Larsen's Human Embryology
- 6th Edition - November 29, 2020
- Authors: Gary C. Schoenwolf, Steven B. Bleyl, Philip R. Brauer, Philippa H. Francis-West
- Language: English
- Paperback ISBN:9 7 8 - 0 - 3 2 3 - 6 9 6 0 4 - 3
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 6 9 6 0 5 - 0
Offering a well-organized, straightforward approach to a highly complex subject, Larsen’s Human Embryology, 6th Edition, provides easy-to-read, comprehensive coverage of human… Read more
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Request a sales quoteOffering a well-organized, straightforward approach to a highly complex subject, Larsen’s Human Embryology, 6th Edition, provides easy-to-read, comprehensive coverage of human embryonic development for today’s students. It integrates anatomy and histology with cellular and molecular mechanisms, focusing on both normal development and congenital anomalies. Highly illustrated with superb drawings and photographs, it features a strong clinical focus based on the most up-to-date scientific discoveries and understanding.
Contains new information on gene editing via CRISPr technology, organoids and the study of human disease, transcription factors and signaling pathways, and single cell sequencing.
Includes clinical scenarios that describe prevention, diagnosis, and treatment of human birth defects and disease.
Features a superior art program, online animations, and high-quality drawings and photographs throughout—ideal for today’s visual learners. · Includes a strong clinical emphasis through the use of Clinical Tasters, Embryology in Practice, and In the Clinic sections.
Provides additional information on mechanisms of development and research approaches and strategies to establish these mechanisms with In the Research Lab sections.
Begins each chapter with an overview of main points as well as a graphical summary, with key terms listed in bold type.
Covers the embryology information that today’s medical students need to know for Board exams, clinics, and more, in a readable, straightforward manner.
Enhanced eBook version included with purchase. Your enhanced eBook allows you to access 50 narrated animations, multiple-choice questions, and all of the text, figures, and references from the book on a variety of devices.
Medical, Dental, Osteopathic schools
- Cover image
- Title page
- Table of Contents
- Dedication
- Copyright
- Content Experts
- Preface
- Acknowledgments
- Video Contents
- Introduction
- Summary
- Why study human embryology?
- Periods of Human Embryology
- Period of Egg and Embryo: Summary of Main Events
- Phases of Human Embryology
- Body Axes: Understanding Embryonic Coordinates
- Want to Learn More?
- 1. Gametogenesis, Fertilization, and First Week
- Summary
- Primordial Germ Cells
- Gametogenesis
- Spermatogenesis
- Oogenesis
- Ovulation
- Menstrual Cycle
- Fertilization
- Cleavage
- End of First Week: Initiating Implantation
- 2. Second Week: Becoming Bilaminar and Fully Implanting
- Summary
- Becoming Fully Implanted
- Embryoblast Reorganizes Into Epiblast and Hypoblast
- Development of Amniotic Cavity
- Development Of Yolk SAC and Chorionic Cavity
- Uteroplacental Circulatory System Begins to Develop During the Second Week
- 3. Third Week: Becoming Trilaminar and Establishing Body Axes
- Summary
- Overview of Gastrulation: Forming Three Primary Germ Layers and Body Axes
- Specifics of Gastrulation: Moving Cells to New Locations and Making Organ Rudiments That Undergo Inductive Interactions
- Formation of Neural Plate
- Caudal Elongation of Embryo
- Primary Versus Secondary Body Development
- 4. Fourth Week: Forming the Embryo
- Summary
- Tube-Within-A-Tube Body Plan Arises Through Body Folding
- Neurulation: Establishing Neural Tube, Rudiment of Central Nervous System
- Secondary Neurulation
- Cranial-Caudal Regionalization of Neural Tube
- Neural Crest Cells
- Somite Differentiation: Forming Dermamyotome And Sclerotome
- 5. Principles and Mechanisms of Morphogenesis and Dysmorphogenesis
- Summary
- Principles of Morphogenesis and Dysmorphogenesis
- Animal Models
- Using Animal Models to Predict Human Risk
- Experimental Techniques
- Signaling Pathways
- Embryonic Stem Cells, Organoids, and Cloning
- 6. Fetal Development and the Fetus as a Patient
- Summary
- During Fetal Period, Embryonic Organ Systems Mature and Fetus Grows
- Development of Placenta
- Development of Umbilical Cord
- Exchange of Substances Between Maternal and Fetal Blood in Placenta
- Intrauterine Growth Restriction
- Maternal Diabetes and Obesity
- Placenta Produces Several Important Hormones
- Production and Resorption of Amniotic Fluid
- Twinning
- Prenatal Diagnosis Assesses Health of Unborn
- Treating Fetus in Utero
- Fetal Cord Blood and Stem Cells
- Preterm Birth
- 7. Development of the Skin and Its Derivatives
- Summary
- Origin of Epidermis and Dermis Of Skin
- Development of Skin Derivatives
- Development of Hair
- Development of Sebaceous and Sweat Glands
- Development of Mammary Glands
- Development of Nails
- 8. Development of the Musculoskeletal System
- Summary
- Tissue Origins and Differentiation of Musculoskeletal System
- Somites Differentiate Into Sclerotome and Dermamyotome
- Resegmentation of Sclerotomes
- Myotomes Develop at Segmental Levels
- Long Bone and Joint Development
- Development of Limb Muscles
- 9. Development of the Central Nervous System
- Summary
- Structural Divisions of Nervous System
- Functional Divisions of Nervous System
- Primary Brain Vesicles Subdivide to form Secondary Brain Vesicles
- Formation of Brain Flexures
- Cytodifferentiation of Neural Tube
- Differentiation of Spinal Cord
- Differentiation of Brain
- Growth of Brain
- 10. Development of the Peripheral Nervous System
- Summary
- Structural Divisions of Nervous System
- Functional Divisions of Nervous System
- Origin of PNS
- Development of Trunk Pns
- Development of Cranial Pns
- Differences in Preganglionic and Postganglionic Fiber Length Between Parasympathetic and Sympathetic Divisions of Autonomic Nervous System
- 11. Development of the Respiratory System and Body Cavities
- Summary
- Development of Lungs and Respiratory Tree
- Partitioning of Coelom and Formation of Diaphragm
- 12. Development of the Heart
- Summary
- Establishing Cardiac Lineage
- Formation of Primary Heart Tube
- Cardiac Looping
- Formation of Primitive Blood Vessels Associated With the Endocardial Tube
- Coordinated Remodeling of Heart Tube and Primitive Vasculature Produces Systemic and Pulmonary Circulations
- Septation of Heart
- Development of Pacemaker and Conduction System
- Development of Epicardium and Coronary Vasculature
- 13. Development of the Vasculature
- Summary
- Formation of Blood and Vasculature Begins Early in Third Week
- Vasculogenesis and Angiogenesis
- Arteries Versus Veins
- Development of Aortic Arch Arteries
- Dorsal Aorta Develops Ventral, Lateral, and Posterolateral Branches
- Primitive Embryonic Venous System is Divided Into Vitelline, Umbilical, and Cardinal Systems
- Development of Lymphatic System
- Dramatic Changes Occur in Circulatory System at Birth
- 14. Development of the Gastrointestinal Tract
- Summary
- Body Folding
- Dorsal Mesentery Initially Suspends Abdominal Gut Tube
- Three Regions of Primitive Gut
- Development of Abdominal Foregut
- Spleen Development
- Ventral Mesentery Derivatives
- Midgut Development
- Cytodifferentiation of Gut Endodermal Epithelium
- Development of Outer Intestinal Wall and its Innervation
- Hindgut Development
- 15. Development of the Urinary System
- Summary
- Three Nephric Systems Arise During Development
- Relocation of Kidneys
- Contributions of Hindgut Endoderm to Urinary Tract
- Development of Suprarenal Gland
- 16. Development of the Reproductive System
- Summary
- Reproductive System Arises With Urinary System
- In Presence of Y Chromosome, Male Development Occurs
- In Absence of Y Chromosome, Female Development Occurs
- Development of External Genitalia
- Suspension of Mesonephric-Gonadal Complex Within Abdomen
- Development of Inguinal Canals
- Descent of Testes
- Ovaries Become Suspended in Broad Ligament of Uterus And are Held High in Abdominal Cavity by Cranial Suspensory Ligaments
- 17. Development of the Pharyngeal Apparatus and Face
- Summary
- Origin of Skull
- Development of Pharyngeal Arches
- Development of Face
- Development of Nasal and Oral Cavities
- Development of Sinuses
- Fate of Pharyngeal Clefts
- Pharyngeal Arches Give Rise to Tongue
- Development of Thyroid Gland
- Development of Pharyngeal Pouches
- Development of Salivary Glands
- Development of Teeth
- 18. Development of the Ears
- Summary
- Ear Consists of Three Individual Components
- Development of Inner Ear
- Development of Middle Ear
- Development of External Ear
- 19. Development of the Eyes
- Summary
- Eye Originates From Several Embryonic Tissue Layers
- Development of Optic Cup and Lens
- Development of Eyelids
- 20. Development of the Limbs
- Summary
- Epithelial-Mesenchymal Interactions Control Limb Outgrowth
- Morphogenesis of Limb
- Tissue Origins of Limb Structures
- Differentiation of Limb Bones
- Innervation of Developing Limb
- Figure Credits
- Index
- No. of pages: 608
- Language: English
- Edition: 6
- Published: November 29, 2020
- Imprint: Elsevier
- Paperback ISBN: 9780323696043
- eBook ISBN: 9780323696050
GS
Gary C. Schoenwolf
Affiliations and expertise
University of Utah School of Medicine, Salt Lake City, UtahSB
Steven B. Bleyl
Affiliations and expertise
University of Utah School of Medicine, Salt Lake City, UtahPB
Philip R. Brauer
Affiliations and expertise
Creighton University School of Medicine, Omaha, NebraskaPF
Philippa H. Francis-West
Affiliations and expertise
King's College London Dental Institute, London, United Kingdom