Kryger's Principles and Practice of Sleep Medicine

1 Normal Sleep and Its Variants

1. History of Sleep Physiology and Medicine

2. Normal Human Sleep: An Overview

3. Normal Aging

4. Daytime Sleepiness and Alertness

5. Sleep Deprivation

2 Sleep Mechanisms and Phylogeny

6. Introduction/Defining Sleep

7. Neural Control of Sleep in Mamma Is

8. Rapid Eye Movement Sleep Control and Function

9. Deep-Brain Imaging of Brain Neurons and Glia during Sleep

10. Evolution of Mammalian Sleep

11. Sleep in Nonmammalian Vertebrates

3 Genetics and Genomic Basis of Sleep

12. Introduction: Genetics and Genomics of Sleep

13. Genetics and Genomics of Circadian Clocks

14. Genetics and Genomic Basis of Sleep in Simple Model Organisms

15. Genetic and Genomic Basis of Sleep in Rodents

16. Genetics and Genomic Basis of Sleep in Healthy Humans

17. Genetics and Genomic Basis of Sleep Disorders in Humans

4 Physiology in Sleep

18. Introduction to Physiology in Sleep

19. What Neuroimaging Reveals about the Brain Areas Generating, Maintaining, and Regulating Sleep

20. Cardiovascular Physiology and Coupling with Respiration: Central and Autonomic Regulation

21. Cardiovascular Physiology: Autonomic Control in Health and in Sleep Disorders

22. Respiratory Physiology. Central Neural Control of Respiratory Neurons and Motoneurons during Sleep

23. Respiratory Physiology Understanding the Control of Ventilation

24. Physiology of Upper and lower Airways

25. 5 Respiratory Physiology Sleep at High Altitude

26. Sleep and Host Defense

27. Endocrine Physiology in Relation to Sleep and Sleep Disturbances

28. Thermoregulation in Sleep and Hibernation

29. Memory Processing in Relation to Sleep

30. Sensory and Motor Processing during Sleep and Wakefulness

31. Local and Use-Dependent Aspects of Sleep

32. Pathophysiology of Sleep-Wake Disturbances after Traumatic Brain Injury

5 Chronobiology

33. Introduction

34. Master Circadian Clock and Master Circadian Rhythm

35. Anatomy of the Mammalian Circadian Sys tern

36. Physiology of the Mammalian Circadian System

37. Human Circadian Timing System and Sleep-Wake Regulation

38. Sleep Homeostasis and Models of Sleep Regulation

39. Circadian Rhythms in Sleepiness, Alertness, and Performance

40. Central and Peripheral Circadian Clocks

41. Circadian Dysregulation and Cardiometabolic and Immune Health

42. Circadian Dysregulation in Brain Aging and Neuropsychiatrie Health

43. Circadian Disorders of the Sleep-Wake Cycle

6 Pharmacology

44. Introduction

45. Adenosinergic Control of Sleep

46. Catecholamines

47. GABA: Its Metabolism, Receptors, and the Drugs for Treating Insomnias and Hypersomnias

48. Histamine

49. Orexin/Hypocretin

50. Serotonin and Sleep

51. Melatonin

52. Opioid Actions on Sleep and Breathing

53. Clinical Pharmacology of Drugs that Affect Sleep and Wake

7 Psychobiology and Dreaming

54. Introduction

55. Why We Dream

56. Dream Content: Quantitative Findings

57. Neural Correlates of Dreaming

58. The Neurobiology of Dreaming

59. Lucid Dreaming

60. What Is the Function of Nightmares?

61. Dreams and Nightmares in Posttraumatic Stress Disorder

62. Incorporation of Waking Experiences into Dreams

63. Emotion, Motivation, and Reward in Relation to Dreaming

64. Dreaming during Pregnancy

8 Impact, Presentation, and Diagnosis

65. Approach to the Patient with Disordered Sleep

66. Cardinal Manifestations of Sleep Disorders

67. Physical Examination in Sleep Medicine

68. Clinical Tools and Tests in Sleep Medicine

69. Classification of Sleep Disorders

70. Epidemiology of Sleep Medicine

71. Sleep Medicine, Public Policy, and Public Health

9 Legal Aspects of Sleep Medicine

72. Introduction

73. Sleep Forensics: Criminal Culpability for Sleep-Related Violence

74. Legal Obligations of Persons Who Have Sleep Disorders or Who Treat or Hire Them

75. Legal Aspects of Fatigue- and Safety-Sensitive Professions

76. Sleep Medicine Clinical Practice and Compliance— United States

77. Sleep Medicine Clinical Practice and Compliance—Europe

10 Occupational Sleep Medicine

78. Introduction

79. Performance Deficits During Sleep Loss and Their Operational Consequences

80. Sleep and Sleep Disorders in Operational Settings

81. Shift Work, Shift-Work Disorder, Jet Lag. and Jet Lag Disorder

82. Fatigue Countermeasures

83. Sleep, Sleepiness, and Performance Prediction Modeling

84. Fatigue RiskManagemen f Systems

85. Safety Cases and Assessing Alternative Means of Regulatory Compliance in Fatigue RiskManagemenf

86. Fatigue Proofing

87. Sleep Health in Athlete Populations: Unique Challenges and Practical Solutions

88. Assessment of the Occupational Sleep Medicine Field

11 Insomnia

89. Advances in Insomnia Pathophysiology and Treatment: An Introduction

90. Insomnia: Epidemiology, Risk Factors, and Health Disparities

91. Etiology and Pathophysiology of Insomnia

92. Pediatric Insomnia and Its Developmental Trajectories

93. Insomnia Diagnosis, Assessment, and Evaluation

94. Insomnia with Short Sleep Duration and Multidimensional Sleep Health

95. Behavioral Treatment I: Therapeutic Approaches and Implementation

96. Behavioral Treatment II: Efficacy, Effectiveness, and Dissemination

97. Behavioral Treatment III: Digital and Telehealth Approaches

98. Pharmacologic Treatment I: Therapeutic Approaches and Implementation

99. Pharmacologic Treatment II: Efficacy, Effectiveness, and Contraindications

100. Pharmacologic Treatment III: Sequenced and Combined Psychologic and Pharmacologic Treatments for Insomnia

12 Neurologic Disorders

101. Introduction

102. Parkinsonism

103. Sleep-Wake Disturbances and Stroke

104. Sleep and Neuromuscular Diseases

105. Alzheimer Disease and Other Demen tias

106. Epilepsy, Sleep, and Sleep Disorders

107. Sleep and Headache

108. Sleep Disorders after Traumatic Brain Injury

109. Autoimmune Disorders (Autoimmune Encephalitides and Multiple Sclerosis)

13 Hypersomnias

110. Central Disorders of Hypersomnolence

111. Narcolepsy: Pathophysiology and Genetic Predisposition

112. Narcolepsy: Diagnosis and Management

113. Idiopathic Hypersomnia

114. Kleine-Levin Syndrome

14 Parasomnias

115. Parasomnias and Sleep-Related Movement Disorders: Overview and Approach

116. Disorders of Arousal

117. Sleep-Related Eating Disorder

118. Rapid Eye Movement Sleep Parasomnias

119. Nightmares and Dream Disturbances

120. Other Parasomnias

121. Restless Legs Syndrome /Willis-Ekbom Disease) and Periodic Limb Movements during Sleep

122. Sleep-Related Movement Disorders and Their Unique Motor Manifestations

15 Sleep Breathing Disorders

123. Introduction

124. Central Sleep Apnea: Definitions, Pathophysiology, Genetics, and Epidemiology

125. Central Sleep Apnea: Diagnosis and Management

126. Anatomy and Physiology of Upper Airway Obstruction

127. Snoring and Pathologic Upper Airway Resistance Syndromes

128. Obstructive Sleep Apnea: Heritable Phenotypes and Genetics

129. Deep Phenotyping of Sleep Apnea

130. Clinical and Physiologic Heterogeneity of Obstructive Sleep Apnea

131. Obstructive Sleep Apnea: Clinical Features, Evaluation, and Principles of Management

132. Positive Airway Pressure Treatment for Obstructive Sleep Apnea

133. Pharmacologic Treatments for Obstructive Sleep Apnea

134. Alternative Strategies to Management of Sleep-Disordered Breathing

135. Brain Health in Sleep Apnea: Cognition, Performance, Mechanisms, and Treatment

136. Obstructive Sleep Apnea and Metabolic Disorders

137. Overlap Syndromes of Sleep and Breathing Disorders

138. Obesity-Hypoventilation Syndrome

139. Obstructive Sleep Apnea, Obesity, and Bariatric Surgery

140. Advanced Modes of Positive Pressure Therapy for Sleep-Disordered Breathing

141. Sleep and Breathing at High Altitude

142. Evolution of Sleep-Disordered Breathing across the Adult Years

16 Cardiovascular Disorders

143. Introduction

144. Sleep-Related Cardiac Risk

145. Cardiac A rrhythmogenesis during Sleep: Mechanisms, Diagnosis, and Therapy

146. Cardiovascular Effects of Sleep-Related Breathing Disorders

147. Systemic and Pulmonary Hypertension in Obstructive Sleep Apnea

148. Coronary Artery Disease and Obstructive Sleep Apnea

149. Heart Failure

150. Sleep-Disordered Breathing and Stroke

151. Insomnia and Cardiovascular Disease

17 Other Medical Disorders

152. Introduction

153. Sleep and Cancer across the Life Span

154. Fibromyalgia and Chronic Fatigue Syndromes

155. Endocrine Disorders

156. Pain and Sleep

157. Sleep and Chronic Kidney Disease

158. Sleep in the Critically III Patient

159. Perioperative Sleep Medicine

160. Sleep and Gastrointestinal Health

18 Psychiatric Disorders

161. Introduction

162. Emotion and Sleep

163. Anxiety Disorders and Posttraumatic Stress Disorder

164. Affearve Disorders

165. Schizophrenia and Sleep

166. Substance Abuse

19 Dentistry and Otorhinolaryngology

167. Dentistry and Otorhinolaryngology in Sleep Medicine: Below the BraiAtttpd Above the Larynx

168. Oronasopharyngeal Growth and Malformations with Orthodontic Management

169. Sleep Bruxism: Definition, Prevalence, Classification, Etiology, and Consequences

170. Assessment of Sleep Bruxism

171. Management of Sleep Bruxism: Psychological, DentaL and Medical Approaches in Adults

172. Orofacial Pain/Temporomandibular Disorders in Relation to Sleep Bruxism and Breathing Disorders

173. Oral Appliances for the Treatment of Sleep-Disordered Breathing

174. Anesthesia in Upper Airway Surgery

175. Upper Airway Surgery to Treat Obstructive Sleep- Disordered Breathing

176. Pharmacotherapy and Behavioral Complementary, and Alternative Medicine for Sleep Bruxism

20 From Childhood to Adulthood

177. Overview: Transition from Pediatric-Oriented to Adult-Oriented Health Care in Sleep Medicine

178. Sleep-Related Breathing Disorders in Children

179. Neuromuscular and Neurological Disorders

180. Transitional Care for Adolescents with Narcolepsy and Other Central Disorders of Hypersomnolence

181. Congenital Heart Disease

182. Sleep in Intersex and Transgender Individuals

21 Sleep in Women

183. Introduction

184. Sex Effects and Differences in Circadian Rhythms and Sleep

185. The Menstrual Cycle, Sleep, and Circadian Rhythms

186. Sleep and Sleep Disorders Associated with Pregnancy

187. Sleep-Disordered Breathing in Pregnancy

188. Postpartum Period and Early Parenthood

189. Sleep and Menopause

22 Sleep Medicine in the Elderly

190. Introduction

191. Psychiatric and Medical Comorbidities and E ffects oiMedications in Older Adults

192. Obstructive Sleep Apnea in Older Adults

193. Insomnia in Older Adults

194. Orcadian Rhythms in Older Adults

195. Sleep in Long-Term Care Settings

23 Methodology

196. Section Introduction: Polysomnography and Beyond

197. Sleep Stage Scoring

198. Central Nervous System Arousals and the Cyclic Alternating Pattern

199. Neurologic Monitoring Techniques

200. Monitoring Techniques for Evaluating Suspected Sleep-Related Breathing and Cardiovascular Disorders

201. Sleep Telemedicine and Remote PAP Adherence Monitoring

202. Cardiopulmonary Coupling

203. Pulse Wave Analysis

204. Recording and Scoring Sleep-Related Movements

205. Home Sleep Testing for Sleep-Related Breathing Disorders

206. Consumer Sleep Tracking: Landscape and CTA/ANSI Performance Standards

207. Evaluating Sleepiness and Fatigue

208. The Assessment of Insomnia

209. Surveys, Sampling, and Polling Methods for Sleep and Public Health

210. Techniques for Clinical Assessment of Circadian Rhythm Disorders

211. Actigraphy Methods and Technical Issues

212. Imaging

213. COVID-19 and Sleep