapter 107. Anticancer Drugs II: Noncytotoxic Agents
Drugs for Breast Cancer
Drugs for Prostate Cancer
Targeted Anticancer Drugs
Immunostimulants
Unit XIX: Drugs For Eyes, Ears, And Skin
Chapter 108. Drugs for Eye Conditions and Diseases
Drugs for Glaucoma
Cycloplegics and Mydriatics
Drugs for Allergic Conjunctivitis
Drugs for Age-Related Macular Degeneration
Additional Ophthalmic Drugs
Chapter 109. Drugs for Skin Conditions
Anatomy of the Skin
Topical Drug Formulations
Topical Glucocorticoids
Keratolytic Agents
Acne
Drugs for Rosacea
Sunscreens
Psoriasis
Drugs for Actinic Keratoses
Drugs for Atopic Dermatitis
Agents for Wart Removal
Drugs for Miscellaneous Skin and Hair Conditions
Skin Infections and Infestations
Local Anesthetics
Chapter 110. Drugs for Ear Conditions
Anatomy of the Ear
Otitis Media and its Management
Acute Otitis Externa
Unit XX: Toxicology
Chapter 111. Management of Poisoning
Fundamentals of Treatment
Drugs and Procedures used to Minimize Poison Absorption
Drugs and Procedures used for Poison Removal
Specific Antidotes
Poison Control Centers
Chapter 112. Potential Weapons of Biologic, Radiologic, and Chemical Terrorism
Bacteria and Viruses
Biotoxins
Chemical Weapons
Radiologic Weapons
Appendix A. Canadian Drug Information*
Canadian Drug Legislation
Prescription Drugs (Schedule F)
Cannabis in Canada
Nonprescription Medications—National Drug Schedules
New Drug Development in Canada
Patent Laws
Drug Advertising
International System of Units
Drug Serum Concentrations
Further Reading
Appendix B. Prototype Drugs and Their Major Uses
Peripheral Nervous System Drugs
Central Nervous System Drugs
Diuretics
Drugs That Affect the Heart, Blood Vessels, and Blood
Drugs for Endocrine Disorders
Women’s Health
Men’s Health
Antiinflammatory, Antiallergic, and Immunologic Drugs
Drugs for Bone and Joint Disorders
Respiratory Tract Drugs
Gastrointestinal Drugs
Drugs for Weight Loss
Drugs for Bacterial Infections
Drugs for Fungal Infections
Drugs for Viral Infections
Drugs for Parasitic Diseases
Anticancer Drugs: Cytotoxic Agents
Anticancer Drugs: Hormonal Agents, Targeted Drugs, and Other Noncytotoxic Anticancer Drugs
Other Important Drugs
Drugs for Hereditary Angioedema
Index
Special Interest Topics

Life Sciences

Physical Sciences & Engineering

Social Sciences & Humanities

Health

Lehne's Pharmacology for Nursing Care

Purchase options

Institutional subscription on ScienceDirect

Jacqueline Rosenjack Burchum

Laura D. Rosenthal