Kinase Targets and Drug Discovery

Kinase Targets and Drug Discovery is a comprehensive resource covering the critical role of kinases as regulators of cellular functions and their implications in a range of diseases, from cancers to cardiovascular disorders and inflammatory conditions. In light of rapid advancements in kinase biology and emerging therapeutic modalities, this book addresses the urgent need for updated insights in the field, making it an essential guide for pharmaceutical researchers. The book is structured into three key parts, beginning with an overview of kinases as drug targets. Readers will explore foundational concepts through chapters detailing the functions of kinases, the role of kinase inhibitors in disease therapy, and the challenges faced in their discovery. The second section focuses on innovative strategies in kinase drug discovery, covering screening and computational approaches, as well as the development of covalent, macrocyclic, allosteric inhibitors, and kinase degraders. The final part examines clinical applications, detailing how kinase inhibition can be harnessed for cancer therapies, non-oncologic diseases, and even non-catalytic functions. Kinase Targets and Drug Discovery serves as an indispensable resource for pharmacologists, medicinal chemists, and researchers in both academia and industry. By bridging the gap between foundational research and clinical application, this book equips professionals with the latest insights and practical approaches to advance their understanding and contribute meaningfully to the evolving landscape of drug discovery.