Intra-and Intermolecular Interactions, Radiation Effects in DNA Cells, and Repair Mechanisms

Contributors

Preface

Foreword

Contents Vol. 1

Contents Vol. 2


17. Renaturation of DNA in the Absence and in the Presence of Cu2+ Ions

I. Introduction

II. Renaturation Kinetics of Polynucleotides in the Absence of Cupric Ions

III. Renaturation Kinetics of DNA in the Presence of Cupric Ions

IV. Conclusion

References


18. Interactions in Nucleic Acids

I. Monomer Interactions

II. Structure and Conformation of Polynucleotides

III. Interactions between Nucleic Acids and Small Aromatic Molecules

References


19. The Polymer and Salt-induced Condensation of DNA

I. Polymer and Salt Induced Condensation

II. Volume Exclusion and Phase Separation

III. Monomolecular Condensation

IV. Interaction Properties

V. The effect on Water Activity

VI. Secondary and Tertiary Structure

VII. Collapse of Single Molecules

VIII. Folds in DNA

IX. Summary

References


20. The Interaction of Nucleotides with Bovine Pancreatic Ribonuclease

I. Introduction

II. Description of the Ribonuclease-Nucleotide Complex as Determined by X-Ray Crystallography and its Implications for Specificity

III. The Catalytic Mechanism

IV. Correlation of the Information Obtained by Other Techniques with the Model of Ribonuclease-Nucleotide Complex Obtained from X-Ray Crystalography

V. Conformational Changes of Ribonuclease

VI. Some Outstanding Problems in our Understanding of Ribonucleasenucleotide Interactions

References

Note added in Proof

Acknowledgments


21. The Measurement of Radiation-Induced Strand Breaks in the DNA of Mammalian Cells

I. Introduction

II. Experimental Techniques

III. Analysis of Data

IV. Experimental Studies of Native DNA

V. Experimental Studies of Denatured DNA

VI. The Introduction of Strand Breaks by Agencies other than High Energy Radiation

Acknowledgments

References

Note added in proof


22. Stability and Evolution of DNA from the Point of View of Molecular Radiobiology

I. Some General Evolutionary Problems: Outline of the Present Review

II. Prebiotic Evolution

III. Elements of Stabilization of Genetic Information

IV. Elements of Variability of Genetic Information

V. Increase in Genetic Information and Cellular Radiation Radiosensitivity

Acknowledgments

References

Author Index

Subject Index