Kelley's Textbook of Rheumatology

Expert Consult Premium Edition - Enhanced Online Features and Print, 2-Volume Set

9th Edition - September 21, 2012
Latest edition
Authors: Gary S. Firestein, Ralph C. Budd, Sherine E Gabriel, Iain B. McInnes, James R. O'Dell
Language: English

Kelley's Textbook of Rheumatology delivers the state-of-the-art scientific and clinical know-how you need to offer your patients the most effective diagnosis and care. This rh… Read more

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Kelley's Textbook of Rheumatology delivers the state-of-the-art scientific and clinical know-how you need to offer your patients the most effective diagnosis and care. This rheumatology book’s sweeping updates highlight current advances and breakthroughs that impact your practice. With Kelley's Textbook of Rheumatology, you'll be ready to handle the toughest clinical challenges you face.

VOLUME I

STRUCTURE AND FUNCTION OF

BONE, JOINTS, AND CONNECTIVE

TISSUE, 1

1
Biology of the Normal Joint, 1

2
Synovium, 20

3
Cartilage and Chondrocytes, 33

4
Biology, Physiology, and Morphology

of Bone, 61

5
Muscle: Anatomy, Physiology,

and Biochemistry, 67

6
Biomechanics, 79

7
Regenerative Medicine and Tissue

Engineering, 90

8
Proteinases and Matrix

Degradation, 97

CELLS INVOLVED IN

AUTOIMMUNE DISEASES

AND INFLAMMATION, 117

9
Dendritic Cells, 117

10
Mononuclear Phagocytes in Rheumatic

Diseases, 134

11
Neutrophils, 152

12
Eosinophils, 170

13
T Lymphocytes, 174

14
B Cells, 191

15
Fibroblasts and Fibroblast-like

Synoviocytes, 215

16
Mast Cells, 232

17
Platelets, 245

EFFECTOR MECHANISMS IN

AUTOIMMUNITY AND

INFLAMMATION, 255

18
Innate Immunity, 255

19
Adaptive Immunity and Organization of Lymphoid

Tissues, 268

20
Autoimmunity, 281

21
Genetics of Rheumatic Diseases, 299

22
Epigenetics, 316

23
Complement System, 325

24
Prostaglandins, Leukotrienes, and Related

Compounds, 340

25
Cell Recruitment and Angiogenesis, 358

26
Cytokines, 369

27
Cell Survival and Death in Rheumatic

Diseases , 382

28
Experimental Models for Rheumatoid

Arthritis, 400

29
Neural Regulation of Pain and Infl ammation, 413

BROAD ISSUES IN THE APPROACH TO

RHEUMATIC DISEASE, 431

30
Principles of Epidemiology in Rheumatic

Disease, 431

31
Economic Burden of Rheumatic

Diseases, 440

32
Clinical Trial Design and Analysis, 452

33
Assessment of Health Outcomes, 462

34
Biologic Markers, 476

35
Occupational and Recreational Musculoskeletal

Disorders, 493

36
Cardiovascular Risk in Rheumatic

Disease, 505

37
Cancer Risk in Rheumatic Diseases, 515

38
Introduction to Physical Medicine, Physical

Therapy, and Rehabilitation, 528

39
Pregnancy in the Rheumatic Diseases, 540

EVALUATION OF GENERALIZED AND

LOCALIZED SYMPTOMS, 559

40
History and Physical Examination of the

Musculoskeletal System, 559

41
Acute Monoarthritis, 577

42
Polyarticular Arthritis, 587

43
The Skin and Rheumatic Diseases, 599

44
The Eye and Rheumatic Diseases, 617

DIFFERENTIAL DIAGNOSIS OF REGIONAL

AND DIFFUSE MUSCULOSKELETAL

PAIN, 625

45
Neck Pain, 625

46
Shoulder Pain, 639

47
Low Back Pain, 665

48
Hip and Knee Pain, 683

49
Foot and Ankle Pain, 700

50
Hand and Wrist Pain, 708

51
Temporomandibular Joint Pain, 721

52
Fibromyalgia, 733

DIAGNOSTIC TESTS AND PROCEDURES IN

RHEUMATIC DISEASES, 753

53
Synovial Fluid Analyses, Synovial Biopsy,

and Synovial Pathology , 753

54
Arthrocentesis and Injection of Joints and Soft

Tissue, 770

55
Antinuclear Antibodies, 789

56
Autoantibodies in Rheumatoid Arthritis, 804

57
Acute Phase Reactants and the Concept

of Infl ammation, 818

58
Imaging Modalities in Rheumatic Diseases , 830

PHARMACOLOGY OF ANTIRHEUMATIC

DRUGS, 871

59
Prostanoid Biology and Its Therapeutic

Targeting, 871

60
Glucocorticoid Therapy, 894

61
Traditional DMARDs: Methotrexate, Lefl unomide,

Sulfasalazine, Hydroxychloroquine, and

Combination Therapies, 917

62
Immunosuppressive Drugs, 941

63
Anticytokine Therapies, 957

64
Cell-Targeted Biologics and Targets:

Rituximab, Abatacept, and Other

Biologics, 978

65
Antihyperuricemic Agents, 1001

66
Analgesic Agents in Rheumatic

Disease, 1014

67
Psychosocial Management of Rheumatic

Diseases, 1034

68
Nutrition and Rheumatic Diseases, 1044

VOLUME II

RHEUMATOID ARTHRITIS, 1059

69
Etiology and Pathogenesis of Rheumatoid

Arthritis , 1059

70
Clinical Features of Rheumatoid

Arthritis , 1109

71
Treatment of Rheumatoid Arthritis, 1137

72
Early Synovitis and Early Undifferentiated

Arthritis, 1161

73
Sjögren’s Syndrome, 1169

SPONDYLOARTHROPATHIES, 1193

74
Pathogenesis of Ankylosing Spondylitis and

Reactive Arthritis, 1193

75
Ankylosing Spondylitis, 1202

76
Reactive Arthritis and Undifferentiated

Spondyloarthritis, 1221

77
Psoriatic Arthritis, 1232

78
Enteropathic Arthritis, 1251

SYSTEMIC LUPUS ERYTHEMATOSUS AND

RELATED SYNDROMES, 1269

79
Etiology and Pathogenesis of Systemic Lupus

Erythematosus, 1269

80
Clinical Features of Systemic Lupus

Erythematosus, 1283

81
Treatment of Systemic Lupus

Erythematosus, 1304

82
Antiphospholipid Syndrome, 1331

SCLERODERMA, INFLAMMATORY

MYOPATHIES, AND OVERLAP

SYNDROMES, 1343

83
Etiology and Pathogenesis of Scleroderma, 1343

84
Clinical Features and Treatment of

Scleroderma, 1366

85
Infl ammatory Diseases of Muscle and Other

Myopathies, 1404

86
Overlap Syndromes, 1431

VASCULITIS, 1453

87
Classifi cation and Epidemiology of Systemic

Vasculitis, 1453

88
Giant Cell Arteritis, Polymyalgia Rheumatica, and

Takayasu’s Arteritis, 1461

89
Antineutrophil Cytoplasm Antibody–Associated

Vasculitis, 1481

90
Polyarteritis Nodosa and Related Disorders, 1498

91
Immune Complex–Mediated Small Vessel

Vasculitis, 1508

92
Primary Angiitis of the Central Nervous

System, 1518

93
Behçet’s Disease, 1525

CRYSTAL-INDUCED AND

INFLAMMASOME-MEDIATED

INFLAMMATION, 1533

94
Etiology and Pathogenesis of Hyperuricemia

and Gout , 1533

95
Clinical Features and Treatment of Gout, 1554

96
Calcium Crystal Disease: Calcium

Pyrophosphate Dihydrate and Basic

Calcium Phosphate , 1576

97
Familial Autoinfl ammatory Syndromes, 1597

CARTILAGE, BONE, AND HERITABLE

CONNECTIVE TISSUE DISORDERS, 1617

98
Pathogenesis of Osteoarthritis, 1617

99
Clinical Features of Osteoarthritis, 1636

100
Treatment of Osteoarthritis , 1646

101
Metabolic Bone Disease, 1660

102
Proliferative Bone Diseases, 1680

103
Osteonecrosis, 1692

104
Relapsing Polychondritis , 1712

105
Heritable Diseases of Connective Tissue, 1719

RHEUMATIC DISEASES OF

CHILDHOOD, 1741

106
Etiology and Pathogenesis of Juvenile

Idiopathic Arthritis, 1741

107
Treatment of Juvenile Idiopathic Arthritis, 1752

108
Pediatric Systemic Lupus Erythematosus,

Dermatomyositis, Scleroderma, and

Vasculitis, 1771

INFECTION AND ARTHRITIS, 1801

109
Bacterial Arthritis, 1801

110
Lyme Disease, 1815

111
Mycobacterial Infections of Bones

and Joints, 1829

112
Fungal Infections of Bones and

Joints, 1841

113
Rheumatic Manifestations of Human

Immunodefi ciency Virus Infection, 1851

114
Viral Arthritis, 1865

115
Poststreptococcal Arthritis and Rheumatic

Fever, 1875

ARTHRITIS ACCOMPANYING

SYSTEMIC DISEASE, 1889

116
Amyloidosis, 1889

117
Sarcoidosis , 1898

118
Hemochromatosis, 1907

119
Hemophilic Arthropathy, 1915

120
Rheumatologic Manifestations of

Hemoglobinopathies, 1924

121
Endocrine Diseases and the Musculoskeletal

System, 1927

122
Musculoskeletal Syndromes in Malignancy, 1934

123
Tumors and Tumor-like Lesions of Joints and

Related Structures, 1951

Gary S. Firestein

Gary Firestein, MD, is a board-certified rheumatologist who diagnoses and treats patients with autoimmune conditions as well as diseases of the joints, muscles and bones. A professor at UC San Diego School of Medicine, Dr. Firestein is distinguished for his research and serves as director of the Altman Clinical and Translational Research Institute and the senior associate vice chancellor for health sciences. Dr. Firestein's research interest focuses on the pathogenesis and treatment of rheumatoid arthritis. Dr. Firestein is the recipient of many awards and honors, including the Arthritis Foundation's Jane Wyman Humanitarian Award in 2010 for his contributions to rheumatology; the Arthritis Foundation Lee C. Howley Sr. Prize for Arthritis Research; and the American College of Rheumatology Distinguished Investigator Award. He has been elected to the American Society for Clinical Investigation and the Association of American Physicians. He has served as an editor for the Textbook of Rheumatology for since the 7th edition (2004).

Affiliations and expertise

Distinguished Professor of Medicine, Senior Associate Vice Chancellor for Health Sciences, Director, Altman Clinical and Translational Research Institute, USA

Ralph C. Budd

Affiliations and expertise

Professor of Medicine and Microbiology and Molecular Genetics, Director, Vermont Center for Immunology and Infectious Diseases, University of Vermont College of Medicine Distinguished University Professor, The University of Vermont College of Medicine, Burlington, Vermont

Sherine E Gabriel

Affiliations and expertise

Professor and Dean, Rutgers Robert Wood Johnson Medical School, CEO, Robert Wood Johnson Medical Group, Emeritus Professor, Mayo Clinic, New Brunswick, New Jersey

Iain B. McInnes

Iain McInnes is Director of the Institute of Infection, Immunity and Inflammation at the University of Glasgow, UK. He has extensive experience in leading multicenter programs nationally and internationally. He is Director of the Scottish MRC Clinical Pharmacology and Pathology Clinical PhD Training Program, Chief Investigator for the Scottish Early RA Cohort (SERA) and the related SMS-IC biomarker discovery program (PROMISERA), and chief investigator of numerous global phase II and III clinical trials of novel immune therapies. He has served as member or chair of numerous national grant-funding panels and as chair of several European League Against Rheumatism (EULAR) scientific committees – he is now Treasurer and President Elect of EULAR serving on its Steering Committee. He is formerly Chairman of the Foundation for European Rheumatology Research (Foreum) Scientific Committee and leads the EULAR-supported European Roadmap Program that is defining the research agenda for rheumatology for the next decade.

Affiliations and expertise

Muirhead Professor of Medicine, Arthritis Research UK Professor of Rheumatology, Director of Institute of Infection,Immunity, and Inflammation, College of Medical, Veterinary, and Life Sciences, University of Glasgow, Glasgow, Scotland, United Kingdom

James R. O'Dell

James R. O’Dell, MD is the Stokes Shackleford Professor of Internal Medicine, Vice-Chairman of Internal Medicine and Chief of the Division of Rheumatology at the University of Nebraska Medical Center (UNMC) in Omaha. Dr. O’Dell founded and has directed the Rheumatoid Arthritis Investigational Network (RAIN) for the last 25 years. Dr. O’Dell is the PI of the large multinational RA research study based at the VA through their cooperative studies program. Dr. O’Dell has published extensively, mostly in the area of rheumatoid arthritis. He has presented frequently at national and international meetings and has more than 100 published articles in top-level rheumatology journals. He has served on numerous American College of Rheumatology (ACR) committees over the last 20 years, including time on both the ACR and REF BOD, as well as a two-year term as President of the Research and Education Foundation of the ACR and was President of the College (2011-2012). Additionally, he is Editor-in-Chief of Up To Date for Rheumatology.

Affiliations and expertise

Bruce Professor and Vice Chairman of Internal Medicine, University of Nebraska Medical Center, Chief of Rheumatology, Department of Medicine, Omaha Veterans Affairs, Omaha, Nebraska, USA

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Kelley's Textbook of Rheumatology

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About the authors

Gary S. Firestein

Ralph C. Budd

Sherine E Gabriel

Iain B. McInnes

James R. O'Dell

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