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iPSCs for Modeling Central Nervous System Disorders, Volume 6
- 1st Edition - April 28, 2021
- Editor: Alexander Birbrair
- Language: English
- Paperback ISBN:9 7 8 - 0 - 3 2 3 - 8 5 7 6 4 - 2
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 8 5 6 4 2 - 3
The series Advances in Stem Cell Biology is a timely and expansive collection of comprehensive information and new discoveries in the field of stem cell biology. iPSCs… Read more
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Request a sales quoteThe series Advances in Stem Cell Biology is a timely and expansive collection of comprehensive information and new discoveries in the field of stem cell biology.
iPSCs for Modeling Central Nervous System Disorders, Volume 6 addresses how induced pluripotent stem cells can be used to model various CNS disorders.
Somatic cells can be reprogrammed into Induced pluripotent stem cells by the expression of specific transcription factors. These cells are transforming biomedical research in the last 15 years. The volume teaches readers about current advances in the field. This book describes the use of induced pluripotent stem cells to model several CNS diseases in vitro, enabling us to study the cellular and molecular mechanisms involved in different CNS pathologies. Further insights into these mechanisms will have important implications for our understanding of CNS disease appearance, development, and progression. In recent years, remarkable progress has been made in the obtention of induced pluripotent stem cells and their differentiation into several cell types, tissues and organs using state-of-art techniques. These advantages facilitated identification of key targets and definition of the molecular basis of several CNS disorders. This volume will cover what we know so far about the use of iPSCs to model different CNS disorders, such as: Alzheimer’s disease, Autism, Amyotrophic Lateral Sclerosis, Schizophrenia, Fragile X Syndrome, Spinal Muscular Atrophy, Rett Syndrome, Angelman syndrome, Parkinson`s Disease, Leber Hereditary Optic Neuropathy, Anorexia Nervosa, and more.
The volume is written for researchers and scientists interested in stem cell therapy, cell biology, regenerative medicine, and neuroscience; and is contributed by world-renowned authors in the field.
iPSCs for Modeling Central Nervous System Disorders, Volume 6 addresses how induced pluripotent stem cells can be used to model various CNS disorders.
Somatic cells can be reprogrammed into Induced pluripotent stem cells by the expression of specific transcription factors. These cells are transforming biomedical research in the last 15 years. The volume teaches readers about current advances in the field. This book describes the use of induced pluripotent stem cells to model several CNS diseases in vitro, enabling us to study the cellular and molecular mechanisms involved in different CNS pathologies. Further insights into these mechanisms will have important implications for our understanding of CNS disease appearance, development, and progression. In recent years, remarkable progress has been made in the obtention of induced pluripotent stem cells and their differentiation into several cell types, tissues and organs using state-of-art techniques. These advantages facilitated identification of key targets and definition of the molecular basis of several CNS disorders. This volume will cover what we know so far about the use of iPSCs to model different CNS disorders, such as: Alzheimer’s disease, Autism, Amyotrophic Lateral Sclerosis, Schizophrenia, Fragile X Syndrome, Spinal Muscular Atrophy, Rett Syndrome, Angelman syndrome, Parkinson`s Disease, Leber Hereditary Optic Neuropathy, Anorexia Nervosa, and more.
The volume is written for researchers and scientists interested in stem cell therapy, cell biology, regenerative medicine, and neuroscience; and is contributed by world-renowned authors in the field.
- Provides overview of the fast-moving field of induced pluripotent stem cell technology and its application in neurobiology
- Covers the following CNS diseases: Alzheimer’s disease, Autism, Amyotrophic Lateral Sclerosis, Schizophrenia, Fragile X Syndrome, Spinal Muscular Atrophy, Rett Syndrome, Angelman syndrome, Parkinson`s Disease, Leber Hereditary Optic Neuropathy, Anorexia Nervosa, and more
- Contains description of cutting-edge research on the development of disease-specific human pluripotent stem cells. These cells allow us to study cellular and molecular processes involved in several CNS human diseases
Researchers and scientists in stem cell therapy, cell biology, regenerative medicine, and organ transplantation. Graduate and undergraduate students in the above fields
- Cover image
- Title page
- Table of Contents
- Advances in Stem Cell Biology
- Copyright
- Dedication
- Contributors
- About the editor
- Preface
- Chapter 1. In vitro human stem cell–mediated central nervous system platforms: progress and challenges∗
- Introduction: early platform approaches
- Human central nervous system and induced pluripotent stem cell platform design aspirations-neuronal modeling
- Induced pluripotent stem cell central nervous system platforms-extracellular matrixes
- Initial practical decisions—specific and generic platforms
- Induced pluripotent stem cells and pharmacogenetics
- Induced pluripotent stem cell platform basic building approaches
- Induced pluripotent stem cell platform advanced building approaches
- Induced pluripotent stem cell platform imaging approaches
- Future challenges and developments
- Chapter 2. Human induced pluripotent stem cell– based modeling of Alzheimer’s disease, a glial perspective
- Introduction
- Modeling Alzheimer’s disease using human induced pluripotent stem cell-derived astrocytes
- Modeling Alzheimer’s disease using induced pluripotent stem cell-derived microglia
- Modeling Alzheimer’s disease using induced pluripotent stem cell-derived brain organoids
- Chapter 3. Human induced pluripotent stem cell-based studies; a new route toward modeling autism spectrum disorders
- Introduction
- Clinical, genetic, and epigenetic bases of autism spectrum disorders
- Studies based on induced pluripotent stem cell-derived cells
- Brain organoids as a model for neuronal development and activity in autism spectrum disorder
- The use of induced pluripotent stem cell-derived cells in the development of therapeutic strategies
- Conclusion
- Chapter 4. Induced pluripotent stem cells as models for Amyotrophic Lateral Sclerosis
- Background to Amyotrophic Lateral Sclerosis disease
- Induced pluripotent stem cell-derived cells that are relevant for modeling Amyotrophic Lateral Sclerosis: motor neurons, microglia, astrocytes, cortical cells, and Schwann cells
- Cellular and biochemical processes that recapitulate symptoms of the disease: oxidative stress (reactive oxygen species and free radicals), electric activity (microelectrode arrays), protein aggregates, inflammatory role of dendritic cells, spine and dendritic structure
- Autophagy and Amyotrophic Lateral Sclerosis
- Senescence and Amyotrophic Lateral Sclerosis
- Stepping stones to Amyotrophic Lateral Sclerosis drug discovery; potential targets; attempts and prospective
- Advantages and future directions of induced pluripotent stem cell models of Amyotrophic Lateral Sclerosis
- Summary and prospective—“disease in a dish models”
- Chapter 5. Induced pluripotent stem cells for modeling schizophrenia pathogenesis
- Introduction
- Methodological considerations in induced pluripotent stem cell-based modeling of schizophrenia
- Phenotypes of neural progenies derived from schizophrenia induced pluripotent stem cells
- Future directions and considerations
- Chapter 6. Human pluripotent stem cells in the research of Fragile X Syndrome
- Introduction
- Modeling Fragile X Syndrome in animals and in human stem cells
- Neuronal differentiation of FXS-hESCs and FXS-hiPSCs
- Role of human stem cells in the development of Fragile X Syndrome therapies
- Perspective on the research of Fragile X Syndrome using human stem cell
- Chapter 7. Induced pluripotent stem cells for modeling of spinal muscular atrophy
- Introduction
- Introduction to spinal muscular atrophy
- Model systems of spinal muscular atrophy
- Application of induced pluripotent stem cell technology in spinal muscular atrophy
- Induced pluripotent stem cell disease modeling of other spinal muscular atrophy disease relevant cells
- Future directions of induced pluripotent stem cell-derived technology in spinal muscular atrophy research
- Chapter 8. Induced pluripotent stem cells for modeling of Rett Syndrome
- Introduction
- Types of Rett syndrome
- Pathogenesis of Rett syndrome
- Methyl-CpG-binding protein 2 as epigenetic regulator
- CDKL5
- Pathogenesis of FOXG1
- Role of FOXG1 in reelin signaling pathway
- Interaction of methyl-CpG-binding protein 2, CDKL5, and FOXG1
- Common mutations in Rett syndrome
- Modeling Rett syndrome
- Organismic model for methyl-CpG-binding protein 2
- Organismic model for CDKL5
- Organismic model for FOXG1
- Induced pluripotent stem cells generation methods
- Induced pluripotent stem cells in modeling Rett Syndrome
- Induced pluripotent stem cells for methyl-CpG-binding protein 2 mutation
- Induced pluripotent stem cells generation with CDKL5 mutation
- Induced pluripotent stem cells for FOXG1
- Three-dimensional cultures for Rett syndrome
- Drugs screening and treatment
- Conclusion
- Chapter 9. Induced pluripotent stem cells for modeling Angelman syndrome
- Introduction
- Conclusions and future perspectives
- Chapter 10. Induced pluripotent stem cells for modeling of X-linked dystonia-parkinsonism
- Introduction
- Clinical, imaging, and electrophysiological features
- Genetics
- Induced pluripotent stem cell-based functional studies
- Conclusions
- Perspectives
- Chapter 11. Studying non–cell-autonomous neurodegeneration in Parkinson’s disease with induced pluripotent stem cells
- Introduction
- Non–cell-autonomous mechanism in Parkinson’s disease
- In vitro induced pluripotent stem cell glial models of Parkinson’s disease
- Future perspectives
- Chapter 12. Induced pluripotent stem cell–based leber hereditary optic neuropathy model
- Leber’s hereditary optic neuropathy
- Homoplasmy and incomplete penetrance
- Factors of retinal ganglion cell death in Leber’s hereditary optic neuropathy
- Mitochondrial biogenesis
- Traditional cell models
- Leber’s hereditary optic neuropathy induced pluripotent stem cell–based cell model
- Mitochondrial dynamics in Leber’s hereditary optic neuropathy induced pluripotent stem cell-based optic nerve
- Advances of induced pluripotent stem cell modeling in mitochondrial diseases
- Future prospects and challenges
- Chapter 13. Investigating the pathophysiology of anorexia nervosa using induced pluripotent stem cells: background, current trends, and perspectives
- Introduction
- Bain imaging studies in anorexia nervosa
- Mouse models in anorexia nervosa
- Studies using induced pluripotent stem cell and perspectives
- Conclusion
- Index
- No. of pages: 352
- Language: English
- Edition: 1
- Published: April 28, 2021
- Imprint: Academic Press
- Paperback ISBN: 9780323857642
- eBook ISBN: 9780323856423
AB
Alexander Birbrair
Dr. Alexander Birbrair received his bachelor’s biomedical degree from Santa Cruz State University in Brazil. He completed his PhD in Neuroscience, in the field of stem cell biology, at the Wake Forest School of Medicine under the mentorship of Osvaldo Delbono. Then, he joined as a postdoc in stem cell biology at Paul Frenette’s laboratory at Albert Einstein School of Medicine in New York. In 2016, he was appointed faculty at Federal University of Minas Gerais in Brazil, where he started his own lab. His laboratory is interested in understanding how the cellular components of different tissues function and control disease progression. His group explores the roles of specific cell populations in the tissue microenvironment by using state-of-the-art techniques. His research is funded by the Serrapilheira Institute, CNPq, CAPES, and FAPEMIG. In 2018, Alexander was elected affiliate member of the Brazilian Academy of Sciences (ABC), and, in 2019, he was elected member of the Global Young Academy (GYA), and in 2021, he was elected affiliate member of The World Academy of Sciences (TWAS). He is the Founding Editor and Editor-in-Chief of Current Tissue Microenvironment Reports, and Associate Editor of Molecular Biotechnology. Alexander also serves in the editorial board of several other international journals: Stem Cell Reviews and Reports, Stem Cell Research, Stem Cells and Development, and Histology and Histopathology.
Affiliations and expertise
Department of Pathology, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
Department of Radiology, Columbia University Medical Center, Medical Center, USARead iPSCs for Modeling Central Nervous System Disorders, Volume 6 on ScienceDirect