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Kumar and Clark's Clinical Medicine
- 9th Edition
- Editors: Adam Feather, David Randall, Mona Waterhouse
- Language: English
The ninth edition of this best-selling textbook of clinical medicine builds even further on its formidable, prize-winning formula of excellence, comprehensiveness and ac… Read more
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The ninth edition of this best-selling textbook of clinical medicine builds even further on its formidable, prize-winning formula of excellence, comprehensiveness and accessibility.
‘This book is stunning in its breadth and ease-of-use. It still remains the "gold standard", thorough guide to clinical medicine its forefathers were.’
BMA Medical Book Awards judges.New to this edition:
- 2 new chapters: Global Health and Women’s Health.
- 25 new authors.
- New online editor, Adam Feather, with a team of young doctors to augment the e-book which accompanies the print book with clinical tips, key learning points, drug tips, learning challenges, case studies and MCQs.
- Full text redesign to incorporate:
New system overview diagrams for clinical chapters.
New coloured headings to help identify content relating to disease, management, investigations etc.
New icons to aid text navigation.
11 new members and a new co-editor, Senaka Rajapakse, of the International Advisory Board.
Edited by Kumar and Clark, clinicians and educators of world-renowned expertise.
Authors comprise consultants at the top of their fields, paired with younger doctors closer to the exam experience, to ensure authority and relevance.
Enhanced e-book accompanies the print book, for ease of transportation and use on the move.
International Advisory Board, led by Professor Janaka de Silva and Professor Senaka Rajapakse, providing guidance for global coverage from across the world.
Contributions to the e-book by members of the International Advisory Board to amplify areas of clinical importance in their parts of the world
- Cover image
- Title Page
- Table of Contents
- Copyright
- Acknowledgements
- Online Special Topics
- Contributors
- Online contributors
- International Advisory Board
- Preface to the Ninth Edition
- How to Use This Book
- Section 1 Good medical practice
- 1 Ethics, law and communication
- Ethics and the Law
- Communication
- 2 Clinical pharmacology
- Introduction
- Why Do Patients Need Drugs?
- The Choice of Drug
- The Dose
- Pharmacokinetics
- Pharmacodynamics
- Affordability and Cost-Effectiveness
- Prescribing in Special Populations
- Monitoring Drug Therapy
- Adverse Drug Reactions
- Drug Interactions
- Inter-Individual Variability in Drug Response
- Evidence-Based Medicine
- Statistical Analyses
- Information Sources
- Significant websites
- 3 Palliative medicine and symptom control
- Introduction and General Aspects
- Symptom Control
- Extending Palliative Care to People with Non-Malignant Disease
- Palliative Care of the Frail Elderly
- Care of the Dying
- Further reading
- Bibliography
- Significant websites
- 4 Global health
- Introduction
- Millennium Development Goals
- Global Burden of Disease
- Poverty
- Water and Sanitation
- Organizations and the Global Health Agenda
- Education
- Maternal Health and Child Health
- Mental Health
- Accidents and Trauma
- Conflict and Catastrophe
- Economics and Politics in Global Health
- Social Determinants of Health
- Human Rights and the Value of Engagement in Global Health
- Bibliography
- 5 Environmental medicine
- Disease and the Environment
- Environmental Temperature
- Heat Injury
- Cold Injury
- High Altitude
- Diving
- Drowning
- Air Pollution
- Ionizing Radiation
- Electric Shock
- Lightning Strike
- Smoke
- Noise
- Bioterrorism/Biowarfare
- Travel
- Building-Related Illnesses
- 6 Poisoning
- Introduction
- Clinical approach to the poisoned patient
- Principles of Management of Poisoning
- Specific Poisons
- Significant websites
- Section 2 Clinical sciences
- 7 Molecular cell biology and human genetics
- Cell Biology
- Human Genetics
- Bibliography
- Significant websites
- 8 The immune system and disease
- Anatomy and Principles of the Immune System
- Innate Immune System
- Adaptive Immune System
- Cell Migration
- HLA Molecules and Antigen Presentation
- The Immune System in Concert
- Laboratory Investigations of the Immune System
- Clinical Immunodeficiency
- Type I (Immediate) Hypersensitivity and Allergic Disease
- Autoimmune Disease
- Organ Rejection in Clinical Transplantation
- Immune-Based Therapies
- 9 Water, electrolytes and acid–base balance
- Water and Electrolytes
- Acid–Base Disorders
- Further reading
- Bibliography
- 10 Nutrition
- Introduction
- Water and Electrolyte Balance
- Dietary Requirements
- Protein–Energy Malnutrition
- Vitamins
- Minerals
- Nutrition and Ageing
- Obesity
- Nutritional Support
- Food Allergy and Food Intolerance
- Alcohol
- Bibliography
- Significant websites
- Section 3 Clinical practice
- 11 Infectious diseases and tropical medicine
- Infection and Infectious Disease
- Viral Infections
- Transmissible Spongiform Encephalopathies (Prion Diseases)
- Bacterial Infections
- Fungal Infections
- Protozoal Infections
- Helminthic Infections
- Arthropod Ectoparasites
- 12 Sexually transmitted infections and human immunodeficiency virus
- Sexually Transmitted Infections
- Human Immunodeficiency Virus and Acquired Immunodeficiency Syndrome
- Bibliography
- 13 Gastrointestinal disease
- Introduction
- Clinical Approach to the Patient with Gastrointestinal Disease
- The Mouth
- The Salivary Glands
- The Pharynx and Oesophagus
- The Stomach and Duodenum
- Acute and Chronic Gastrointestinal Bleeding
- The Small Intestine
- Inflammatory Bowel Disease
- The Colon and Rectum
- Diarrhoea
- Functional Gastrointestinal Disorders
- The Acute Abdomen
- The Peritoneum
- Bibliography
- Significant websites
- 14 Liver disease
- Introduction
- Anatomy of the Liver and Biliary System
- Functions of the Liver
- Clinical Approach to the Patient with Liver Disease
- Jaundice
- Hepatitis
- Acute Hepatic Failure
- Autoimmune Hepatitis
- Drug-Induced Chronic Hepatitis
- Chronic Hepatitis of Unknown Cause
- Non-Alcoholic Fatty Liver Disease
- Cirrhosis
- Alcoholic Liver Disease
- Budd–Chiari Syndrome
- Hepatic Sinusoidal Obstruction Syndrome
- Fibropolycystic Diseases
- Liver Abscess
- Other Infections of the Liver
- Liver Disease in Pregnancy
- Liver Tumours
- Miscellaneous Conditions of the Liver
- Drugs and the Liver
- Bibliography
- 15 Biliary tract and pancreatic disease
- The Gall Bladder and Biliary System
- The Pancreas
- 16 Haematological disease
- The Red Cell
- The Spleen
- Blood Transfusion
- The White Cell
- Haemostasis and Thrombosis
- Bibliography
- Significant websites
- 17 Malignant disease
- Cancer Treatment
- Acute Oncology
- Haematological Malignancies
- Common Solid Tumour Treatment
- 18 Rheumatic disease
- Introduction
- Anatomy and Physiology of the Normal Joint
- Clinical Approach to the Patient with Rheumatic Disease
- Common Regional Musculoskeletal Problems
- Chronic Pain Syndromes
- Analgesic and Anti-Inflammatory Drugs for Musculoskeletal Problems
- Disorders of collagen
- Osteoarthritis
- Inflammatory Arthritis
- Rheumatoid arthritis
- Infections of Joints
- Autoimmune Rheumatic Diseases
- Systemic Inflammatory Vasculitis
- Arthritis in Children
- Rheumatological Problems Seen in Other Diseases
- Miscellaneous Arthropathies
- 19 Bone disease
- Anatomy and Physiology of Bone
- Clinical Approach to the Patient with Bone Disease
- Osteoporosis
- Osteonecrosis
- Paget's Disease of Bone
- Rickets and Osteomalacia
- Bone Infections
- Neoplastic Disease Of Bone
- Other Bone Disorders
- Bibliography
- Significant websites
- 20 Kidney and urinary tract disease
- Anatomy and Physiology of the Kidney and Urinary Tract
- Clinical Approach to the Patient with Kidney and Urinary Tract Disease
- The Glomerulus and Glomerular Disease
- Kidney Involvement in Other Diseases
- Hypertension and the Kidney
- Other Vascular Disorders of the Kidney
- Renal Calculi and Nephrocalcinosis
- Urinary Tract Obstruction
- Drugs and the Kidney
- Urinary Tract Infection
- Tubulointerstitial Nephritis
- Acute Kidney Injury
- Chronic Kidney Disease
- Cystic Renal Disease
- Tumours of the Kidney and Genitourinary Tract
- Diseases of the Prostate Gland
- The Urinary Tract in the Elderly
- Bibliography
- Significant websites
- 21 Neurological disease
- Introduction
- Clinical Approach to the Patient with Neurological Disease
- Functional Neuroanatomy
- Cranial Nerves
- Motor Control Systems
- Lower Motor Neurone Lesions
- Sensory Pathways and Pain
- Bladder Control and Sexual Dysfunction
- Investigation of Neurological Disease
- Unconsciousness and Coma
- Stroke
- Intracranial haemorrhage
- Headache, Migraine and Facial Pain
- Epilepsy and Loss of Consciousness
- Movement Disorders
- Neuroinflammatory Disorders
- Nervous System Infection
- Brain Tumours
- Hydrocephalus
- Traumatic Brain Injury
- Spinal Cord Disease
- Neurodegenerative Diseases
- Congenital Disorders
- Neurogenetic Disorders
- Paraneoplastic Syndromes
- Peripheral Nerve Disease
- Muscle Diseases
- Bibliography
- Significant websites
- 22 Psychological medicine
- Introduction
- Clinical Approach to the Patient with a Psychiatric Disorder
- Classification of Psychiatric Disorders
- Aetiology of Psychiatric Disorders
- Psychiatric Aspects of Physical Diseases
- The Sick Role and Illness Behaviour
- Functional Somatic Syndromes
- Somatoform Disorders
- Dissociative/Conversion Disorders
- Sleep Difficulties
- Mood (Affective) Disorders
- Suicide and Self-Harm
- Anxiety Disorders
- Alcohol Misuse and Dependence
- Drug Misuse and Dependence
- Schizophrenia
- Organic Mental Disorders
- Eating Disorders
- Sexual Disorders
- Personality Disorders
- Involuntary Detention or Commitment
- Mental Capacity Act
- Further reading
- Significant websites
- 23 Cardiovascular disease
- Cardiac Arrhythmias
- Heart Failure
- Coronary Artery Disease
- Valvular Heart Disease
- Infective Endocarditis
- Congenital Heart Disease
- Marfan Syndrome
- Pulmonary Heart Disease
- Myocardial and Endocardial Disease
- Pericardial Disease
- Systemic Hypertension
- Peripheral Vascular Disease
- Significant websites
- 24 Respiratory disease
- Introduction
- Anatomy of the Respiratory System
- Physiology of the Respiratory System
- Clinical Approach to the Patient with Respiratory Disease
- Smoking
- Diseases of the Upper Respiratory Tract
- Diseases of the Lower Respiratory Tract
- Asthma
- Pneumonia
- Tuberculosis
- Diffuse Parenchymal Lung Diseases
- Occupational Lung Disease
- Lung Cysts
- Tumours of the Respiratory Tract
- Disorders of the Chest Wall and Pleura
- Disorders of the Diaphragm
- Mediastinal Lesions
- Significant websites
- 25 Critical care medicine
- Introduction
- Clinical Approach to the Critically Ill Patient
- Applied Cardiorespiratory Physiology
- Disturbances of Acid–Base Balance
- Shock, Sepsis and Acute Disturbances of Haemodynamic Function
- Respiratory Failure
- Acute Respiratory Distress Syndrome
- Acute Kidney Injury
- Neurocritical Care
- Outcomes
- Bibliography
- Significant websites
- 26 Endocrine disease
- Introduction
- Clinical Approach to the Patient with Endocrine Disease
- The Pituitary Gland and Hypothalamus
- The Thyroid Axis
- Reproduction and Sex
- The Adrenal Axis
- The Thirst Axis
- Disorders of Calcium Metabolism
- Other Endocrine Disorders
- Bibliography
- Significant websites
- 27 Diabetes mellitus
- Introduction
- Classification of Diabetes
- Clinical Approach to the Patient with Diabetes
- Management of Diabetes
- Diabetic Metabolic Emergencies
- Complications of Diabetes
- Special Situations in Diabetes
- Hypoglycaemia in the Non-Diabetic Patient
- Significant websites
- 28 Lipid and metabolic disorders
- Disorders of Lipid Metabolism
- Inborn Errors of Carbohydrate Metabolism
- Inborn Errors of Amino Acid Metabolism
- Lysosomal Storage Diseases
- Amyloidosis
- The Porphyrias
- Bibliography
- Significant websites
- 29 Women's health
- Introduction
- The Life Course Approach
- Miscarriage
- Heavy Menstrual Bleeding
- Abortion/Termination of Pregnancy
- Urinary Incontinence
- Domestic Abuse and Violence
- Medical Problems in Pregnancy
- Prescribing in Pregnancy
- 30 Ear, nose and throat and eye disease
- Disorders of the Ear
- Disorders of the Nose
- Disorders of the Throat
- Disorders of the Eye
- 31 Skin disease
- Introduction
- Structure and Function of the Skin
- Clinical Approach to the Patient with Skin Disease
- Infections
- Papulo-Squamous/Inflammatory Rashes
- Facial Rashes
- Photodermatology
- Erythroderma
- Cutaneous Signs of Systemic Disease
- Bullous Disease
- Skin Tumours
- Disorders of Blood Vessels and Lymphatics
- Disorders of Collagen and Elastic Tissue
- Disorders of Pigmentation
- Disorders of the Nails
- Disorders of Hair
- Birth Marks/Neonatal Rashes
- Drug Eruptions
- Human Immunodeficiency Virus and the Skin
- Principles of Topical Therapy
- Bibliography
- Significant Websites
- Index
- Language: English
- Edition: 9
- Published:
- Imprint: Elsevier
AF
Adam Feather
Affiliations and expertise
Consultant Physician and Clinical Director, St Mary's Hospital, The Isle of WightDR
David Randall
Affiliations and expertise
Clinical Research Fellow, Barts and The London School of Medicine and Dentistry, QMUL; Specialty Registrar in Renal Medicine, Barts Health NHS Trust, London, UK