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Kelley's Textbook of Rheumatology

Expert Consult Premium Edition - Enhanced Online Features and Print, 2-Volume Set

  • 9th Edition - September 21, 2012
  • Latest edition
  • Authors: Gary S. Firestein, Ralph C. Budd, Sherine E Gabriel, Iain B. McInnes, James R. O'Dell
  • Language: English

Kelley's Textbook of Rheumatology delivers the state-of-the-art scientific and clinical know-how you need to offer your patients the most effective diagnosis and care. This rh… Read more

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Description

Kelley's Textbook of Rheumatology delivers the state-of-the-art scientific and clinical know-how you need to offer your patients the most effective diagnosis and care. This rheumatology book’s sweeping updates highlight current advances and breakthroughs that impact your practice. With Kelley's Textbook of Rheumatology, you'll be ready to handle the toughest clinical challenges you face.

Key features

  • Search the entire contents online at www.expertconsult.com, download all of images, and watch videos demonstrating the complete musculoskeletal exam, including abnormal findings and the arthroscopic presentation of diseased joints.

  • Review basic science advances and their clinical implications in one place and get dependable, evidence-based guidance with the integrated chapter format that readers of Kelley's Textbook of Rheumatology have always appreciated.

  • Gain a thorough understanding of the "whys" and "hows" of rheumatic disease management with detailed coverage of the very latest breakthroughs and the newest clinical algorithms.

Readership

Rheumatologists

Orthopedics

Table of contents

VOLUME I

STRUCTURE AND FUNCTION OF

BONE, JOINTS, AND CONNECTIVE

TISSUE, 1

1

Biology of the Normal Joint, 1

2

Synovium, 20

3

Cartilage and Chondrocytes, 33

4

Biology, Physiology, and Morphology

of Bone, 61

5

Muscle: Anatomy, Physiology,

and Biochemistry, 67

6

Biomechanics, 79

7

Regenerative Medicine and Tissue

Engineering, 90

8

Proteinases and Matrix

Degradation, 97

CELLS INVOLVED IN

AUTOIMMUNE DISEASES

AND INFLAMMATION, 117

9

Dendritic Cells, 117

10

Mononuclear Phagocytes in Rheumatic

Diseases, 134

11

Neutrophils, 152

12

Eosinophils, 170

13

T Lymphocytes, 174

14

B Cells, 191

15

Fibroblasts and Fibroblast-like

Synoviocytes, 215

16

Mast Cells, 232

17

Platelets, 245

EFFECTOR MECHANISMS IN

AUTOIMMUNITY AND

INFLAMMATION, 255

18

Innate Immunity, 255

19

Adaptive Immunity and Organization of Lymphoid

Tissues, 268

20

Autoimmunity, 281

21

Genetics of Rheumatic Diseases, 299

22

Epigenetics, 316

23

Complement System, 325

24

Prostaglandins, Leukotrienes, and Related

Compounds, 340

25

Cell Recruitment and Angiogenesis, 358

26

Cytokines, 369

27

Cell Survival and Death in Rheumatic

Diseases , 382

28

Experimental Models for Rheumatoid

Arthritis, 400

29

Neural Regulation of Pain and Infl ammation, 413

BROAD ISSUES IN THE APPROACH TO

RHEUMATIC DISEASE, 431

30

Principles of Epidemiology in Rheumatic

Disease, 431

31

Economic Burden of Rheumatic

Diseases, 440

32

Clinical Trial Design and Analysis, 452

33

Assessment of Health Outcomes, 462

34

Biologic Markers, 476

35

Occupational and Recreational Musculoskeletal

Disorders, 493

36

Cardiovascular Risk in Rheumatic

Disease, 505

37

Cancer Risk in Rheumatic Diseases, 515

38

Introduction to Physical Medicine, Physical

Therapy, and Rehabilitation, 528

39

Pregnancy in the Rheumatic Diseases, 540

EVALUATION OF GENERALIZED AND

LOCALIZED SYMPTOMS, 559

40

History and Physical Examination of the

Musculoskeletal System, 559

41

Acute Monoarthritis, 577

42

Polyarticular Arthritis, 587

43

The Skin and Rheumatic Diseases, 599

44

The Eye and Rheumatic Diseases, 617

DIFFERENTIAL DIAGNOSIS OF REGIONAL

AND DIFFUSE MUSCULOSKELETAL

PAIN, 625

45

Neck Pain, 625

46

Shoulder Pain, 639

47

Low Back Pain, 665

48

Hip and Knee Pain, 683

49

Foot and Ankle Pain, 700

50

Hand and Wrist Pain, 708

51

Temporomandibular Joint Pain, 721

52

Fibromyalgia, 733

DIAGNOSTIC TESTS AND PROCEDURES IN

RHEUMATIC DISEASES, 753

53

Synovial Fluid Analyses, Synovial Biopsy,

and Synovial Pathology , 753

54

Arthrocentesis and Injection of Joints and Soft

Tissue, 770

55

Antinuclear Antibodies, 789

56

Autoantibodies in Rheumatoid Arthritis, 804

57

Acute Phase Reactants and the Concept

of Infl ammation, 818

58

Imaging Modalities in Rheumatic Diseases , 830

PHARMACOLOGY OF ANTIRHEUMATIC

DRUGS, 871

59

Prostanoid Biology and Its Therapeutic

Targeting, 871

60

Glucocorticoid Therapy, 894

61

Traditional DMARDs: Methotrexate, Lefl unomide,

Sulfasalazine, Hydroxychloroquine, and

Combination Therapies, 917

62

Immunosuppressive Drugs, 941

63

Anticytokine Therapies, 957

64

Cell-Targeted Biologics and Targets:

Rituximab, Abatacept, and Other

Biologics, 978

65

Antihyperuricemic Agents, 1001

66

Analgesic Agents in Rheumatic

Disease, 1014

67

Psychosocial Management of Rheumatic

Diseases, 1034

68

Nutrition and Rheumatic Diseases, 1044

VOLUME II

RHEUMATOID ARTHRITIS, 1059

69

Etiology and Pathogenesis of Rheumatoid

Arthritis , 1059

70

Clinical Features of Rheumatoid

Arthritis , 1109

71

Treatment of Rheumatoid Arthritis, 1137

72

Early Synovitis and Early Undifferentiated

Arthritis, 1161

73

Sjögren’s Syndrome, 1169

SPONDYLOARTHROPATHIES, 1193

74

Pathogenesis of Ankylosing Spondylitis and

Reactive Arthritis, 1193

75

Ankylosing Spondylitis, 1202

76

Reactive Arthritis and Undifferentiated

Spondyloarthritis, 1221

77

Psoriatic Arthritis, 1232

78

Enteropathic Arthritis, 1251

SYSTEMIC LUPUS ERYTHEMATOSUS AND

RELATED SYNDROMES, 1269

79

Etiology and Pathogenesis of Systemic Lupus

Erythematosus, 1269

80

Clinical Features of Systemic Lupus

Erythematosus, 1283

81

Treatment of Systemic Lupus

Erythematosus, 1304

82

Antiphospholipid Syndrome, 1331

SCLERODERMA, INFLAMMATORY

MYOPATHIES, AND OVERLAP

SYNDROMES, 1343

83

Etiology and Pathogenesis of Scleroderma, 1343

84

Clinical Features and Treatment of

Scleroderma, 1366

85

Infl ammatory Diseases of Muscle and Other

Myopathies, 1404

86

Overlap Syndromes, 1431

VASCULITIS, 1453

87

Classifi cation and Epidemiology of Systemic

Vasculitis, 1453

88

Giant Cell Arteritis, Polymyalgia Rheumatica, and

Takayasu’s Arteritis, 1461

89

Antineutrophil Cytoplasm Antibody–Associated

Vasculitis, 1481

90

Polyarteritis Nodosa and Related Disorders, 1498

91

Immune Complex–Mediated Small Vessel

Vasculitis, 1508

92

Primary Angiitis of the Central Nervous

System, 1518

93

Behçet’s Disease, 1525

CRYSTAL-INDUCED AND

INFLAMMASOME-MEDIATED

INFLAMMATION, 1533

94

Etiology and Pathogenesis of Hyperuricemia

and Gout , 1533

95

Clinical Features and Treatment of Gout, 1554

96

Calcium Crystal Disease: Calcium

Pyrophosphate Dihydrate and Basic

Calcium Phosphate , 1576

97

Familial Autoinfl ammatory Syndromes, 1597

CARTILAGE, BONE, AND HERITABLE

CONNECTIVE TISSUE DISORDERS, 1617

98

Pathogenesis of Osteoarthritis, 1617

99

Clinical Features of Osteoarthritis, 1636

100

Treatment of Osteoarthritis , 1646

101

Metabolic Bone Disease, 1660

102

Proliferative Bone Diseases, 1680

103

Osteonecrosis, 1692

104

Relapsing Polychondritis , 1712

105

Heritable Diseases of Connective Tissue, 1719

RHEUMATIC DISEASES OF

CHILDHOOD, 1741

106

Etiology and Pathogenesis of Juvenile

Idiopathic Arthritis, 1741

107

Treatment of Juvenile Idiopathic Arthritis, 1752

108

Pediatric Systemic Lupus Erythematosus,

Dermatomyositis, Scleroderma, and

Vasculitis, 1771

INFECTION AND ARTHRITIS, 1801

109

Bacterial Arthritis, 1801

110

Lyme Disease, 1815

111

Mycobacterial Infections of Bones

and Joints, 1829

112

Fungal Infections of Bones and

Joints, 1841

113

Rheumatic Manifestations of Human

Immunodefi ciency Virus Infection, 1851

114

Viral Arthritis, 1865

115

Poststreptococcal Arthritis and Rheumatic

Fever, 1875

ARTHRITIS ACCOMPANYING

SYSTEMIC DISEASE, 1889

116

Amyloidosis, 1889

117

Sarcoidosis , 1898

118

Hemochromatosis, 1907

119

Hemophilic Arthropathy, 1915

120

Rheumatologic Manifestations of

Hemoglobinopathies, 1924

121

Endocrine Diseases and the Musculoskeletal

System, 1927

122

Musculoskeletal Syndromes in Malignancy, 1934

123

Tumors and Tumor-like Lesions of Joints and

Related Structures, 1951

Review quotes

"The ninth edition has many positive changes, including in the presentation, such as color coding of sections and charts and diagrams, which have made the information easier to assimilate. The book also provides up-to-date information while keeping with the traditional feel of previous editions. In times where electronic media have taken over print media, <B><I>Kelley's</I></B> still draws readers. It is likely the most definitive rheumatology book not only in the U.S., but also in the rest of the world".- Deepali P Sen, M.D.(Washington University Medical Center) Doody 5 star review!

Product details

  • Edition: 9
  • Latest edition
  • Published: September 21, 2012
  • Language: English

About the authors

GF

Gary S. Firestein

Gary Firestein, MD, is a board-certified rheumatologist who diagnoses and treats patients with autoimmune conditions as well as diseases of the joints, muscles and bones. A professor at UC San Diego School of Medicine, Dr. Firestein is distinguished for his research and serves as director of the Altman Clinical and Translational Research Institute and the senior associate vice chancellor for health sciences. Dr. Firestein's research interest focuses on the pathogenesis and treatment of rheumatoid arthritis. Dr. Firestein is the recipient of many awards and honors, including the Arthritis Foundation's Jane Wyman Humanitarian Award in 2010 for his contributions to rheumatology; the Arthritis Foundation Lee C. Howley Sr. Prize for Arthritis Research; and the American College of Rheumatology Distinguished Investigator Award. He has been elected to the American Society for Clinical Investigation and the Association of American Physicians. He has served as an editor for the Textbook of Rheumatology for since the 7th edition (2004).
Affiliations and expertise
Distinguished Professor of Medicine, Senior Associate Vice Chancellor for Health Sciences, Director, Altman Clinical and Translational Research Institute, USA

RB

Ralph C. Budd

Affiliations and expertise
Professor of Medicine and Microbiology and Molecular Genetics, Director, Vermont Center for Immunology and Infectious Diseases, University of Vermont College of Medicine Distinguished University Professor, The University of Vermont College of Medicine, Burlington, Vermont

SG

Sherine E Gabriel

Affiliations and expertise
Professor and Dean, Rutgers Robert Wood Johnson Medical School, CEO, Robert Wood Johnson Medical Group, Emeritus Professor, Mayo Clinic, New Brunswick, New Jersey

IM

Iain B. McInnes

Iain McInnes is Director of the Institute of Infection, Immunity and Inflammation at the University of Glasgow, UK. He has extensive experience in leading multicenter programs nationally and internationally. He is Director of the Scottish MRC Clinical Pharmacology and Pathology Clinical PhD Training Program, Chief Investigator for the Scottish Early RA Cohort (SERA) and the related SMS-IC biomarker discovery program (PROMISERA), and chief investigator of numerous global phase II and III clinical trials of novel immune therapies. He has served as member or chair of numerous national grant-funding panels and as chair of several European League Against Rheumatism (EULAR) scientific committees – he is now Treasurer and President Elect of EULAR serving on its Steering Committee. He is formerly Chairman of the Foundation for European Rheumatology Research (Foreum) Scientific Committee and leads the EULAR-supported European Roadmap Program that is defining the research agenda for rheumatology for the next decade.
Affiliations and expertise
Muirhead Professor of Medicine, Arthritis Research UK Professor of Rheumatology, Director of Institute of Infection,Immunity, and Inflammation, College of Medical, Veterinary, and Life Sciences, University of Glasgow, Glasgow, Scotland, United Kingdom

JO

James R. O'Dell

James R. O’Dell, MD is the Stokes Shackleford Professor of Internal Medicine, Vice-Chairman of Internal Medicine and Chief of the Division of Rheumatology at the University of Nebraska Medical Center (UNMC) in Omaha. Dr. O’Dell founded and has directed the Rheumatoid Arthritis Investigational Network (RAIN) for the last 25 years. Dr. O’Dell is the PI of the large multinational RA research study based at the VA through their cooperative studies program. Dr. O’Dell has published extensively, mostly in the area of rheumatoid arthritis. He has presented frequently at national and international meetings and has more than 100 published articles in top-level rheumatology journals. He has served on numerous American College of Rheumatology (ACR) committees over the last 20 years, including time on both the ACR and REF BOD, as well as a two-year term as President of the Research and Education Foundation of the ACR and was President of the College (2011-2012). Additionally, he is Editor-in-Chief of Up To Date for Rheumatology.
Affiliations and expertise
Bruce Professor and Vice Chairman of Internal Medicine, University of Nebraska Medical Center, Chief of Rheumatology, Department of Medicine, Omaha Veterans Affairs, Omaha, Nebraska, USA

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